Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_A08
(687 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P49606|CYAA_USTMA Adenylate cyclase (ATP pyrophosphate-l... 80 7e-15
sp|Q921G6|LRCH4_MOUSE Leucine-rich repeats and calponin hom... 77 3e-14
sp|Q9UQ13|SHOC2_HUMAN Leucine-rich repeat protein SHOC-2 (R... 75 2e-13
sp|O88520|SHOC2_MOUSE Leucine-rich repeat protein SHOC-2 (R... 75 2e-13
sp|O61967|LAP1_CAEEL Lap1 protein (Lethal protein 413) 74 3e-13
sp|Q80VQ1|LRRC1_MOUSE Leucine-rich repeat-containing protein 1 74 4e-13
sp|O75427|LRCH4_HUMAN Leucine-rich repeats and calponin hom... 74 4e-13
sp|Q8CHE4|PHLPP_MOUSE PH domain leucine-rich repeat protein... 73 8e-13
sp|Q9BYS8|LRRC2_HUMAN Leucine-rich repeat-containing protein 2 72 2e-12
sp|P34268|FLII_CAEEL Flightless-I protein homolog 70 4e-12
>sp|P49606|CYAA_USTMA Adenylate cyclase (ATP pyrophosphate-lyase) (Adenylyl cyclase)
Length = 2493
Score = 79.7 bits (195), Expect = 7e-15
Identities = 39/96 (40%), Positives = 60/96 (62%)
Frame = +2
Query: 92 NLKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQ 271
++ LR+L+++NN+F+ FP+V+C++ SL D S N I +P I NL LE F+L N+
Sbjct: 1201 SISTLRNLNISNNRFEEFPKVICDVPSLVDLDVSFNSITELPAEIANLINLERFILAGNE 1260
Query: 272 LESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKL 379
LE LPD + EL+ LR + L NK+ + G +L
Sbjct: 1261 LEKLPDSMSELVSLRTIDLRRNKVQDVSSLLGLPRL 1296
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/144 (32%), Positives = 68/144 (47%), Gaps = 22/144 (15%)
Frame = +2
Query: 104 LRSLHVANNKF-DTFPEVVCEISSLEFFDASDNMIRSIPK-SIRNLKVLETFMLYENQLE 277
L+ L + +N+ D V+ E++SLE + S N I IP S++ L L + NQL
Sbjct: 1512 LQKLRLGDNRLGDDVFSVLSELTSLEVLNLSFNEIFEIPDFSLQTLTKLRELYISGNQLS 1571
Query: 278 SLP-DELCELIQLRCLWLGNNKLTQLPKQFGRLKLL-------------------DWSWH 397
++P D+L L +LR L L NKLT LP + G+LK L DW+W+
Sbjct: 1572 TIPSDDLVVLQELRILHLNCNKLTTLPTELGKLKKLANLDVGNNVLKYNIANWHYDWNWN 1631
Query: 398 YTSTTLDGNPLQHPTLEICKKGAD 469
N + LEI K +D
Sbjct: 1632 MNPELRYLNLSGNTRLEIKTKLSD 1655
Score = 47.4 bits (111), Expect = 4e-05
Identities = 25/87 (28%), Positives = 46/87 (52%)
Frame = +2
Query: 95 LKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQL 274
L L L + N+ P+ + ++ LE S+N++ ++P+SI +LK L+ +++ N L
Sbjct: 1361 LPALVKLTLDGNQLVVLPDTLGDLKRLEMLSCSNNLLATLPESIGDLKALKELLVHNNNL 1420
Query: 275 ESLPDELCELIQLRCLWLGNNKLTQLP 355
++LP L L + L +N L P
Sbjct: 1421 KTLPQTLWLCESLAHINLSSNLLESFP 1447
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/75 (38%), Positives = 37/75 (49%)
Frame = +2
Query: 158 CEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNN 337
C+++SL+ +S NM R L L L NQL LPD L +L +L L NN
Sbjct: 1338 CDLTSLDL--SSTNMTRLEEGLFPQLPALVKLTLDGNQLVVLPDTLGDLKRLEMLSCSNN 1395
Query: 338 KLTQLPKQFGRLKLL 382
L LP+ G LK L
Sbjct: 1396 LLATLPESIGDLKAL 1410
Score = 37.4 bits (85), Expect = 0.037
Identities = 21/71 (29%), Positives = 32/71 (45%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P +G L LE ++ I +LK L+ L V NN T P+ + SL
Sbjct: 1377 LPDTLGDLKRLEMLSCSNNLLATLPESIGDLKALKELLVHNNNLKTLPQTLWLCESLAHI 1436
Query: 185 DASDNMIRSIP 217
+ S N++ S P
Sbjct: 1437 NLSSNLLESFP 1447
Score = 36.6 bits (83), Expect = 0.064
Identities = 19/65 (29%), Positives = 36/65 (55%)
Frame = +2
Query: 92 NLKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQ 271
+LK+L L +NN T PE + ++ +L+ +N ++++P+++ + L L N
Sbjct: 1383 DLKRLEMLSCSNNLLATLPESIGDLKALKELLVHNNNLKTLPQTLWLCESLAHINLSSNL 1442
Query: 272 LESLP 286
LES P
Sbjct: 1443 LESFP 1447
Score = 35.4 bits (80), Expect = 0.14
Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 2/93 (2%)
Frame = +2
Query: 110 SLHVANNKFDTFP-EVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLESLP 286
SL ++ N P + V SSL S+ ++ IP+S+R+ + L + N++ L
Sbjct: 1113 SLDLSGNPMSDLPLDFVQLCSSLRTLRLSNLALKRIPQSVRHSETLTHLDVSNNRIVELA 1172
Query: 287 DELCELI-QLRCLWLGNNKLTQLPKQFGRLKLL 382
+LI +L L + NN+L LP F + L
Sbjct: 1173 HVSLDLIPELMSLKVQNNRLFDLPSYFSSISTL 1205
Score = 33.1 bits (74), Expect = 0.70
