Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_P12
(728 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 214 2e-55
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 210 4e-54
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 207 2e-53
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 206 7e-53
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 201 2e-51
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 197 2e-50
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 194 2e-49
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 194 2e-49
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 193 3e-49
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 193 4e-49
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 214 bits (544), Expect = 2e-55
Identities = 103/169 (60%), Positives = 127/169 (75%), Gaps = 3/169 (1%)
Frame = +3
Query: 87 Q*LVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKERDYPYTAQDGDCEYSKEKVVAHCQ 263
Q LVDCS+D GNQGCNGGLMD AFQYI + G L+ E YPY A+DG C+Y E VA+
Sbjct: 164 QNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDT 223
Query: 264 GFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVG 443
GF DI E+ L + +ATVGPISV +DAS+PS QFY +G+Y E NCSS LDHGVL VG
Sbjct: 224 GFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVG 282
Query: 444 YGND--EDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYP 584
YG + + ++ YWLVKNSWGK WG++GYIK++KD++N CG+AT ASYP
Sbjct: 283 YGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYP 331
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 210 bits (534), Expect = 4e-54
Identities = 105/169 (62%), Positives = 125/169 (73%), Gaps = 3/169 (1%)
Frame = +3
Query: 87 Q*LVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKERDYPYTAQDGDCEYSKEKVVAHCQ 263
Q LVDCS+ GNQGCNGGLMD AFQYI + G L+ E YPY A+DG C+Y E VA+
Sbjct: 164 QNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDT 223
Query: 264 GFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVG 443
GF DI E+ L + +ATVGPISV +DAS+PS QFY +G+Y E NCSS LDHGVL VG
Sbjct: 224 GFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVG 282
Query: 444 YGND-EDSQQN-YWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYP 584
YG + DS +N YWLVKNSWG WG+ GYIK++KD+DN CG+AT ASYP
Sbjct: 283 YGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYP 331
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 207 bits (528), Expect = 2e-53
Identities = 98/167 (58%), Positives = 124/167 (74%), Gaps = 1/167 (0%)
Frame = +3
Query: 87 Q*LVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKERDYPYTAQDGDCEYSKEKVVAHCQ 263
Q LVDCS +GN GCNGGLMD+AF+YI G ++ E+ YPY A D C ++K V A +
Sbjct: 174 QNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDR 233
Query: 264 GFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVG 443
GFTDI G E+ +AE +ATVGP+SV IDAS+ SFQFY GVY+E C + LDHGVL VG
Sbjct: 234 GFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVG 293
Query: 444 YGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYP 584
+G DE S ++YWLVKNSWG +WG G+IKM ++K+NQCGIA+ +SYP
Sbjct: 294 FGTDE-SGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYP 339
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 206 bits (523), Expect = 7e-53
Identities = 100/171 (58%), Positives = 122/171 (71%), Gaps = 3/171 (1%)
Frame = +3
Query: 87 Q*LVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKERDYPYTAQDGDCEYSKEKVVAHCQ 263
Q LVDCS GNQGCNGG M AFQY+ + G L+ E YPY A D C+Y E VA+
Sbjct: 164 QNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDT 223
Query: 264 GFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVG 443
GFT ++ G E+ L + +ATVGPISV +DA + SFQFYK+G+Y E +CSS LDHGVL VG
Sbjct: 224 GFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVG 283
Query: 444 YGNDEDSQQN--YWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 590
YG + + N YWLVKNSWG WG NGY+K++KDK+N CGIAT ASYPN+
Sbjct: 284 YGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
Score = 30.4 bits (67), Expect = 5.0
Identities = 13/17 (76%), Positives = 14/17 (82%)
Frame = -2
Query: 52 LPDSVNWVKKGYVTQVK 2
LP SV+W KKGYVT VK
Sbjct: 114 LPKSVDWRKKGYVTPVK 130
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 201 bits (511), Expect = 2e-51
Identities = 94/169 (55%), Positives = 119/169 (70%), Gaps = 1/169 (0%)
Frame = +3
Query: 87 Q*LVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKERDYPYTAQDGDCEYSKEKVVAHCQ 263
Q LVDCS +GN GCNGGLMD+AF+YI G ++ E+ YPY D C ++K + A
Sbjct: 172 QNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDT 231
Query: 264 GFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVG 443
GF DI G EE + + +AT+GP+SV IDAS+ SFQ Y GVY+E C LDHGVL VG
Sbjct: 232 GFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVG 291
Query: 444 YGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 590
