Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_I01
(811 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P54813|YME1_CAEEL YME1 protein homolog 172 1e-42
sp|O88967|YMEL1_MOUSE ATP-dependent metalloprotease YME1L1 ... 164 2e-40
sp|Q96TA2|YMEL1_HUMAN ATP-dependent metalloprotease YME1L1 ... 163 5e-40
sp|Q925S8|YMEL1_RAT ATP-dependent metalloprotease YME1L1 (Y... 163 5e-40
sp|P46508|YME1_SCHMA YME1 protein homolog 142 1e-33
sp|P94304|FTSH_BACPF Cell division protein ftsH homolog 139 7e-33
sp|P32795|YME1_YEAST YME1 protein (TAT-binding homolog 11) ... 139 9e-33
sp|Q98PE4|FTSH_MYCPU Cell division protein ftsH homolog 137 3e-32
sp|P37476|FTSH_BACSU Cell division protein ftsH homolog 130 4e-30
sp|Q89AF2|FTSH_BUCBP Cell division protein ftsH 130 4e-30
>sp|P54813|YME1_CAEEL YME1 protein homolog
Length = 676
Score = 172 bits (435), Expect = 1e-42
Identities = 95/239 (39%), Positives = 155/239 (64%), Gaps = 10/239 (4%)
Frame = +2
Query: 2 VSMDHIWEAESKILMGSVRNKPSLVSE--NRNTAFHESGHCIVGYFTPNHPGKIKQITIL 175
V+M ++ EA ++LMG R + E NRNTA+HE+GH +V +T + + ++TI+
Sbjct: 427 VTMAYLDEARDRVLMGPARTGGRIPDEEANRNTAYHEAGHTLVSLYTKDAT-PLHKVTII 485
Query: 176 PRGNSGGHSSLIPKEDSYNMSKNQLLAVIDSLMGGRAAEELLNGSDNISTGIYDDLQRAT 355
PRG S GH++++P++DSY ++K Q+LA +D +MGGR AEEL+ G D ++TG DDL +AT
Sbjct: 486 PRGQSLGHTAMLPEKDSYQLTKAQMLATLDVMMGGRVAEELIFGDDKVTTGAADDLSKAT 545
Query: 356 KYARSMVMSYSMSEDVGLQ--TISDGNCS-CGGRPLSGKLADTIDIEVNKILKESYERAK 526
+ A MV + MS+ VGL+ T D + L+ + A+ ID E+N++L+ESY+RAK
Sbjct: 546 QLAVQMVKVFGMSDKVGLRDFTAQDNESALVKVSDLAPQTAELIDAEINRVLQESYKRAK 605
Query: 527 SLIQQHEKEWNAIATYLLKYETLKHEDIELIIQG---KKPKVAIIHE--EIQKNKKSFV 688
+++ +KE +A LL+YETL ++++ +I G K+P A + + E ++N+ S V
Sbjct: 606 VILETKKKEHQLLAEALLEYETLSADEVKRVISGQKIKRPTPAAVKKSNETKRNQPSLV 664
>sp|O88967|YMEL1_MOUSE ATP-dependent metalloprotease YME1L1 (YME1-like protein 1)
(ATP-dependent metalloprotease FtsH1)
Length = 715
Score = 164 bits (416), Expect = 2e-40
Identities = 91/215 (42%), Positives = 137/215 (63%), Gaps = 1/215 (0%)
Frame = +2
Query: 2 VSMDHIWEAESKILMGSVRNKPSLVSENRN-TAFHESGHCIVGYFTPNHPGKIKQITILP 178
V+M + ++ KILMG R + ++N+ TA+HESGH I+ Y+T + I + TI+P
Sbjct: 507 VTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAM-PINKATIMP 565
Query: 179 RGNSGGHSSLIPKEDSYNMSKNQLLAVIDSLMGGRAAEELLNGSDNISTGIYDDLQRATK 358
RG + GH SL+P+ D +N ++ QLLA +D MGGR AEEL+ G+D+I+TG D ATK
Sbjct: 566 RGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATK 625
Query: 359 YARSMVMSYSMSEDVGLQTISDGNCSCGGRPLSGKLADTIDIEVNKILKESYERAKSLIQ 538
A+ MV + MSE +G+ T SD LS + I+ E+ +L+ESYERAK +++
Sbjct: 626 IAKRMVTKFGMSEKLGVMTYSDTG------KLSPETQSAIEQEIRILLRESYERAKHILK 679
Query: 539 QHEKEWNAIATYLLKYETLKHEDIELIIQGKKPKV 643
H KE +A LL YETL ++I+++++GKK +V
