Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_M14
(848 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P48052|CBPA2_HUMAN Carboxypeptidase A2 precursor 170 5e-42
sp|O02350|CBPA_ANOGA Zinc carboxypeptidase A precursor 164 2e-40
sp|P19222|CBPA2_RAT Carboxypeptidase A2 precursor 164 4e-40
sp|Q8R4H4|CBPA5_MOUSE Carboxypeptidase A5 precursor 150 3e-36
sp|Q9UI42|CBPA4_HUMAN Carboxypeptidase A4 precursor (Carbox... 145 1e-34
sp|Q8WXQ8|CBPA5_HUMAN Carboxypeptidase A5 precursor 145 1e-34
sp|P00730|CBPA1_BOVIN Carboxypeptidase A1 precursor 144 4e-34
sp|P09954|CBPA1_PIG Carboxypeptidase A1 precursor 142 9e-34
sp|Q6P8K8|CBPA4_MOUSE Carboxypeptidase A4 precursor 136 6e-32
sp|Q7TPZ8|CBPA1_MOUSE Carboxypeptidase A1 precursor 135 2e-31
>sp|P48052|CBPA2_HUMAN Carboxypeptidase A2 precursor
Length = 417
Score = 170 bits (430), Expect = 5e-42
Identities = 111/292 (38%), Positives = 159/292 (54%), Gaps = 11/292 (3%)
Frame = +1
Query: 1 LSVIFFFPSLISSSYD-----GYKVIEVNLKTEYEIKFILQLT--EKYEADIWKGPSKVI 159
+ +I FF +L Y G +V+E+ E +IK +LQL E + D WK P+
Sbjct: 1 MRLILFFGALFGHIYCLETFVGDQVLEIVPSNEEQIKNLLQLEAQEHLQLDFWKSPTTPG 60
Query: 160 ST-HVMLSPKYFNDFTEALKKDGIEFKIILENVEDAINKESFMNTNVRLFKLFKKEGPNV 336
T HV + L+ GI + I++E+V+ ++KE+ LF ++ N
Sbjct: 61 ETAHVRVPFVNVQAVKVFLESQGIAYSIMIEDVQVLLDKEN----EEMLFNRRRERSGNF 116
Query: 337 N-DHFATYEEIMQWISFLTNKY-SFVTSNSYGKSYEGRDLKYVKISTGPNRKAILIDGGI 510
N + T EEI Q + L ++ V+ + G S+E R + +K STG ++ AI +D GI
Sbjct: 117 NFGAYHTLEEISQEMDNLVAEHPGLVSKVNIGSSFENRPMNVLKFSTGGDKPAIWLDAGI 176
Query: 511 HSREWLAVSTVTYMLEKMISDYEVGK-PGTLSLLSYYDVYFIPVFNPDGYVFSHTPGNRL 687
H+REW+ +T + K++SDY GK P S+L D++ +PV NPDGYVFS T NR+
Sbjct: 177 HAREWVTQATALWTANKIVSDY--GKDPSITSILDALDIFLLPVTNPDGYVFSQTK-NRM 233
Query: 688 WRKNRKPFNYYGKTCYGVDLNRNFDSQFAGAGTSSNPCDDIYRGPYAFSEPE 843
WRK R + G C GVD NRN+D+ F G G SSNPC D Y GP A SE E
Sbjct: 234 WRKTRSKVS--GSLCVGVDPNRNWDAGFGGPGASSNPCSDSYHGPSANSEVE 283
>sp|O02350|CBPA_ANOGA Zinc carboxypeptidase A precursor
Length = 433
Score = 164 bits (416), Expect = 2e-40
Identities = 95/271 (35%), Positives = 153/271 (56%), Gaps = 3/271 (1%)
