Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_N11
(499 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 164 8e-41
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 163 2e-40
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 163 2e-40
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 161 7e-40
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 158 6e-39
sp|O35186|CATK_RAT Cathepsin K precursor 156 3e-38
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 156 3e-38
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 154 1e-37
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 154 1e-37
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 153 2e-37
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 164 bits (416), Expect = 8e-41
Identities = 83/160 (51%), Positives = 110/160 (68%)
Frame = +2
Query: 14 TAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHT 193
+AVP KF N L+ +W +K T R Y + RR +WE+N+K I+ HN EY GKH
Sbjct: 16 SAVP-KFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHG 72
Query: 194 YSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVK 373
+++ +N F DMTNEEF+ + +G + + +G + P + LP SVDWR+KGYVTPVK
Sbjct: 73 FTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVK 130
Query: 374 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCS 493
NQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 131 NQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCS 170
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 163 bits (413), Expect = 2e-40
Identities = 82/165 (49%), Positives = 105/165 (63%)
Frame = +2
Query: 5 VAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLG 184
+ I + KF + LN +W +K T R Y + RR +WE+N+K I+ HN EY G
Sbjct: 12 LGIASAAPKF--DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQG 69
Query: 185 KHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVT 364
KH +++ +N F DMTNEEF+ G K +G + P +P SVDWR+KGYVT
Sbjct: 70 KHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDWREKGYVT 127
Query: 365 PVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGA 499
PVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS A
Sbjct: 128 PVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRA 172
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 163 bits (412), Expect = 2e-40
Identities = 77/145 (53%), Positives = 97/145 (66%)
Frame = +2
Query: 62 WETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEF 241
W +K + ++Y+ D RR IWE+N+K+IQ+HNL +DLG TY+LGLNQF DMT EEF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 242 KAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGS 421
KAKYL M + N +P +DWR+ GYVT VK+Q CGSCW+FS TG+
Sbjct: 81 KAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGT 140
Query: 422 LEGQYFRKNNRLISFSEQQLVDCSG 496
+EGQY + ISFSEQQLVDCSG
Sbjct: 141 MEGQYMKNERTSISFSEQQLVDCSG 165
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 161 bits (408), Expect = 7e-40
Identities = 79/149 (53%), Positives = 98/149 (65%)
Frame = +2
Query: 50 LNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMT 229
L +W +K R Y + RR +WE+N+K I+ HN EY GKH++++ +N F DMT
Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84
Query: 230 NEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFS 409
+EEF+ G KP +G + P P SVDWR+KGYVTPVKNQ QCGSCW+FS
Sbjct: 85 SEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFS 142
Query: 410 ATGSLEGQYFRKNNRLISFSEQQLVDCSG 496
ATG+LEGQ FRK RLIS SEQ LVDCSG
Sbjct: 143 ATGALEGQMFRKTGRLISLSEQNLVDCSG 171
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 158 bits (400), Expect = 6e-39
Identities = 78/152 (51%), Positives = 100/152 (65%)
Frame = +2
Query: 38 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 217
++ L+ +W +K T GR Y + RR +WE+N+K I+ HN EY GKH +S+ +N F
Sbjct: 21 LDQNLDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAF 80
Query: 218 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 397
DMTNEEF+ G K +G + + V P SVDWR+KGYVT VKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDWREKGYVTAVKNQGQCGSC 138
Query: 398 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCS 493
W+FSATG+LEGQ FRK +L+S SEQ LVDCS
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCS 170
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 156 bits (394), Expect = 3e-38
Identities = 77/154 (50%), Positives = 101/154 (65%), Gaps = 2/154 (1%)
Frame = +2
Query: 35 SVNSELNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLN 211
S L+ +WE +K T G++Y+ D I+RRLIWE+NLK I HNLE LG HTY L +N
Sbjct: 17 SPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMN 76
Query: 212 QFADMTNEEFKAKYLGI-MKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQC 388
DMT+EE K G+ + + T PE G +P S+D+R+KGYVTPVKNQ QC
Sbjct: 77 HLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQC 136
Query: 389 GSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDC 490
GSCW+FS+ G+LEGQ +K +L++ S Q LVDC
Sbjct: 137 GSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDC 170
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 156 bits (394), Expect = 3e-38
Identities = 78/154 (50%), Positives = 97/154 (62%)
Frame = +2
Query: 38 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 217
++ L+ W +K T R Y + RR +WE+N K I HN EY GKH + + +N F
Sbjct: 21 LDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHAFRMAMNAF 80
Query: 218 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 397
DMTNEEF+ G K +G + P + V P SVDW +KGYVTPVKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWTKKGYVTPVKNQGQCGSC 138
Query: 398 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSGA 499
W+FSATG+LEGQ FRK +L+S SEQ LVDCS A
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRA 172
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 154 bits (389), Expect = 1e-37
Identities = 77/149 (51%), Positives = 98/149 (65%), Gaps = 2/149 (1%)
Frame = +2
Query: 50 LNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADM 226
L+ WE +K T ++Y+ D I+RRLIWE+NLKYI HNLE LG HTY L +N DM
Sbjct: 22 LDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDM 81
Query: 227 TNEEFKAKYLGI-MKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWS 403
TNEE K G+ + + T P+ G P SVD+R+KGYVTPVKNQ QCGSCW+
Sbjct: 82 TNEEVVQKMTGLKVPASHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA 141
Query: 404 FSATGSLEGQYFRKNNRLISFSEQQLVDC 490
FS+ G+LEGQ +K +L++ S Q LVDC
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDC 170
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 154 bits (388), Expect = 1e-37
Identities = 77/150 (51%), Positives = 102/150 (68%), Gaps = 3/150 (2%)
Frame = +2
Query: 50 LNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADM 226
L+ +WE +K T+ ++Y+ D I+RRLIWE+NLK+I HNLE LG HTY L +N DM
Sbjct: 22 LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDM 81
Query: 227 TNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCW 400
T+EE K G+ K P+ S T P+ G P S+D+R+KGYVTPVKNQ QCGSCW
Sbjct: 82 TSEEVVQKMTGL-KVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCW 140
Query: 401 SFSATGSLEGQYFRKNNRLISFSEQQLVDC 490
+FS+ G+LEGQ +K +L++ S Q LVDC
Sbjct: 141 AFSSVGALEGQLKKKTGKLLNLSPQNLVDC 170
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 153 bits (387), Expect = 2e-37
Identities = 80/165 (48%), Positives = 104/165 (63%), Gaps = 2/165 (1%)
Frame = +2
Query: 2 VVAITAVPQKFSVNSELNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYD 178
VV+ P++ L+ WE +K T ++Y+ D I+RRLIWE+NLKYI HNLE
Sbjct: 11 VVSFALYPEEI-----LDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEAS 65
Query: 179 LGKHTYSLGLNQFADMTNEEFKAKYLGI-MKTKPTLEGSTYMAPENIGVLPASVDWRQKG 355
LG HTY L +N DMT+EE K G+ + + T PE G P SVD+R+KG
Sbjct: 66 LGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKG 125
Query: 356 YVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDC 490
YVTPVKNQ QCGSCW+FS+ G+LEGQ +K +L++ S Q LVDC
Sbjct: 126 YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDC 170
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,929,567
Number of Sequences: 369166
Number of extensions: 1109590
Number of successful extensions: 3292
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3065
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3161
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 3119256630
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)