Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_N09
(857 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9WVK4|EHD1_MOUSE EH-domain containing protein 1 (mPAST1) 360 3e-99
sp|Q9H4M9|EHD1_HUMAN EH-domain containing protein 1 (Testil... 360 4e-99
sp|Q9NZN3|EHD3_HUMAN EH-domain containing protein 3 351 1e-96
sp|Q9QXY6|EHD3_MOUSE EH-domain containing protein 3 350 4e-96
sp|Q9H223|EHD4_HUMAN EH-domain containing protein 4 (Hepato... 336 6e-92
sp|Q9EQP2|EHD4_MOUSE EH-domain containing protein 4 (mPAST2) 331 2e-90
sp|Q9NZN4|EHD2_HUMAN EH-domain containing protein 2 306 5e-83
sp|P13666|SRCA_RABIT Sarcalumenin precursor 119 1e-26
sp|O51461|ENGA_BORBU GTP-binding protein engA 37 0.092
sp|Q8R5M4|OPTN_RAT Optineurin (FIP-2-like protein) 34 0.60
>sp|Q9WVK4|EHD1_MOUSE EH-domain containing protein 1 (mPAST1)
Length = 534
Score = 360 bits (924), Expect = 3e-99
Identities = 183/282 (64%), Positives = 218/282 (77%)
Frame = +1
Query: 4 VIEWFAERVDRIILLFDAHKLDISDEFKRVIELLKGYEDKIRIVLNKADRIDSQQLMRVY 183
V+EWFAERVDRIILLFDAHKLDISDEF VI+ LK +EDKIR+VLNKAD+I++QQLMRVY
Sbjct: 174 VLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVY 233
Query: 184 GALMWSLGKVLYTPEVTRVYIGSFWDQTLHYDTNRKLFELEEHDLMSDLQSLPANAALRK 363
GALMWSLGK++ TPEV RVYIGSFW L NRKLFE EE DL D+QSLP NAALRK
Sbjct: 234 GALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRK 293
Query: 364 LNDLIRRARLAKVHAYIISSLKNQMPSLLGKDSKKKELISNLQRTYDQISKEHSISIGDF 543
LNDLI+RARLAKVHAYIISSLK +MP++ GK+SKKKEL++NL Y +I +EH IS GDF
Sbjct: 294 LNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISSGDF 353
Query: 544 PKIDRMQEVLQDCDFKTFSTLKMKLIEDVDSMLANDVAKLMQMIPKEQSDDSGQFEHRVK 723
P + +MQE+LQ DF F LK KL++ VD MLAND+A+LM M+ +E+S Q VK
Sbjct: 354 PSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQ---AVK 410
Query: 724 GGAFDVQQDNLFGVGASDGINKGKFDDDWVVGRKRYEYDEIF 849
GGAFD + FG G +G +G D +WVVG+ + YDEIF
Sbjct: 411 GGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIF 452
>sp|Q9H4M9|EHD1_HUMAN EH-domain containing protein 1 (Testilin) (hPAST1)
Length = 534
Score = 360 bits (923), Expect = 4e-99
Identities = 183/282 (64%), Positives = 218/282 (77%)
Frame = +1
Query: 4 VIEWFAERVDRIILLFDAHKLDISDEFKRVIELLKGYEDKIRIVLNKADRIDSQQLMRVY 183
V+EWFAERVDRIILLFDAHKLDISDEF VI+ LK +EDKIR+VLNKAD+I++QQLMRVY