Identities = 18/54 (33%), Positives = 30/54 (55%)
Frame = +2
Query: 197 NMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPK 358
N + +P ++ +LK LE N L +LP+ + +L L+ L + NN L LP+
Sbjct: 1372 NQLVVLPDTLGDLKRLEMLSCSNNLLATLPESIGDLKALKELLVHNNNLKTLPQ 1425
>sp|Q921G6|LRCH4_MOUSE Leucine-rich repeats and calponin homology domain containing
protein 4
Length = 680
Score = 77.4 bits (189), Expect = 3e-14
Identities = 47/127 (37%), Positives = 68/127 (53%)
Frame = +2
Query: 104 LRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLESL 283
LR L ++NNK P + + SL D S N ++S+P + +L+ L + NQL +L
Sbjct: 138 LRVLIISNNKLGALPPDISTLGSLRQLDVSSNELQSLPVELCSLRSLRDLNVRRNQLSTL 197
Query: 284 PDELCELIQLRCLWLGNNKLTQLPKQFGRLKLLDWSWHYTSTTLDGNPLQHPTLEICKKG 463
PDEL +L +R L N+++++P F RL+ H LD NPLQ P +IC KG
Sbjct: 198 PDELGDLPLVR-LDFSCNRISRIPVSFCRLR------HLQVVLLDSNPLQSPPAQICLKG 250
Query: 464 ADEIEKY 484
I KY
Sbjct: 251 KLHIFKY 257
Score = 60.5 bits (145), Expect = 4e-09
Identities = 40/124 (32%), Positives = 59/124 (47%), Gaps = 3/124 (2%)
Frame = +2
Query: 92 NLKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQ 271
+L + ++ N+F PE C++ SLE N ++ + ++ NL L L NQ
Sbjct: 66 DLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLKCLNPALGNLTALTYLNLSRNQ 125
Query: 272 LESLPDELCELIQLRCLWLGNNKLTQLP---KQFGRLKLLDWSWHYTSTTLDGNPLQHPT 442
L SLP +C+L LR L + NNKL LP G L+ LD + N LQ
Sbjct: 126 LSSLPPYICQL-PLRVLIISNNKLGALPPDISTLGSLRQLD---------VSSNELQSLP 175
Query: 443 LEIC 454
+E+C
Sbjct: 176 VELC 179
>sp|Q9UQ13|SHOC2_HUMAN Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8)
Length = 582
Score = 75.1 bits (183), Expect = 2e-13
Identities = 43/121 (35%), Positives = 62/121 (51%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P E+G L NL +A + NLKKLR L + +NK P VV + SL
Sbjct: 138 LPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTL 197
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
N I ++ K I+NL L + EN+++ LP E+ EL L L + +N+L LPK+
Sbjct: 198 YLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEI 257
Query: 365 G 367
G
Sbjct: 258 G 258
Score = 66.6 bits (161), Expect = 6e-11
Identities = 44/113 (38%), Positives = 61/113 (53%)
Frame = +2
Query: 113 LHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDE 292
L++A N+ PE V + SLE S+N+++ +P + NL+ L L EN+LESLP+E
Sbjct: 407 LNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNE 466
Query: 293 LCELIQLRCLWLGNNKLTQLPKQFGRLKLLDWSWHYTSTTLDGNPLQHPTLEI 451
+ L L+ L L NN+LT LP+ G L L T L N L H EI
Sbjct: 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNL------THLGLGENLLTHLPEEI 513
Score = 63.5 bits (153), Expect = 5e-10
Identities = 42/152 (27%), Positives = 68/152 (44%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P + G T++ + ++ L L L ++NN P + + L
Sbjct: 394 LPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLREL 453
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
D +N + S+P I LK L+ +L NQL +LP + L L L LG N LT LP++
Sbjct: 454 DLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEI 513
Query: 365 GRLKLLDWSWHYTSTTLDGNPLQHPTLEICKK 460
G L+ L+ + + L P + L +C K
Sbjct: 514 GTLENLEELYLNDNPNLHSLPFE---LALCSK 542
Score = 58.9 bits (141), Expect = 1e-08
Identities = 32/101 (31%), Positives = 49/101 (48%)
Frame = +2
Query: 83 EIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLY 262
+IKNL KL L + NK P + E+ +L D + N + +PK I N + L
Sbjct: 210 DIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQ 269
Query: 263 ENQLESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLLD 385
N+L LPD + L L L L N+L+ +P+ + L+
Sbjct: 270 HNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALE 310
Score = 52.4 bits (124), Expect = 1e-06
Identities = 32/123 (26%), Positives = 54/123 (43%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P I LT L + E+ L L +L ++ N + P+ + + L
Sbjct: 115 LPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRML 174
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
D N +R IP + L L T L N++ ++ ++ L +L L + NK+ QLP +