Frame = +1
Query: 43 YDGYKVIEVNLKTEYEIKFILQLTEKYEADIWKGPSKVISTH--VMLSPKYFNDFTEALK 216
YD Y++ V +E +++ + + + ++ I+ ++ + ++++P DFTE L+
Sbjct: 34 YDNYRLYRVTPHSEAQLRSVAAMEQASDSLIFLETARKLGDRFDIVVAPHKLADFTETLE 93
Query: 217 KDGIEFKIILENVEDAINKESFMNTNVRLFKLFKKEGPNVNDHFATYEEIMQWISFLTNK 396
D I ++I +NV+ A ++E TN R +GP + + T EEI W+ L ++
Sbjct: 94 SDYIPHELIEQNVQRAFDEERVRLTNKRA------KGPFDWNDYHTLEEIHAWLDQLASE 147
Query: 397 Y-SFVTSNSYGKSYEGRDLKYVKISTGPNRKAILIDGGIHSREWLAVSTVTYMLEKMISD 573
+ V G+S++ R +K VK+S GP R + ++GGIH+REW++ +TVTY+L ++++
Sbjct: 148 HPKEVELLDAGRSHQNRTMKGVKLSYGPGRPGVFLEGGIHAREWISPATVTYILNQLLTS 207
Query: 574 YEVGKPGTLSLLSYYDVYFIPVFNPDGYVFSHTPGNRLWRKNRKPFNYYGKTCYGVDLNR 753
+ +L +D Y P NPDGY ++ NRLWRK RK YG CYG D NR
Sbjct: 208 EDA---KVRALAEKFDWYVFPNANPDGYAYTFQV-NRLWRKTRKA---YGPFCYGADPNR 260
Query: 754 NFDSQFAGAGTSSNPCDDIYRGPYAFSEPET 846
N+D +A GTS+N C D Y G AFSE ET
Sbjct: 261 NWDFHWAEQGTSNNACSDTYHGSEAFSEVET 291
>sp|P19222|CBPA2_RAT Carboxypeptidase A2 precursor
Length = 417
Score = 164 bits (414), Expect = 4e-40
Identities = 102/273 (37%), Positives = 151/273 (55%), Gaps = 5/273 (1%)
Frame = +1
Query: 40 SYDGYKVIEVNLKTEYEIKFILQLT--EKYEADIWKGPSKVIST-HVMLSPKYFNDFTEA 210
++ G +V+E+ E +I+ +LQL E E D WK P+ T HV +
Sbjct: 19 TFVGDQVLEIIPSHEEQIRTLLQLEAEEHLELDFWKSPTIPGETVHVRVPFASIQAVKVF 78
Query: 211 LKKDGIEFKIILENVEDAINKESFMNTNVRLFKLFKKEGPNVN-DHFATYEEIMQWI-SF 384
L+ GI++ I++E+V+ +++E LF ++ G N N + + T EEI Q + +
Sbjct: 79 LESQGIDYSIMIEDVQVLLDQER----EEMLFNQQRERGGNFNFEAYHTLEEIYQEMDNL 134
Query: 385 LTNKYSFVTSNSYGKSYEGRDLKYVKISTGPNRKAILIDGGIHSREWLAVSTVTYMLEKM 564
+ V+ + G S+E R + +K STG ++ AI +D GIH+REW+ +T + K+
Sbjct: 135 VAENPGLVSKVNLGSSFENRPMNVLKFSTGGDKPAIWLDAGIHAREWVTQATALWTANKI 194
Query: 565 ISDYEVGKPGTLSLLSYYDVYFIPVFNPDGYVFSHTPGNRLWRKNRKPFNYYGKTCYGVD 744
SDY P SLL+ D++ +PV NPDGYVFS T NR+WRK R + G C GVD
Sbjct: 195 ASDYGT-DPAITSLLNTLDIFLLPVTNPDGYVFSQTT-NRMWRKTRSKRS--GSGCVGVD 250
Query: 745 LNRNFDSQFAGAGTSSNPCDDIYRGPYAFSEPE 843
NRN+D+ F G G SS+PC D Y GP SE E
Sbjct: 251 PNRNWDANFGGPGASSSPCSDSYHGPKPNSEVE 283
