Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_P03
(751 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P46467|VPS4B_MOUSE Vacuolar sorting protein 4b (SKD1 pro... 297 2e-80
sp|O75351|VPS4B_HUMAN Vacuolar sorting protein 4b (SKD1 pro... 295 9e-80
sp|Q8VEJ9|VPS4A_MOUSE Vacuolar sorting protein 4a 288 1e-77
sp|Q9UN37|VPS4A_HUMAN Vacuolar sorting protein 4a (SKD2 pro... 285 7e-77
sp|Q09803|VPS4_SCHPO Suppressor protein of bem1/bed5 double... 239 6e-63
sp|P52917|VPS4_YEAST Vacuolar protein sorting-associated pr... 229 8e-60
sp|Q5XIK7|KATL1_RAT Katanin p60 ATPase-containing subunit A... 131 2e-30
sp|Q8K0T4|KATL1_MOUSE Katanin p60 ATPase-containing subunit... 130 4e-30
sp|Q9BW62|KATL1_HUMAN Katanin p60 ATPase-containing subunit... 128 1e-29
sp|Q6E0V2|KTNA1_RAT Katanin p60 ATPase-containing subunit A... 122 8e-28
>sp|P46467|VPS4B_MOUSE Vacuolar sorting protein 4b (SKD1 protein)
Length = 444
Score = 297 bits (761), Expect = 2e-80
Identities = 150/216 (69%), Positives = 175/216 (81%)
Frame = +2
Query: 2 SIIFIDEIDSLCSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAI 181
SIIFIDEIDSLC +R +N+SE+A+RIKTEFLVQMQGV DND +L+L ATNIPW LDSAI
Sbjct: 229 SIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAI 288
Query: 182 RRRFEKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVR 361
RRRFEKRIYI LPEA ARA MF+L +G+ Q+ LT +F ELG ++GYSGADISI VR
Sbjct: 289 RRRFEKRIYIPLPEAHARAAMFRLHLGST--QNSLTEADFQELGRKTDGYSGADISIIVR 346
Query: 362 DALMVPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLE 541
DALM PVRKVQ+ATHF++VRGPS DP+ IV+DLLTPCSPG PGAIEM W V +KLLE
Sbjct: 347 DALMQPVRKVQSATHFKKVRGPSRADPNCIVNDLLTPCSPGDPGAIEMTWMDVPGDKLLE 406
Query: 542 PCVTFADMKLALSRNKPTVNQKDLEKLIQFTTDFGQ 649
P V+ DM +LS KPTVN++DL KL +FT DFGQ
Sbjct: 407 PVVSMWDMLRSLSSTKPTVNEQDLLKLKKFTEDFGQ 442
>sp|O75351|VPS4B_HUMAN Vacuolar sorting protein 4b (SKD1 protein)
Length = 444
Score = 295 bits (755), Expect = 9e-80
Identities = 149/216 (68%), Positives = 172/216 (79%)
Frame = +2
Query: 2 SIIFIDEIDSLCSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAI 181
SIIFIDEIDSLC +R +N+SE+A+RIKTEFLVQMQGV DND +L+L ATNIPW LDSAI
Sbjct: 229 SIIFIDEIDSLCGSRSENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVLDSAI 288
Query: 182 RRRFEKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVR 361
RRRFEKRIYI LPE ARA MFKL +G Q+ LT +F ELG ++GYSGADISI VR
Sbjct: 289 RRRFEKRIYIPLPEPHARAAMFKLHLGTT--QNSLTEADFRELGRKTDGYSGADISIIVR 346
Query: 362 DALMVPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLE 541
DALM PVRKVQ+ATHF++VRGPS DP+ +V DLLTPCSPG PGAIEM W V +KLLE
Sbjct: 347 DALMQPVRKVQSATHFKKVRGPSRADPNHLVDDLLTPCSPGDPGAIEMTWMDVPGDKLLE 406
Query: 542 PCVTFADMKLALSRNKPTVNQKDLEKLIQFTTDFGQ 649
P V+ +DM +LS KPTVN+ DL KL +FT DFGQ
Sbjct: 407 PVVSMSDMLRSLSNTKPTVNEHDLLKLKKFTEDFGQ 442
