Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_M09
(544 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X compo... 108 6e-24
sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X compo... 108 8e-24
sp|P16451|ODPX_YEAST Pyruvate dehydrogenase protein X compo... 92 1e-18
sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltran... 90 3e-18
sp|O94709|ODPX_SCHPO Putative pyruvate dehydrogenase protei... 88 1e-17
sp|P20285|ODP2_NEUCR Dihydrolipoyllysine-residue acetyltran... 88 2e-17
sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltran... 87 2e-17
sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltran... 87 2e-17
sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltran... 87 3e-17
sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltran... 86 6e-17
>sp|O00330|ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (Lipoyl-containing
pyruvate dehydrogenase complex component X) (E3-binding
protein) (E3BP) (proX)
Length = 501
Score = 108 bits (271), Expect = 6e-24
Identities = 50/86 (58%), Positives = 67/86 (77%)
Frame = +1
Query: 13 IKMPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKD 192
I MPSLSPTM EG IV+W KKEG+ +SAGD +C+++TDKAVV ++A ++GILAKI+ +
Sbjct: 59 ILMPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEG 118
Query: 193 SQGIQVGEAIALLAGEDEDWKTVEIP 270
S+ I++G I L+ E EDWK VEIP
Sbjct: 119 SKNIRLGSLIGLIVEEGEDWKHVEIP 144
>sp|Q8BKZ9|ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (Lipoyl-containing
pyruvate dehydrogenase complex component X)
Length = 501
Score = 108 bits (270), Expect = 8e-24
Identities = 48/86 (55%), Positives = 69/86 (80%)
Frame = +1
Query: 13 IKMPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKD 192
+ MPSLSPTM +G IV+W +KEG+ +SAGD +C+++TDKAVV ++A+++GILAKI+ +
Sbjct: 59 VLMPSLSPTMEQGNIVKWLRKEGEAVSAGDSLCEIETDKAVVTLDANDDGILAKIVVEEG 118
Query: 193 SQGIQVGEAIALLAGEDEDWKTVEIP 270
++ IQ+G IAL+ E EDWK VEIP
Sbjct: 119 AKNIQLGSLIALMVEEGEDWKQVEIP 144
>sp|P16451|ODPX_YEAST Pyruvate dehydrogenase protein X component, mitochondrial precursor
(Dihydrolipoamide dehydrogenase-binding protein of
pyruvate dehydrogenase complex) (E3-binding protein)
(E3BP)
Length = 410
Score = 91.7 bits (226), Expect = 1e-18
Identities = 44/94 (46%), Positives = 65/94 (69%)
Frame = +1
Query: 19 MPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKDSQ 198
MP++SPTM +GGIV W K G+ SAGD+I +V+TDK+ + +EA ++G LAKILK + S+
Sbjct: 37 MPAMSPTMEKGGIVSWKYKVGEPFSAGDVILEVETDKSQIDVEALDDGKLAKILKDEGSK 96
Query: 199 GIQVGEAIALLAGEDEDWKTVEIPAGGATVGVKA 300
+ VGE IA +A D+D T+++P T K+
Sbjct: 97 DVDVGEPIAYIADVDDDLATIKLPQEANTANAKS 130
>sp|Q9R9N3|ODP2_RHIME Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 447
Score = 90.1 bits (222), Expect = 3e-18
Identities = 44/96 (45%), Positives = 63/96 (65%)
Frame = +1
Query: 13 IKMPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKD 192
I MP+LSPTM EG + +W KEGDK+ +GD+I +++TDKA + +EA +EG +AKI+
Sbjct: 5 ITMPALSPTMEEGNLAKWLVKEGDKVKSGDVIAEIETDKATMEVEAVDEGTVAKIVVPAG 64
Query: 193 SQGIQVGEAIALLAGEDEDWKTVEIPAGGATVGVKA 300
++G++V IA+LA E ED T GA V A
Sbjct: 65 TEGVKVNALIAVLAAEGEDVATAAKGGNGAAGAVPA 100
>sp|O94709|ODPX_SCHPO Putative pyruvate dehydrogenase protein X component, mitochondrial
precursor (Dihydrolipoamide dehydrogenase-binding
protein of pyruvate dehydrogenase complex)
Length = 456
Score = 88.2 bits (217), Expect = 1e-17
Identities = 42/94 (44%), Positives = 66/94 (70%)
Frame = +1
Query: 4 ATLIKMPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILK 183
A++ +MP+LSPTM EG I +W+ KEGD +GD++ +V+TDKA + +E + GILAK+L
Sbjct: 35 ASMFRMPALSPTMEEGNITKWHFKEGDSFKSGDILLEVETDKATMDVEVQDNGILAKVLI 94
Query: 184 AKDSQGIQVGEAIALLAGEDEDWKTVEIPAGGAT 285
K S I VG+ IA++A +++ K +E+P A+
