Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_K14
(629 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O61998|HSP90_BRUPA Heat shock protein 90 209 4e-54
sp|P11501|HS90A_CHICK Heat shock protein HSP 90-alpha 206 4e-53
sp|P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (HSP 86) 204 1e-52
sp|P07901|HS90A_MOUSE Heat shock protein HSP 90-alpha (HSP ... 204 1e-52
sp|O02705|HS90A_PIG Heat shock protein HSP 90-alpha (HSP 86) 204 1e-52
sp|Q9GKX7|HS90A_HORSE Heat shock protein HSP 90-alpha (HSP 86) 204 1e-52
sp|P46633|HS90A_CRIGR Heat shock protein HSP 90-alpha (HSP 86) 203 3e-52
sp|Q04619|HS90B_CHICK Heat shock cognate protein HSP 90-beta 201 1e-51
sp|Q9GKX8|HS90B_HORSE Heat shock protein HSP 90-beta (HSP 84) 201 1e-51
sp|P08238|HS90B_HUMAN Heat shock protein HSP 90-beta (HSP 8... 201 1e-51
>sp|O61998|HSP90_BRUPA Heat shock protein 90
Length = 717
Score = 209 bits (533), Expect = 4e-54
Identities = 102/124 (82%), Positives = 114/124 (91%)
Frame = +2
Query: 2 FEEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALR 181
FEE K FE LCKVMKDIL+KKVEKV VSNRLVSSPCCIVTS+YGWSANMERIMKAQALR
Sbjct: 543 FEEDKVKFENLCKVMKDILEKKVEKVAVSNRLVSSPCCIVTSEYGWSANMERIMKAQALR 602
Query: 182 DSSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSGFTLEE 361
DSSTMGYMAAKKHLEINPDHS++K L+ RV+ADKNDK+VKDLV+LL+ET+LLSSGF+LE+
Sbjct: 603 DSSTMGYMAAKKHLEINPDHSVIKALRERVEADKNDKTVKDLVVLLFETALLSSGFSLED 662
Query: 362 STSH 373
H
Sbjct: 663 PQLH 666
Score = 45.8 bits (107), Expect = 9e-05
Identities = 29/58 (50%), Positives = 40/58 (68%), Gaps = 5/58 (8%)
Frame = +3
Query: 357 KSPQVMGNRIHRMIKLGLGI-EDDDVEMDATEAGD----VPVVASTAEEDAGKMEEVD 515
+ PQ+ +RI+RMIKLGL I ED++ E A+ +G+ VP + AEEDA +MEEVD
Sbjct: 661 EDPQLHASRIYRMIKLGLDITEDEEEEAIASVSGEKDECVPNLVG-AEEDASRMEEVD 717
>sp|P11501|HS90A_CHICK Heat shock protein HSP 90-alpha
Length = 728
Score = 206 bits (524), Expect = 4e-53
Identities = 99/123 (80%), Positives = 115/123 (93%)
Frame = +2
Query: 5 EEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRD 184
EE+KA FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW+ANMERIMKAQALRD
Sbjct: 558 EEKKAKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRD 617
Query: 185 SSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSGFTLEES 364
+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LE+
Sbjct: 618 NSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDP 677
Query: 365 TSH 373
+H
Sbjct: 678 QTH 680
Score = 46.2 bits (108), Expect = 7e-05
Identities = 24/54 (44%), Positives = 34/54 (62%), Gaps = 1/54 (1%)
Frame = +3
Query: 357 KSPQVMGNRIHRMIKLGLGIEDDDVEM-DATEAGDVPVVASTAEEDAGKMEEVD 515
+ PQ NRI+RMIKLGLGI++DD +A+ A + ++D +MEEVD
Sbjct: 675 EDPQTHANRIYRMIKLGLGIDEDDTAAEEASPAVTEEMPPLEGDDDTSRMEEVD 728
>sp|P07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (HSP 86)
Length = 732
Score = 204 bits (520), Expect = 1e-52
Identities = 98/123 (79%), Positives = 114/123 (92%)
Frame = +2
Query: 5 EEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRD 184
EE+K FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW+ANMERIMKAQALRD
Sbjct: 562 EEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRD 621
Query: 185 SSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSGFTLEES 364
+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LE+
Sbjct: 622 NSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDP 681
Query: 365 TSH 373
+H
Sbjct: 682 QTH 684
Score = 48.5 bits (114), Expect = 1e-05
Identities = 26/56 (46%), Positives = 36/56 (64%), Gaps = 3/56 (5%)
Frame = +3
Query: 357 KSPQVMGNRIHRMIKLGLGIEDDDVEMDATEAG---DVPVVASTAEEDAGKMEEVD 515
+ PQ NRI+RMIKLGLGI++DD D T A ++P + ++D +MEEVD