>sp|Q8R4H4|CBPA5_MOUSE Carboxypeptidase A5 precursor
Length = 436
Score = 150 bits (380), Expect = 3e-36
Identities = 95/276 (34%), Positives = 154/276 (55%), Gaps = 8/276 (2%)
Frame = +1
Query: 40 SYDGYKVIEVNLKTEYEIKFI--LQLTEKYEADIWKGPSKVISTHVMLSPKYFNDFTEA- 210
++ G +V+ V K E ++ + L+ + + D W+GP++ M P F++
Sbjct: 36 NFTGDQVLRVLAKNEKQLSLLRDLETQKPQKVDFWRGPARPSLPVDMRVP--FSELPSVK 93
Query: 211 --LKKDGIEFKIILENVEDAINKESFMNTNVRLFKLFKKEGPNVNDHFATYEEIMQWI-S 381
LK G+ + I++++++ +++E R +L + + T +EI WI +
Sbjct: 94 AYLKSHGLAYSIMIKDIQVLLDEERDAMAKSR--RLERSTNSFSYSSYHTLDEIYSWIDN 151
Query: 382 FLTNKYSFVTSNSYGKSYEGRDLKYVKISTG-PNRKAILIDGGIHSREWLAVSTVTYMLE 558
F+ + V+ GKS+E R + +K STG PNR AI ID GIHSREW+ +T ++ +
Sbjct: 152 FVAEHSNLVSKIHIGKSFENRSILVLKFSTGGPNRPAIWIDTGIHSREWITHATGIWISQ 211
Query: 559 KMISDYEVGKPGTLS-LLSYYDVYFIPVFNPDGYVFSHTPGNRLWRKNRKPFNYYGKTCY 735
K+++ Y GK L +L+ D++ V NPDG+ F+H+ NRLWRKN+ + G C
Sbjct: 212 KIVNAY--GKDHVLKRILNTMDIFIEIVTNPDGFAFTHSM-NRLWRKNKS--SQPGIFCI 266
Query: 736 GVDLNRNFDSQFAGAGTSSNPCDDIYRGPYAFSEPE 843
GVDLNRN+ + F G G++ NPC + YRGP SEPE
Sbjct: 267 GVDLNRNWKAGFGGNGSNKNPCSETYRGPAPESEPE 302
>sp|Q9UI42|CBPA4_HUMAN Carboxypeptidase A4 precursor (Carboxypeptidase A3)
Length = 421
Score = 145 bits (366), Expect = 1e-34
Identities = 95/294 (32%), Positives = 151/294 (51%), Gaps = 16/294 (5%)
Frame = +1
Query: 10 IFFFPSLISSS------YDGYKVIEVNLKTEYEIKFILQL--TEKYEADIWKGPSKVIST 165
I F +LI SS + G +V+ +N++ EI + QL + + + WK PS
Sbjct: 4 ILFIGALIGSSICGQEKFFGDQVLRINVRNGDEISKLSQLVNSNNLKLNFWKSPSSFNRP 63
Query: 166 HVMLSPKY-FNDFTEALKKDGIEFKIILENVEDAI-NKESFMNTNVRLFKLFKKEGPNVN 339
+L P F L+ G+E+ + +E+++ + N++ M N +E + N
Sbjct: 64 VDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDDEMQHNEG------QERSSNN 117
Query: 340 DHFATYEEIMQWISFLTNKYS----FVTSNSYGKSYEGRDLKYVKISTGPN--RKAILID 501
++ Y + + N + G S+E R + +K STG R A+ ++
Sbjct: 118 FNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLN 177
Query: 502 GGIHSREWLAVSTVTYMLEKMISDYEVGKPGTLSLLSYYDVYFIPVFNPDGYVFSHTPGN 681
GIHSREW++ +T + K++SDY+ P S+L D++ +PV NPDGYV++ T N