>sp|Q8VEJ9|VPS4A_MOUSE Vacuolar sorting protein 4a
Length = 437
Score = 288 bits (736), Expect = 1e-77
Identities = 142/216 (65%), Positives = 172/216 (79%)
Frame = +2
Query: 2 SIIFIDEIDSLCSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAI 181
SIIFIDE+DSLC +R +N+SE+A+RIKTEFLVQMQGV ++ND L+L ATNIPW LDSAI
Sbjct: 222 SIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAI 281
Query: 182 RRRFEKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVR 361
RRRFEKRIYI LPE ARA+MF+L +G+ P H+LT N EL +EGYSGADISI VR
Sbjct: 282 RRRFEKRIYIPLPEEAARAQMFRLHLGSTP--HNLTDANIHELARKTEGYSGADISIIVR 339
Query: 362 DALMVPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLE 541
D+LM PVRKVQ+ATHF++V GPS T+PSV++ DLLTPCSPG PGAIEM W V +KLLE
Sbjct: 340 DSLMQPVRKVQSATHFKKVCGPSRTNPSVMIDDLLTPCSPGDPGAIEMTWMDVPGDKLLE 399
Query: 542 PCVTFADMKLALSRNKPTVNQKDLEKLIQFTTDFGQ 649
P V +DM +L+ +PTVN DL K+ +F+ DFGQ
Sbjct: 400 PVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQ 435
>sp|Q9UN37|VPS4A_HUMAN Vacuolar sorting protein 4a (SKD2 protein) (hVPS4) (VPS4-1)
Length = 437
Score = 285 bits (730), Expect = 7e-77
Identities = 140/216 (64%), Positives = 172/216 (79%)
Frame = +2
Query: 2 SIIFIDEIDSLCSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAI 181
SIIFIDE+DSLC +R +N+SE+A+RIKTEFLVQMQGV ++ND L+L ATNIPW LDSAI
Sbjct: 222 SIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAI 281
Query: 182 RRRFEKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVR 361
RRRFEKRIYI LPE ARA+MF+L +G+ P H+LT N EL +EGYSGADISI VR
Sbjct: 282 RRRFEKRIYIPLPEEAARAQMFRLHLGSTP--HNLTDANIHELARKTEGYSGADISIIVR 339
Query: 362 DALMVPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLE 541
D+LM PVRKVQ+ATHF++V GPS T+PS+++ DLLTPCSPG PGA+EM W V +KLLE
Sbjct: 340 DSLMQPVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPGAMEMTWMDVPGDKLLE 399
Query: 542 PCVTFADMKLALSRNKPTVNQKDLEKLIQFTTDFGQ 649
P V +DM +L+ +PTVN DL K+ +F+ DFGQ
Sbjct: 400 PVVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQ 435
>sp|Q09803|VPS4_SCHPO Suppressor protein of bem1/bed5 double mutants
Length = 432
Score = 239 bits (610), Expect = 6e-63
Identities = 123/215 (57%), Positives = 152/215 (70%)
Frame = +2
Query: 2 SIIFIDEIDSLCSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAI 181
SIIFIDEIDSLC +R + +SES++RIKTEFLVQM GV D VL+L ATNIPW LDSAI
Sbjct: 223 SIIFIDEIDSLCGSRSEGESESSRRIKTEFLVQMNGVGKDESGVLVLGATNIPWTLDSAI 282
Query: 182 RRRFEKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVR 361
RRRFEKRIYI LP A ARA MF+L++G P +LT Q+F EL +++GYSG+DISI VR
Sbjct: 283 RRRFEKRIYIPLPNAHARARMFELNVGKIPS--ELTSQDFKELAKMTDGYSGSDISIVVR 340
Query: 362 DALMVPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLE 541
DA+M PVR++ TATHF+ V L+TPCSPG P A E +W V+ E ++E
Sbjct: 341 DAIMEPVRRIHTATHFKEVYDNKSN------RTLVTPCSPGDPDAFESSWLEVNPEDIME 394