Sbjct: 679 EDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPL--EGDDDTSRMEEVD 732
>sp|P07901|HS90A_MOUSE Heat shock protein HSP 90-alpha (HSP 86) (Tumor specific
transplantation 86 kDa antigen) (TSTA)
Length = 733
Score = 204 bits (520), Expect = 1e-52
Identities = 98/123 (79%), Positives = 114/123 (92%)
Frame = +2
Query: 5 EEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRD 184
EE+K FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW+ANMERIMKAQALRD
Sbjct: 563 EEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRD 622
Query: 185 SSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSGFTLEES 364
+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LE+
Sbjct: 623 NSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDP 682
Query: 365 TSH 373
+H
Sbjct: 683 QTH 685
Score = 49.3 bits (116), Expect = 8e-06
Identities = 26/56 (46%), Positives = 37/56 (66%), Gaps = 3/56 (5%)
Frame = +3
Query: 357 KSPQVMGNRIHRMIKLGLGIEDDDVEMDATEAG---DVPVVASTAEEDAGKMEEVD 515
+ PQ NRI+RMIKLGLGI++DD +D T A ++P + ++D +MEEVD
Sbjct: 680 EDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMPPL--EGDDDTSRMEEVD 733
>sp|O02705|HS90A_PIG Heat shock protein HSP 90-alpha (HSP 86)
Length = 733
Score = 204 bits (520), Expect = 1e-52
Identities = 98/123 (79%), Positives = 114/123 (92%)
Frame = +2
Query: 5 EEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRD 184
EE+K FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW+ANMERIMKAQALRD
Sbjct: 563 EEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRD 622
Query: 185 SSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSGFTLEES 364
+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LE+
Sbjct: 623 NSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDP 682
Query: 365 TSH 373
+H
Sbjct: 683 QTH 685
Score = 47.0 bits (110), Expect = 4e-05
Identities = 25/56 (44%), Positives = 36/56 (64%), Gaps = 3/56 (5%)
Frame = +3
Query: 357 KSPQVMGNRIHRMIKLGLGIEDDDVEMDATEAG---DVPVVASTAEEDAGKMEEVD 515
+ PQ NRI+RMIKLGLGI++DD D + A ++P + ++D +MEEVD
Sbjct: 680 EDPQTHANRIYRMIKLGLGIDEDDPTADDSSAAVTEEMPPL--EGDDDTSRMEEVD 733
>sp|Q9GKX7|HS90A_HORSE Heat shock protein HSP 90-alpha (HSP 86)
Length = 719
Score = 204 bits (520), Expect = 1e-52
Identities = 98/123 (79%), Positives = 114/123 (92%)
Frame = +2
Query: 5 EEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRD 184
EE+K FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW+ANMERIMKAQALRD
Sbjct: 552 EEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRD 611
Query: 185 SSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSGFTLEES 364
+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LE+
Sbjct: 612 NSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDP 671
Query: 365 TSH 373
+H
Sbjct: 672 QTH 674
Score = 41.2 bits (95), Expect = 0.002
Identities = 22/53 (41%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Frame = +3
Query: 357 KSPQVMGNRIHRMIKLGLGIEDDDVEMDATEAG---DVPVVASTAEEDAGKME 506
+ PQ NRI+RMIKLGLGI++DD D + A ++P + ++D +ME
Sbjct: 669 EDPQTHANRIYRMIKLGLGIDEDDPTADDSSAAVTEEMPPL--EGDDDTSRME 719
>sp|P46633|HS90A_CRIGR Heat shock protein HSP 90-alpha (HSP 86)
Length = 733
Score = 203 bits (516), Expect = 3e-52
Identities = 97/123 (78%), Positives = 114/123 (92%)
Frame = +2
Query: 5 EEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRD 184
EE+K FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS YGW+ANMERI+KAQALRD
Sbjct: 563 EEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIIKAQALRD 622
Query: 185 SSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSGFTLEES 364
+STMGYMAAKKHLEINPDHSI++TL+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LE+
Sbjct: 623 NSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDP 682