Sbjct: 178 AGIHSREWISQATAIWTARKIVSDYQ-RDPAITSILEKMDIFLLPVANPDGYVYTQTQ-N 235
Query: 682 RLWRKNRKPFNYYGKTCYGVDLNRNFDSQFAGAGTSSNPCDDIYRGPYAFSEPE 843
RLWRK R G +C G D NRN+++ FAG G S NPC ++Y GP+A SE E
Sbjct: 236 RLWRKTRS--RNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVE 287
>sp|Q8WXQ8|CBPA5_HUMAN Carboxypeptidase A5 precursor
Length = 436
Score = 145 bits (366), Expect = 1e-34
Identities = 95/276 (34%), Positives = 150/276 (54%), Gaps = 8/276 (2%)
Frame = +1
Query: 40 SYDGYKVIEVNLKTEYEIKFI--LQLTEKYEADIWKGPSKVISTHVMLSP-KYFNDFTEA 210
++ G +V+ V K E ++ + L+ + + D W+GP++ M P D
Sbjct: 36 NFTGDQVLRVLAKDEKQLSLLGDLEGLKPQKVDFWRGPARPSLPVDMRVPFSELKDIKAY 95
Query: 211 LKKDGIEFKIILENVEDAINKESFMNTNVRLFKLFKKEGPNVNDHFATYEEIMQWISFLT 390
L+ G+ + I++++++ +++E R +L + + T EEI WI
Sbjct: 96 LESHGLAYSIMIKDIQVLLDEERQAMAKSR--RLERSTNSFSYSSYHTLEEIYSWIDNFV 153
Query: 391 NKYSFVTSN-SYGKSYEGRDLKYVKISTGPNRK-AILIDGGIHSREWLAVSTVTYMLEKM 564
++S + S G S+E + + +K STG +R AI ID GIHSREW+ +T + K+
Sbjct: 154 MEHSDIVSKIQIGNSFENQSILVLKFSTGGSRHPAIWIDTGIHSREWITHATGIWTANKI 213
Query: 565 ISDYEVGKPGTLS-LLSYYDVYFIPVFNPDGYVFSHTPGNRLWRKNR--KPFNYYGKTCY 735
+SDY GK L+ +L+ D++ V NPDG+ F+H+ NRLWRKN+ +P G C
Sbjct: 214 VSDY--GKDRVLTDILNAMDIFIELVTNPDGFAFTHSM-NRLWRKNKSIRP----GIFCI 266
Query: 736 GVDLNRNFDSQFAGAGTSSNPCDDIYRGPYAFSEPE 843
GVDLNRN+ S F G G++SNPC + Y GP SEPE
Sbjct: 267 GVDLNRNWKSGFGGNGSNSNPCSETYHGPSPQSEPE 302
>sp|P00730|CBPA1_BOVIN Carboxypeptidase A1 precursor
Length = 419
Score = 144 bits (362), Expect = 4e-34
Identities = 94/281 (33%), Positives = 148/281 (52%), Gaps = 8/281 (2%)
Frame = +1
Query: 25 SLISSSYDGYKVIEVNLKTEYEIKFILQLT--EKYEADIWKGPSKVISTHVMLSP-KYFN 195
+L + G++V+ + E E++ + +L E + D W+GP + S + P
Sbjct: 14 ALGKEDFVGHQVLRITAADEAEVQTVKELEDLEHLQLDFWRGPGQPGSPIDVRVPFPSLQ 73
Query: 196 DFTEALKKDGIEFKIILENVEDAINKESFMNTNVRLFKLFKKEGPNVNDHFATY---EEI 366
L+ GI ++I++E+V+ +++E ++F + ++ATY +EI
Sbjct: 74 AVKVFLEAHGIRYRIMIEDVQSLLDEEQ-----EQMFASQSRARSTNTFNYATYHTLDEI 128
Query: 367 MQWISFLTNKY-SFVTSNSYGKSYEGRDLKYVKISTG-PNRKAILIDGGIHSREWLAVST 540
++ L ++ V+ G+SYEGR + +K STG NR AI ID GIHSREW+ +T
