Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_H02
(814 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9WUB0|UB7I3_MOUSE Ubiquitin-conjugating enzyme 7-intera... 65 3e-10
sp|Q9BYM8|UB7I3_HUMAN Ubiquitin-conjugating enzyme 7-intera... 64 4e-10
sp|Q62921|UB7I3_RAT Ubiquitin-conjugating enzyme 7-interact... 64 5e-10
sp|Q8IWT3|PARC_HUMAN p53-associated parkin-like cytoplasmic... 55 2e-07
sp|Q80TT8|PARC_MOUSE p53-associated parkin-like cytoplasmic... 55 2e-07
sp|Q925F3|UB7I4_MOUSE Ubiquitin-conjugating enzyme 7-intera... 52 3e-06
sp|P50876|UB7I4_HUMAN Ubiquitin-conjugating enzyme 7-intera... 47 8e-05
sp|O76924|ARI2_DROME Ariadne-2 protein (Ari-2) 45 3e-04
sp|O95376|ARI2_HUMAN Ariadne-2 protein homolog (ARI-2) (Tri... 42 0.002
sp|Q9Y4X5|ARI1_HUMAN Ariadne-1 protein homolog (ARI-1) (Ubi... 42 0.002
>sp|Q9WUB0|UB7I3_MOUSE Ubiquitin-conjugating enzyme 7-interacting protein 3
(UbcM4-interacting protein 28)
Length = 498
Score = 64.7 bits (156), Expect = 3e-10
Identities = 48/202 (23%), Positives = 81/202 (40%), Gaps = 8/202 (3%)
Frame = +3
Query: 63 CMKCKGTGIVDDSFTLRLCNHMFCHKCLCEYIKFHINCKIKCP----VENCNKNISDQII 230
C C ++ LR C H FC +CL I+ ++ CP +C + ++ I
Sbjct: 270 CPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVACPFIDSTYSCPGKLLEREI 329
Query: 231 RKCLSNPEIALYEQMSLC----KSTKSARKCLTSNCSAIMFIEDNKAIFQCQFCDQPNCL 398
R LS + + + + +ST S C T +C F ED+ F C C + NCL
Sbjct: 330 RALLSPEDYQRFLDLGVSIAENRSTLSYH-CKTPDCRGWCFFEDDVNEFTCPVCTRVNCL 388
Query: 399 KCEKRHYPNQCGDLNHNEDAIEAAAKVAMSRHRREALEEQMKNNAYIPNSESFECGICNS 578
C+ H C + + +D A +R E L+ ++ E+ C C
Sbjct: 389 LCKAIHEHMNCRE--YQDDLALRAQNDVAARQTTEMLKVMLQ------QGEAMHCPQCRI 440
Query: 579 FILpreGLIIRNCFHCYCKSCF 644
+ ++G C C+ + C+
Sbjct: 441 VVQKKDGCDWIRCTVCHTEICW 462
Score = 56.6 bits (135), Expect = 8e-08
Identities = 26/110 (23%), Positives = 52/110 (47%), Gaps = 11/110 (10%)
Frame = +3
Query: 516 QMKNNAYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCFEETLKNVN--------F 671
Q++ + + N+E EC +C S + P E +++R C H +C+ C + T++N
Sbjct: 255 QLEQRSLVLNTEPTECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVACPFI 314
Query: 672 TSNFKCPKCGIEINNQEIIKAVGVEKLIGMACKEAAPK---MFCCKYPDC 812
S + CP +E + ++ ++ + + A + + CK PDC
Sbjct: 315 DSTYSCPGKLLEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDC 364
>sp|Q9BYM8|UB7I3_HUMAN Ubiquitin-conjugating enzyme 7-interacting protein 3 (Hepatitis B
virus X-associated protein 4) (HBV-associated factor 4)
(RING finger protein 54)
