Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_I06
(759 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydra... 138 1e-32
sp|P28651|CAH8_MOUSE Carbonic anhydrase-related protein (CA... 132 8e-31
sp|P35219|CAH8_HUMAN Carbonic anhydrase-related protein (CA... 132 1e-30
sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydra... 132 1e-30
sp|P00920|CAH2_MOUSE Carbonic anhydrase 2 (Carbonic anhydra... 131 2e-30
sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydrat... 131 2e-30
sp|Q7M316|CAH1_GORGO Carbonic anhydrase I (Carbonate dehydr... 131 2e-30
sp|P27139|CAH2_RAT Carbonic anhydrase II (Carbonate dehydra... 130 3e-30
sp|P35217|CAH1_MACNE Carbonic anhydrase 1 (Carbonic anhydra... 130 4e-30
sp|P00915|CAH1_HUMAN Carbonic anhydrase 1 (Carbonic anhydra... 129 7e-30
>sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 138 bits (348), Expect = 1e-32
Identities = 75/179 (41%), Positives = 108/179 (60%), Gaps = 4/179 (2%)
Frame = -2
Query: 725 FKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLVHYNSTKYSSLSEAVNETDGLLVLGV 546
++L QFHFHWG ++ G+GSEH ++GK +P ELHLVH+N TKY+S EA N+ DGL V+GV
Sbjct: 88 YRLKQFHFHWGASD-GKGSEHTVDGKCYPAELHLVHWN-TKYASFGEAANKPDGLAVVGV 145
Query: 545 MIQIAGKNIDFQNFIQCLQSVRENPTINLHEKNAYXXXXXXXXXNTDRYFTYSGSLTTPP 366
+QI N Q + + +++ + + + Y+TY GSLTTPP
Sbjct: 146 FLQIGEDNPKLQKILDAMDAIKSKGK----QTSFTNFDPTCLLPKSLEYWTYPGSLTTPP 201
Query: 365 CNESVIWIVFEYPITMSQEQILQFQNV----HCDDGCETHSNYRPVCPVNDRKVKRSFK 201
ESV WIV + PI++S EQ+ +F+++ + C +NYRP P+ DRKV SFK
Sbjct: 202 LYESVTWIVCKQPISVSSEQMKKFRSLLFTAEEEKACCMVNNYRPPQPLKDRKVCASFK 260
>sp|P28651|CAH8_MOUSE Carbonic anhydrase-related protein (CARP) (CA-VIII)
Length = 291
Score = 132 bits (333), Expect = 8e-31
Identities = 69/198 (34%), Positives = 113/198 (57%), Gaps = 12/198 (6%)
Frame = -2
Query: 758 VTGVPEHKGDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLVHYNSTKYSSLSEAV 579
++G P +G F+L + FHWG EN GSEH +N K++P ELHL+H+NST + S+ EAV
Sbjct: 100 LSGGPLPQGQEFELYEVRFHWGR-ENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAV 158
Query: 578 NETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVR---ENPTINLHEKNAYXXXXXXXXXNT 408
+ G+ ++ + +QI +++ + + LQ ++ ++ TI N
Sbjct: 159 GKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRD--- 215
Query: 407 DRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQNVHCD-------DGCE--THS 255
Y+ Y GSLT PPC+E V WI+F YP+T+SQ QI +F+ + +GC+
Sbjct: 216 --YWVYEGSLTIPPCSEGVTWILFRYPLTISQMQIEEFRRLRTHVKGAELVEGCDGILGD 273
Query: 254 NYRPVCPVNDRKVKRSFK 201
N+RP P++DR ++ +F+
Sbjct: 274 NFRPTQPLSDRVIRAAFQ 291
>sp|P35219|CAH8_HUMAN Carbonic anhydrase-related protein (CARP) (CA-VIII)
Length = 290
Score = 132 bits (331), Expect = 1e-30
Identities = 69/198 (34%), Positives = 113/198 (57%), Gaps = 12/198 (6%)
Frame = -2
Query: 758 VTGVPEHKGDVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLVHYNSTKYSSLSEAV 579
++G P +G F+L + FHWG EN GSEH +N K++P ELHL+H+NST + S+ EAV
Sbjct: 99 LSGGPLPQGHEFELYEVRFHWGR-ENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAV 157
Query: 578 NETDGLLVLGVMIQIAGKNIDFQNFIQCLQSVR---ENPTINLHEKNAYXXXXXXXXXNT 408
+ G+ ++ + +QI +++ + + LQ ++ ++ TI N
Sbjct: 158 GKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRD--- 214
Query: 407 DRYFTYSGSLTTPPCNESVIWIVFEYPITMSQEQILQFQNVHCD-------DGCE--THS 255
