Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_L12
(805 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9JKK7|TMOD2_MOUSE Tropomodulin-2 (Neuronal tropomodulin... 134 2e-31
sp|P70566|TMOD2_RAT Tropomodulin-2 (Neuronal tropomodulin) ... 134 3e-31
sp|P49813|TMOD1_MOUSE Tropomodulin-1 (Erythrocyte tropomodu... 133 6e-31
sp|P28289|TMOD1_HUMAN Tropomodulin-1 (Erythrocyte tropomodu... 131 2e-30
sp|P70567|TMOD1_RAT Tropomodulin-1 (Erythrocyte tropomoduli... 131 2e-30
sp|Q9NZR1|TMOD2_HUMAN Tropomodulin-2 (Neuronal tropomodulin... 130 5e-30
sp|Q9JHJ0|TMOD3_MOUSE Tropomodulin-3 (Ubiquitous tropomodul... 122 9e-28
sp|Q9NYL9|TMOD3_HUMAN Tropomodulin-3 (Ubiquitous tropomodul... 121 2e-27
sp|Q9JLH8|TMOD4_MOUSE Tropomodulin-4 (Skeletal muscle tropo... 118 2e-26
sp|Q9NZQ9|TMOD4_HUMAN Tropomodulin-4 (Skeletal muscle tropo... 115 1e-25
>sp|Q9JKK7|TMOD2_MOUSE Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
Length = 351
Score = 134 bits (338), Expect = 2e-31
Identities = 79/226 (34%), Positives = 126/226 (55%)
Frame = +1
Query: 43 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYHASVENKEQMCGGFQGVAKYESCKPV 222
D E +EAL +A++ EL DLAAVLG + +LN ++ N + G + V K E KPV
Sbjct: 116 DPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNGQGRKGPVRNVVKGEKAKPV 175
Query: 223 PDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNISEDVIKRLCEXXXXXXXXXXXXXXX 402
+EP N T+VE+ +++++AND SL+EVNLNN+KNI +K +
Sbjct: 176 FEEPPNPTNVEASLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKSLETNTHVKKFSLAA 235
Query: 403 IGLSNSGCDHFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRVVNQQQ 582
++ F +L+ N L++LN+ESN++ G I+ L+ A+ RE L E+++ NQ+Q
Sbjct: 236 TRSNDPVALAFAEMLKVNKTLKSLNVESNFITGTGILALVEAL-RENDTLTEIKIDNQRQ 294
Query: 583 KVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVD 720
+ LG VE EI ++++EN+ + G R R+ + N D
Sbjct: 295 Q-LGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNND 339
>sp|P70566|TMOD2_RAT Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
Length = 351
Score = 134 bits (337), Expect = 3e-31
Identities = 79/226 (34%), Positives = 126/226 (55%)
Frame = +1
Query: 43 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYHASVENKEQMCGGFQGVAKYESCKPV 222
D E +EAL +A++ EL DLAAVLG + +LN ++ N + G + V K E KPV
Sbjct: 116 DPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETTNGQGRKGPVRNVVKGEKAKPV 175
Query: 223 PDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNISEDVIKRLCEXXXXXXXXXXXXXXX 402
+EP N T+VE+ +++++AND SL+EVNLNN+KNI +K +
Sbjct: 176 FEEPPNPTNVEASLQQMKANDPSLQEVNLNNIKNIPIPTLKEFAKALETNTHVRKFSLAA 235
Query: 403 IGLSNSGCDHFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRVVNQQQ 582
++ F +L+ N L++LN+ESN++ G I+ L+ A+ RE L E+++ NQ+Q
Sbjct: 236 TRSNDPVALAFAEMLKVNKTLKSLNVESNFITGAGILALVEAL-RENDTLTEIKIDNQRQ 294
Query: 583 KVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVD 720
+ LG VE EI ++++EN+ + G R R+ + N D
Sbjct: 295 Q-LGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNND 339
>sp|P49813|TMOD1_MOUSE Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
Length = 359