Sbjct: 680 THAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEV 714
>sp|Q96TA2|YMEL1_HUMAN ATP-dependent metalloprotease YME1L1 (YME1-like protein 1)
(ATP-dependent metalloprotease FtsH1) (Meg-4)
(Presenilin-associated metalloprotease) (PAMP)
Length = 773
Score = 163 bits (413), Expect = 5e-40
Identities = 90/215 (41%), Positives = 137/215 (63%), Gaps = 1/215 (0%)
Frame = +2
Query: 2 VSMDHIWEAESKILMGSVRNKPSLVSENRN-TAFHESGHCIVGYFTPNHPGKIKQITILP 178
V+M + ++ KILMG R + ++N+ TA+HESGH I+ Y+T + I + TI+P
Sbjct: 565 VTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAM-PINKATIMP 623
Query: 179 RGNSGGHSSLIPKEDSYNMSKNQLLAVIDSLMGGRAAEELLNGSDNISTGIYDDLQRATK 358
RG + GH SL+P+ D +N ++ QLLA +D MGGR AEEL+ G+D+I+TG D ATK
Sbjct: 624 RGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATK 683
Query: 359 YARSMVMSYSMSEDVGLQTISDGNCSCGGRPLSGKLADTIDIEVNKILKESYERAKSLIQ 538
A+ MV + MSE +G+ T SD LS + I+ E+ +L++SYERAK +++
Sbjct: 684 IAKRMVTKFGMSEKLGVMTYSDTG------KLSPETQSAIEQEIRILLRDSYERAKHILK 737
Query: 539 QHEKEWNAIATYLLKYETLKHEDIELIIQGKKPKV 643
H KE +A LL YETL ++I+++++GKK +V
Sbjct: 738 THAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEV 772
>sp|Q925S8|YMEL1_RAT ATP-dependent metalloprotease YME1L1 (YME1-like protein 1)
(ATP-dependent metalloprotease FtsH1) (Meg-4)
Length = 715
Score = 163 bits (413), Expect = 5e-40
Identities = 91/215 (42%), Positives = 136/215 (63%), Gaps = 1/215 (0%)
Frame = +2
Query: 2 VSMDHIWEAESKILMGSVRNKPSLVSENRN-TAFHESGHCIVGYFTPNHPGKIKQITILP 178
V+M + ++ KILMG R + ++N+ TA+HESGH I+ Y+T + I + TI+P
Sbjct: 507 VTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAM-PINKATIMP 565
Query: 179 RGNSGGHSSLIPKEDSYNMSKNQLLAVIDSLMGGRAAEELLNGSDNISTGIYDDLQRATK 358
RG + GH SL+P+ D +N + QLLA +D MGGR AEEL+ G+D+I+TG D ATK
Sbjct: 566 RGPTLGHVSLLPENDRWNEIRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATK 625
Query: 359 YARSMVMSYSMSEDVGLQTISDGNCSCGGRPLSGKLADTIDIEVNKILKESYERAKSLIQ 538
A+ MV + MSE +G+ T SD LS + I+ E+ +L+ESYERAK +++
Sbjct: 626 IAKRMVTKFGMSEKLGVMTYSDTG------KLSPETQSAIEQEIRILLRESYERAKHILK 679
Query: 539 QHEKEWNAIATYLLKYETLKHEDIELIIQGKKPKV 643
H KE +A LL YETL ++I+++++GKK +V
Sbjct: 680 THAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEV 714
>sp|P46508|YME1_SCHMA YME1 protein homolog
Length = 662
Score = 142 bits (357), Expect = 1e-33
Identities = 74/210 (35%), Positives = 123/210 (58%)
Frame = +2
Query: 2 VSMDHIWEAESKILMGSVRNKPSLVSENRNTAFHESGHCIVGYFTPNHPGKIKQITILPR 181
V M H+W+A +++MG + +P NR +AFHE+GH +V T + + ++TI+PR
Sbjct: 392 VEMHHLWDARDRLIMGPAKRRPLDDQTNRVSAFHEAGHALVALLTADSI-PLHKVTIIPR 450
Query: 182 GNSGGHSSLIPKEDSYNMSKNQLLAVIDSLMGGRAAEELLNGSDNISTGIYDDLQRATKY 361
G +GG +S + ++D M++ QLLA +D LMGGR EEL+ G+D ++ G DD ++AT
Sbjct: 451 GEAGGLTSFLQEKDISFMTRAQLLAQLDVLMGGRVGEELVFGADKVTNGAADDFRKATIL 510