Sbjct: 95 EKGS-NIPVGKNIAIVADAEDNLKDLELPKDEAS 127
>sp|P20285|ODP2_NEUCR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (E2)
(Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2) (MRP3)
Length = 458
Score = 87.8 bits (216), Expect = 2e-17
Identities = 41/81 (50%), Positives = 56/81 (69%)
Frame = +1
Query: 7 TLIKMPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKA 186
T++KMP+LSPTM+ GGI W KK GDKI G+++ +++TDKA + E EEG+LAKILK
Sbjct: 35 TVVKMPALSPTMTSGGIGAWQKKPGDKIEPGEVLVEIETDKAQMDFEFQEEGVLAKILKD 94
Query: 187 KDSQGIQVGEAIALLAGEDED 249
+ + VG IA+L E D
Sbjct: 95 SGEKDVAVGNPIAILVEEGTD 115
>sp|Q92HK7|ODP2_RICCN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 412
Score = 87.4 bits (215), Expect = 2e-17
Identities = 40/79 (50%), Positives = 60/79 (75%)
Frame = +1
Query: 13 IKMPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKD 192
I MP+LSPTM+EG + W KKEGDK++ G++I +++TDKA + +EA +EGILAKI+ ++
Sbjct: 5 ILMPALSPTMTEGNLARWLKKEGDKVNPGEVIAEIETDKATMEVEAVDEGILAKIVIPQN 64
Query: 193 SQGIQVGEAIALLAGEDED 249
SQ + V IA+L+ E E+
Sbjct: 65 SQNVPVNSLIAVLSEEGEE 83
>sp|Q9ZD20|ODP2_RICPR Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 408
Score = 87.4 bits (215), Expect = 2e-17
Identities = 40/79 (50%), Positives = 59/79 (74%)
Frame = +1
Query: 13 IKMPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKD 192
I MP+LSPTM EG + W KKEGDK++ G++I +++TDKA + +E+ +EGILAKI+ ++
Sbjct: 5 ILMPALSPTMREGNLARWLKKEGDKVNPGEVIAEIETDKATMEVESVDEGILAKIIIPQN 64
Query: 193 SQGIQVGEAIALLAGEDED 249
SQ + V IA+L+ E ED
Sbjct: 65 SQNVPVNSLIAVLSEEGED 83
>sp|O66119|ODP2_ZYMMO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex (E2) (Dihydrolipoamide
acetyltransferase component of pyruvate dehydrogenase
complex)
Length = 440
Score = 86.7 bits (213), Expect = 3e-17
Identities = 40/87 (45%), Positives = 60/87 (68%)
Frame = +1
Query: 13 IKMPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKD 192
+KMP+LSPTM+EG + +W KEGD + AGD++ +++TDKA++ E + GI+AKIL +
Sbjct: 5 VKMPALSPTMTEGTLAKWLVKEGDAVKAGDILAEIETDKAIMEFETVDAGIIAKILVPEG 64
Query: 193 SQGIQVGEAIALLAGEDEDWKTVEIPA 273
S+ I VG+ IA++A ED V A
Sbjct: 65 SENIAVGQVIAVMAEAGEDVSQVAASA 91
>sp|P10515|ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate
dehydrogenase complex, mitochondrial precursor (Pyruvate
dehydrogenase complex E2 subunit) (PDCE2) (E2)
(Dihydrolipoamide S-acetyltransferase component of
pyruvate dehydrogenase complex) (PDC-E2) (70 kDa
mitochondrial autoantigen of primary biliary cirrhosis)
(PBC) (M2 antigen complex 70 kDa subunit)
Length = 614
Score = 85.9 bits (211), Expect = 6e-17
Identities = 41/79 (51%), Positives = 55/79 (69%)
Frame = +1
Query: 13 IKMPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKD 192
+ +PSLSPTM G I W KKEGDKI+ GDLI +V+TDKA VG E+ EE +AKIL A+
Sbjct: 61 VPLPSLSPTMQAGTIARWEKKEGDKINEGDLIAEVETDKATVGFESLEECYMAKILVAEG 120
Query: 193 SQGIQVGEAIALLAGEDED 249
++ + +G I + G+ ED
Sbjct: 121 TRDVPIGAIICITVGKPED 139
Score = 76.6 bits (187), Expect = 4e-14
Identities = 32/79 (40%), Positives = 54/79 (68%)
Frame = +1
Query: 13 IKMPSLSPTMSEGGIVEWYKKEGDKISAGDLICDVQTDKAVVGMEADEEGILAKILKAKD 192
+ +P+LSPTM+ G + W KK G+K+S GDL+ +++TDKA +G E EEG LAKIL +
Sbjct: 188 VLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEG 247
Query: 193 SQGIQVGEAIALLAGEDED 249
++ + +G + ++ ++ D
Sbjct: 248 TRDVPLGTPLCIIVEKEAD 266
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,998,710
Number of Sequences: 369166
Number of extensions: 1058689
Number of successful extensions: 3626
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3500
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3620
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3734833040
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)