Sbjct: 175 DLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEI 234
Query: 365 GRL 373
G L
Sbjct: 235 GEL 237
Score = 52.4 bits (124), Expect = 1e-06
Identities = 32/99 (32%), Positives = 50/99 (50%)
Frame = +2
Query: 86 IKNLKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYE 265
IK L +L L++ +NK + P V + +L S+N + S+P S+ NLK L L
Sbjct: 119 IKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRH 178
Query: 266 NQLESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLL 382
N+L +P + L L L+L N++T + K L L
Sbjct: 179 NKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKL 217
Score = 50.4 bits (119), Expect = 4e-06
Identities = 36/104 (34%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Frame = +2
Query: 86 IKNLKKLRS-----LHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLET 250
IK L K R L ++ P + E++ L N ++S+P + L L T
Sbjct: 91 IKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMT 150
Query: 251 FMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLL 382
L EN L SLPD L L +LR L L +NKL ++P RL L
Sbjct: 151 LALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSL 194
Score = 50.4 bits (119), Expect = 4e-06
Identities = 32/112 (28%), Positives = 52/112 (46%), Gaps = 1/112 (0%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P EIG L NL + EI N ++ +L + +N+ P+ + +SSL
Sbjct: 230 LPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRL 289
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDE-LCELIQLRCLWLGNN 337
N + +IP+S+ LE L N + +LP+ L L++L L L N
Sbjct: 290 GLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARN 341
Score = 49.7 bits (117), Expect = 7e-06
Identities = 33/118 (27%), Positives = 55/118 (46%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
V K+I L+ L ++ EI L L +L VA+N+ + P+ + + +
Sbjct: 207 VEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNL 266
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPK 358
D N + +P +I NL L L N+L ++P L + L L L NN ++ LP+
Sbjct: 267 DLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPE 324
Score = 43.5 bits (101), Expect = 5e-04
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 1/92 (1%)
Frame = +2
Query: 110 SLHVANNKFDTFP-EVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLESLP 286
SL++ +N+ + P + L + DN + S+P + L NQL +P
Sbjct: 359 SLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIP 418
Query: 287 DELCELIQLRCLWLGNNKLTQLPKQFGRLKLL 382
+++ L+ L L L NN L +LP G L+ L
Sbjct: 419 EDVSGLVSLEVLILSNNLLKKLPHGLGNLRKL 450
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 2/102 (1%)
Frame = +2
Query: 86 IKNLKKLRSLHVANNKFDTFPEV-VCEISSLEFFDASDNMIRSIPKSI-RNLKVLETFML 259
+ +L KL SL +A N F +P + S++ + N I IP I KVL +
Sbjct: 327 LSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNM 386
Query: 260 YENQLESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLLD 385
+NQL SLP + + L L N+LT++P+ L L+
Sbjct: 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLE 428
>sp|O88520|SHOC2_MOUSE Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8)
Length = 582
Score = 74.7 bits (182), Expect = 2e-13
Identities = 43/121 (35%), Positives = 62/121 (51%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P E+G L NL +A + NLKKLR L + +NK P VV + SL
Sbjct: 138 LPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTL 197
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
N I ++ K I+NL L + EN+++ LP E+ EL L L + +N+L LPK+
Sbjct: 198 YLRFNRITTVEKDIKNLPKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEI 257
Query: 365 G 367
G
Sbjct: 258 G 258
Score = 65.1 bits (157), Expect = 2e-10
Identities = 43/113 (38%), Positives = 61/113 (53%)
Frame = +2
Query: 113 LHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDE 292
L++A N+ PE V + SLE S+N+++ +P + NL+ L L EN+LESLP+E
Sbjct: 407 LNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNE 466
Query: 293 LCELIQLRCLWLGNNKLTQLPKQFGRLKLLDWSWHYTSTTLDGNPLQHPTLEI 451
+ L L+ L L NN+L+ LP+ G L L T L N L H EI
Sbjct: 467 IAYLKDLQKLVLTNNQLSTLPRGIGHLTNL------THLGLGENLLTHLPEEI 513