Sbjct: 129 YDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDLGIHSREWITQAT 188
Query: 541 VTYMLEKMISDYEVGKPGTLSLLSYYDVYFIPVFNPDGYVFSHTPGNRLWRKNRKPFNYY 720
+ +K DY P ++L D++ V NPDG+ F+H+ NRLWRK R +
Sbjct: 189 GVWFAKKFTEDYGQD-PSFTAILDSMDIFLEIVTNPDGFAFTHSQ-NRLWRKTRSVTS-- 244
Query: 721 GKTCYGVDLNRNFDSQFAGAGTSSNPCDDIYRGPYAFSEPE 843
C GVD NRN+D+ F AG SS+PC + Y G YA SE E
Sbjct: 245 SSLCVGVDANRNWDAGFGKAGASSSPCSETYHGKYANSEVE 285
>sp|P09954|CBPA1_PIG Carboxypeptidase A1 precursor
Length = 419
Score = 142 bits (359), Expect = 9e-34
Identities = 92/280 (32%), Positives = 149/280 (53%), Gaps = 8/280 (2%)
Frame = +1
Query: 28 LISSSYDGYKVIEVNLKTEYEIKFILQLT--EKYEADIWKGPSKV-ISTHVMLSPKYFND 198
L + G++V+ +++ E +++ + +L E + D W+GP++ V +
Sbjct: 15 LAKEDFVGHQVLRISVDDEAQVQKVKELEDLEHLQLDFWRGPARPGFPIDVRVPFPSIQA 74
Query: 199 FTEALKKDGIEFKIILENVEDAINKESFMNTNVRLFKLFKKEGPNVNDHFATY---EEIM 369
L+ GI + I++E+V+ +++E ++F + ++ATY EEI
Sbjct: 75 VKVFLEAHGIRYTIMIEDVQLLLDEEQ-----EQMFASQGRARTTSTFNYATYHTLEEIY 129
Query: 370 QWISFLTNKY-SFVTSNSYGKSYEGRDLKYVKISTGPN-RKAILIDGGIHSREWLAVSTV 543
++ L ++ V+ G SYEGR + +K STG N R AI ID GIHSREW+ ++
Sbjct: 130 DFMDILVAEHPQLVSKLQIGSSYEGRPIYVLKFSTGGNNRPAIWIDTGIHSREWVTQASG 189
Query: 544 TYMLEKMISDYEVGKPGTLSLLSYYDVYFIPVFNPDGYVFSHTPGNRLWRKNRKPFNYYG 723
+ +K+ DY P ++L D++ V NPDG+ F+H+ NR+WRK R + G
Sbjct: 190 VWFAKKITEDYGQD-PAFTAILDNLDIFLEIVTNPDGFAFTHSE-NRMWRKTRSRTS--G 245
Query: 724 KTCYGVDLNRNFDSQFAGAGTSSNPCDDIYRGPYAFSEPE 843
C GVD NRN+D+ F GAG SSNPC + Y G + SE E
Sbjct: 246 SFCVGVDPNRNWDAGFGGAGASSNPCSETYHGKFPNSEVE 285
>sp|Q6P8K8|CBPA4_MOUSE Carboxypeptidase A4 precursor
Length = 420
Score = 136 bits (343), Expect = 6e-32
Identities = 89/290 (30%), Positives = 152/290 (52%), Gaps = 12/290 (4%)
Frame = +1
Query: 10 IFFFPSLISSS------YDGYKVIEVNLKTEYEIKFILQL--TEKYEADIWKGPSKVIST 165
+ FF +LI + + G +V +N++ EI+ + +L ++ + +WK PS
Sbjct: 4 LLFFGALIGAGICGRDKFFGDQVFRINVRNGDEIRKLTELVNSDHLKLSVWKSPSTFDRP 63
Query: 166 HVMLSPKY-FNDFTEALKKDGIEFKIILENVEDAI-NKESFMNTNVRLFKLFKKEGPNVN 339
+L P LK G+++ + +E+++ + N++ M N + + +
