Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_D10
(617 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P40123|CAP2_HUMAN Adenylyl cyclase-associated protein 2 ... 174 1e-43
sp|Q9CYT6|CAP2_MOUSE Adenylyl cyclase-associated protein 2 ... 171 2e-42
sp|P52481|CAP2_RAT Adenylyl cyclase-associated protein 2 (C... 169 5e-42
sp|Q01518|CAP1_HUMAN Adenylyl cyclase-associated protein 1 ... 167 3e-41
sp|Q08163|CAP1_RAT Adenylyl cyclase-associated protein 1 (C... 163 3e-40
sp|P40124|CAP1_MOUSE Adenylyl cyclase-associated protein 1 ... 163 3e-40
sp|P54654|CAP_DICDI Adenylyl cyclase-associated protein (CAP) 139 4e-33
sp|P36621|CAP_SCHPO Adenylyl cyclase-associated protein (CAP) 137 2e-32
sp|P40122|CAP_CHLVR Adenylyl cyclase-associated protein (CAP) 131 2e-30
sp|P17555|CAP_YEAST Adenylyl cyclase-associated protein (CAP) 115 7e-26
>sp|P40123|CAP2_HUMAN Adenylyl cyclase-associated protein 2 (CAP 2)
Length = 477
Score = 174 bits (442), Expect = 1e-43
Identities = 85/224 (37%), Positives = 130/224 (58%), Gaps = 19/224 (8%)
Frame = +1
Query: 1 WVGVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYT 180
W+ VSP P P++KEM DA+ FYTNRV+KDYK + HVDW K+++ +++ELQ+++K+H+T
Sbjct: 145 WIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHT 204
Query: 181 TGLTWSSQCAAPVATTC------------------VXXXXXXXXXXKSTADDGAADKHLA 306
TGLTWS PVA+T + + ++ A
Sbjct: 205 TGLTWSK--TGPVASTVSAFSVLSSGPGLPPPPPPLPPPGPPPLFENEGKKEESSPSRSA 262
Query: 307 LFSEINKGSEVTSGLKKVTDDMKTHKNPNLRA-GSTVPAKVKPEVAAKPGHGTKPAQVKP 483
LF+++N+G +T GL+ VTDD KT+KNP+LRA G + K + + P+Q
Sbjct: 263 LFAQLNQGEAITKGLRHVTDDQKTYKNPSLRAQGGQTQSPTKSHTPSPTSPKSYPSQKHA 322
Query: 484 ADMRLDGNKWTVEYFHNKKDIVLSDTSIKQTLYVFKCDNSVITV 615
+ L+G KW VEY ++ D+V+S+T +KQ Y+FKC+ S I +
Sbjct: 323 PVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCEKSTIQI 366
>sp|Q9CYT6|CAP2_MOUSE Adenylyl cyclase-associated protein 2 (CAP 2)
Length = 476
Score = 171 bits (432), Expect = 2e-42
Identities = 81/223 (36%), Positives = 126/223 (56%), Gaps = 18/223 (8%)
Frame = +1
Query: 1 WVGVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYT 180
W+ VSP P P++KEM DA+ FYTNRV+KDYK + HVDW ++++ +++ELQ+++++H+T
Sbjct: 145 WIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVRSYLNIWSELQAYIREHHT 204
Query: 181 TGLTWSSQCAAPVATTC------------------VXXXXXXXXXXKSTADDGAADKHLA 306
TGLTWS PVA+T + + A
Sbjct: 205 TGLTWSK--TGPVASTASAFSILSSGPGLPPPPPPPPPPGPPPPFENEDKKEEPSPSRSA 262
Query: 307 LFSEINKGSEVTSGLKKVTDDMKTHKNPNLRAGSTVPAKVKPEVAAKPGHGTKPAQVKPA 486
LF+++N+G +T GL+ VTDD KT+KNP+LRA + + K + + Q
Sbjct: 263 LFAQLNQGEAITKGLRHVTDDKKTYKNPSLRAQGQIRSPTKTHTPSPTSPKSNSPQKHTP 322
Query: 487 DMRLDGNKWTVEYFHNKKDIVLSDTSIKQTLYVFKCDNSVITV 615
+ L+G KW VEY ++ D+V+S+T +KQ Y+FKCD S + +
