Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_M17
(772 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9EQU5|SET_MOUSE SET protein (Phosphatase 2A inhibitor I... 196 4e-50
sp|Q63945|SET_RAT SET protein (Phosphatase 2A inhibitor I2P... 195 1e-49
sp|Q01105|SET_HUMAN SET protein (Phosphatase 2A inhibitor I... 190 4e-48
sp|P53997|SET_DROME SET protein 178 2e-44
sp|Q18240|SPR2_CAEEL Suppressor of presenilin 2 159 6e-39
sp|Q9UJ04|TSYL4_HUMAN Testis-specific Y-encoded-like protei... 120 3e-27
sp|O88852|TSYL1_MOUSE Testis-specific Y-encoded-like protei... 119 1e-26
sp|Q9H0U9|TSYL1_HUMAN Testis-specific Y-encoded-like protei... 118 2e-26
sp|P13825|ASP_PLAFS Aspartic acid-rich protein precursor 115 1e-25
sp|Q8VD63|TSYL4_MOUSE Testis-specific Y-encoded-like protei... 113 7e-25
>sp|Q9EQU5|SET_MOUSE SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A)
(Template-activating factor I) (TAF-I)
Length = 289
Score = 196 bits (499), Expect = 4e-50
Identities = 102/217 (47%), Positives = 137/217 (63%), Gaps = 2/217 (0%)
Frame = +1
Query: 4 ASAPKIQ-KTESNGKVDQDQVLNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQP 180
A+APK++ K+ S G ++ IE IDEVQ++ID+LNEQASEEIL+VE+K+N+ RQP
Sbjct: 19 AAAPKLEDKSASPGLPKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQP 78
Query: 181 LFQQRANLIKTIPNFWINALSNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIM 360
FQ+R+ LI IPNFW+ NHPQ+ L+ E DE+ L LT ++V EF+DIKSG++I
Sbjct: 79 FFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDF 138
Query: 361 TFSPNEYFNNTTITKSIHVGES-EIKTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXX 537
F N YF N ++K H+ ES + + + WK GK+ K +++ N
Sbjct: 139 YFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQN--KASRKRQHE 196
Query: 538 XPISFMQWFTSDIANSMVELGEVIKDDLWPNPLQYYL 648
P SF WFT ELGEVIKDD+WPNPLQYYL
Sbjct: 197 EPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYL 233
>sp|Q63945|SET_RAT SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A)
(Template-activating factor I) (TAF-I) (Liver
regeneration-related protein LRRGR00002)
Length = 289
Score = 195 bits (495), Expect = 1e-49
Identities = 101/216 (46%), Positives = 136/216 (62%), Gaps = 2/216 (0%)
Frame = +1
Query: 7 SAPKIQ-KTESNGKVDQDQVLNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPL 183
+APK++ K+ S G ++ IE IDEVQ++ID+LNEQASEEIL+VE+K+N+ RQP
Sbjct: 20 AAPKLEDKSASPGLPKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPF 79
Query: 184 FQQRANLIKTIPNFWINALSNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMT 363
FQ+R+ LI IPNFW+ NHPQ+ L+ E DE+ L LT ++V EF+DIKSG++I
Sbjct: 80 FQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFY 139
Query: 364 FSPNEYFNNTTITKSIHVGES-EIKTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXX 540
F N YF N ++K H+ ES + + + WK GK+ K +++ N
Sbjct: 140 FDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQN--KASRKRQHEE 197
Query: 541 PISFMQWFTSDIANSMVELGEVIKDDLWPNPLQYYL 648
P SF WFT ELGEVIKDD+WPNPLQYYL
Sbjct: 198 PESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYL 233
>sp|Q01105|SET_HUMAN SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A)
(Template-activating factor I) (TAF-I) (HLA-DR
associated protein II) (PHAPII) (Inhibitor of granzyme
A-activated DNase) (IGAAD)
Length = 290
Score = 190 bits (482), Expect = 4e-48
Identities = 95/192 (49%), Positives = 124/192 (64%), Gaps = 1/192 (0%)
Frame = +1
Query: 76 IEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQ 255
IE IDEVQ++ID+LNEQASEEIL+VE+K+N+ RQP FQ+R+ LI IPNFW+ NHPQ
Sbjct: 45 IEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQ 104