Query: 542 PCVTFADMKLALSRNKPTVNQKDLEKLIQFTTDFG 646
P +T D A+ + KPT+N D+EK QFT DFG
Sbjct: 395 PKLTVRDFYSAVRKVKPTLNAGDIEKHTQFTKDFG 429
>sp|P52917|VPS4_YEAST Vacuolar protein sorting-associated protein VPS4 (END13 protein)
(DOA4-independent degradation protein 6)
Length = 437
Score = 229 bits (583), Expect = 8e-60
Identities = 116/216 (53%), Positives = 157/216 (72%)
Frame = +2
Query: 2 SIIFIDEIDSLCSNRGDNDSESAKRIKTEFLVQMQGVSSDNDNVLILAATNIPWALDSAI 181
SIIFIDE+D+L RG+ +SE+++RIKTE LVQM GV +D+ VL+L ATNIPW LDSAI
Sbjct: 227 SIIFIDEVDALTGTRGEGESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIPWQLDSAI 286
Query: 182 RRRFEKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADISIAVR 361
RRRFE+RIYI LP+ AR MF++++G+ P LT +++ LG ++EGYSG+DI++ V+
Sbjct: 287 RRRFERRIYIPLPDLAARTTMFEINVGDTPCV--LTKEDYRTLGAMTEGYSGSDIAVVVK 344
Query: 362 DALMVPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDSEKLLE 541
DALM P+RK+Q+ATHF+ V S D + LTPCSPG GAIEM+W +++++L E
Sbjct: 345 DALMQPIRKIQSATHFKDV---STEDDE---TRKLTPCSPGDDGAIEMSWTDIEADELKE 398
Query: 542 PCVTFADMKLALSRNKPTVNQKDLEKLIQFTTDFGQ 649
P +T D A+ +PTVN+ DL K QFT DFGQ
Sbjct: 399 PDLTIKDFLKAIKSTRPTVNEDDLLKQEQFTRDFGQ 434
>sp|Q5XIK7|KATL1_RAT Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit
A-like 1) (p60 katanin-like 1)
Length = 488
Score = 131 bits (329), Expect = 2e-30
Identities = 84/220 (38%), Positives = 124/220 (56%), Gaps = 7/220 (3%)
Frame = +2
Query: 8 IFIDEIDSLCSNRGDNDS-ESAKRIKTEFLVQMQGVSS--DNDN----VLILAATNIPWA 166
IFIDEIDS+CS RG +D E+++R+K+E L+QM GV +ND+ V++LAATN PW
Sbjct: 302 IFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWD 361
Query: 167 LDSAIRRRFEKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADI 346
+D A+RRR EKRIYI LP A RAE+ K+S+ D+ + ++ +EGYSGADI
Sbjct: 362 IDEALRRRLEKRIYIPLPTAKGRAELLKISLREVELDPDI---HLEDIAEKTEGYSGADI 418
Query: 347 SIAVRDALMVPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDS 526
+ RDA ++ +R RR+ G SP + + S
Sbjct: 419 TNICRDASLMAMR--------RRINGLSPEEIRAL------------------------S 446
Query: 527 EKLLEPCVTFADMKLALSRNKPTVNQKDLEKLIQFTTDFG 646
++ L+ VT D++LAL + +V+ DLEK ++ +FG
Sbjct: 447 KEELQMPVTRGDLELALKKIAKSVSAADLEKYEKWMVEFG 486
>sp|Q8K0T4|KATL1_MOUSE Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit
A-like 1) (p60 katanin-like 1)
Length = 488
Score = 130 bits (327), Expect = 4e-30
Identities = 84/220 (38%), Positives = 124/220 (56%), Gaps = 7/220 (3%)
Frame = +2
Query: 8 IFIDEIDSLCSNRGDNDS-ESAKRIKTEFLVQMQGVSS--DNDN----VLILAATNIPWA 166
IFIDEIDS+CS RG +D E+++R+K+E L+QM GV +ND+ V++LAATN PW
Sbjct: 302 IFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWD 361
Query: 167 LDSAIRRRFEKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADI 346
+D A+RRR EKRIYI LP A RAE+ K+S+ D+ + ++ +EGYSGADI
