Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_P19
(537 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinas... 94 3e-19
sp|Q05511|HEPS_RAT Serine protease hepsin [Contains: Serine... 89 5e-18
sp|P05981|HEPS_HUMAN Serine protease hepsin (Transmembrane ... 89 5e-18
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 89 7e-18
sp|O35453|HEPS_MOUSE Serine protease hepsin [Contains: Seri... 88 1e-17
sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase)... 87 2e-17
sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contai... 86 4e-17
sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma p... 79 5e-15
sp|P08419|ELA2_PIG Elastase-2 precursor 79 9e-15
sp|Q8VHJ4|TM11D_RAT Transmembrane protease, serine 11D prec... 79 9e-15
>sp|P98072|ENTK_BOVIN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1035
Score = 93.6 bits (231), Expect = 3e-19
Identities = 53/148 (35%), Positives = 74/148 (50%), Gaps = 5/148 (3%)
Frame = +3
Query: 12 GEWPWIVSLKNPVLRKLLEKHTPTYMNWSLVGSDNHICGGTLINSEWIVTALHCMYHYIP 191
G WPW+V+L Y + D +CG +L++ +W+V+A HC+Y
Sbjct: 810 GAWPWVVAL---------------YFD------DQQVCGASLVSRDWLVSAAHCVYGRNM 848
Query: 192 QPVPILSNWSATLGAYNISGKSEHSISI-LIDKVVYRKSFFDN--NNDFAMMHLSQPVNF 362
+P S W A LG + S + I LID++V + NND AMMHL VN+
Sbjct: 849 EP----SKWKAVLGLHMASNLTSPQIETRLIDQIVINPHYNKRRKNNDIAMMHLEMKVNY 904
Query: 363 TDYIYPACLP--TTLATPGQMCYAVGWG 440
TDYI P CLP + PG++C GWG
Sbjct: 905 TDYIQPICLPEENQVFPPGRICSIAGWG 932
>sp|Q05511|HEPS_RAT Serine protease hepsin [Contains: Serine protease hepsin
non-catalytic chain; Serine protease hepsin catalytic
chain]
Length = 416
Score = 89.4 bits (220), Expect = 5e-18
Identities = 51/167 (30%), Positives = 78/167 (46%), Gaps = 11/167 (6%)
Frame = +3
Query: 3 SYYGEWPWIVSLKNPVLRKLLEKHTPTYMNWSLVGSDNHICGGTLINSEWIVTALHCMYH 182
S G WPW VSL+ H+CGG+L++ +W++TA HC
Sbjct: 168 SSLGRWPWQVSLRY---------------------DGTHLCGGSLLSGDWVLTAAHCF-- 204
Query: 183 YIPQPVPILSNWSATLGAYNISGKSEHSISILIDKVVYRKSFF--------DNNNDFAMM 338
P+ +LS W GA ++ S H++ + + V+Y + +N+ND A++
Sbjct: 205 --PERNRVLSRWRVFAGA--VARTSPHAVQLGVQAVIYHGGYLPFRDPTIDENSNDIALV 260
Query: 339 HLSQPVNFTDYIYPACLPTT--LATPGQMCYAVGWG-TSFSIQNTVI 470
HLS + T+YI P CLP G++C GWG T F Q V+
Sbjct: 261 HLSSSLPLTEYIQPVCLPAAGQALVDGKVCTVTGWGNTQFYGQQAVV 307
>sp|P05981|HEPS_HUMAN Serine protease hepsin (Transmembrane protease, serine 1)
[Contains: Serine protease hepsin non-catalytic chain;
Serine protease hepsin catalytic chain]
Length = 417
Score = 89.4 bits (220), Expect = 5e-18
Identities = 48/155 (30%), Positives = 73/155 (47%), Gaps = 10/155 (6%)
Frame = +3
Query: 12 GEWPWIVSLKNPVLRKLLEKHTPTYMNWSLVGSDNHICGGTLINSEWIVTALHCMYHYIP 191
G WPW VSL+ H+CGG+L++ +W++TA HC P
Sbjct: 172 GRWPWQVSLRY---------------------DGAHLCGGSLLSGDWVLTAAHCF----P 206
Query: 192 QPVPILSNWSATLGAYNISGKSEHSISILIDKVVYRKSFF--------DNNNDFAMMHLS 347
+ +LS W GA ++ S H + + + VVY + +N+ND A++HLS
Sbjct: 207 ERNRVLSRWRVFAGA--VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLS 264