Sbjct: 64 VDILVPSVSLLPVKSFLKSQGLDYSVTIEDLQALLDNEDEEMQHNEGIERSGDFNYGAYH 123
Query: 340 DHFATYEEIMQWISFLTNKYSFVTSNSYGKSYEGRDLKYVKISTGPNRK--AILIDGGIH 513
A Y E+ S T+ V+ G+++E R + +K STG +K AI ++ GIH
Sbjct: 124 PLEAIYHEMD---SIATDFPELVSRVKIGETFEKRPMYVLKFSTGGGKKRPAIWLNAGIH 180
Query: 514 SREWLAVSTVTYMLEKMISDYEVGKPGTLSLLSYYDVYFIPVFNPDGYVFSHTPGNRLWR 693
+REW++ +T + K+++DY+ P S+L D++ +PV NPDGYV++ + NRLWR
Sbjct: 181 AREWISQATAIWTARKIVTDYKKD-PAITSILKKVDIFLLPVANPDGYVYTQSQ-NRLWR 238
Query: 694 KNRKPFNYYGKTCYGVDLNRNFDSQFAGAGTSSNPCDDIYRGPYAFSEPE 843
K R G C G D NRN+++ FAG GTS NPC ++Y G + SE E
Sbjct: 239 KTRS--RNPGSRCVGADPNRNWNASFAGEGTSDNPCSEVYHGSHPNSEVE 286
>sp|Q7TPZ8|CBPA1_MOUSE Carboxypeptidase A1 precursor
Length = 419
Score = 135 bits (339), Expect = 2e-31
Identities = 85/279 (30%), Positives = 151/279 (54%), Gaps = 9/279 (3%)
Frame = +1
Query: 34 SSSYDGYKVIEVNLKTEYEIKFILQLTE--KYEADIWKGPSKV-ISTHVMLSPKYFNDFT 204
+ ++ G++V+ ++ E +++ + +L E + D W+ P++ + V +
Sbjct: 17 NENFVGHQVLRISATDEAQVQKVRELEELEHLKLDFWRDPARAGLPIDVRVPFPTIQSVK 76
Query: 205 EALKKDGIEFKIILENVEDAINKESFMNTNVRLFKLFKKEGPNVND-HFATY---EEIMQ 372
L+ I ++I++E+V+ +++E + F+ + + ++ATY +EI +
Sbjct: 77 AFLEYHDISYEIMIEDVQSLLDEEK------QQMSAFQARALSTDAFNYATYHTLDEIYE 130
Query: 373 WISFLTNKY-SFVTSNSYGKSYEGRDLKYVKISTG-PNRKAILIDGGIHSREWLAVSTVT 546
++ L ++ V+ G ++EGR + +K STG NR AI ID GIHSREW+ ++
Sbjct: 131 FMDLLVTEHPQLVSKIQIGSTFEGRPINVLKFSTGGTNRPAIWIDTGIHSREWVTQASGV 190
Query: 547 YMLEKMISDYEVGKPGTLSLLSYYDVYFIPVFNPDGYVFSHTPGNRLWRKNRKPFNYYGK 726
+ +K+ DY +P ++L D++ V NPDG+V++H NR+WRK R + G
Sbjct: 191 WFAKKITKDYGQ-EPTLTAILDNMDIFLEIVTNPDGFVYTHKT-NRMWRKTRS--HTEGS 246
Query: 727 TCYGVDLNRNFDSQFAGAGTSSNPCDDIYRGPYAFSEPE 843
C GVD NRN+D+ F G SSNPC + YRG + SE E
Sbjct: 247 LCVGVDPNRNWDAAFGMPGASSNPCSETYRGKFPNSEVE 285
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,244,069
Number of Sequences: 369166
Number of extensions: 2075074
Number of successful extensions: 5656
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5332
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5529
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)