Sbjct: 323 VLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCDKSTLQI 365
>sp|P52481|CAP2_RAT Adenylyl cyclase-associated protein 2 (CAP 2)
Length = 477
Score = 169 bits (428), Expect = 5e-42
Identities = 80/223 (35%), Positives = 125/223 (56%), Gaps = 18/223 (8%)
Frame = +1
Query: 1 WVGVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYT 180
W+ VSP P P++KEM DA+ FYTNRV++DYK + HVDW ++++ +++ELQ+++K+H+T
Sbjct: 146 WIAVSPKPGPYVKEMNDAATFYTNRVLRDYKHSDLRHVDWVRSYLKIWSELQAYIKEHHT 205
Query: 181 TGLTWSSQCAAPVATTC------------------VXXXXXXXXXXKSTADDGAADKHLA 306
TGLTWS PVA+T + + A
Sbjct: 206 TGLTWSK--TGPVASTASAFSILSSGPGLPPPPPPPPPPGPPPPFENEGGKEEPSPSRSA 263
Query: 307 LFSEINKGSEVTSGLKKVTDDMKTHKNPNLRAGSTVPAKVKPEVAAKPGHGTKPAQVKPA 486
LF+++N+G +T GL+ VTDD K +KNP+LRA + + K + + Q
Sbjct: 264 LFAQLNQGEAITKGLRHVTDDKKIYKNPSLRAQGQIRSPTKTRTPSPTSSKSNSPQKHAP 323
Query: 487 DMRLDGNKWTVEYFHNKKDIVLSDTSIKQTLYVFKCDNSVITV 615
+ L+G KW VEY ++ D+V+S+T +KQ Y+FKCD S + +
Sbjct: 324 VLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCDKSTLQI 366
>sp|Q01518|CAP1_HUMAN Adenylyl cyclase-associated protein 1 (CAP 1)
Length = 475
Score = 167 bits (422), Expect = 3e-41
Identities = 89/224 (39%), Positives = 131/224 (58%), Gaps = 19/224 (8%)
Frame = +1
Query: 1 WVGVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYT 180
WV ++P P P++KEM DA+ FYTNRV+K+YK+ + HVDW KA+++++TELQ+++K+ +T
Sbjct: 143 WVAMAPKPGPYVKEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHT 202
Query: 181 TGLTWSSQCAAPVATTC---------------VXXXXXXXXXXKSTADDGAADKHLALFS 315
TGL WS PVA S+ D +A + ALF+
Sbjct: 203 TGLAWSK--TGPVAKELSGLPSGPSAGSGPPPPPPGPPPPPVSTSSGSDESASRS-ALFA 259
Query: 316 EINKGSEVTSGLKKVTDDMKTHKNPNLRAGS-TVPAKVKPEVAAKPGHGTKPAQV---KP 483
+IN+G +T LK V+DDMKTHKNP L+A S V + KP A KP P + +P
Sbjct: 260 QINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKRATKKEP 319
Query: 484 ADMRLDGNKWTVEYFHNKKDIVLSDTSIKQTLYVFKCDNSVITV 615
A + L+G KW VE N ++V+ DT +KQ Y++KC N+ + +
Sbjct: 320 AVLELEGKKWRVENQENVSNLVIEDTELKQVAYIYKCVNTTLQI 363
>sp|Q08163|CAP1_RAT Adenylyl cyclase-associated protein 1 (CAP 1)
Length = 474
Score = 163 bits (413), Expect = 3e-40
Identities = 91/225 (40%), Positives = 131/225 (58%), Gaps = 20/225 (8%)
Frame = +1
Query: 1 WVGVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYT 180
WV ++ P PF+KEM DA+ FYTNRV+K+Y++ + HVDW +A+++++TELQ+++K+ +T
Sbjct: 142 WVALAAKPGPFVKEMNDAAMFYTNRVLKEYRDVDKKHVDWVRAYLSIWTELQAYIKEFHT 201
Query: 181 TGLTWSSQCAAPVATTCVXXXXXXXXXX----------------KSTADDGAADKHLALF 312
TGL WS PVA S +DD A+ ALF
Sbjct: 202 TGLAWSK--TGPVAKELSGLPSGPSVGSGPPPPPPGPPPPPVPTSSGSDDSASRS--ALF 257
Query: 313 SEINKGSEVTSGLKKVTDDMKTHKNPNLRAGS-TVPAKVKPEVAAKP--GHGTKPAQVK- 480
++IN+G +T LK V+DDMKTHKNP L+A S V + KP A KP KPA K
Sbjct: 258 AQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKPATKKE 317
