Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_N07
(694 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 246 5e-65
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 245 7e-65
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 244 1e-64
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 234 1e-61
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 230 2e-60
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 221 2e-57
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 202 5e-52
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 179 6e-45
sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3... 161 2e-39
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 159 5e-39
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 246 bits (627), Expect = 5e-65
Identities = 116/203 (57%), Positives = 139/203 (68%), Gaps = 1/203 (0%)
Frame = +2
Query: 86 PIHTPLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 262
P PLS DLINY+N TTW+AG IS ++K+ G V+ P KLP R
Sbjct: 21 PSFHPLSDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGP---KLPGRVAFGE 76
Query: 263 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 442
+ LP TFDAR QW C +IG+IRDQ +CGSCWAFGAVEAI+DR CIH+NG +SAE
Sbjct: 77 DIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAE 136
Query: 443 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 622
DLLTCCG +CGDGCNGG+PSGAW +W GLV+GG Y +H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRP 196
Query: 623 NCTGEFPTPKCKKACQAGYSKTY 691
CTGE TP+C K+C+AGYS +Y
Sbjct: 197 PCTGEGDTPRCNKSCEAGYSPSY 219
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 245 bits (626), Expect = 7e-65
Identities = 114/199 (57%), Positives = 139/199 (69%), Gaps = 1/199 (0%)
Frame = +2
Query: 98 PLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLNRVRL 274
PLS +L+N+VN TTWKAG +S ++K+ G ++ P KLP+R V L
Sbjct: 25 PLSDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGP---KLPQRDAFAADVVL 80
Query: 275 PTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLT 454
P +FDAR QWP C +I EIRDQ +CGSCWAFGAVEAI+DR CIHSNG +SAED+LT
Sbjct: 81 PESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLT 140
Query: 455 CCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTG 634
CCG CGDGCNGGFPSGAW++W GLV+GG Y +H+GC+ Y+ P C HHV G P CTG
Sbjct: 141 CCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTG 200
Query: 635 EFPTPKCKKACQAGYSKTY 691
E TPKC K C+ GYS +Y
Sbjct: 201 EGDTPKCNKTCEPGYSPSY 219
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 244 bits (624), Expect = 1e-64
Identities = 113/203 (55%), Positives = 139/203 (68%), Gaps = 1/203 (0%)
Frame = +2
Query: 86 PIHTPLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 262
P PLS D+INY+N TTW+AG IS ++K+ G V+ PN LP+R
Sbjct: 21 PSSHPLSDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPN---LPERVGFSE 76
Query: 263 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 442
+ LP +FDAR QW C +I +IRDQ +CGSCWAFGAVEA++DR CIH+NG +SAE
Sbjct: 77 DINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAE 136
Query: 443 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 622
DLLTCCG +CGDGCNGG+PSGAW++W GLV+GG Y +H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRP 196
Query: 623 NCTGEFPTPKCKKACQAGYSKTY 691
CTGE TPKC K C+AGYS +Y
Sbjct: 197 PCTGEGDTPKCNKMCEAGYSTSY 219
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 234 bits (598), Expect = 1e-61
Identities = 108/202 (53%), Positives = 137/202 (67%)
Frame = +2
Query: 86 PIHTPLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR 265
P PLS +L+NYVN TTW+AG +S ++++ G K P+R
Sbjct: 21 PSFHPLSDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFL--GGPKPPQRVMFTED 77
Query: 266 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 445
++LP +FDAR QWP+C +I EIRDQ +CGSCWAFGAVEAI+DR CIH+N + +SAED
Sbjct: 78 LKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAED 137
Query: 446 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 625
LLTCCG CGDGCNGG+P+ AW++W GLV+GG Y +H+GC+ Y+ P C HHV G P
Sbjct: 138 LLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPP 197
Query: 626 CTGEFPTPKCKKACQAGYSKTY 691
CTGE TPKC K C+ GYS TY
Sbjct: 198 CTGEGDTPKCSKICEPGYSPTY 219
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 230 bits (587), Expect = 2e-60
Identities = 106/204 (51%), Positives = 135/204 (66%), Gaps = 1/204 (0%)
Frame = +2
Query: 83 IPIHTPLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLN 262
IP + PLS DL+N++N + TT +AG +S ++K+ G K P+R
Sbjct: 20 IPYYPPLSSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFL--GGPKAPERVDFAE 76
Query: 263 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 442
+ LP TFD R QWP C +I EIRDQ +CGSCWAFGAVEAI+DR C+H+N + +SAE
Sbjct: 77 DMDLPDTFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAE 136
Query: 443 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 622
DLL+CCGF CG GCNGG+PSGAW YW GLV+GG Y +H+GC+ Y P C HHV G P
Sbjct: 137 DLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRP 196