Score = 63.9 bits (154), Expect = 4e-10
Identities = 42/152 (27%), Positives = 68/152 (44%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P + G T++ + ++ L L L ++NN P + + L
Sbjct: 394 LPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLREL 453
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
D +N + S+P I LK L+ +L NQL +LP + L L L LG N LT LP++
Sbjct: 454 DLEENKLESLPNEIAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHLGLGENLLTHLPEEI 513
Query: 365 GRLKLLDWSWHYTSTTLDGNPLQHPTLEICKK 460
G L+ L+ + + L P + L +C K
Sbjct: 514 GTLENLEELYLNDNPNLHSLPFE---LALCSK 542
Score = 58.2 bits (139), Expect = 2e-08
Identities = 32/101 (31%), Positives = 48/101 (47%)
Frame = +2
Query: 83 EIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLY 262
+IKNL KL L + NK P + E+ +L D + N + +PK I N + L
Sbjct: 210 DIKNLPKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQ 269
Query: 263 ENQLESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLLD 385
N L LPD + L L L L N+L+ +P+ + L+
Sbjct: 270 HNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALE 310
Score = 51.6 bits (122), Expect = 2e-06
Identities = 31/99 (31%), Positives = 50/99 (50%)
Frame = +2
Query: 86 IKNLKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYE 265
+K L +L L++ +NK + P V + +L S+N + S+P S+ NLK L L
Sbjct: 119 VKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRH 178
Query: 266 NQLESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLL 382
N+L +P + L L L+L N++T + K L L
Sbjct: 179 NKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLPKL 217
Score = 51.2 bits (121), Expect = 2e-06
Identities = 31/123 (25%), Positives = 54/123 (43%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P + LT L + E+ L L +L ++ N + P+ + + L
Sbjct: 115 LPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRML 174
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
D N +R IP + L L T L N++ ++ ++ L +L L + NK+ QLP +
Sbjct: 175 DLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLPKLSMLSIRENKIKQLPAEI 234
Query: 365 GRL 373
G L
Sbjct: 235 GEL 237
Score = 50.4 bits (119), Expect = 4e-06
Identities = 37/104 (35%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Frame = +2
Query: 86 IKNLKKLRS-----LHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLET 250
IK L K R L ++ P V E++ L N ++S+P + L L T
Sbjct: 91 IKELNKCREENSMRLDLSKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMT 150
Query: 251 FMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLL 382
L EN L SLPD L L +LR L L +NKL ++P RL L
Sbjct: 151 LALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSL 194
Score = 49.7 bits (117), Expect = 7e-06
Identities = 32/112 (28%), Positives = 51/112 (45%), Gaps = 1/112 (0%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P EIG L NL + EI N ++ +L + +N P+ + +SSL
Sbjct: 230 LPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNDLLDLPDTIGNLSSLNRL 289
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDE-LCELIQLRCLWLGNN 337
N + +IP+S+ LE L N + +LP+ L L++L L L N
Sbjct: 290 GLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARN 341
Score = 48.5 bits (114), Expect = 2e-05
Identities = 33/118 (27%), Positives = 54/118 (45%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
V K+I L L ++ EI L L +L VA+N+ + P+ + + +
Sbjct: 207 VEKDIKNLPKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNL 266
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPK 358
D N + +P +I NL L L N+L ++P L + L L L NN ++ LP+
Sbjct: 267 DLQHNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPE 324
Score = 43.5 bits (101), Expect = 5e-04
Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 1/92 (1%)
Frame = +2
Query: 110 SLHVANNKFDTFP-EVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLESLP 286
SL++ +N+ + P + L + DN + S+P + L NQL +P
Sbjct: 359 SLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIP 418
Query: 287 DELCELIQLRCLWLGNNKLTQLPKQFGRLKLL 382
+++ L+ L L L NN L +LP G L+ L
Sbjct: 419 EDVSGLVSLEVLILSNNLLKKLPHGLGNLRKL 450