Query: 348 QPVNFTDYIYPACLPTT--LATPGQMCYAVGWGTS 446
P+ T+YI P CLP G++C GWG +
Sbjct: 265 SPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNT 299
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 89.0 bits (219), Expect = 7e-18
Identities = 54/149 (36%), Positives = 75/149 (50%), Gaps = 5/149 (3%)
Frame = +3
Query: 12 GEWPWIVSLKNPVLRKLLEKHTPTYMNWSLVGSDNHICGGTLINSEWIVTALHCMYHYIP 191
G WPW+V L Y L +CG +L++S+W+V+A HC+Y
Sbjct: 794 GAWPWVVGL---------------YYGGRL------LCGASLVSSDWLVSAAHCVYGRNL 832
Query: 192 QPVPILSNWSATLGAYNISG-KSEHSISILIDKVVYRKSFFDN--NNDFAMMHLSQPVNF 362
+P S W+A LG + S S ++ LID++V + +ND AMMHL VN+
Sbjct: 833 EP----SKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNY 888
Query: 363 TDYIYPACLP--TTLATPGQMCYAVGWGT 443
TDYI P CLP + PG+ C GWGT
Sbjct: 889 TDYIQPICLPEENQVFPPGRNCSIAGWGT 917
>sp|O35453|HEPS_MOUSE Serine protease hepsin [Contains: Serine protease hepsin
non-catalytic chain; Serine protease hepsin catalytic
chain]
Length = 436
Score = 88.2 bits (217), Expect = 1e-17
Identities = 50/167 (29%), Positives = 78/167 (46%), Gaps = 11/167 (6%)
Frame = +3
Query: 3 SYYGEWPWIVSLKNPVLRKLLEKHTPTYMNWSLVGSDNHICGGTLINSEWIVTALHCMYH 182
S G WPW VSL+ H+CGG+L++ +W++TA HC
Sbjct: 188 SSLGRWPWQVSLRY---------------------DGTHLCGGSLLSGDWVLTAAHCF-- 224
Query: 183 YIPQPVPILSNWSATLGAYNISGKSEHSISILIDKVVYRKSFF--------DNNNDFAMM 338
P+ +LS W GA ++ S H++ + + V+Y + +N+ND A++
Sbjct: 225 --PERNRVLSRWRVFAGA--VARTSPHAVQLGVQAVIYHGGYLPFRDPTIDENSNDIALV 280
Query: 339 HLSQPVNFTDYIYPACLPTT--LATPGQMCYAVGWG-TSFSIQNTVI 470
HLS + T+YI P CLP G++C GWG T F Q ++
Sbjct: 281 HLSSSLPLTEYIQPVCLPAAGQALVDGKVCTVTGWGNTQFYGQQAMV 327
>sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic mini chain; Enteropeptidase non-catalytic
heavy chain; Enteropeptidase catalytic light chain]
Length = 1034
Score = 87.4 bits (215), Expect = 2e-17
Identities = 52/148 (35%), Positives = 75/148 (50%), Gaps = 5/148 (3%)
Frame = +3
Query: 12 GEWPWIVSLKNPVLRKLLEKHTPTYMNWSLVGSDNHICGGTLINSEWIVTALHCMYHYIP 191
G WPW+V+L Y N L +CG +L++ +W+V+A HC+Y
Sbjct: 809 GAWPWVVAL---------------YYNGQL------LCGASLVSRDWLVSAAHCVYGRNL 847
Query: 192 QPVPILSNWSATLGAYNISG-KSEHSISILIDKVVYRKSFFDN--NNDFAMMHLSQPVNF 362
+P S W A LG + S S ++ LID++V + ++D AMMHL VN+
Sbjct: 848 EP----SKWKAILGLHMTSNLTSPQIVTRLIDEIVINPHYNRRRKDSDIAMMHLEFKVNY 903
Query: 363 TDYIYPACLP--TTLATPGQMCYAVGWG 440
TDYI P CLP + PG++C GWG
Sbjct: 904 TDYIQPICLPEENQVFPPGRICSIAGWG 931
>sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1069
Score = 86.3 bits (212), Expect = 4e-17
Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 5/148 (3%)
Frame = +3
Query: 12 GEWPWIVSLKNPVLRKLLEKHTPTYMNWSLVGSDNHICGGTLINSEWIVTALHCMYHYIP 191
G WPW+V+L + ++ T D +CG +L++S+W+V+A HC+Y
Sbjct: 839 GAWPWVVALYHR------DRST-----------DRLLCGASLVSSDWLVSAAHCVYRRNL 881
Query: 192 QPVPILSNWSATLGAYNISG-KSEHSISILIDKVVYRKSFFDNN--NDFAMMHLSQPVNF 362
P + W+A LG + S S + ++D++V + ND AMMHL VN+