Query: 623 NCTGE-FPTPKCKKACQAGYSKTY 691
CTGE TP+C + C+ GYS +Y
Sbjct: 197 PCTGEGGETPRCSRHCEPGYSPSY 220
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 221 bits (562), Expect = 2e-57
Identities = 104/203 (51%), Positives = 131/203 (64%), Gaps = 5/203 (2%)
Frame = +2
Query: 98 PLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 265
PLS ++I+++N WKA + RF S+ D R ++G K+ K R+P ++
Sbjct: 29 PLSDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKR-NRRPTVDHHDLN 87
Query: 266 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 445
V +P+ FD+R +WP CKSI +IRDQS CGSCWAFGAVEA+TDR CI S G Q+ +SA D
Sbjct: 88 VEIPSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALD 147
Query: 446 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 625
L++CC CGDGC GGFP AW YWV G+VTGG H GCQ Y FPKC HH G YP
Sbjct: 148 LISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPA 206
Query: 626 C-TGEFPTPKCKKACQAGYSKTY 691
C T + TP+CK+ CQ GY Y
Sbjct: 207 CGTKIYKTPQCKQTCQKGYKTPY 229
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 202 bits (515), Expect = 5e-52
Identities = 96/203 (47%), Positives = 125/203 (61%), Gaps = 5/203 (2%)
Frame = +2
Query: 98 PLSFDLINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 265
PLS D+I+Y+N W+A + RF S+ D R +G ++ + + KR+P ++
Sbjct: 28 PLSDDIISYINEHPNAGWRAEKSNRFHSLDDARIQMGARREEPDLRR-KRRPTVDHNDWN 86
Query: 266 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 445
V +P+ FD+R +WP CKSI IRDQS CGSCW+FGAVEA++DR CI S G Q +SA D
Sbjct: 87 VEIPSNFDSRKKWPGCKSIATIRDQSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVD 146
Query: 446 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 625
LLTCC CG GC GG AW YWV +G+VT H GC+ Y FPKC HH G YP
Sbjct: 147 LLTCCE-SCGLGCEGGILGPAWDYWVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPP 205
Query: 626 CTGE-FPTPKCKKACQAGYSKTY 691
C + + TP+CK+ CQ Y Y
Sbjct: 206 CGSKIYNTPRCKQTCQRKYKTPY 228
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 179 bits (454), Expect = 6e-45
Identities = 99/207 (47%), Positives = 127/207 (61%), Gaps = 12/207 (5%)
Frame = +2
Query: 110 DLINYVNYVAQTTWKAGPTTRFQSI-SDIRKVLGVMKDPNNFKLP-KRKPLLNRVR---- 271
DLI+YVN Q W A RF S+ + K + N+ +L K K L++ +
Sbjct: 45 DLIDYVNE-NQNLWTAKKQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDL 103
Query: 272 -LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDL 448
+P +FD+R WPKC SI IRDQS+CGSCWAFGAVEA++DR CI S+G +SA+DL
Sbjct: 104 DIPESFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDL 163
Query: 449 LTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHV----IGP 616
L+CC CG GCNGG P AW YWV DG+VTG Y A+ GC+ Y FP C HH P
Sbjct: 164 LSCCK-SCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDP 222
Query: 617 YPNCTGEFPTPKCKKACQAGYS-KTYA 694
P+ +PTPKC+K C + Y+ KTY+
Sbjct: 223 CPH--DLYPTPKCEKKCVSDYTDKTYS 247
>sp|P43507|CPR3_CAEEL Cathepsin B-like cysteine proteinase 3 precursor (Cysteine
protease-related 3)
Length = 370
Score = 161 bits (407), Expect = 2e-39
Identities = 88/198 (44%), Positives = 110/198 (55%), Gaps = 9/198 (4%)
Frame = +2
Query: 113 LINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNRV-------- 268
L+++VN V QT+W A IS+ VM L K + + +
Sbjct: 35 LVDHVNTV-QTSWVA----EHNEISEFEMKFKVMDVKFAEPLEKDSDVASELFVRGEIVP 89
Query: 269 -RLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 445
LP TFDAR +WP C +I IR+Q+ CGSCWAFGA E I+DR CI SNGTQ P IS ED
Sbjct: 90 EPLPDTFDAREKWPDCNTIKLIRNQATCGSCWAFGAAEVISDRVCIQSNGTQQPVISVED 149
Query: 446 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 625
+L+CCG CG GC GG+ A +W + G VTGG+YG H GC Y+F C+ N
Sbjct: 150 ILSCCGTTCGYGCKGGYSIEALRFWASSGAVTGGDYGGH-GCMPYSFAPCT-------KN 201
Query: 626 CTGEFPTPKCKKACQAGY 679
C E TP CK CQ+ Y
Sbjct: 202 CP-ESTTPSCKTTCQSSY 218
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 159 bits (403), Expect = 5e-39
Identities = 87/192 (45%), Positives = 108/192 (56%), Gaps = 7/192 (3%)
Frame = +2
Query: 113 LINYVNYVAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNRV---RLPTT 283
LI+YVN AQ W AG + K+ + D K + ++ +P
Sbjct: 32 LIDYVNS-AQKLWTAG-----HQVIPKEKITKKLMDVKYLVPHKDEDIVATEVSDAIPDH 85
Query: 284 FDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCG 463
FDAR QWP C SI IRDQS+CGSCWAF A EAI+DR CI SNG +S+EDLL+CC
Sbjct: 86 FDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVNTLLSSEDLLSCCT 145
Query: 464 --FRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIG-PYPNCTG 634
F CG+GC GG+P AW +WV GLVTGG Y GC+ Y+ C V G +P C
Sbjct: 146 GMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCGETVNGVKWPACPE 205
Query: 635 EF-PTPKCKKAC 667
+ PTPKC +C
Sbjct: 206 DTEPTPKCVDSC 217
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,892,616
Number of Sequences: 369166
Number of extensions: 1813088
Number of successful extensions: 5301
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4891
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5151
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5976365205
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)