Query: 362 ARSMVMSYSMSEDVGLQTISDGNCSCGGRPLSGKLADTIDIEVNKILKESYERAKSLIQQ 541
A++MV + S +G + I D L D ID EV+++L +S R ++L+
Sbjct: 511 AQNMVKRFGFSSKIGPRVIPDTQ----DEQLGEATRDLIDKEVDQLLNDSLTRVRTLLSS 566
Query: 542 HEKEWNAIATYLLKYETLKHEDIELIIQGK 631
K+ +A LL +ETL +++ ++ GK
Sbjct: 567 QSKQHKLLAEALLHFETLTKDEVLAVLAGK 596
>sp|P94304|FTSH_BACPF Cell division protein ftsH homolog
Length = 679
Score = 139 bits (351), Expect = 7e-33
Identities = 91/248 (36%), Positives = 140/248 (56%), Gaps = 14/248 (5%)
Frame = +2
Query: 2 VSMDHIWEAESKILMGSVRNKPSLVS--ENRNTAFHESGHCIVGYFTPNHPGKIKQITIL 175
+SM HI EA +++ G + K ++S E + A+HE+GH +VG N + ++TI+
Sbjct: 394 ISMIHIEEAIDRVIAGPAK-KSRVISPKEKKIVAWHEAGHTVVGVKLEN-ADMVHKVTIV 451
Query: 176 PRGNSGGHSSLIPKEDSYNMSKNQLLAVIDSLMGGRAAEELLNGSDNISTGIYDDLQRAT 355
PRG +GG++ ++PKED Y M++ +LL I L+GGR AEE+ G +STG ++D QRAT
Sbjct: 452 PRGMAGGYAVMLPKEDRYFMTQPELLDKIIGLLGGRVAEEVTFG--EVSTGAHNDFQRAT 509
Query: 356 KYARSMVMSYSMSEDVGLQTISDGNCSCGGRPLSGK-----------LADTIDIEVNKIL 502
AR MV Y MSE +G G+ GG+ G+ +A ID+EV +I+
Sbjct: 510 GIARKMVTEYGMSEKLGPMQFISGS---GGQVFLGRDIQNEQNYSDAIAHEIDLEVQRII 566
Query: 503 KESYERAKSLIQQHEKEWNAIATYLLKYETLKHEDIE-LIIQGKKPKVAIIHEEIQKNKK 679
KE Y R K ++ +++ + +A LL ETL E I+ L+ +GK P ++ +K K
Sbjct: 567 KECYARCKQILLENKDSLDLVAKTLLDMETLDAEQIKSLVHEGKLPDDHHLNAHPEKEKA 626
Query: 680 SFVDATSN 703
S D N
Sbjct: 627 SESDVKVN 634
>sp|P32795|YME1_YEAST YME1 protein (TAT-binding homolog 11) (OSD1 protein)
Length = 747
Score = 139 bits (350), Expect = 9e-33
Identities = 85/212 (40%), Positives = 124/212 (58%), Gaps = 1/212 (0%)
Frame = +2
Query: 2 VSMDHIWEAESKILMGSVRNKPSLVSENRN-TAFHESGHCIVGYFTPNHPGKIKQITILP 178
V M H A+ KILMG+ R L R TAFHE+GH I+ +T N + + TILP
Sbjct: 506 VDMSHFEWAKDKILMGAERKTMVLTDAARKATAFHEAGHAIMAKYT-NGATPLYKATILP 564
Query: 179 RGNSGGHSSLIPKEDSYNMSKNQLLAVIDSLMGGRAAEELLNGSDNISTGIYDDLQRATK 358
RG + G + +P+ D +++K + A +D MGG+ AEEL+ G DN ++G DLQ AT
Sbjct: 565 RGRALGITFQLPEMDKVDITKRECQARLDVCMGGKIAEELIYGKDNTTSGCGSDLQSATG 624
Query: 359 YARSMVMSYSMSEDVGLQTISDGNCSCGGRPLSGKLADTIDIEVNKILKESYERAKSLIQ 538
AR+MV Y MS+DVG +S+ S K+ D D EV ++LK+S ERA+ L+
Sbjct: 625 TARAMVTQYGMSDDVGPVNLSE-----NWESWSNKIRDIADNEVIELLKDSEERARRLLT 679
Query: 539 QHEKEWNAIATYLLKYETLKHEDIELIIQGKK 634
+ E + +A L++YETL +IE + +G+K
Sbjct: 680 KKNVELHRLAQGLIEYETLDAHEIEQVCKGEK 711
>sp|Q98PE4|FTSH_MYCPU Cell division protein ftsH homolog
Length = 725
Score = 137 bits (345), Expect = 3e-32
Identities = 90/238 (37%), Positives = 136/238 (57%), Gaps = 9/238 (3%)
Frame = +2
Query: 23 EAESKILMGSVRNKPSLVSEN-RNTAFHESGHCIVGYFTPNHPGKIKQITILPRGNSGGH 199
EA +++ G + + E + A+HE+GH +VG K+++ITI+PRGN+GG+
Sbjct: 447 EAIDRVMAGPAKKSRVISQEELKAVAYHEAGHAVVGLKVKGG-NKVQKITIIPRGNAGGY 505
Query: 200 SSLIPKEDSYNMSKNQLLAVIDSLMGGRAAEELLNGSDNISTGIYDDLQRATKYARSMVM 379