Sbjct: 882 DP----TRWTAVLGLHMQSNLTSPQVVRRVVDQIVINPHYDRRRKVNDIAMMHLEFKVNY 937
Query: 363 TDYIYPACLP--TTLATPGQMCYAVGWG 440
TDYI P CLP + PG+ C GWG
Sbjct: 938 TDYIQPICLPEENQIFIPGRTCSIAGWG 965
>sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 79.3 bits (194), Expect = 5e-15
Identities = 48/176 (27%), Positives = 85/176 (48%), Gaps = 4/176 (2%)
Frame = +3
Query: 3 SYYGEWPWIVSLKNPVLRKLLEKHTPTYMNWSLVGSDNHICGGTLINSEWIVTALHCMYH 182
S +GEWPW VSL+ + + H+CGG+LI +W++TA HC
Sbjct: 397 SSWGEWPWQVSLQVKLT------------------AQRHLCGGSLIGHQWVLTAAHCF-- 436
Query: 183 YIPQPVPILSNWSATLGAYNISGKSEHSISILIDKVVYRKSF--FDNNNDFAMMHLSQPV 356
+P+ W G N+S ++ + I +++ +++ + N+D A++ L P+
Sbjct: 437 ---DGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPL 493
Query: 357 NFTDYIYPACLPT--TLATPGQMCYAVGWGTSFSIQNTVINPILKHTTLLITQAKE 518
N+T++ P CLP+ +T C+ GWG FS + I IL+ + + +E
Sbjct: 494 NYTEFQKPICLPSKGDTSTIYTNCWVTGWG--FSKEKGEIQNILQKVNIPLVTNEE 547
>sp|P08419|ELA2_PIG Elastase-2 precursor
Length = 269
Score = 78.6 bits (192), Expect = 9e-15
Identities = 49/169 (28%), Positives = 77/169 (45%), Gaps = 7/169 (4%)
Frame = +3
Query: 18 WPWIVSLKNPVLRKLLEKHTPTYMNWSLVGSDNHICGGTLINSEWIVTALHCMYHYIPQP 197
WPW VSL+ + G H CGGTL++ W++TA HC
Sbjct: 40 WPWQVSLQ-----------------YDSSGQWRHTCGGTLVDQSWVLTAAHC-------- 74
Query: 198 VPILSNWSATLGAYNISGKSEHSISILIDKVVYRKSF----FDNNNDFAMMHLSQPVNFT 365
+ + LG +++S S+++ + K+V + + N ND A++ L+ PV+ T
Sbjct: 75 ISSSRTYRVVLGRHSLSTNEPGSLAVKVSKLVVHQDWNSNQLSNGNDIALLKLASPVSLT 134
Query: 366 DYIYPACLPT--TLATPGQMCYAVGWGTSFSIQNTVINP-ILKHTTLLI 503
D I CLP T+ +CY GWG +Q +P IL+ LL+
Sbjct: 135 DKIQLGCLPAAGTILPNNYVCYVTGWG---RLQTNGASPDILQQGQLLV 180
>sp|Q8VHJ4|TM11D_RAT Transmembrane protease, serine 11D precursor (Airway trypsin-like
protease) (AT) (Adrenal secretory serine protease) (AsP)
[Contains: Transmembrane protease, serine 11D
non-catalytic chain; Transmembrane protease, serine 11D
catalytic chain]
Length = 417
Score = 78.6 bits (192), Expect = 9e-15
Identities = 51/157 (32%), Positives = 71/157 (45%), Gaps = 3/157 (1%)
Frame = +3
Query: 12 GEWPWIVSLKNPVLRKLLEKHTPTYMNWSLVGSDNHICGGTLINSEWIVTALHCMYHYI- 188
G+WPW VSL+ ++ H CGGTLI++ W++TA HC Y
Sbjct: 195 GDWPWQVSLQL---------------------NNVHHCGGTLISNLWVLTAAHCFRSYSN 233
Query: 189 PQPVPILSNWSATLGAYNISGKSEHSISILIDKVVYRKSFFDNNNDFAMMHLSQPVNFTD 368
PQ W+AT G IS + + ++ Y +ND A++ L +PV FT
Sbjct: 234 PQ------QWTATFGVSTISPRLRVRVRAILAHAEYNS--ITRDNDIAVVQLDRPVTFTR 285
Query: 369 YIYPACLP--TTLATPGQMCYAVGWGTSFSIQNTVIN 473
I+ CLP T P + Y GWG+ NTV N
Sbjct: 286 NIHRVCLPAATQNIMPDSVAYVTGWGSLTYGGNTVTN 322
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,871,221
Number of Sequences: 369166
Number of extensions: 1472947
Number of successful extensions: 4413
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3805
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3968
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3699545625
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)