Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_N22
(408 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 62 4e-10
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 61 8e-10
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 60 2e-09
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 59 3e-09
sp|P81013|GRN1_CYPCA Granulin-1 55 4e-08
sp|P81015|GRN3_CYPCA Granulin-3 54 1e-07
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 54 1e-07
sp|P81014|GRN2_CYPCA Granulin-2 49 4e-06
sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 49 4e-06
sp|P25777|ORYB_ORYSA Oryzain beta chain precursor 44 2e-04
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 62.0 bits (149), Expect = 4e-10
Identities = 35/109 (32%), Positives = 48/109 (44%), Gaps = 2/109 (1%)
Frame = +2
Query: 2 EGTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPD 181
+ T CDL+ +CI + + + P Y V +K + +CPD
Sbjct: 247 QDTVCDLIQSKCISK----------DYTTDLMTKLPGYPVNE-------VKCDLEVSCPD 289
Query: 182 GGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC--VTGGC 322
G TCC + TG +GCCPF+ VCC D CC G+ C TG C
Sbjct: 290 G------YTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTC 332
Score = 55.1 bits (131), Expect = 5e-08
Identities = 27/68 (39%), Positives = 35/68 (51%)
Frame = +2
Query: 116 TVERSTLREFMIKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAP 295
+V+ S F K+G+ C G C Q+CC G + CCP+ GVCC D R CC
Sbjct: 498 SVQPSMDLTFGSKVGNVE-CGAGHFCHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPI 556
Query: 296 GYHCVTGG 319
G+HC G
Sbjct: 557 GFHCSAKG 564
Score = 54.7 bits (130), Expect = 7e-08
Identities = 20/49 (40%), Positives = 26/49 (53%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 319
C D C TCC + +G +GCCP VCC D + CC G+ C+ G
Sbjct: 363 CDDFSSCPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKCMDEG 411
Score = 54.3 bits (129), Expect = 9e-08
Identities = 31/101 (30%), Positives = 42/101 (41%)
Frame = +2
Query: 5 GTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDG 184
G +CDLV+ RCI + P+++ P R+ ++ K CPD
Sbjct: 167 GASCDLVHTRCISPTGTH---PLLKKF-------PAQRTNRAVASFSVVCPDAKTQCPDD 216
Query: 185 GQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
TCC + TG YGCCP +CC D CC C
Sbjct: 217 S------TCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 251
Score = 51.6 bits (122), Expect = 6e-07
Identities = 22/52 (42%), Positives = 29/52 (55%)
Frame = +2
Query: 164 KNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 319
+++CPDG +C L +G CCPFS GV C D + CC G+HC G
Sbjct: 64 RDHCPDG------YSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADG 109
Score = 48.1 bits (113), Expect = 7e-06
Identities = 20/50 (40%), Positives = 23/50 (46%)
Frame = +2
Query: 158 GDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
G + CPD TCC+M G +GCCP CC D CC G C
Sbjct: 127 GSQFECPDSA------TCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 47.8 bits (112), Expect = 9e-06
Identities = 29/98 (29%), Positives = 41/98 (41%)
Frame = +2
Query: 14 CDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPDGGQC 193
C L ++ C Q + ++ + D K V ++TL ++ GD C C
Sbjct: 393 CCLDHQHCCPQGFKCMDEGYCQKGDRMVAGLEKMPVRQTTL----LQHGDIG-CDQHTSC 447
Query: 194 AGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
QTCC G + CC VCC D + CC GY C
Sbjct: 448 PVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTC 485
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 61.2 bits (147), Expect = 8e-10
Identities = 32/104 (30%), Positives = 48/104 (46%)
Frame = +2
Query: 2 EGTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPD 181
+ T CDL+ +C+ + N + + P +TV +K + +CPD
Sbjct: 249 QDTVCDLIQSKCLSKENATTD---------LLTKLPAHTVGD-------VKCDMEVSCPD 292
Query: 182 GGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVT 313
G TCC + +G +GCCPF+ VCC D CC G+ C T
Sbjct: 293 G------YTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDT 330
Score = 57.4 bits (137), Expect = 1e-08
Identities = 23/55 (41%), Positives = 28/55 (50%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGGCA*LGS 337
C + C TCC + +G +GCCP VCC D + CC GY CV G GS
Sbjct: 366 CDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGS 420
Score = 53.9 bits (128), Expect = 1e-07
Identities = 21/49 (42%), Positives = 25/49 (51%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 319
C +G C QTCC + CCP+ GVCC D R CC G+ C G