Score = 42.0 bits (97), Expect = 0.002
Identities = 33/130 (25%), Positives = 59/130 (45%), Gaps = 3/130 (2%)
Frame = +2
Query: 2 HVPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEF 181
H+PKEIG T + + I NL L L + N+ P + + S+LE
Sbjct: 252 HLPKEIGNCTQITNLDLQHNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEE 311
Query: 182 FDASDNMIRSIPKS-IRNLKVLETFMLYENQLESLP-DELCELIQLRCLWLGNNKLTQLP 355
+ +N I ++P+S + +L L + L N + P + + L + +N++ ++P
Sbjct: 312 LNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIP 371
Query: 356 -KQFGRLKLL 382
F R K+L
Sbjct: 372 FGIFSRAKVL 381
Score = 41.2 bits (95), Expect = 0.003
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 2/102 (1%)
Frame = +2
Query: 86 IKNLKKLRSLHVANNKFDTFPEV-VCEISSLEFFDASDNMIRSIPKSI-RNLKVLETFML 259
+ +L KL SL +A N F +P + S++ + N I IP I KVL +
Sbjct: 327 LSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNM 386
Query: 260 YENQLESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLLD 385
+NQL SLP + + L L N+LT++P+ L L+
Sbjct: 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLE 428
>sp|O61967|LAP1_CAEEL Lap1 protein (Lethal protein 413)
Length = 699
Score = 74.3 bits (181), Expect = 3e-13
Identities = 48/150 (32%), Positives = 72/150 (48%), Gaps = 23/150 (15%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISS---- 172
+P EIG LT L + ++N K L +L++++N F PE +CE SS
Sbjct: 74 LPAEIGNLTQLIELNLNRNSIAKLPDTMQNCKLLTTLNLSSNPFTRLPETICECSSITIL 133
Query: 173 -------------------LEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDEL 295
L +A DN++R+IP SI L+ LE L +N+LE+LP E+
Sbjct: 134 SLNETSLTLLPSNIGSLTNLRVLEARDNLLRTIPLSIVELRKLEELDLGQNELEALPAEI 193
Query: 296 CELIQLRCLWLGNNKLTQLPKQFGRLKLLD 385
+L LR ++ N LT LP ++LD
Sbjct: 194 GKLTSLREFYVDINSLTSLPDSISGCRMLD 223
Score = 68.9 bits (167), Expect = 1e-11
Identities = 46/151 (30%), Positives = 70/151 (46%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P IG LTNL + I L+KL L + N+ + P + +++SL F
Sbjct: 143 LPSNIGSLTNLRVLEARDNLLRTIPLSIVELRKLEELDLGQNELEALPAEIGKLTSLREF 202
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
N + S+P SI ++L+ + ENQ+ LP+ L + L L + N++ +LP F
Sbjct: 203 YVDINSLTSLPDSISGCRMLDQLDVSENQIIRLPENLGRMPNLTDLNISINEIIELPSSF 262
Query: 365 GRLKLLDWSWHYTSTTLDGNPLQHPTLEICK 457
G LK L D N L + T EI K
Sbjct: 263 GELKRLQ------MLKADRNSLHNLTSEIGK 287
Score = 55.8 bits (133), Expect = 1e-07
Identities = 33/123 (26%), Positives = 55/123 (44%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P +I LE + + +L+ LR L V++N+ P + ++ L
Sbjct: 28 IPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELAVLPAEIGNLTQLIEL 87
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
+ + N I +P +++N K+L T L N LP+ +CE + L L LT LP
Sbjct: 88 NLNRNSIAKLPDTMQNCKLLTTLNLSSNPFTRLPETICECSSITILSLNETSLTLLPSNI 147
Query: 365 GRL 373
G L
Sbjct: 148 GSL 150
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/126 (24%), Positives = 51/126 (40%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P+ +G + NL + LK+L+ L N + + SL
Sbjct: 235 LPENLGRMPNLTDLNISINEIIELPSSFGELKRLQMLKADRNSLHNLTSEIGKCQSLTEL 294
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
N + +P +I +L+ L T + N L +PD + L L L N LT+LP
Sbjct: 295 YLGQNFLTDLPDTIGDLRQLTTLNVDCNNLSDIPDTIGNCKSLTVLSLRQNILTELPMTI 354
Query: 365 GRLKLL 382
G+ + L
Sbjct: 355 GKCENL 360
Score = 41.6 bits (96), Expect = 0.002
Identities = 30/120 (25%), Positives = 52/120 (43%)
Frame = +2
Query: 98 KKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLE 277
+++ S+ + + P + LE + + N I+ + + +L+ L + +N+L
Sbjct: 13 RQVDSIDRSQSNLQAIPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELA 72
Query: 278 SLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLLDWSWHYTSTTLDGNPLQHPTLEICK 457
LP E+ L QL L L N + +LP KLL T+ L NP IC+
Sbjct: 73 VLPAEIGNLTQLIELNLNRNSIAKLPDTMQNCKLL------TTLNLSSNPFTRLPETICE 126
>sp|Q80VQ1|LRRC1_MOUSE Leucine-rich repeat-containing protein 1
Length = 524
Score = 73.9 bits (180), Expect = 4e-13