Query: 365 TSH 373
+H
Sbjct: 683 QTH 685
Score = 49.3 bits (116), Expect = 8e-06
Identities = 26/56 (46%), Positives = 37/56 (66%), Gaps = 3/56 (5%)
Frame = +3
Query: 357 KSPQVMGNRIHRMIKLGLGIEDDDVEMDATEAG---DVPVVASTAEEDAGKMEEVD 515
+ PQ NRI+RMIKLGLGI++DD +D T A ++P + ++D +MEEVD
Sbjct: 680 EDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMPPL--EGDDDTSRMEEVD 733
>sp|Q04619|HS90B_CHICK Heat shock cognate protein HSP 90-beta
Length = 725
Score = 201 bits (511), Expect = 1e-51
Identities = 96/123 (78%), Positives = 113/123 (91%)
Frame = +2
Query: 5 EEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRD 184
EE KA FE LCK+MK+ILDKKVEKVT+SNRLVSSPCCIVTS YGW+ANMERIMKAQALRD
Sbjct: 555 EESKAKFETLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRD 614
Query: 185 SSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSGFTLEES 364
+STMGYM AKKHLEINPDH I++TL+ + DA+KNDK+VKDLV+LL+ET+LLSSGF+LE+
Sbjct: 615 NSTMGYMMAKKHLEINPDHPIVETLRQKADANKNDKAVKDLVVLLFETALLSSGFSLEDP 674
Query: 365 TSH 373
+H
Sbjct: 675 QTH 677
Score = 47.0 bits (110), Expect = 4e-05
Identities = 25/56 (44%), Positives = 35/56 (62%), Gaps = 3/56 (5%)
Frame = +3
Query: 357 KSPQVMGNRIHRMIKLGLGIEDDDV---EMDATEAGDVPVVASTAEEDAGKMEEVD 515
+ PQ NRI+RMIKLGLGI++D+V E ++P + +ED +MEEVD
Sbjct: 672 EDPQTHSNRIYRMIKLGLGIDEDEVIAEESSIAPPDEIPPL--EGDEDTSRMEEVD 725
>sp|Q9GKX8|HS90B_HORSE Heat shock protein HSP 90-beta (HSP 84)
Length = 724
Score = 201 bits (511), Expect = 1e-51
Identities = 96/123 (78%), Positives = 113/123 (91%)
Frame = +2
Query: 5 EEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRD 184
EE KA FE LCK+MK+ILDKKVEKVT+SNRLVSSPCCIVTS YGW+ANMERIMKAQALRD
Sbjct: 554 EESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRD 613
Query: 185 SSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSGFTLEES 364
+STMGYM AKKHLEINPDH I++TL+ + +ADKNDK+VKDLV+LL+ET+LLSSGF+LE+
Sbjct: 614 NSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDP 673
Query: 365 TSH 373
+H
Sbjct: 674 QTH 676
Score = 49.7 bits (117), Expect = 6e-06
Identities = 27/56 (48%), Positives = 37/56 (66%), Gaps = 3/56 (5%)
Frame = +3
Query: 357 KSPQVMGNRIHRMIKLGLGIEDDDV---EMDATEAGDVPVVASTAEEDAGKMEEVD 515
+ PQ NRI+RMIKLGLGI++D+V E A ++P + +EDA +MEEVD
Sbjct: 671 EDPQTHSNRIYRMIKLGLGIDEDEVAAEEPSAAVPDEIPPL--EGDEDASRMEEVD 724
>sp|P08238|HS90B_HUMAN Heat shock protein HSP 90-beta (HSP 84) (HSP 90)
Length = 724
Score = 201 bits (511), Expect = 1e-51
Identities = 96/123 (78%), Positives = 113/123 (91%)
Frame = +2
Query: 5 EEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRD 184
EE KA FE LCK+MK+ILDKKVEKVT+SNRLVSSPCCIVTS YGW+ANMERIMKAQALRD
Sbjct: 554 EESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRD 613
Query: 185 SSTMGYMAAKKHLEINPDHSIMKTLKARVDADKNDKSVKDLVMLLYETSLLSSGFTLEES 364
+STMGYM AKKHLEINPDH I++TL+ + +ADKNDK+VKDLV+LL+ET+LLSSGF+LE+
Sbjct: 614 NSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDP 673
Query: 365 TSH 373
+H
Sbjct: 674 QTH 676
Score = 50.1 bits (118), Expect = 5e-06
Identities = 27/56 (48%), Positives = 38/56 (67%), Gaps = 3/56 (5%)
Frame = +3
Query: 357 KSPQVMGNRIHRMIKLGLGIEDDDV---EMDATEAGDVPVVASTAEEDAGKMEEVD 515
+ PQ NRI+RMIKLGLGI++D+V E +A ++P + +EDA +MEEVD
Sbjct: 671 EDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPL--EGDEDASRMEEVD 724
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,373,031
Number of Sequences: 369166
Number of extensions: 1067633
Number of successful extensions: 3137
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2978
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3080
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5023626210
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)