Sbjct: 362 IDEALRRRLEKRIYIPLPTAKGRAELLKISLREVELDPDV---HLEDIADKTEGYSGADI 418
Query: 347 SIAVRDALMVPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDS 526
+ RDA ++ +R RR+ G SP + + S
Sbjct: 419 TNICRDASLMAMR--------RRINGLSPEEIRAL------------------------S 446
Query: 527 EKLLEPCVTFADMKLALSRNKPTVNQKDLEKLIQFTTDFG 646
++ L+ VT D++LAL + +V+ DLEK ++ +FG
Sbjct: 447 KEELQMPVTRGDLELALKKIAKSVSAADLEKYEKWMVEFG 486
>sp|Q9BW62|KATL1_HUMAN Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit
A-like 1) (p60 katanin-like 1)
Length = 490
Score = 128 bits (322), Expect = 1e-29
Identities = 84/220 (38%), Positives = 123/220 (55%), Gaps = 7/220 (3%)
Frame = +2
Query: 8 IFIDEIDSLCSNRGDNDS-ESAKRIKTEFLVQMQGVSS--DNDN----VLILAATNIPWA 166
IFIDEIDS+CS RG +D E+++R+K+E L+QM GV +ND+ V++LAATN PW
Sbjct: 304 IFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWD 363
Query: 167 LDSAIRRRFEKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADI 346
+D A+RRR EKRIYI LP A RAE+ K+++ D+ ++ +E EGYSGADI
Sbjct: 364 IDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAE---KIEGYSGADI 420
Query: 347 SIAVRDALMVPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDS 526
+ RDA ++ +R RR+ G SP + + S
Sbjct: 421 TNVCRDASLMAMR--------RRINGLSPEEIRAL------------------------S 448
Query: 527 EKLLEPCVTFADMKLALSRNKPTVNQKDLEKLIQFTTDFG 646
++ L+ VT D +LAL + +V+ DLEK ++ +FG
Sbjct: 449 KEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFG 488
>sp|Q6E0V2|KTNA1_RAT Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1)
(p60 katanin)
Length = 491
Score = 122 bits (307), Expect = 8e-28
Identities = 82/220 (37%), Positives = 120/220 (54%), Gaps = 7/220 (3%)
Frame = +2
Query: 8 IFIDEIDSLCSNRGDNDS-ESAKRIKTEFLVQMQGV--SSDNDN----VLILAATNIPWA 166
IFIDEIDS+CS RG ++ E+++R+K E LVQM GV +S+ND+ V++LAATN PW
Sbjct: 305 IFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWD 364
Query: 167 LDSAIRRRFEKRIYIALPEAGARAEMFKLSMGNKPGQHDLTPQNFSELGHLSEGYSGADI 346
+D A+RRR EKRIYI LP A R E+ ++S+ D+ N + + EGYSGADI
Sbjct: 365 IDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDV---NLASIAENMEGYSGADI 421
Query: 347 SIAVRDALMVPVRKVQTATHFRRVRGPSPTDPSVIVSDLLTPCSPGSPGAIEMNWQTVDS 526
+ RDA ++ +R RR+ G LTP + EM+ T
Sbjct: 422 TNVCRDASLMAMR--------RRIEG-------------LTPEEIRNLSREEMHMPT--- 457
Query: 527 EKLLEPCVTFADMKLALSRNKPTVNQKDLEKLIQFTTDFG 646
T D ++AL + +V+ D+E+ ++ +FG
Sbjct: 458 --------TMEDFEMALKKVSKSVSAADIERYEKWIVEFG 489
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,855,846
Number of Sequences: 369166
Number of extensions: 1952648
Number of successful extensions: 7101
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6410
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6840
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6824907600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)