Identities = 43/127 (33%), Positives = 67/127 (52%)
Frame = +2
Query: 2 HVPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEF 181
++P+ IG L +L+ + EI NLK L L V+ N+ + PE + ++SL +
Sbjct: 188 NLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTY 247
Query: 182 FDASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQ 361
S N++ +IP+ I LK L L +N+L LP+ + + L L L N+L LPK
Sbjct: 248 LVISQNLLETIPEGIGKLKKLSILKLDQNRLTQLPEAIGDCENLTELVLTENRLLTLPKS 307
Query: 362 FGRLKLL 382
G+LK L
Sbjct: 308 IGKLKKL 314
Score = 62.8 bits (151), Expect = 8e-10
Identities = 38/126 (30%), Positives = 60/126 (47%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P+ IG L NL + + L++L L + NN+ PE + + L+
Sbjct: 143 LPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDL 202
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
N + +P+ I NLK L + EN+LE LP+E+ L L L + N L +P+
Sbjct: 203 WLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTYLVISQNLLETIPEGI 262
Query: 365 GRLKLL 382
G+LK L
Sbjct: 263 GKLKKL 268
Score = 62.0 bits (149), Expect = 1e-09
Identities = 47/149 (31%), Positives = 65/149 (43%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P EI L + I K L+ + N PE E+ +L
Sbjct: 74 LPPEIANFMQLVELDVSRNDIPEIPESIAFCKALQVADFSGNPLTRLPESFPELQNLTCL 133
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
+D ++S+P++I NL L + L EN L LPD L +L +L L LGNN++ LP+
Sbjct: 134 SVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESI 193
Query: 365 GRLKLLDWSWHYTSTTLDGNPLQHPTLEI 451
G L L W LDGN L EI
Sbjct: 194 GALLHLKDLW------LDGNQLSELPQEI 216
Score = 60.1 bits (144), Expect = 5e-09
Identities = 30/96 (31%), Positives = 55/96 (57%)
Frame = +2
Query: 95 LKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQL 274
L+ L L V + + PE + + +L + +N++ +P S+ L+ LE L N++
Sbjct: 127 LQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEI 186
Query: 275 ESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLL 382
+LP+ + L+ L+ LWL N+L++LP++ G LK L
Sbjct: 187 YNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNL 222
Score = 59.7 bits (143), Expect = 7e-09
Identities = 39/128 (30%), Positives = 60/128 (46%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P+ L NL ++ I NL L SL + N P+ + ++ LE
Sbjct: 120 LPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEEL 179
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
D +N I ++P+SI L L+ L NQL LP E+ L L CL + N+L +LP++
Sbjct: 180 DLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEI 239
Query: 365 GRLKLLDW 388
L L +
Sbjct: 240 SGLTSLTY 247
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/152 (28%), Positives = 69/152 (45%), Gaps = 3/152 (1%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P+EI LT+L + I LKKL L + N+ PE + + +L
Sbjct: 235 LPEEISGLTSLTYLVISQNLLETIPEGIGKLKKLSILKLDQNRLTQLPEAIGDCENLTEL 294
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
++N + ++PKSI LK L N+L SLP E+ L + +N+LT+LP +
Sbjct: 295 VLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTMFCIRDNRLTRLPAEV 354
Query: 365 GR---LKLLDWSWHYTSTTLDGNPLQHPTLEI 451
+ L +LD + GN L H L +
Sbjct: 355 SQAVELHVLD---------VAGNRLHHLPLSL 377
Score = 57.0 bits (136), Expect = 5e-08
Identities = 33/122 (27%), Positives = 59/122 (48%)
Frame = +2
Query: 2 HVPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEF 181
++P + L LE + I L L+ L + N+ P+ + + +L
Sbjct: 165 YLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLC 224
Query: 182 FDASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQ 361
D S+N + +P+ I L L ++ +N LE++P+ + +L +L L L N+LTQLP+
Sbjct: 225 LDVSENRLERLPEEISGLTSLTYLVISQNLLETIPEGIGKLKKLSILKLDQNRLTQLPEA 284
Query: 362 FG 367
G
Sbjct: 285 IG 286
Score = 54.7 bits (130), Expect = 2e-07
Identities = 35/127 (27%), Positives = 57/127 (44%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P++ L L ++ EI N +L L V+ N PE + +L+
Sbjct: 51 LPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESIAFCKALQVA 110
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
D S N + +P+S L+ L + + L+SLP+ + L L L L N LT LP
