Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_J20
(601 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9D8Y8|ING5_MOUSE Inhibitor of growth protein 5 152 5e-37
sp|Q8WYH8|ING5_HUMAN Inhibitor of growth protein 5 (p28ING5) 151 1e-36
sp|Q9UNL4|ING4_HUMAN Inhibitor of growth protein 4 (p29ING4) 147 3e-35
sp|Q8C0D7|ING4_MOUSE Inhibitor of growth protein 4 147 3e-35
sp|Q9QXV3|ING1_MOUSE Inhibitor of growth protein 1 113 3e-25
sp|Q9UK53|ING1_HUMAN Inhibitor of growth protein 1 113 3e-25
sp|Q9H160|ING2_HUMAN Inhibitor of growth protein 2 (p33ING2... 112 9e-25
sp|Q9ESK4|ING2_MOUSE Inhibitor of growth protein 2 (p33ING2... 108 8e-24
sp|Q8VEK6|ING3_MOUSE Inhibitor of growth protein 3 (p47ING3... 105 1e-22
sp|Q9NXR8|ING3_HUMAN Inhibitor of growth protein 3 (p47ING3... 102 1e-21
>sp|Q9D8Y8|ING5_MOUSE Inhibitor of growth protein 5
Length = 240
Score = 152 bits (385), Expect = 5e-37
Identities = 80/216 (37%), Positives = 108/216 (50%), Gaps = 28/216 (12%)
Frame = +2
Query: 2 VPPHLQQKFKVMYELDKKIMDVTKKIQFLTXXXXXXXXXXSKSDHLNEVAKIERLFSQGR 181
+P LQ+ F++M ELD++ D +I L S + + + KI+ +S+ +
Sbjct: 17 LPCELQRNFQLMRELDQRTEDKKAEIDILAAEYISTVKTLSSAQRVEHLQKIQSAYSKCK 76
Query: 182 DMCNDKVSLAENIYEMIDKQIRSLDTDLQHYXXXXXXXXXXXXXXXYSMNTV-------- 337
+ +DKV LA YEM+DK IR LD DL + ++
Sbjct: 77 EYSDDKVQLAMQTYEMVDKHIRRLDADLARFEADLKDRMDGSDFESTGARSLKKGRSQKE 136
Query: 338 -------------DDIPSMVA-------LTMALTDNKDEILDMPVDPNEPVYCLCHQVSF 457
+D P L+ + ++LDMPVDPNEP YCLCHQVS+
Sbjct: 137 KRSSRGRGRRTSEEDTPKKKKHKSGSEFTDSILSVHPSDVLDMPVDPNEPTYCLCHQVSY 196
Query: 458 GEMVACDNKICPIEWFHFACVGLTSKPKGMWFCPNC 565
GEM+ CDN CPIEWFHFACV LT+KPKG WFCP C
Sbjct: 197 GEMIGCDNPDCPIEWFHFACVDLTTKPKGKWFCPRC 232
>sp|Q8WYH8|ING5_HUMAN Inhibitor of growth protein 5 (p28ING5)
Length = 240
Score = 151 bits (381), Expect = 1e-36
Identities = 80/216 (37%), Positives = 106/216 (49%), Gaps = 28/216 (12%)
Frame = +2
Query: 2 VPPHLQQKFKVMYELDKKIMDVTKKIQFLTXXXXXXXXXXSKSDHLNEVAKIERLFSQGR 181
+P LQ+ F++M ELD++ D +I L S + + KI+ +S+ +
Sbjct: 17 LPCELQRNFQLMRELDQRTEDKKAEIDILAAEYISTVKTLSPDQRVERLQKIQNAYSKCK 76
Query: 182 DMCNDKVSLAENIYEMIDKQIRSLDTDLQHYXXXXXXXXXXXXXXXYS------------ 325
+ +DKV LA YEM+DK IR LD DL +
Sbjct: 77 EYSDDKVQLAMQTYEMVDKHIRRLDADLARFEADLKDKMEGSDFESSGGRGLKKGRGQKE 136
Query: 326 ---------MNTVDDIPSMVA-------LTMALTDNKDEILDMPVDPNEPVYCLCHQVSF 457
+ +D P L+ + ++LDMPVDPNEP YCLCHQVS+
Sbjct: 137 KRGSRGRGRRTSEEDTPKKKKHKGGSEFTDTILSVHPSDVLDMPVDPNEPTYCLCHQVSY 196
Query: 458 GEMVACDNKICPIEWFHFACVGLTSKPKGMWFCPNC 565
GEM+ CDN CPIEWFHFACV LT+KPKG WFCP C
Sbjct: 197 GEMIGCDNPDCPIEWFHFACVDLTTKPKGKWFCPRC 232
>sp|Q9UNL4|ING4_HUMAN Inhibitor of growth protein 4 (p29ING4)
Length = 249
Score = 147 bits (370), Expect = 3e-35
Identities = 80/226 (35%), Positives = 109/226 (48%), Gaps = 38/226 (16%)
Frame = +2
Query: 2 VPPHLQQKFKVMYELDKKIMDVTKKIQFLTXXXXXXXXXXSKSDHLNEVAKIERLFSQGR 181