Sbjct: 174 VLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVY 233
Query: 184 GALMWSLGKVLYTPEVTRVYIGSFWDQTLHYDTNRKLFELEEHDLMSDLQSLPANAALRK 363
GALMWSLGK++ TPEV RVYIGSFW L NRKLFE EE DL D+QSLP NAALRK
Sbjct: 234 GALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRK 293
Query: 364 LNDLIRRARLAKVHAYIISSLKNQMPSLLGKDSKKKELISNLQRTYDQISKEHSISIGDF 543
LNDLI+RARLAKVHAYIISSLK +MP++ GK+SKKKEL++NL Y +I +EH IS GDF
Sbjct: 294 LNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDF 353
Query: 544 PKIDRMQEVLQDCDFKTFSTLKMKLIEDVDSMLANDVAKLMQMIPKEQSDDSGQFEHRVK 723
P + +MQE+LQ DF F LK KL++ VD MLAND+A+LM M+ +E+S Q VK
Sbjct: 354 PSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQV---VK 410
Query: 724 GGAFDVQQDNLFGVGASDGINKGKFDDDWVVGRKRYEYDEIF 849
GGAFD + FG G +G +G D +WVVG+ + YDEIF
Sbjct: 411 GGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIF 452
>sp|Q9NZN3|EHD3_HUMAN EH-domain containing protein 3
Length = 546
Score = 351 bits (901), Expect = 1e-96
Identities = 181/282 (64%), Positives = 215/282 (76%)
Frame = +1
Query: 4 VIEWFAERVDRIILLFDAHKLDISDEFKRVIELLKGYEDKIRIVLNKADRIDSQQLMRVY 183
V+EWFAERVDRIILLFDAHKLDISDEF VI+ LK +EDK+R+VLNKAD+I++QQLMRVY
Sbjct: 174 VLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVY 233
Query: 184 GALMWSLGKVLYTPEVTRVYIGSFWDQTLHYDTNRKLFELEEHDLMSDLQSLPANAALRK 363
GALMWSLGK++ TPEV RVYIGSFW L NRKLFE EE DL D+QSLP NAALRK
Sbjct: 234 GALMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRK 293
Query: 364 LNDLIRRARLAKVHAYIISSLKNQMPSLLGKDSKKKELISNLQRTYDQISKEHSISIGDF 543
LNDLI+RARLAKVHAYIISSLK +MPS+ GKD+KKKEL++NL Y +I +EH IS GDF
Sbjct: 294 LNDLIKRARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNNLAEIYGRIEREHQISPGDF 353
Query: 544 PKIDRMQEVLQDCDFKTFSTLKMKLIEDVDSMLANDVAKLMQMIPKEQSDDSGQFEHRVK 723
P + RMQ+ LQ DF F LK KL+E VD MLA+D+A+LM ++ +E+S Q VK
Sbjct: 354 PNLKRMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEESQRPIQM---VK 410
Query: 724 GGAFDVQQDNLFGVGASDGINKGKFDDDWVVGRKRYEYDEIF 849
GGAF+ FG G +G +G D +WVV R + YDEIF
Sbjct: 411 GGAFEGTLHGPFGHGYGEGAGEGIDDAEWVVARDKPMYDEIF 452
>sp|Q9QXY6|EHD3_MOUSE EH-domain containing protein 3
Length = 535
Score = 350 bits (897), Expect = 4e-96
Identities = 179/282 (63%), Positives = 215/282 (76%)
Frame = +1
Query: 4 VIEWFAERVDRIILLFDAHKLDISDEFKRVIELLKGYEDKIRIVLNKADRIDSQQLMRVY 183
V+EWFAERVDRIILLFDAHKLDISDEF VI+ LK +EDK+R+VLNKAD+I++QQLMRVY