Y+ Y GSLT PPC+E V WI+F YP+T+SQ QI +F+ + +GC+
Sbjct: 215 --YWVYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEGCDGILGD 272
Query: 254 NYRPVCPVNDRKVKRSFK 201
N+RP P++DR ++ +F+
Sbjct: 273 NFRPTQPLSDRVIRAAFQ 290
>sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 259
Score = 132 bits (331), Expect = 1e-30
Identities = 71/179 (39%), Positives = 106/179 (59%), Gaps = 5/179 (2%)
Frame = -2
Query: 725 FKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLVHYNSTKYSSLSEAVNETDGLLVLGV 546
++L+QFHFHWG+++ G+GSEH +N K + ELHLVH+N TKY +AV DGL VLG+
Sbjct: 87 YRLIQFHFHWGSSD-GQGSEHTVNKKKYAAELHLVHWN-TKYGDFGKAVKHPDGLAVLGI 144
Query: 545 MIQIAGKNIDFQNFIQCLQSVR-ENPTINLHEKNAYXXXXXXXXXNTDRYFTYSGSLTTP 369
++I Q + L S++ + +++ + + Y+TY GSLTTP
Sbjct: 145 FLKIGSATPGLQKVVDTLSSIKTKGKSVDFTDFDPRGLLPESLD-----YWTYPGSLTTP 199
Query: 368 PCNESVIWIVFEYPITMSQEQILQFQNVHCDDGCETH----SNYRPVCPVNDRKVKRSF 204
P E V WIV + PIT+S EQ+L+F+N++ + E N+RP P+ R+VK SF
Sbjct: 200 PLLECVTWIVLKEPITVSSEQMLKFRNLNFNKEAEPEEPMVDNWRPTQPLKGRQVKASF 258
>sp|P00920|CAH2_MOUSE Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 131 bits (330), Expect = 2e-30
Identities = 74/181 (40%), Positives = 106/181 (58%), Gaps = 4/181 (2%)
Frame = -2
Query: 731 DVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLVHYNSTKYSSLSEAVNETDGLLVL 552
D ++L+QFHFHWG+++ G+GSEH +N K + ELHLVH+N TKY +AV + DGL VL
Sbjct: 86 DSYRLIQFHFHWGSSD-GQGSEHTVNKKKYAAELHLVHWN-TKYGDFGKAVQQPDGLAVL 143
Query: 551 GVMIQIAGKNIDFQNFIQCLQSVRENPTINLHEKNAYXXXXXXXXXNTDRYFTYSGSLTT 372
G ++I + Q ++ L S++ T A N D Y+TY GSLTT
Sbjct: 144 GYFLKIGPASQGLQKVLEALHSIK---TKGKRAAFANFDPCSLLPGNLD-YWTYPGSLTT 199
Query: 371 PPCNESVIWIVFEYPITMSQEQILQFQNVHCDDGCETH----SNYRPVCPVNDRKVKRSF 204
PP E V WIV PIT+S EQ+ F+ ++ ++ + N+RP P+ +RK+K SF
Sbjct: 200 PPLLECVTWIVLREPITVSSEQMSHFRTLNFNEEGDAEEAMVDNWRPAQPLKNRKIKASF 259
Query: 203 K 201
K
Sbjct: 260 K 260
>sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydratase)
Length = 260
Score = 131 bits (330), Expect = 2e-30
Identities = 75/184 (40%), Positives = 105/184 (57%), Gaps = 8/184 (4%)
Frame = -2
Query: 728 VFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLVHYNSTKYSSLSEAVNETDGLLVLG 549
+++L QFHFHWG++++ +GSEH I G +PCELHLVH+N TKY + EA ++ DGL V+G
Sbjct: 87 IYRLRQFHFHWGSSDD-KGSEHTIAGTKFPCELHLVHWN-TKYPNFGEAASKPDGLAVVG 144
Query: 548 VMIQIAGKNIDFQNFIQCLQSV----RENPTINLHEKNAYXXXXXXXXXNTDRYFTYSGS 381
V ++I N Q + L + R+ N K Y+TY GS
Sbjct: 145 VFLKIGAANPRLQKVLDALDDIKSKGRQTTFANFDPKTLLPASLD--------YWTYEGS 196
Query: 380 LTTPPCNESVIWIVFEYPITMSQEQILQFQNVHCDDGCETH----SNYRPVCPVNDRKVK 213
LTTPP ESV WIV + PI++S Q+ +F+++ ET NYRP P+ RKV+
Sbjct: 197 LTTPPLLESVTWIVLKEPISVSPAQMAKFRSLLFSSEGETPCCMVDNYRPPQPLKGRKVR 256
Query: 212 RSFK 201
SFK
Sbjct: 257 ASFK 260
>sp|Q7M316|CAH1_GORGO Carbonic anhydrase I (Carbonate dehydratase I) (CA-I)
Length = 261
Score = 131 bits (329), Expect = 2e-30
Identities = 72/184 (39%), Positives = 102/184 (55%), Gaps = 8/184 (4%)
Frame = -2
Query: 731 DVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLVHYNSTKYSSLSEAVNETDGLLVL 552
D ++L QFHFHWG+T N GSEH ++G + ELHL H+NS KYSSL+EA ++ DGL V+
Sbjct: 87 DSYRLFQFHFHWGST-NEHGSEHTVDGVKYSAELHLTHWNSAKYSSLAEAASKADGLAVI 145
Query: 551 GVMIQIAGKNIDFQNFIQCLQSVREN----PTINLHEKNAYXXXXXXXXXNTDRYFTYSG 384
GV++++ N Q + LQ+++ P N ++TY G
Sbjct: 146 GVLMKVGEANPKLQKILDALQAIKTKGKRAPFTNFDPSTLLPSSLD--------FWTYPG 197