Query: 256 LMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EI 432
+ L+ E DE+ L LT ++V EF+DIKSG++I F N YF N ++K H+ ES +
Sbjct: 105 VSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDP 164
Query: 433 KTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGEVIK 612
+ + WK GK+ K +++ N P SF WFT ELGEVIK
Sbjct: 165 SSKSTEIKWKSGKDLTKRSSQTQN--KASRKRQHEEPESFFTWFTDHSDAGADELGEVIK 222
Query: 613 DDLWPNPLQYYL 648
DD+WPNPLQYYL
Sbjct: 223 DDIWPNPLQYYL 234
>sp|P53997|SET_DROME SET protein
Length = 269
Score = 178 bits (451), Expect = 2e-44
Identities = 91/230 (39%), Positives = 136/230 (59%), Gaps = 14/230 (6%)
Frame = +1
Query: 1 MASAPKIQKTE-------SNGKVDQDQVLNSLIEKIDEVQSDIDKLNEQASEEILEVEKK 159
M+S PK K + ++ ++ + +E+ID Q++ID LNE+ASEEIL+VE+K
Sbjct: 1 MSSVPKRAKLDGAPADGNTSAAAGNNEEESEALEQIDACQNEIDALNEKASEEILKVEQK 60
Query: 160 FNQKRQPLFQQRANLIKTIPNFWINALSNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIK 339
+N+ R+P +++R+ L+K IPNFW+ + NHPQ+ ++ E +E+ L +L L+VEEF+DIK
Sbjct: 61 YNKLRKPCYEKRSELVKRIPNFWVTSFINHPQVSGILDEEEEECLHALNKLEVEEFEDIK 120
Query: 340 SGFKIIMTFSPNEYFNNTTITKSIHVGESEIK-------TTCDPVDWKEGKNFVKSLNES 498
SG++I F N YF N +TK H+ + +T P+ WKEGKN +K L
Sbjct: 121 SGYRINFHFDENPYFENKVLTKEFHLNSAAASENGDWPASTSTPIKWKEGKNLLKLL--- 177
Query: 499 LNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGEVIKDDLWPNPLQYYL 648
L +F WF+ + E+ E+IKDDLWPNPLQYYL
Sbjct: 178 LTKPYGNKKKRNSEYKTFFDWFSDNTDPVNDEIAELIKDDLWPNPLQYYL 227
>sp|Q18240|SPR2_CAEEL Suppressor of presenilin 2
Length = 312
Score = 159 bits (403), Expect = 6e-39
Identities = 85/196 (43%), Positives = 113/196 (57%)
Frame = +1
Query: 61 VLNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINAL 240
V LIE +D +Q +D ++E A+EE+L+VE+ FNQKR P++++R L I NFW A
Sbjct: 27 VKEKLIE-LDAIQHQLDVMSENAAEEVLKVEQIFNQKRLPIYEKRKKLTTKIDNFWQTAF 85
Query: 241 SNHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVG 420
NH L T I E EDLL +L L+V+EF+D++SGFKIIMTF PNEYF N ITKS H+
Sbjct: 86 LNHHLLSTAIPEEQEDLLAALRDLEVQEFEDLRSGFKIIMTFDPNEYFTNEVITKSYHLQ 145
Query: 421 ESEIKTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELG 600
T ++WKE K +F++W T E+
Sbjct: 146 SESPSTEITEIEWKENKK-------------PPFPEDGDSAHTFLEWLTYAALPDSDEIA 192
Query: 601 EVIKDDLWPNPLQYYL 648
EVIKDDL+ NPLQYY+
Sbjct: 193 EVIKDDLYVNPLQYYV 208
>sp|Q9UJ04|TSYL4_HUMAN Testis-specific Y-encoded-like protein 4 (TSPY-like 4)
Length = 414
Score = 120 bits (302), Expect = 3e-27
Identities = 60/196 (30%), Positives = 102/196 (52%), Gaps = 1/196 (0%)
Frame = +1
Query: 64 LNSLIEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALS 243
+N+ ++ ++ + ++ +N QA L++E+KF + R+ Q+R+ +I+ IP FW+ A
Sbjct: 200 INNCMDSLEAIDQELSNVNAQADRAFLQLERKFGRMRRLHMQRRSFIIQNIPGFWVTAFR 259
Query: 244 NHPQLMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGE 423
NHPQL +I+ DED+L+ + +L+VEE ++G K F N YF N + K
Sbjct: 260 NHPQLSPMISGQDEDMLRYMINLEVEELKHPRAGCKFKFIFQGNPYFRNEGLVKEYERRS 319
Query: 424 S-EIKTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELG 600
S + + P+ W G++ ++ + SF WF+ +
Sbjct: 320 SGRVVSLSTPIRWHRGQDPQAHIHRNREGNTIP---------SFFNWFSDHSLLEFDRIA 370
Query: 601 EVIKDDLWPNPLQYYL 648
E+IK +LWPNPLQYYL
Sbjct: 371 EIIKGELWPNPLQYYL 386
>sp|O88852|TSYL1_MOUSE Testis-specific Y-encoded-like protein 1 (TSPY-like 1)
Length = 379
Score = 119 bits (297), Expect = 1e-26
Identities = 63/192 (32%), Positives = 100/192 (52%), Gaps = 4/192 (2%)
Frame = +1
Query: 85 IDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQLMT 264
++ +Q ++D +N QA +E+KF + R+ ++R +I+ IP FW+ A NHPQL