Sbjct: 174 VLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVLNKADQIETQQLMRVY 233
Query: 184 GALMWSLGKVLYTPEVTRVYIGSFWDQTLHYDTNRKLFELEEHDLMSDLQSLPANAALRK 363
GALMWSLGK++ TPEV RVYIGSFW L NRKLFE EE DL D+QSLP NAALRK
Sbjct: 234 GALMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQDLFRDIQSLPRNAALRK 293
Query: 364 LNDLIRRARLAKVHAYIISSLKNQMPSLLGKDSKKKELISNLQRTYDQISKEHSISIGDF 543
LNDLI+RARLAKVHAYIISSLK +MPS+ GKD+KKKEL++NL Y +I +EH IS GDF
Sbjct: 294 LNDLIKRARLAKVHAYIISSLKKEMPSVFGKDTKKKELVNNLAEIYGRIEREHQISPGDF 353
Query: 544 PKIDRMQEVLQDCDFKTFSTLKMKLIEDVDSMLANDVAKLMQMIPKEQSDDSGQFEHRVK 723
P + +MQ+ LQ DF F LK KL+E VD MLA+D+A+LM ++ +E++ Q VK
Sbjct: 354 PNLKKMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQLMVLVRQEETQRPVQM---VK 410
Query: 724 GGAFDVQQDNLFGVGASDGINKGKFDDDWVVGRKRYEYDEIF 849
GGAF+ FG G +G +G D +WVV R + YDEIF
Sbjct: 411 GGAFEGTLQGPFGHGYGEGAGEGIDDAEWVVARDKPMYDEIF 452
>sp|Q9H223|EHD4_HUMAN EH-domain containing protein 4 (Hepatocellular carcinoma-associated
protein 10/11)
Length = 541
Score = 336 bits (861), Expect = 6e-92
Identities = 168/283 (59%), Positives = 213/283 (75%)
Frame = +1
Query: 1 QVIEWFAERVDRIILLFDAHKLDISDEFKRVIELLKGYEDKIRIVLNKADRIDSQQLMRV 180
QV++WFAERVDRIILLFDAHKLDISDEF I+ +G +DKIR+VLNKAD++D+QQLMRV
Sbjct: 176 QVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRV 235
Query: 181 YGALMWSLGKVLYTPEVTRVYIGSFWDQTLHYDTNRKLFELEEHDLMSDLQSLPANAALR 360
YGALMWSLGKV+ TPEV RVYIGSFW Q L NR+LFE E DL D+QSLP AA+R
Sbjct: 236 YGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVR 295
Query: 361 KLNDLIRRARLAKVHAYIISSLKNQMPSLLGKDSKKKELISNLQRTYDQISKEHSISIGD 540
KLNDLI+RARLAKVHAYIIS LK +MPS+ GK++KK+ELIS L Y Q+ +E+ IS GD
Sbjct: 296 KLNDLIKRARLAKVHAYIISYLKKEMPSVFGKENKKRELISRLPEIYIQLQREYQISAGD 355
Query: 541 FPKIDRMQEVLQDCDFKTFSTLKMKLIEDVDSMLANDVAKLMQMIPKEQSDDSGQFEHRV 720
FP++ MQE L++ DF F +LK KLIE VD+ML+N ++ LM +I +E++ Q V
Sbjct: 356 FPEVKAMQEQLENYDFTKFHSLKPKLIEAVDNMLSNKISPLMNLISQEETSTPTQL---V 412
Query: 721 KGGAFDVQQDNLFGVGASDGINKGKFDDDWVVGRKRYEYDEIF 849
+GGAFD + F G +G +G +++WVV + + YDE+F
Sbjct: 413 QGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELF 455
>sp|Q9EQP2|EHD4_MOUSE EH-domain containing protein 4 (mPAST2)
Length = 541
Score = 331 bits (848), Expect = 2e-90
Identities = 166/283 (58%), Positives = 211/283 (74%)