Sbjct: 111 DFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSL 170
Query: 365 GRLKLLD 385
+L+ L+
Sbjct: 171 TQLRRLE 177
Score = 53.9 bits (128), Expect = 4e-07
Identities = 34/125 (27%), Positives = 57/125 (45%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
+P+ IG L L + I + + L L + N+ T P+ + ++ L
Sbjct: 258 IPEGIGKLKKLSILKLDQNRLTQLPEAIGDCENLTELVLTENRLLTLPKSIGKLKKLSNL 317
Query: 185 DASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQF 364
+A N + S+PK I L F + +N+L LP E+ + ++L L + N+L LP
Sbjct: 318 NADRNKLVSLPKEIGGCCSLTMFCIRDNRLTRLPAEVSQAVELHVLDVAGNRLHHLPLSL 377
Query: 365 GRLKL 379
LKL
Sbjct: 378 TTLKL 382
Score = 40.4 bits (93), Expect = 0.004
Identities = 25/95 (26%), Positives = 41/95 (43%)
Frame = +2
Query: 98 KKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLE 277
+ L L + N+ PE ++ L SDN I+ +P I N L + N +
Sbjct: 36 RSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIP 95
Query: 278 SLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLL 382
+P+ + L+ N LT+LP+ F L+ L
Sbjct: 96 EIPESIAFCKALQVADFSGNPLTRLPESFPELQNL 130
Score = 38.5 bits (88), Expect = 0.017
Identities = 20/58 (34%), Positives = 34/58 (58%), Gaps = 1/58 (1%)
Frame = +2
Query: 212 IPKSI-RNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLL 382
+P+ I R + LE +L NQL LP++ +L++LR L L +N++ +LP + L
Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQL 84
>sp|O75427|LRCH4_HUMAN Leucine-rich repeats and calponin homology domain containing
protein 4 (Leucine-rich neuronal protein)
Length = 683
Score = 73.9 bits (180), Expect = 4e-13
Identities = 46/127 (36%), Positives = 66/127 (51%)
Frame = +2
Query: 104 LRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLESL 283
LR L V+NNK P + + SL D S N ++S+P + L L + NQL +L
Sbjct: 138 LRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTL 197
Query: 284 PDELCELIQLRCLWLGNNKLTQLPKQFGRLKLLDWSWHYTSTTLDGNPLQHPTLEICKKG 463
P+EL +L +R L N+++++P F RL+ H LD NPLQ P ++C KG
Sbjct: 198 PEELGDLPLVR-LDFSCNRVSRIPVSFCRLR------HLQVILLDSNPLQSPPAQVCLKG 250
Query: 464 ADEIEKY 484
I KY
Sbjct: 251 KLHIFKY 257
>sp|Q8CHE4|PHLPP_MOUSE PH domain leucine-rich repeat protein phosphatase (Pleckstrin
homology domain containing family E protein 1)
(Suprachiasmatic nucleus circadian oscillatory protein)
Length = 1687
Score = 72.8 bits (177), Expect = 8e-13
Identities = 37/101 (36%), Positives = 61/101 (60%)
Frame = +2
Query: 83 EIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLY 262
E++ KL+SL+++NN FP VC I +L + S N +R +P ++ +++ L+TF+L
Sbjct: 642 ELQRFTKLKSLNLSNNHLGAFPSAVCSIPTLAELNVSCNALREVPAAVGDMQNLQTFLLD 701
Query: 263 ENQLESLPDELCELIQLRCLWLGNNKLTQLPKQFGRLKLLD 385
N L+SLP EL + QL L L N+ T +P+ +L +D
Sbjct: 702 GNFLQSLPAELESMHQLSYLGLSFNEFTDIPEVLEKLTAVD 742
Score = 54.7 bits (130), Expect = 2e-07
Identities = 39/124 (31%), Positives = 70/124 (56%), Gaps = 7/124 (5%)
Frame = +2
Query: 101 KLRSLHVANNKFDTFP-EVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQLE 277
+L+ LH+A N+ +FP + ++ LE D S N +++IP +I N + + T + + N +E
Sbjct: 993 RLKILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTTIMNCRRMHTVIAHSNCIE 1052
Query: 278 SLPDELCELIQLRCLWLGNNKLTQ--LPKQF-GRLKLLDWSWHYTSTTLDGNP---LQHP 439
P E+ +L +++C+ L N+L++ LP+ +L+ LD L GNP L H
Sbjct: 1053 VFP-EVMQLPEVKCVDLSCNELSEITLPENLPPKLQELD---------LTGNPRLALDHK 1102
Query: 440 TLEI 451
+LE+
Sbjct: 1103 SLEL 1106
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/131 (28%), Positives = 66/131 (50%), Gaps = 6/131 (4%)
Frame = +2
Query: 104 LRSLHVANNKF---DTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYENQL 274
L++L+ ++N+ D +P + L + D S N + S+P+ + + LE + NQ+
Sbjct: 830 LKALYASSNELAQLDVYPVP----NYLSYMDVSRNCLESVPEWVCESRKLEVLDIGHNQI 885
Query: 275 ESLPDELCELIQLRCLWLGNNKLTQLPKQFGR--LKLLDWSWHYTSTTLDGNPL-QHPTL 445
LP L LR L G+N+L +LP++ R +++LD H T L N L + +L
Sbjct: 886 CELPARLFCNSSLRKLLAGHNRLARLPERLERTSVEVLDVQ-HNQITELPPNLLMKADSL 944
Query: 446 EICKKGADEIE 478
A+++E
Sbjct: 945 RFLNASANKLE 955