Query: 383 SLTTPPCNESVIWIVFEYPITMSQEQILQFQ----NVHCDDGCETHSNYRPVCPVNDRKV 216
SLT PP ESV WI+ + I++S EQ+ QF+ NV D+ N RP P+ R V
Sbjct: 198 SLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTV 257
Query: 215 KRSF 204
+ SF
Sbjct: 258 RASF 261
>sp|P27139|CAH2_RAT Carbonic anhydrase II (Carbonate dehydratase II) (CA-II)
Length = 260
Score = 130 bits (328), Expect = 3e-30
Identities = 74/179 (41%), Positives = 104/179 (58%), Gaps = 4/179 (2%)
Frame = -2
Query: 725 FKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLVHYNSTKYSSLSEAVNETDGLLVLGV 546
++L+QFHFHWG+++ G+GSEH +N K + ELHLVH+N TKY +AV DGL VLG+
Sbjct: 88 YRLIQFHFHWGSSD-GQGSEHTVNKKKYAAELHLVHWN-TKYGDFGKAVQHPDGLAVLGI 145
Query: 545 MIQIAGKNIDFQNFIQCLQSVRENPTINLHEKNAYXXXXXXXXXNTDRYFTYSGSLTTPP 366
++I + Q + L S++ T A N D Y+TY GSLTTPP
Sbjct: 146 FLKIGPASQGLQKITEALHSIK---TKGKRAAFANFDPCSLLPGNLD-YWTYPGSLTTPP 201
Query: 365 CNESVIWIVFEYPITMSQEQILQFQNVHCDDGCETH----SNYRPVCPVNDRKVKRSFK 201
E V WIV + PIT+S EQ+ F+ ++ + E N+RP P+ +RK+K SFK
Sbjct: 202 LLECVTWIVLKEPITVSSEQMSHFRKLNFNSEGEAEELMVDNWRPAQPLKNRKIKASFK 260
>sp|P35217|CAH1_MACNE Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase
I) (CA-I)
Length = 261
Score = 130 bits (327), Expect = 4e-30
Identities = 72/184 (39%), Positives = 105/184 (57%), Gaps = 8/184 (4%)
Frame = -2
Query: 731 DVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLVHYNSTKYSSLSEAVNETDGLLVL 552
D ++L QFHFHWG++ N GSEH ++G + ELH+VH+NS KYSSL+EAV++ DGL V+
Sbjct: 87 DSYRLFQFHFHWGSS-NEYGSEHTVDGVKYSSELHIVHWNSAKYSSLAEAVSKADGLAVI 145
Query: 551 GVMIQIAGKNIDFQNFIQCLQSVREN----PTINLHEKNAYXXXXXXXXXNTDRYFTYSG 384
GV++++ N Q + L +++ P N ++TYSG
Sbjct: 146 GVLMKVGEANPKLQKVLDALHAIKTKGKRAPFTNFDPSTLLPSSLD--------FWTYSG 197
Query: 383 SLTTPPCNESVIWIVFEYPITMSQEQILQFQ----NVHCDDGCETHSNYRPVCPVNDRKV 216
SLT PP ESV WI+ + I++S EQ+ QF+ NV D+ + N RP P+ R V
Sbjct: 198 SLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNPVPSQRNNRPTQPLKGRTV 257
Query: 215 KRSF 204
+ SF
Sbjct: 258 RASF 261
>sp|P00915|CAH1_HUMAN Carbonic anhydrase 1 (Carbonic anhydrase I) (Carbonate dehydratase
I) (CA-I)
Length = 261
Score = 129 bits (325), Expect = 7e-30
Identities = 71/184 (38%), Positives = 102/184 (55%), Gaps = 8/184 (4%)
Frame = -2
Query: 731 DVFKLVQFHFHWGNTENGEGSEHQINGKSWPCELHLVHYNSTKYSSLSEAVNETDGLLVL 552
D ++L QFHFHWG+T N GSEH ++G + ELH+ H+NS KYSSL+EA ++ DGL V+
Sbjct: 87 DSYRLFQFHFHWGST-NEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVI 145
Query: 551 GVMIQIAGKNIDFQNFIQCLQSVREN----PTINLHEKNAYXXXXXXXXXNTDRYFTYSG 384
GV++++ N Q + LQ+++ P N ++TY G
Sbjct: 146 GVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLD--------FWTYPG 197
Query: 383 SLTTPPCNESVIWIVFEYPITMSQEQILQFQ----NVHCDDGCETHSNYRPVCPVNDRKV 216
SLT PP ESV WI+ + I++S EQ+ QF+ NV D+ N RP P+ R V
Sbjct: 198 SLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTV 257
Query: 215 KRSF 204
+ SF
Sbjct: 258 RASF 261
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,640,904
Number of Sequences: 369166
Number of extensions: 1476058
Number of successful extensions: 3346
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3069
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3175
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6970118400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)