Sbjct: 521 CGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARG 569
Score = 52.4 bits (124), Expect = 4e-07
Identities = 33/102 (32%), Positives = 42/102 (41%), Gaps = 1/102 (0%)
Frame = +2
Query: 5 GTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGD-KNNCPD 181
G CDLV+ RCI + T AK + P R+ + D ++ CPD
Sbjct: 168 GAFCDLVHTRCITPTG---------THPLAK-KLPAQRTNRAVALSSSVMCPDARSRCPD 217
Query: 182 GGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
G TCC + +G YGCCP CC D CC C
Sbjct: 218 GS------TCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVC 253
Score = 50.8 bits (120), Expect = 1e-06
Identities = 20/46 (43%), Positives = 23/46 (50%), Gaps = 1/46 (2%)
Frame = +2
Query: 173 CPDGG-QCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
CPD +C TCC+M G +GCCP CC D CC G C
Sbjct: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFC 171
Score = 45.4 bits (106), Expect = 4e-05
Identities = 18/45 (40%), Positives = 20/45 (44%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
C C QTCC G + CC VCC D + CC GY C
Sbjct: 444 CDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTC 488
Score = 43.9 bits (102), Expect = 1e-04
Identities = 17/49 (34%), Positives = 21/49 (42%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 319
C C+ +C +G CCPF V C D CC G+HC G
Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADG 109
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 59.7 bits (143), Expect = 2e-09
Identities = 33/104 (31%), Positives = 49/104 (47%)
Frame = +2
Query: 2 EGTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPD 181
+ T CDL+ +C+ ++ T D + P Y V+ +K + +CP+
Sbjct: 248 QDTVCDLIQSKCLSKNY---------TTDLLT-KLPGYPVKE-------VKCDMEVSCPE 290
Query: 182 GGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVT 313
G TCC + TG +GCCPF+ VCC D CC G+ C T
Sbjct: 291 G------YTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHT 328
Score = 57.8 bits (138), Expect = 8e-09
Identities = 25/56 (44%), Positives = 31/56 (55%)
Frame = +2
Query: 152 KIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 319
K+G+ C +G C QTCC G + CCP+ GVCC D R CC G+HC G
Sbjct: 511 KVGNVE-CGEGHFCHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARG 565
Score = 54.3 bits (129), Expect = 9e-08
Identities = 31/102 (30%), Positives = 41/102 (40%), Gaps = 1/102 (0%)
Frame = +2
Query: 5 GTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGD-KNNCPD 181
G +CDLV+ RC+ + + + P R+ F + D K CPD
Sbjct: 167 GASCDLVHTRCVSPTGT----------HTLLKKFPAQKTNRAVSLPFSVVCPDAKTQCPD 216
Query: 182 GGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
TCC + TG YGCCP +CC D CC C
Sbjct: 217 DS------TCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVC 252
Score = 54.3 bits (129), Expect = 9e-08
Identities = 20/49 (40%), Positives = 27/49 (55%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 319
C D +C TCC + +G +GCCP VCC D + CC G+ C+ G
Sbjct: 364 CDDFTRCPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQG 412
Score = 51.2 bits (121), Expect = 8e-07
Identities = 21/50 (42%), Positives = 25/50 (50%)
Frame = +2
Query: 170 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 319
+C G C +C L +G CCPFS GV C D CC G+HC G
Sbjct: 60 SCQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADG 109
Score = 48.1 bits (113), Expect = 7e-06
Identities = 20/50 (40%), Positives = 23/50 (46%)
Frame = +2
Query: 158 GDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
G + CPD TCC+M G +GCCP CC D CC G C
Sbjct: 127 GSQFECPDSA------TCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASC 170
Score = 47.4 bits (111), Expect = 1e-05
Identities = 21/53 (39%), Positives = 25/53 (47%)
Frame = +2
Query: 149 IKIGDKNNCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
++IGD C C QTCC G + CC VCC D + CC GY C
Sbjct: 435 LQIGDIG-CDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTC 486
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 59.3 bits (142), Expect = 3e-09
Identities = 24/49 (48%), Positives = 27/49 (55%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 319
C D C QTCC G + CCPF GVCC D R CC G+HC + G
Sbjct: 518 CGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQG 566
Score = 58.2 bits (139), Expect = 6e-09
Identities = 31/104 (29%), Positives = 47/104 (45%)
Frame = +2
Query: 2 EGTTCDLVNKRCIHQSNEPIEWPVVETIDSAKIETPKYTVERSTLREFMIKIGDKNNCPD 181