YG DE S +YWLVKNSWG +WG GYIKM+++++NQCGIAT +SYP +
Sbjct: 292 YGTDE-SGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 197 bits (501), Expect = 2e-50
Identities = 97/169 (57%), Positives = 119/169 (70%), Gaps = 1/169 (0%)
Frame = +3
Query: 87 Q*LVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKERDYPYTAQDGDCEYSKEKVVAHCQ 263
Q LVDCS D+GN GC GG M SAF YI G ++ E YPY A+D C + + A C
Sbjct: 156 QQLVDCSTDYGNDGCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICT 215
Query: 264 GFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVG 443
G ++ H +EE L E ++ VGPISV IDAS+ SFQFY +GVY E+NCS T LDHGVLAVG
Sbjct: 216 GSVEVQH-TEEALQEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVG 274
Query: 444 YGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 590
YG +S ++YWLVKNSWG SWG GYIKMS+++DN CGIA+ SYP +
Sbjct: 275 YGT--ESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 194 bits (493), Expect = 2e-49
Identities = 95/171 (55%), Positives = 118/171 (69%), Gaps = 3/171 (1%)
Frame = +3
Query: 87 Q*LVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKERDYPYTAQDGDCEYSKEKVVAHCQ 263
Q LVDCS GN+GCNGGLMD AFQY+ G L+ E YPY A + C+Y+ + VA+
Sbjct: 164 QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDT 223
Query: 264 GFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVG 443
GF DI E+ L + +ATVGPISV IDA + SF FYK G+Y E +CSS +DHGVL VG
Sbjct: 224 GFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVG 282
Query: 444 YG--NDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 590
YG + E YWLVKNSWG+ WG+ GY+KM+KD+ N CGIA+ ASYP +
Sbjct: 283 YGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 194 bits (493), Expect = 2e-49
Identities = 93/167 (55%), Positives = 118/167 (70%), Gaps = 1/167 (0%)
Frame = +3
Query: 87 Q*LVDCSNDFGNQGCNGGLMDSAFQYIM-QYGLEKERDYPYTAQDGDCEYSKEKVVAHCQ 263
Q LVDCS +G QGCNGG M+ AF YI G++ E YPY A+DG C + V A C
Sbjct: 157 QQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCS 216
Query: 264 GFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVG 443
G T+I+ GSE L + + +GPISV IDA++ SFQFY +GVY E +CS + LDH VLAVG
Sbjct: 217 GHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVG 276
Query: 444 YGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYP 584
YG+ + Q++WLVKNSW SWG GYIKMS++++N CGIAT+ASYP
Sbjct: 277 YGS--EGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYP 321
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 193 bits (491), Expect = 3e-49
Identities = 97/169 (57%), Positives = 116/169 (68%), Gaps = 1/169 (0%)
Frame = +3
Query: 87 Q*LVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKERDYPYTAQDGDCEYSKEKVVAHCQ 263
Q LVD S GNQGCNGGLMD+AFQYI + G L+ E YPY A D C Y E A
Sbjct: 51 QNLVDSSRPQGNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDT 110
Query: 264 GFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAVG 443
GF DI E+ L + +ATVGPISV IDA + SFQFYK+G+Y + +CSS LDHGVL VG
Sbjct: 111 GFVDIPQ-REKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVG 169
Query: 444 YGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 590
YG E + +W+VKNSWG WG GY+KM+KD++N CGIAT ASYP +
Sbjct: 170 YG-FEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
Score = 30.4 bits (67), Expect = 5.0
Identities = 12/17 (70%), Positives = 14/17 (82%)
Frame = -2
Query: 52 LPDSVNWVKKGYVTQVK 2
+P SV+W KKGYVT VK
Sbjct: 1 VPKSVDWTKKGYVTPVK 17
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 193 bits (490), Expect = 4e-49
Identities = 100/172 (58%), Positives = 119/172 (69%), Gaps = 4/172 (2%)
Frame = +3
Query: 87 Q*LVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKERDYPYTAQD-GDCEYSKEKVVAHC 260
Q LVDCS GNQGCNGGLMD+AFQYI G L+ E YPY A D C Y E A+
Sbjct: 164 QNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAAND 223
Query: 261 QGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKAGVYDEENCSSTQLDHGVLAV 440
GF DI E+ L + +ATVGPISV IDA + SFQFYK+G+Y + +CS LDHGVL V
Sbjct: 224 TGFVDIPQ-REKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVV 282
Query: 441 GYGND-EDSQQN-YWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 590
GYG + DS N +W+VKNSWG WG NGY+KM+KD++N CGIAT ASYP +
Sbjct: 283 GYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
Score = 30.4 bits (67), Expect = 5.0
Identities = 12/17 (70%), Positives = 14/17 (82%)
Frame = -2
Query: 52 LPDSVNWVKKGYVTQVK 2
+P SV+W KKGYVT VK
Sbjct: 114 VPKSVDWTKKGYVTPVK 130
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,844,051
Number of Sequences: 369166
Number of extensions: 1762976
Number of successful extensions: 5095
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4433
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4646
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6486082400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)