+ + P+E+ YN SK +LLA I S MGGRAAE ++ G +NISTG DD+ RATK AR MV
Sbjct: 506 NLMTPEEEKYNASKKELLATIASYMGGRAAEMIIYGKENISTGASDDISRATKIARKMVT 565
Query: 380 SYSMSEDVGLQTISDGNCSCGGRPLS-----GKLADTIDIEVNKILKESYERAKSLIQQH 544
+ MS ++ D GR S K+A ID+E+ KI+ S E A I+Q+
Sbjct: 566 EWGMSALGPIKYEEDTENPFLGRDYSKGTFGSKMAHEIDLEIRKIISASEEIAIKAIEQN 625
Query: 545 EKEWNAIATYLLKYETLKHEDIELIIQGKKPKVAIIHEEIQ---KNKKSFVDATSNQL 709
+ I LL+ ET+ E+IE I K K+ +E+I+ ++KK ++ NQ+
Sbjct: 626 LELLELIKDSLLENETIVAEEIEYI--EKNMKLPPNNEKIKPDGESKKVNIEDLINQV 681
>sp|P37476|FTSH_BACSU Cell division protein ftsH homolog
Length = 637
Score = 130 bits (327), Expect = 4e-30
Identities = 81/216 (37%), Positives = 123/216 (56%), Gaps = 10/216 (4%)
Frame = +2
Query: 23 EAESKILMGSVRNKPSLVSENRN-TAFHESGHCIVGYFTPNHPGKIKQITILPRGNSGGH 199
EA +++ G + + + RN A+HE GH ++G + + ++TI+PRG +GG+
Sbjct: 396 EATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVL-DEADMVHKVTIVPRGQAGGY 454
Query: 200 SSLIPKEDSYNMSKNQLLAVIDSLMGGRAAEELLNGSDNISTGIYDDLQRATKYARSMVM 379
+ ++P+ED Y +K +LL I L+GGR AEE++ G +STG ++D QRAT AR MV
Sbjct: 455 AVMLpreDRYFQTKPELLDKIVGLLGGRVAEEIIFG--EVSTGAHNDFQRATNIARRMVT 512
Query: 380 SYSMSEDVGLQTI--SDGNCSCGGRPL------SGKLADTIDIEVNKILKESYERAKSLI 535
+ MSE +G S G GR S ++A ID E+ +I+KE YERAK ++
Sbjct: 513 EFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYERAKQIL 572
Query: 536 QQHEKEWNAIATYLLKYETLKHEDIE-LIIQGKKPK 640
++ + IA LLK ETL E I+ LI G P+
Sbjct: 573 TENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPE 608
>sp|Q89AF2|FTSH_BUCBP Cell division protein ftsH
Length = 610
Score = 130 bits (327), Expect = 4e-30
Identities = 76/218 (34%), Positives = 130/218 (59%), Gaps = 8/218 (3%)
Frame = +2
Query: 2 VSMDHIWEAESKILMGSVRNKPSLVSENR-NTAFHESGHCIVGYFTPNHPGKIKQITILP 178
V M A+ KI MGS R + + + +TA+HE+GH IVG P H K +TI+P
Sbjct: 380 VMMSDFESAKDKITMGSERRSMVMTEKQKESTAYHEAGHVIVGRLVPEHDPAHK-VTIIP 438
Query: 179 RGNSGGHSSLIPKEDSYNMSKNQLLAVIDSLMGGRAAEELLNGSDNISTGIYDDLQRATK 358
RG + G + +PK+D +++KN+L + I +L GGR AEE++ G +N+STG ++D++ AT
Sbjct: 439 RGRALGVTFFLPKDDVLSINKNKLESQISTLYGGRLAEEIIYGVNNVSTGAHNDIKVATN 498
Query: 359 YARSMVMSYSMSEDVG--LQTISDGNCSCG-----GRPLSGKLADTIDIEVNKILKESYE 517
AR+MV + S+ +G L + +G G + +S + A ID EV +++++Y
Sbjct: 499 LARNMVTQWGFSKKLGPLLYSEEEGEIFLGRTVTKSKHMSDETARIIDEEVKLLVEKNYN 558
Query: 518 RAKSLIQQHEKEWNAIATYLLKYETLKHEDIELIIQGK 631
RAK +++++ +A+ L+KYET+ I+ +++ K
Sbjct: 559 RAKKILEENLDILHAMKDALIKYETINSRQIDDLMKRK 596
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,016,011
Number of Sequences: 369166
Number of extensions: 1902829
Number of successful extensions: 5081
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4809
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4975
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)