+P LQ+ F++M +LD++ D+ +I L S + L + +I+ + + +
Sbjct: 17 LPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLKQIQEAYGKCK 76
Query: 182 DMCNDKVSLAENIYEMIDKQIRSLDTDLQHYXXXXXXXXXXXXXXXYSM----------- 328
+ +DKV LA YEM+DK IR LDTDL + S
Sbjct: 77 EFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQK 136
Query: 329 ------------NTVDDIPSMVALTMALTDNKDE---------------ILDMPVDPNEP 427
N+ ++ P + L E +LDMPVDPNEP
Sbjct: 137 EKKAARARSKGKNSDEEAPKTAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEP 196
Query: 428 VYCLCHQVSFGEMVACDNKICPIEWFHFACVGLTSKPKGMWFCPNC 565
YCLCHQVS+GEM+ CDN C IEWFHFACVGLT+KP+G WFCP C
Sbjct: 197 TYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRC 242
>sp|Q8C0D7|ING4_MOUSE Inhibitor of growth protein 4
Length = 249
Score = 147 bits (370), Expect = 3e-35
Identities = 80/226 (35%), Positives = 109/226 (48%), Gaps = 38/226 (16%)
Frame = +2
Query: 2 VPPHLQQKFKVMYELDKKIMDVTKKIQFLTXXXXXXXXXXSKSDHLNEVAKIERLFSQGR 181
+P LQ+ F++M +LD++ D+ +I L S + L + +I+ + + +
Sbjct: 17 LPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCK 76
Query: 182 DMCNDKVSLAENIYEMIDKQIRSLDTDLQHYXXXXXXXXXXXXXXXYSM----------- 328
+ +DKV LA YEM+DK IR LDTDL + S
Sbjct: 77 EFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQK 136
Query: 329 ------------NTVDDIPSMVALTMALTDNKDE---------------ILDMPVDPNEP 427
N+ ++ P + L E +LDMPVDPNEP
Sbjct: 137 EKKAARARSKGKNSDEEAPKAAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEP 196
Query: 428 VYCLCHQVSFGEMVACDNKICPIEWFHFACVGLTSKPKGMWFCPNC 565
YCLCHQVS+GEM+ CDN C IEWFHFACVGLT+KP+G WFCP C
Sbjct: 197 TYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRC 242
>sp|Q9QXV3|ING1_MOUSE Inhibitor of growth protein 1
Length = 279
Score = 113 bits (283), Expect = 3e-25
Identities = 42/58 (72%), Positives = 50/58 (86%)
Frame = +2
Query: 401 DMPVDPNEPVYCLCHQVSFGEMVACDNKICPIEWFHFACVGLTSKPKGMWFCPNCRGK 574
D+P+DPNEP YCLC+QVS+GEM+ CDN CPIEWFHF+CVGL KPKG W+CP CRG+
Sbjct: 202 DLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGE 259
>sp|Q9UK53|ING1_HUMAN Inhibitor of growth protein 1
Length = 422
Score = 113 bits (283), Expect = 3e-25
Identities = 42/58 (72%), Positives = 50/58 (86%)
Frame = +2
Query: 401 DMPVDPNEPVYCLCHQVSFGEMVACDNKICPIEWFHFACVGLTSKPKGMWFCPNCRGK 574
D+P+DPNEP YCLC+QVS+GEM+ CDN CPIEWFHF+CVGL KPKG W+CP CRG+
Sbjct: 345 DLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGE 402
>sp|Q9H160|ING2_HUMAN Inhibitor of growth protein 2 (p33ING2) (Inhibitor of growth 1-like
protein) (ING1Lp) (p32)
Length = 280
Score = 112 bits (279), Expect = 9e-25
Identities = 63/230 (27%), Positives = 104/230 (45%), Gaps = 40/230 (17%)
Frame = +2
Query: 2 VPPHLQQKFKVMYELDKKIMDVTKKIQFLTXXXXXXXXXXSKSDHLNEVAKIERLFSQG- 178
+P +Q+ V+ ELD K + K+I + K D LN+ ++++L +
Sbjct: 38 LPHDMQRNVSVLRELDNKYQETLKEIDDV-------YEKYKKEDDLNQKKRLQQLLQRAL 90
Query: 179 ---RDMCNDKVSLAENIYEMIDKQIRSLDTDLQHYXXXXXXXXXXXXXXXYS-------- 325