Frame = +1
Query: 1 QVIEWFAERVDRIILLFDAHKLDISDEFKRVIELLKGYEDKIRIVLNKADRIDSQQLMRV 180
QV++WFAERVDRIILLFDAHKLDISDEF I+ +G +DKIR+VLNKAD++D+QQLMRV
Sbjct: 176 QVLQWFAERVDRIILLFDAHKLDISDEFSEAIKAFRGQDDKIRVVLNKADQVDTQQLMRV 235
Query: 181 YGALMWSLGKVLYTPEVTRVYIGSFWDQTLHYDTNRKLFELEEHDLMSDLQSLPANAALR 360
YGALMWSLGKV+ TPEV RVYIGSFW Q L NR+LFE E DL D+QSLP AA+R
Sbjct: 236 YGALMWSLGKVINTPEVLRVYIGSFWAQPLQNTDNRRLFEAEAQDLFRDIQSLPQKAAVR 295
Query: 361 KLNDLIRRARLAKVHAYIISSLKNQMPSLLGKDSKKKELISNLQRTYDQISKEHSISIGD 540
KLNDLI+RARLAKVHAYIIS LK +MP++ GK++KK+ELI L Y Q+ +E+ IS GD
Sbjct: 296 KLNDLIKRARLAKVHAYIISYLKKEMPNMFGKENKKRELIYRLPEIYVQLQREYQISAGD 355
Query: 541 FPKIDRMQEVLQDCDFKTFSTLKMKLIEDVDSMLANDVAKLMQMIPKEQSDDSGQFEHRV 720
FP++ MQE L++ DF F +LK KLIE VD+ML N ++ LM +I +E+ + Q V
Sbjct: 356 FPEVKAMQEQLENYDFTKFHSLKPKLIEAVDNMLTNKISSLMGLISQEEMNMPTQM---V 412
Query: 721 KGGAFDVQQDNLFGVGASDGINKGKFDDDWVVGRKRYEYDEIF 849
+GGAFD + F G +G +G +++WVV + + YDE+F
Sbjct: 413 QGGAFDGTTEGPFNQGYGEGAKEGADEEEWVVAKDKPVYDELF 455
>sp|Q9NZN4|EHD2_HUMAN EH-domain containing protein 2
Length = 543
Score = 306 bits (784), Expect = 5e-83
Identities = 161/287 (56%), Positives = 204/287 (71%), Gaps = 5/287 (1%)
Frame = +1
Query: 4 VIEWFAERVDRIILLFDAHKLDISDEFKRVIELLKGYEDKIRIVLNKADRIDSQQLMRVY 183
V+ WFAERVD IILLFDAHKL+ISDEF I L+G+EDKIR+VLNKAD +++QQLMRVY
Sbjct: 174 VLRWFAERVDLIILLFDAHKLEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVY 233
Query: 184 GALMWSLGKVLYTPEVTRVYIGSFWDQTLHYDTNRKLFELEEHDLMSDLQSLPANAALRK 363
GALMW+LGKV+ TPEV RVYIGSFW Q L NR+LFELEE DL D+Q LP +AALRK
Sbjct: 234 GALMWALGKVVGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRK 293
Query: 364 LNDLIRRARLAKVHAYIISSLKNQMPSLLGKDSKKKELISNLQRTYDQISKEHSISIGDF 543
LNDL++RARL +VHAYIIS LK +MPS+ GK++KKK+LI L + +I EH IS GDF
Sbjct: 294 LNDLVKRARLVRVHAYIISYLKKEMPSVFGKENKKKQLILKLPVIFAKIQLEHHISPGDF 353
Query: 544 PKIDRMQEVLQDCDFKTFSTLKMKLIEDVDSMLANDVAKLMQMIPKEQSDDSGQFEHRVK 723
P +MQE+L DF F +LK KL+E +D ML +D+AKLM ++ +E+ + + E V+
Sbjct: 354 PDCQKMQELLMAHDFTKFHSLKPKLLEALDEMLTHDIAKLMPLLRQEELEST---EVGVQ 410
Query: 724 GGAFDVQQDNLF-----GVGASDGINKGKFDDDWVVGRKRYEYDEIF 849
GGAF+ F DG + +WVV + + +YDEIF
Sbjct: 411 GGAFEGTHMGPFVERGPDEAMEDGEEGSDDEAEWVVTKDKSKYDEIF 457
>sp|P13666|SRCA_RABIT Sarcalumenin precursor
Length = 908