Query: 481 PADMRLDGNKWTVEYFHNKKDIVLSDTSIKQTLYVFKCDNSVITV 615
PA + L+G KW VE N ++V+ DT +KQ Y++KC N+ + +
Sbjct: 318 PALLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCVNTTLQI 362
>sp|P40124|CAP1_MOUSE Adenylyl cyclase-associated protein 1 (CAP 1)
Length = 474
Score = 163 bits (413), Expect = 3e-40
Identities = 91/225 (40%), Positives = 131/225 (58%), Gaps = 20/225 (8%)
Frame = +1
Query: 1 WVGVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYT 180
WV ++ P PF+KEM DA+ FYTNRV+K+Y++ + HVDW +A+++++TELQ+++K+ +T
Sbjct: 142 WVALAAKPGPFVKEMNDAAMFYTNRVLKEYRDVDKKHVDWVRAYLSIWTELQAYIKEFHT 201
Query: 181 TGLTWSSQCAAPVATTCVXXXXXXXXXX----------------KSTADDGAADKHLALF 312
TGL WS PVA S +DD A+ ALF
Sbjct: 202 TGLAWSK--TGPVAKELSGLPSGPSVGSGPPPPPPGPPPPPIPTSSGSDDSASRS--ALF 257
Query: 313 SEINKGSEVTSGLKKVTDDMKTHKNPNLRAGS-TVPAKVKPEVAAKP--GHGTKPAQVK- 480
++IN+G +T LK V+DDMKTHKNP L+A S V + KP A KP KPA K
Sbjct: 258 AQINQGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSPKPATKKE 317
Query: 481 PADMRLDGNKWTVEYFHNKKDIVLSDTSIKQTLYVFKCDNSVITV 615
PA + L+G KW VE N ++V+ DT +KQ Y++KC N+ + +
Sbjct: 318 PALLELEGKKWRVENQENVSNLVIDDTELKQVAYIYKCVNTTLQI 362
>sp|P54654|CAP_DICDI Adenylyl cyclase-associated protein (CAP)
Length = 464
Score = 139 bits (351), Expect = 4e-33
Identities = 74/214 (34%), Positives = 119/214 (55%), Gaps = 9/214 (4%)
Frame = +1
Query: 1 WVGVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYT 180
WV V P P P + EM+ +++FYTNR++K++K N VDW ++ +L+ ++K+++T
Sbjct: 151 WVVVEPTPGPHVAEMRGSAEFYTNRILKEFKGVNQDQVDWVSNYVNFLKDLEKYIKQYHT 210
Query: 181 TGLTWS-----SQCAAPVATTCVXXXXXXXXXXKSTADDGAADKHLALFSEINKGSEVTS 345
TGLTW+ ++ A P + + + A+F E++KG VTS
Sbjct: 211 TGLTWNPKGGDAKSATPAPASSAPAAPVAPAVSSTPVESKKGPGLGAVFGELSKGDGVTS 270
Query: 346 GLKKVTDDMK----THKNPNLRAGSTVPAKVKPEVAAKPGHGTKPAQVKPADMRLDGNKW 513
GLKKVT+DMK T K+ ++A T AKV A +PA L GNKW
Sbjct: 271 GLKKVTNDMKSKNFTDKSSVVKAADTKVAKV-------------DAPSRPAVFALQGNKW 317
Query: 514 TVEYFHNKKDIVLSDTSIKQTLYVFKCDNSVITV 615
++EY N K+IV+++ +QT+Y+F+C NS++ +
Sbjct: 318 SIEYQVNNKEIVIAEPDSRQTVYIFQCVNSLVQI 351
>sp|P36621|CAP_SCHPO Adenylyl cyclase-associated protein (CAP)
Length = 551
Score = 137 bits (346), Expect = 2e-32
Identities = 79/235 (33%), Positives = 117/235 (49%), Gaps = 30/235 (12%)
Frame = +1
Query: 1 WVGVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYT 180
WV V P P F+ EM+D+SQFY NRV+K++K K+ ++W ++++ + TEL ++VK H+
Sbjct: 207 WVTVEPTPLSFMSEMKDSSQFYANRVMKEFKGKDDLQIEWVRSYLTLLTELITYVKTHFK 266
Query: 181 TGLTWSSQCAAPVATTCVXXXXXXXXXXKSTAD--------------------------- 279
TGLTWS++ A T + S+ D
Sbjct: 267 TGLTWSTKQDAVPLKTALANLSASKTQAPSSGDSANGGLPPPPPPPPPSNDFWKDSNEPA 326
Query: 280 --DGAADKHLALFSEINKGSEVTSGLKKVTDDMKTHKNPNLRAGSTVPAKVKPEV-AAKP 450