Sbjct: 174 LEAIQLELDTVNAQADRAFQHLEQKFGRMRRHYLERRNYIIQNIPGFWMTAFRNHPQLSA 233
Query: 265 LITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EIKTT 441
+I D ++L+ +TSL+V+E K+G K F N YF N I K V S + +
Sbjct: 234 MIRGRDAEMLRYVTSLEVKELRHPKTGCKFKFFFRRNPYFRNKLIVKEYEVRSSGRVVSL 293
Query: 442 CDPVDWKEG---KNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGEVIK 612
P+ W+ G ++F++ + + SF WF+ + E+IK
Sbjct: 294 STPIIWRRGHEPQSFIRRNQDLI--------------CSFFTWFSDHSLPESDRIAEIIK 339
Query: 613 DDLWPNPLQYYL 648
+DLWPNPLQYYL
Sbjct: 340 EDLWPNPLQYYL 351
>sp|Q9H0U9|TSYL1_HUMAN Testis-specific Y-encoded-like protein 1 (TSPY-like 1)
Length = 438
Score = 118 bits (295), Expect = 2e-26
Identities = 61/195 (31%), Positives = 103/195 (52%), Gaps = 4/195 (2%)
Frame = +1
Query: 76 IEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQ 255
++ ++ +Q ++D +N QA ++E KF + R+ ++R +I+ IP FW+ A NHPQ
Sbjct: 230 MDPLEAIQLELDTVNAQADRAFQQLEHKFGRMRRHYLERRNYIIQNIPGFWMTAFRNHPQ 289
Query: 256 LMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EI 432
L +I D ++L+ +T+L+V+E ++G K F N YF N I K V S +
Sbjct: 290 LSAMIRGQDAEMLRYITNLEVKELRHPRTGCKFKFFFRRNPYFRNKLIVKEYEVRSSGRV 349
Query: 433 KTTCDPVDWKEG---KNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGE 603
+ P+ W+ G ++F++ + + SF WF+ ++ E
Sbjct: 350 VSLSTPIIWRRGHEPQSFIRRNQDLI--------------CSFFTWFSDHSLPESDKIAE 395
Query: 604 VIKDDLWPNPLQYYL 648
+IK+DLWPNPLQYYL
Sbjct: 396 IIKEDLWPNPLQYYL 410
>sp|P13825|ASP_PLAFS Aspartic acid-rich protein precursor
Length = 253
Score = 115 bits (289), Expect = 1e-25
Identities = 59/190 (31%), Positives = 104/190 (54%), Gaps = 3/190 (1%)
Frame = +1
Query: 94 VQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQLMTLIT 273
VQ DI++L+ + + E + ++K++++K++PLF++R +I+ IP FW N L HP L ++
Sbjct: 20 VQKDIEQLDIKCAHEQMNIQKQYDEKKKPLFEKRDEIIQKIPGFWANTLRKHPALSDIVP 79
Query: 274 EHDEDLLQSLTSLDVEEFDDIKSGFKIIMTF--SPNEYFNNTTITKSIHVGESEIKTT-C 444
E D D+L L LD+++ D +KI F E+ T+ K + ++ K C
Sbjct: 80 E-DIDILNHLVKLDLKDNMDNNGSYKITFIFGEKAKEFMEPLTLVKHVTFDNNQEKVVEC 138
Query: 445 DPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGEVIKDDLW 624
+ WKEGKN + ++ + + S +WFT+D ++GE+I+ ++W
Sbjct: 139 TRIKWKEGKNPIAAVTHNRSDLDNEIPKW-----SIFEWFTTDELQDKPDVGELIRREIW 193
Query: 625 PNPLQYYLAV 654
NPL YYL +
Sbjct: 194 HNPLSYYLGL 203
>sp|Q8VD63|TSYL4_MOUSE Testis-specific Y-encoded-like protein 4 (TSPY-like 4)
Length = 406
Score = 113 bits (282), Expect = 7e-25
Identities = 57/192 (29%), Positives = 96/192 (50%), Gaps = 1/192 (0%)
Frame = +1
Query: 76 IEKIDEVQSDIDKLNEQASEEILEVEKKFNQKRQPLFQQRANLIKTIPNFWINALSNHPQ 255
++ ++ + ++ +N QA L++E+KF + R+ Q+R+ +I+ IP FW+ A NHPQ
Sbjct: 196 MDSLEAIDQELSNVNAQADRAFLQLERKFGRMRRLHMQRRSFIIQNIPGFWVTAFRNHPQ 255
Query: 256 LMTLITEHDEDLLQSLTSLDVEEFDDIKSGFKIIMTFSPNEYFNNTTITKSIHVGES-EI 432
L +I+ DED+++ + +L+VEE + G K F N YF N + K S +
Sbjct: 256 LSPMISGQDEDMMRYMINLEVEELKQPRVGCKFKFIFQSNPYFRNEGLVKEYERRSSGRV 315
Query: 433 KTTCDPVDWKEGKNFVKSLNESLNXXXXXXXXXXXXPISFMQWFTSDIANSMVELGEVIK 612
+ P+ W G+ ++ + SF WF+ + E+IK
Sbjct: 316 VSLSTPIRWHRGQEPQAHIHRNREGNTIP---------SFFNWFSDHSLLEFDRIAEIIK 366
Query: 613 DDLWPNPLQYYL 648
+LW NPLQYYL
Sbjct: 367 GELWSNPLQYYL 378
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,866,411
Number of Sequences: 369166
Number of extensions: 1387115
Number of successful extensions: 4849
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4618
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4811
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7163732800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)