+++ ++K+ + + E+++ + R ++ Q + S
Sbjct: 91 INSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKAKMDSSQPERSSR 150
Query: 326 -------------------MNTVDDIP---------SMVALTMALTDNKDEILDMPVDPN 421
+ DD P + A + + ++ +DPN
Sbjct: 151 RPRRQRTSESRDLCHMANGIEDCDDQPPKEKKSKSAKKKKRSKAKQEREASPVEFAIDPN 210
Query: 422 EPVYCLCHQVSFGEMVACDNKICPIEWFHFACVGLTSKPKGMWFCPNCRG 571
EP YCLC+QVS+GEM+ CDN+ CPIEWFHF+CV LT KPKG W+CP CRG
Sbjct: 211 EPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRG 260
>sp|Q9ESK4|ING2_MOUSE Inhibitor of growth protein 2 (p33ING2) (Inhibitor of growth 1-like
protein)
Length = 281
Score = 108 bits (271), Expect = 8e-24
Identities = 62/230 (26%), Positives = 101/230 (43%), Gaps = 40/230 (17%)
Frame = +2
Query: 2 VPPHLQQKFKVMYELDKKIMDVTKKIQFLTXXXXXXXXXXSKSDHLNEVAKIE----RLF 169
+P +Q+ V+ ELD K + K+I + K D N+ +++ R
Sbjct: 39 LPHDMQRNVSVLRELDNKYQETLKEIDDV-------YEKYKKEDDSNQKKRLQQHLQRAL 91
Query: 170 SQGRDMCNDKVSLAENIYEMIDKQIRSLDTDLQHYXXXXXXXXXXXXXXXYSM------- 328
+++ ++K+ + + E+++ + R ++ Q + S
Sbjct: 92 INSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSR 151
Query: 329 -----------------NTVDDIPSMVAL------------TMALTDNKDEILDMPVDPN 421
N +DD + A + + ++ +DPN
Sbjct: 152 RPRRQRTSESRDLCHMTNGIDDCDDQPPKEKRSKSAKKKKRSKAKQEREASPVEFAIDPN 211
Query: 422 EPVYCLCHQVSFGEMVACDNKICPIEWFHFACVGLTSKPKGMWFCPNCRG 571
EP YCLC+QVS+GEM+ CDN+ CPIEWFHF+CV LT KPKG W+CP CRG
Sbjct: 212 EPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRG 261
>sp|Q8VEK6|ING3_MOUSE Inhibitor of growth protein 3 (p47ING3 protein)
Length = 421
Score = 105 bits (261), Expect = 1e-22
Identities = 45/81 (55%), Positives = 56/81 (69%)
Frame = +2
Query: 323 SMNTVDDIPSMVALTMALTDNKDEILDMPVDPNEPVYCLCHQVSFGEMVACDNKICPIEW 502
S +TV S A + +D+ ++ D DPNEP YC+C+QVS+GEMV CDN+ CPIEW
Sbjct: 330 SSSTVVQEVSQQATVVPESDSNSQV-DWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEW 388
Query: 503 FHFACVGLTSKPKGMWFCPNC 565
FH+ CVGLT PKG WFCP C
Sbjct: 389 FHYGCVGLTEAPKGKWFCPQC 409
>sp|Q9NXR8|ING3_HUMAN Inhibitor of growth protein 3 (p47ING3 protein)
Length = 418
Score = 102 bits (253), Expect = 1e-21
Identities = 43/81 (53%), Positives = 55/81 (67%)
Frame = +2
Query: 323 SMNTVDDIPSMVALTMALTDNKDEILDMPVDPNEPVYCLCHQVSFGEMVACDNKICPIEW 502
S +TV S + +D+ ++ D DPNEP YC+C+QVS+GEMV CDN+ CPIEW
Sbjct: 327 SSSTVVQEISQQTTVVPESDSNSQV-DWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEW 385
Query: 503 FHFACVGLTSKPKGMWFCPNC 565
FH+ CVGLT PKG W+CP C
Sbjct: 386 FHYGCVGLTEAPKGKWYCPQC 406
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,439,542
Number of Sequences: 369166
Number of extensions: 1083454
Number of successful extensions: 2383
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2335
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2382
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4602033670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)