Score = 133 bits (334), Expect = 6e-31
Identities = 85/254 (33%), Positives = 138/254 (54%), Gaps = 5/254 (1%)
Frame = +1
Query: 4 KKDLEEMGFDMEFDTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYH-----ASVENKE 168
+K ++ + + + E +EAL NA++ EL D+AA+LG + +++ QY+ +S+ NKE
Sbjct: 100 QKPMDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALGSSSIVNKE 159
Query: 169 QMCGGFQGVAKYESCKPVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNISEDVIKR 348
G V K KPVPDE N TDVE +++++ ND L+EVNLNN++NI +K
Sbjct: 160 ----GLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPELEEVNLNNIRNIPIPTLKA 215
Query: 349 LCEXXXXXXXXXXXXXXXIGLSNSGCDHFVVLLEKNDHLETLNLESNYLNGDSIIKLITA 528
E ++ +L+ N L+TLN+ESN+++G I++L+ A
Sbjct: 216 YAEALKENSYVKKFSIVGTRSNDPVAFALAEMLKVNKVLKTLNVESNFISGAGILRLVEA 275
Query: 529 INREKSGLLELRVVNQQQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLA 708
+ S L+EL++ NQ Q LG +VE EI ++++NTTL G R+R + +
Sbjct: 276 LPHNTS-LVELKIDNQSQP-LGNKVEMEIVNMLEKNTTLLKFGYHFTQQGPRLRASNAMM 333
Query: 709 MNVDKKTRQNRLVN 750
N D R+ RL +
Sbjct: 334 SNND-LVRKRRLAD 346
>sp|P28289|TMOD1_HUMAN Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
Length = 359
Score = 131 bits (330), Expect = 2e-30
Identities = 84/254 (33%), Positives = 139/254 (54%), Gaps = 5/254 (1%)
Frame = +1
Query: 4 KKDLEEMGFDMEFDTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYH-----ASVENKE 168
+K L+ + + + E +EAL NA++ EL D+AA+LG + +++ QY+ +S+ NKE
Sbjct: 100 QKPLDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALSSSSIMNKE 159
Query: 169 QMCGGFQGVAKYESCKPVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNISEDVIKR 348
G V K KPVPDE N TDVE +++++ ND L+EVNLNN++NI +K
Sbjct: 160 ----GLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPKLEEVNLNNIRNIPIPTLKA 215
Query: 349 LCEXXXXXXXXXXXXXXXIGLSNSGCDHFVVLLEKNDHLETLNLESNYLNGDSIIKLITA 528
E ++ +L++N L+TLN+ESN+++G I++L+ A
Sbjct: 216 YAEALKENSYVKKFSIVGTRSNDPVAYALAEMLKENKVLKTLNVESNFISGAGILRLVEA 275
Query: 529 INREKSGLLELRVVNQQQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLA 708
+ S L+E+++ NQ Q LG +VE EI ++++N TL G R+R + +
Sbjct: 276 LPYNTS-LVEMKIDNQSQP-LGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASNAM- 332
Query: 709 MNVDKKTRQNRLVN 750
MN + R+ RL +
Sbjct: 333 MNNNDLVRKRRLAD 346
>sp|P70567|TMOD1_RAT Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
Length = 359
Score = 131 bits (329), Expect = 2e-30
Identities = 85/254 (33%), Positives = 138/254 (54%), Gaps = 5/254 (1%)
Frame = +1
Query: 4 KKDLEEMGFDMEFDTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYH-----ASVENKE 168
+K ++ + + + E +EAL NA++ EL D+AA+LG + +++ QY+ +S+ NKE
Sbjct: 100 QKPMDPVLESVTLEPELEEALANASDAELCDIAAILGMHTLMSNQQYYQALGSSSIVNKE 159
Query: 169 QMCGGFQGVAKYESCKPVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNISEDVIKR 348
G V K KPVPDE N TDVE +++++ ND L+EVNLNN++NI +K
Sbjct: 160 ----GLNSVIKPTQYKPVPDEEPNPTDVEETLERIKNNDPELEEVNLNNIRNIPIPTLKA 215
Query: 349 LCEXXXXXXXXXXXXXXXIGLSNSGCDHFVVLLEKNDHLETLNLESNYLNGDSIIKLITA 528
E ++ +L+ N L+TLN+ESN+++G I+ L+ A
Sbjct: 216 YAESLKENSYVKKFSIVGTRSNDPVAFALAEMLKVNKVLKTLNVESNFISGAGILCLVEA 275
Query: 529 INREKSGLLELRVVNQQQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLA 708
+ S L+EL++ NQ Q LG +VE EI ++++NTTL G R+R + +
Sbjct: 276 LPHNTS-LVELKIDNQSQP-LGNKVEMEIVNMLEKNTTLLKFGYHFTQQGPRLRASNAM- 332
Query: 709 MNVDKKTRQNRLVN 750
MN + R+ RL +
Sbjct: 333 MNNNDLVRKRRLAD 346
>sp|Q9NZR1|TMOD2_HUMAN Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
Length = 351
Score = 130 bits (326), Expect = 5e-30
Identities = 77/226 (34%), Positives = 124/226 (54%)
Frame = +1
Query: 43 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYHASVENKEQMCGGFQGVAKYESCKPV 222
D E +EAL +A++ EL DLAAVLG + +LN ++ N + G + V K E KPV
Sbjct: 116 DPELEEALASASDTELYDLAAVLGVHNLLNNPKFDEETANNKGGKGPVRNVVKGEKVKPV 175
Query: 223 PDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNISEDVIKRLCEXXXXXXXXXXXXXXX 402
+EP N T+VE +++++AND SL+EVNLNN+KNI ++ +
Sbjct: 176 FEEPPNPTNVEISLQQMKANDPSLQEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAA 235
Query: 403 IGLSNSGCDHFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRVVNQQQ 582
++ F +L+ N L +LN+ESN++ G I+ L+ A+ +E L E+++ NQ+Q
Sbjct: 236 TRSNDPVAIAFADMLKVNKTLTSLNIESNFITGTGILALVEAL-KENDTLTEIKIDNQRQ 294
Query: 583 KVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVD 720
+ LG VE EI ++++EN+ + G R R+ + N D
Sbjct: 295 Q-LGTAVEMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNND 339
>sp|Q9JHJ0|TMOD3_MOUSE Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)
Length = 352
Score = 122 bits (307), Expect = 9e-28
Identities = 80/246 (32%), Positives = 130/246 (52%), Gaps = 5/246 (2%)
Frame = +1
Query: 34 MEFDTEFDEALKNATEEELVDLAAVLGFNGMLNQTQY-----HASVENKEQMCGGFQGVA 198
+ D E +EAL +A++ EL DLAA+LG + ++ T + ++ N+E+ F V
Sbjct: 113 ISLDPELEEALTSASDTELCDLAAILGMHNLIADTPFCDVLGSSNGVNQER----FPNVV 168
Query: 199 KYESCKPVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNISEDVIKRLCEXXXXXXX 378
K E PV DEP N T+VE +K++ ND+ L EVNLNN+KNI +K +
Sbjct: 169 KGEKILPVFDEPPNPTNVEESLKRIRENDARLVEVNLNNIKNIPIPTLKDFAKTLEANTH 228
Query: 379 XXXXXXXXIGLSNSGCDHFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLE 558
++ F +L+ N L++LN+ESN++ G ++ LI A+ R+ L+E
Sbjct: 229 VKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDAL-RDNETLME 287
Query: 559 LRVVNQQQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQN 738
L++ NQ+Q+ LG VE E+ ++++ENT + G R R + + N D R+
Sbjct: 288 LKIDNQRQQ-LGTSVELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNND-LVRKR 345
Query: 739 RLVNKH 756
R+ H
Sbjct: 346 RIEGDH 351
>sp|Q9NYL9|TMOD3_HUMAN Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)
Length = 352
Score = 121 bits (304), Expect = 2e-27
Identities = 81/244 (33%), Positives = 127/244 (52%), Gaps = 3/244 (1%)
Frame = +1
Query: 34 MEFDTEFDEALKNATEEELVDLAAVLGFNGMLNQTQY---HASVENKEQMCGGFQGVAKY 204
+ D E +EAL +A++ EL DLAA+LG + ++ T++ S +Q F V K
Sbjct: 113 VSLDPELEEALTSASDTELCDLAAILGMHNLITNTKFCNIMGSSNGVDQE--HFSNVVKG 170
Query: 205 ESCKPVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNISEDVIKRLCEXXXXXXXXX 384
E PV DEP N T+VE +K+ + ND+ L EVNLNN+KNI +K +