Score = 33.1 bits (74), Expect = 0.70
Identities = 36/169 (21%), Positives = 72/169 (42%), Gaps = 1/169 (0%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
VP +G + NL+ E++++ +L L ++ N+F PEV+ ++++++
Sbjct: 685 VPAAVGDMQNLQTFLLDGNFLQSLPAELESMHQLSYLGLSFNEFTDIPEVLEKLTAVDKL 744
Query: 185 DASDNMIRSIP-KSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQ 361
+ N + ++ +++R + ++ L N L L + + +Q +TQL +
Sbjct: 745 CMAGNCVETLRLQALRRMPHIKHVDLRLNILRKLMADEVDFVQ---------HVTQLDLR 795
Query: 362 FGRLKLLDWSWHYTSTTLDGNPLQHPTLEICKKGADEIEKYFKKLYGSS 508
+L LD L Q TL +C + K LY SS
Sbjct: 796 DNKLGDLDAMIFNNIEVLHCERNQLVTLNVC-------GYFLKALYASS 837
>sp|Q9BYS8|LRRC2_HUMAN Leucine-rich repeat-containing protein 2
Length = 371
Score = 71.6 bits (174), Expect = 2e-12
Identities = 45/149 (30%), Positives = 76/149 (51%), Gaps = 1/149 (0%)
Frame = +2
Query: 5 VPKEIGILTNLERI-AXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEF 181
+P E+G NLER+ E+ NLK++ + ++ NKF + P V +S+L++
Sbjct: 182 IPPELGDCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMSNLQW 241
Query: 182 FDASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPKQ 361
D S N + +P+ I L+ L++F+LY+N+L LP + L +L L + + L +LP
Sbjct: 242 LDISSNNLTDLPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELP-- 299
Query: 362 FGRLKLLDWSWHYTSTTLDGNPLQHPTLE 448
L D S +L NP+ + E
Sbjct: 300 ---TALCDSSTPLKFVSLMDNPIDNAQCE 325
>sp|P34268|FLII_CAEEL Flightless-I protein homolog
Length = 1257
Score = 70.5 bits (171), Expect = 4e-12
Identities = 48/147 (32%), Positives = 67/147 (45%), Gaps = 3/147 (2%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDT--FPEVVCEISSLE 178
VP E+ NLE + E+ +L +LRS+ V +N T P + + L
Sbjct: 47 VPDELSRCANLEHLQMAHNQLISVHGELSDLPRLRSVIVRDNNLKTAGIPTDIFRMKDLT 106
Query: 179 FFDASDNMIRSIPKSIRNLKVLETFMLYENQLESLPDELC-ELIQLRCLWLGNNKLTQLP 355
D S N +R +P ++ K L N +E++P+ +C LI L L L NNKL LP
Sbjct: 107 IIDLSRNQLREVPTNLEYAKGSIVLNLSYNNIETIPNSVCANLIDLLFLDLSNNKLDMLP 166
Query: 356 KQFGRLKLLDWSWHYTSTTLDGNPLQH 436
Q RL +L S L NPL H
Sbjct: 167 PQIRRLSMLQ------SLKLSNNPLNH 187
Score = 46.2 bits (108), Expect = 8e-05
Identities = 33/125 (26%), Positives = 54/125 (43%), Gaps = 2/125 (1%)
Frame = +2
Query: 2 HVPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEF 181
++P + + NL + + L+ LR L+++ NK + E +LE
Sbjct: 213 NIPPTLDDMHNLRDVDFSENNLPIVPEALFKLRNLRKLNLSGNKIEKLNMTEGEWENLET 272
Query: 182 FDASDNMIRSIPKSIRNLKVLETFMLYENQL--ESLPDELCELIQLRCLWLGNNKLTQLP 355
+ S N + +P + L L NQL E +P + +LIQL L L NKL +P
Sbjct: 273 LNMSHNQLTVLPDCVVKLTRLTKLYAANNQLTFEGIPSGIGKLIQLTVLHLSYNKLELVP 332
Query: 356 KQFGR 370
+ R
Sbjct: 333 EGISR 337
Score = 45.4 bits (106), Expect = 1e-04
Identities = 28/98 (28%), Positives = 49/98 (50%), Gaps = 2/98 (2%)
Frame = +2
Query: 86 IKNLKKLRSLHVANNKFDTFPEVVCEISSLEFFDASDNMIRSIPKSIRNLKVLETFMLYE 265
+ ++ LR + + N PE + ++ +L + S N I + + + LET +
Sbjct: 218 LDDMHNLRDVDFSENNLPIVPEALFKLRNLRKLNLSGNKIEKLNMTEGEWENLETLNMSH 277
Query: 266 NQLESLPDELCELIQLRCLWLGNNKLT--QLPKQFGRL 373
NQL LPD + +L +L L+ NN+LT +P G+L
Sbjct: 278 NQLTVLPDCVVKLTRLTKLYAANNQLTFEGIPSGIGKL 315
Score = 44.3 bits (103), Expect = 3e-04
Identities = 30/120 (25%), Positives = 58/120 (48%), Gaps = 2/120 (1%)
Frame = +2
Query: 5 VPKEIGILTNLERIAXXXXXXXXXXXEIKNLKKLRSLHVANNKFDTFPEVVCEISSLEFF 184
VP+ + L NL ++ + L +L++++N+ P+ V +++ L
Sbjct: 237 VPEALFKLRNLRKLNLSGNKIEKLNMTEGEWENLETLNMSHNQLTVLPDCVVKLTRLTKL 296
Query: 185 DASDNMI--RSIPKSIRNLKVLETFMLYENQLESLPDELCELIQLRCLWLGNNKLTQLPK 358
A++N + IP I L L L N+LE +P+ + ++L+ L L +N+L LP+
Sbjct: 297 YAANNQLTFEGIPSGIGKLIQLTVLHLSYNKLELVPEGISRCVKLQKLKLDHNRLITLPE 356
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,829,125
Number of Sequences: 369166
Number of extensions: 1263542
Number of successful extensions: 3838
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3270
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3672
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5879188535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)