+ T CDL RC+ Q+ + + P +TV + ++ + +CP+
Sbjct: 249 QDTVCDLRQSRCLSQNKAK----------TLLTKLPSWTV-------WDVECDQEVSCPE 291
Query: 182 GGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVT 313
G QTCC + +G +GCCPF VCC D CC + C T
Sbjct: 292 G------QTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRCHT 329
Score = 53.9 bits (128), Expect = 1e-07
Identities = 35/107 (32%), Positives = 49/107 (45%), Gaps = 6/107 (5%)
Frame = +2
Query: 5 GTTCDLVNKRCIHQ-SNEPI--EWPVVETIDSAKIETPKYT--VERSTLREFMIKIGDKN 169
G +CDLV+ RC+ + P+ + P T + TP + + + L +I
Sbjct: 154 GASCDLVHIRCVTALGSHPLTTKLPAQRTNYTGAEGTPVVSPGLLPAALPTSVI------ 207
Query: 170 NCPDG-GQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
CPD QC TCCL+ +G YGCCP +CC D CC C
Sbjct: 208 -CPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVC 253
Score = 48.1 bits (113), Expect = 7e-06
Identities = 20/46 (43%), Positives = 22/46 (47%), Gaps = 1/46 (2%)
Frame = +2
Query: 173 CPDGG-QCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
CP G +C TCC M G +GCCP CC D CC G C
Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASC 157
Score = 46.6 bits (109), Expect = 2e-05
Identities = 21/50 (42%), Positives = 24/50 (48%)
Frame = +2
Query: 170 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHCVTGG 319
NCP G +C L G CCPFS + C D CC G+HC T G
Sbjct: 52 NCPIG------HSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDG 95
Score = 45.8 bits (107), Expect = 3e-05
Identities = 18/45 (40%), Positives = 20/45 (44%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
C C QTCC G + CC VCC D + CC GY C
Sbjct: 441 CDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTC 485
Score = 33.1 bits (74), Expect = 0.22
Identities = 12/33 (36%), Positives = 17/33 (51%)
Frame = +2
Query: 170 NCPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCC 268
+C + C CC + +G +GCCP S G C
Sbjct: 377 SCDEVVSCRPGNICCRLASGEWGCCPSSEGYLC 409
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 55.5 bits (132), Expect = 4e-08
Identities = 24/45 (53%), Positives = 26/45 (57%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
CPDG TCCL G + CCPFS+G CC D CC GYHC
Sbjct: 10 CPDG------TTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHC 48
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 53.9 bits (128), Expect = 1e-07
Identities = 22/45 (48%), Positives = 24/45 (53%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
C G C TCC G + CCPF +G CC D R CC GYHC
Sbjct: 4 CDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHC 48
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 53.9 bits (128), Expect = 1e-07
Identities = 21/43 (48%), Positives = 24/43 (55%)
Frame = +2
Query: 173 CPDGGQCAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGY 301
C +G C QTCC G CCP+S GVCC D R CC G+
Sbjct: 4 CGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVGF 46
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 48.9 bits (115), Expect = 4e-06
Identities = 19/39 (48%), Positives = 21/39 (53%)
Frame = +2
Query: 191 CAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
C TCC G + CCPF +G CC D R CC GY C
Sbjct: 10 CPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRC 48
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1)
Length = 54
Score = 48.9 bits (115), Expect = 4e-06
Identities = 19/39 (48%), Positives = 21/39 (53%)
Frame = +2
Query: 191 CAGLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGYHC 307
C G +TCC G GCCP+ GVCC D CC G C
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVC 45
>sp|P25777|ORYB_ORYSA Oryzain beta chain precursor
Length = 471
Score = 43.5 bits (101), Expect = 2e-04
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 3/50 (6%)
Frame = +2
Query: 161 DKNNCPDGGQCA---GLQTCCLMYTGHYGCCPFSLGVCCPDLRTCCAPGY 301
D +CP G C G + CL++ GCCP CC D +CC P Y
Sbjct: 387 DNFSCPAGSTCCCAFGFRNLCLVW----GCCPVEGATCCKDHASCCPPDY 432
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,467,716
Number of Sequences: 369166
Number of extensions: 1049902
Number of successful extensions: 3427
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3166
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3387
length of database: 68,354,980
effective HSP length: 98
effective length of database: 50,250,950
effective search space used: 1859285150
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)