Sbjct: 171 EKILPVFDEPPNPTNVEESLKRTKENDAHLVEVNLNNIKNIPIPTLKDFAKALETNTHVK 230
Query: 385 XXXXXXIGLSNSGCDHFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELR 564
++ F +L+ N L++LN+ESN++ G I+ LI A+ R+ L EL+
Sbjct: 231 CFSLAATRSNDPVATAFAEMLKVNKTLKSLNVESNFITGVGILALIDAL-RDNETLAELK 289
Query: 565 VVNQQQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQNRL 744
+ NQ+Q+ LG VE E+ ++++ENT + G R R + + N D R+ R+
Sbjct: 290 IDNQRQQ-LGTAVELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNND-LVRKRRV 347
Query: 745 VNKH 756
H
Sbjct: 348 EGDH 351
>sp|Q9JLH8|TMOD4_MOUSE Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod)
Length = 345
Score = 118 bits (296), Expect = 2e-26
Identities = 71/235 (30%), Positives = 129/235 (54%), Gaps = 2/235 (0%)
Frame = +1
Query: 43 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYHASVENKEQMCG--GFQGVAKYESCK 216
+ E +EAL +AT+ E+ D+AA+LG +++ QY+ ++ + E +C G V + + K
Sbjct: 113 EPELEEALSHATDAEMCDIAAILGMYTLMSNKQYYDAICSGE-ICNTEGISSVVQPDKYK 171
Query: 217 PVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNISEDVIKRLCEXXXXXXXXXXXXX 396
PVPDEP N T++E ++K++ +ND L+EVNLNN+++I V+ LCE
Sbjct: 172 PVPDEPPNPTNIEEMLKRVRSNDKELEEVNLNNIQDIPIPVLSDLCEAMKTNTYVRSFSL 231
Query: 397 XXIGLSNSGCDHFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRVVNQ 576
+ + +L +N L++LN+ESN+++ ++ ++ A+ RE + L ELRV NQ
Sbjct: 232 VATKSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAV-RENATLTELRVDNQ 290
Query: 577 QQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQNR 741
+Q G VE E+ ++++ ++ G R R + N + + +Q +
Sbjct: 291 RQWP-GDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAHAMTRNNELRRQQKK 344
>sp|Q9NZQ9|TMOD4_HUMAN Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod)
Length = 345
Score = 115 bits (288), Expect = 1e-25
Identities = 69/235 (29%), Positives = 128/235 (54%), Gaps = 2/235 (0%)
Frame = +1
Query: 43 DTEFDEALKNATEEELVDLAAVLGFNGMLNQTQYHASVENKEQMCG--GFQGVAKYESCK 216
+ E +EAL +AT+ E+ D+AA+L +++ QY+ ++ + E +C G V + + K
Sbjct: 113 EPELEEALAHATDAEMCDIAAILDMYTLMSNKQYYDALCSGE-ICNTEGISSVVQPDKYK 171
Query: 217 PVPDEPDNDTDVESVIKKLEANDSSLKEVNLNNLKNISEDVIKRLCEXXXXXXXXXXXXX 396
PVPDEP N T++E ++K++ +ND L+EVNLNN+++I ++ LCE
Sbjct: 172 PVPDEPPNPTNIEEILKRVRSNDKELEEVNLNNIQDIPIPMLSELCEAMKANTYVRSFSL 231
Query: 397 XXIGLSNSGCDHFVVLLEKNDHLETLNLESNYLNGDSIIKLITAINREKSGLLELRVVNQ 576
+ + +L +N L++LN+ESN+++ ++ ++ A+ RE + L ELRV NQ
Sbjct: 232 VATRSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAV-RENATLTELRVDNQ 290
Query: 577 QQKVLGVRVEQEINRLIKENTTLQVLGVDLETADARIRIRDHLAMNVDKKTRQNR 741
+Q G VE E+ ++++ ++ G R R + N + + +Q +
Sbjct: 291 RQWP-GDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAQAMTRNNELRRQQKK 344
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.315 0.133 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,168,860
Number of Sequences: 369166
Number of extensions: 1296626
Number of successful extensions: 3202
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3108
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3176
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)