Score = 119 bits (297), Expect = 1e-26
Identities = 71/234 (30%), Positives = 120/234 (51%), Gaps = 13/234 (5%)
Frame = +1
Query: 4 VIEWFAERVDRIILLFDAHKLDISDEFKRVIELLKGYEDKIRIVLNKADRIDSQQLMRVY 183
V +WF +R D I ++FD KLD+ E + + LKG E +IRI+LNKAD + +Q LMRVY
Sbjct: 645 VCQWFIDRADLIFVVFDPTKLDVGLELETLFRQLKGRESQIRIILNKADNLATQMLMRVY 704
Query: 184 GALMWSLGKVLYTPEVTRVYIGSFWDQTLHYDTNRKLFELEEHDLMSDLQSLPANAALRK 363
GAL WSL ++ E RVY+ SFW Q DT+R+LF EE L+ DL + N K
Sbjct: 705 GALFWSLAPLINVTEPPRVYVSSFWPQEYKPDTHRELFLREEISLLEDLNQVIENRLENK 764
Query: 364 LNDLIRRARLAKVHAYII----SSLKNQMPSLLGKDSKKKELISNLQRTY--DQISKEHS 525
+ + + A ++HA ++ + K++M + K+++ + + Y I + +
Sbjct: 765 IAFIRQHAIRVRIHALLVDRYLQTYKDKMTFFSDGELVFKDIVEDPDKFYIFKTILAKTN 824
Query: 526 ISIGDFPKIDRMQEVLQDCDFKTFSTLKMK-------LIEDVDSMLANDVAKLM 666
+S D P + ++ +F L + +E ++ + ++ L+
Sbjct: 825 VSKFDLPNREAYKDFFGINPISSFKLLSQQCSYMGGCFLEKIERAITQELPSLL 878
>sp|O51461|ENGA_BORBU GTP-binding protein engA
Length = 433
Score = 36.6 bits (83), Expect = 0.092
Identities = 19/50 (38%), Positives = 32/50 (64%)
Frame = +1
Query: 22 ERVDRIILLFDAHKLDISDEFKRVIELLKGYEDKIRIVLNKADRIDSQQL 171
E+VD I+L+ D +++ + D ++IE L+ Y K+ +VLNK D D + L
Sbjct: 82 EKVDLILLVLDINEILLEDY--QIIERLRKYSSKVVLVLNKVDTKDKECL 129
>sp|Q8R5M4|OPTN_RAT Optineurin (FIP-2-like protein)
Length = 585
Score = 33.9 bits (76), Expect = 0.60
Identities = 31/162 (19%), Positives = 72/162 (44%), Gaps = 6/162 (3%)
Frame = +1
Query: 226 EVTRVYIGSFWDQTLHYDTNRKLFELEEHDLMSDLQSLPAN-----AALRKLNDLIRRAR 390
E V + S + + T EL + L Q+L + L + +L+ R
Sbjct: 304 ETLNVQVASLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSATPSELNEKQELVYSNR 363
Query: 391 LAKVHAYIISSLKNQMPSLLGKDSKKKELISNLQRTYDQISKEHSISIGDFPKIDRMQ-E 567
++ + S+++++ K ++K ++ LQ T+D++ +EH+ ++ ++ + Q E
Sbjct: 364 KLELQ---VESMRSEIKMEQAKTEEEKSRLATLQATHDKLLQEHNKALRTIEELTKQQAE 420
Query: 568 VLQDCDFKTFSTLKMKLIEDVDSMLANDVAKLMQMIPKEQSD 693
+ + S K++L E + + ++ Q I K++ D
Sbjct: 421 KVDKVQLQELSE-KLELAEQALASKQLQMDEMKQTIAKQEED 461
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,580,662
Number of Sequences: 369166
Number of extensions: 1783997
Number of successful extensions: 5356
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5119
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5345
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)