D D A+F+EINKG +TSGL+KV THKNPNLR P KP++ ++ P
Sbjct: 327 PADNKGDMG-AVFAEINKGEGITSGLRKVDKSEMTHKNPNLRKTGPTPGP-KPKIKSSAP 384
Query: 451 GHGTKPAQVKPADMRLDGNKWTVEYFHNKKDIVLSDTSIKQTLYVFKCDNSVITV 615
+ A VKP + L+ KW VE + IVL + ++ +F C N I +
Sbjct: 385 SKPAETAPVKPPRIELENTKWFVENQVDNHSIVLDSVELNHSVQIFGCSNCTIII 439
>sp|P40122|CAP_CHLVR Adenylyl cyclase-associated protein (CAP)
Length = 481
Score = 131 bits (329), Expect = 2e-30
Identities = 73/232 (31%), Positives = 121/232 (52%), Gaps = 27/232 (11%)
Frame = +1
Query: 1 WVGVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYT 180
WVGV+P P +I++M++++QFYTN+++K+++E + +W +++ + ++VK H+
Sbjct: 137 WVGVAPKPVLYIQQMEESAQFYTNKLLKEFRESDPKQANWATSFIQLLKGFAAYVKDHHQ 196
Query: 181 TGLTWSSQ-CAAPVATTCVXXXXXXXXXXKS-------------------TADDGAADKH 300
GL W+ + AA A V S T + D
Sbjct: 197 AGLMWNKEKSAATPAALAVSAHKPPVPPPPSGFAPPPPPPIQAPTVTHAVTGSHSSEDSR 256
Query: 301 LALFSEINKGSEVTSGLKKVTDDMKTHKNPNLRAGSTVPAK-------VKPEVAAKPGHG 459
LF++++KGSEVT+GLKKVTDDMKTHKNP LR + + P +
Sbjct: 257 SQLFAQLSKGSEVTAGLKKVTDDMKTHKNPELRNQPPLKSSALDPRPYTPPNLKKFSAPV 316
Query: 460 TKPAQVKPADMRLDGNKWTVEYFHNKKDIVLSDTSIKQTLYVFKCDNSVITV 615
+KPA+ KPA +L KW +E ++ +S+ + KQT+Y++KC S + +
Sbjct: 317 SKPAK-KPALFQLQNKKWVIENQDGNTNLEISECNDKQTVYMYKCHASKVHI 367
>sp|P17555|CAP_YEAST Adenylyl cyclase-associated protein (CAP)
Length = 526
Score = 115 bits (289), Expect = 7e-26
Identities = 69/241 (28%), Positives = 118/241 (48%), Gaps = 36/241 (14%)
Frame = +1
Query: 1 WVGVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYT 180
WV V P + + +DA+QF+TNR++K+Y+E + V+W K ++A F L++++K+++T
Sbjct: 179 WVAVD-TPVSMVTDFKDAAQFWTNRILKEYRESDPNAVEWVKKFLASFDNLKAYIKEYHT 237
Query: 181 TGLTW--------------------------SSQCAAPVAT-------TCVXXXXXXXXX 261
TG++W +S AAP V
Sbjct: 238 TGVSWKKDGMDFADAMAQSTKNTGATSSPSPASATAAPAPPPPPPAPPASVFEISNDTPA 297
Query: 262 XKSTADDGAADKHLALFSEINKGSEVTSGLKKVTDDMKTHKNPNLRAGSTVPAKVKPEVA 441
S A+ G A+F+E+N+G +T GLKKV +THKNP LR STV + +
Sbjct: 298 TSSDANKGGIG---AVFAELNQGENITKGLKKVDKSQQTHKNPELRQSSTVSS--TGSKS 352
Query: 442 AKPGHGTKPAQVK---PADMRLDGNKWTVEYFHNKKDIVLSDTSIKQTLYVFKCDNSVIT 612
P KP+ +K P L GNKW +E + N+ + ++ D + +++++ KC ++
Sbjct: 353 GPPPRPKKPSTLKTKRPPRKELVGNKWFIENYENETESLVIDANKDESIFIGKCSQVLVQ 412
Query: 613 V 615
+
Sbjct: 413 I 413
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.315 0.127 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,639,409
Number of Sequences: 369166
Number of extensions: 1185317
Number of successful extensions: 4187
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4014
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4172
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4895780500
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)