Length = 500
Score = 64.3 bits (155), Expect = 4e-10
Identities = 45/201 (22%), Positives = 81/201 (40%), Gaps = 7/201 (3%)
Frame = +3
Query: 63 CMKCKGTGIVDDSFTLRLCNHMFCHKCLCEYIKFHINCKIKCP-VEN---CNKNISDQII 230
C C ++ LR C H FC +CL I+ ++ CP ++N C+ + ++ I
Sbjct: 272 CPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFIDNTYSCSGKLLEREI 331
Query: 231 RKCLSNPEIALYEQMSLCKSTKSAR---KCLTSNCSAIMFIEDNKAIFQCQFCDQPNCLK 401
+ L+ + + + + + + C T +C F ED+ F C C NCL
Sbjct: 332 KALLTPEDYQRFLDLGISIAENRSAFSYHCKTPDCKGWCFFEDDVNEFTCPVCFHVNCLL 391
Query: 402 CEKRHYPNQCGDLNHNEDAIEAAAKVAMSRHRREALEEQMKNNAYIPNSESFECGICNSF 581
C+ H C + + ED A +R E L+ ++ E+ C C
Sbjct: 392 CKAIHEQMNCKE--YQEDLALRAQNDVAARQTTEMLKVMLQ------QGEAMRCPQCQIV 443
Query: 582 ILpreGLIIRNCFHCYCKSCF 644
+ ++G C C+ + C+
Sbjct: 444 VQKKDGCDWIRCTVCHTEICW 464
Score = 52.8 bits (125), Expect = 1e-06
Identities = 38/176 (21%), Positives = 72/176 (40%), Gaps = 28/176 (15%)
Frame = +3
Query: 369 CQFCDQPN------CLKCEKRHYPNQCGDLNHNEDAIEAAAKVAMSRHRREALEEQMKNN 530
C F ++P C + Y E+ A + R ++ ++Q + N
Sbjct: 192 CTFINKPTRPGCEMCCRARPEAYQVPASYQPDEEERARLAGEEEALRQYQQRKQQQQEGN 251
Query: 531 ----------AYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCFEETLKNVNFTSN 680
+ + N+E EC +C S + P E +++R C H +C+ C + T++N + +
Sbjct: 252 YLQHVQLDQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRN-SQEAE 310
Query: 681 FKCP------KCGIEINNQEIIKAVGVEKL-----IGMACKE-AAPKMFCCKYPDC 812
CP C ++ +EI + E +G++ E + + CK PDC
Sbjct: 311 VSCPFIDNTYSCSGKLLEREIKALLTPEDYQRFLDLGISIAENRSAFSYHCKTPDC 366
>sp|Q62921|UB7I3_RAT Ubiquitin-conjugating enzyme 7-interacting protein 3 (RBCC protein
interacting with PKC) (Protein kinase C-binding protein
beta-15)
Length = 498
Score = 63.9 bits (154), Expect = 5e-10
Identities = 48/202 (23%), Positives = 82/202 (40%), Gaps = 8/202 (3%)
Frame = +3
Query: 63 CMKCKGTGIVDDSFTLRLCNHMFCHKCLCEYIKFHINCKIKCP-VEN---CNKNISDQII 230
C C ++ LR C H FC +CL I+ ++ CP ++N C + ++ I
Sbjct: 270 CPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFIDNTYSCPGKLLEREI 329
Query: 231 RKCLSNPEIALYEQMSLC----KSTKSARKCLTSNCSAIMFIEDNKAIFQCQFCDQPNCL 398
R LS + + + + +ST S C T +C F ED+ F C C + NCL
Sbjct: 330 RALLSPEDYQRFLDLGVSIAENRSTLSYH-CKTPDCRGWCFFEDDVNEFTCPVCTRVNCL 388
Query: 399 KCEKRHYPNQCGDLNHNEDAIEAAAKVAMSRHRREALEEQMKNNAYIPNSESFECGICNS 578
C+ H C + + +D A ++ E L ++ E+ C C
Sbjct: 389 LCKAIHERMNCRE--YQDDLAHRARNDVAAQQTTEMLRVMLQ------QGEAMYCPQCRI 440
Query: 579 FILpreGLIIRNCFHCYCKSCF 644
+ ++G C C+ + C+
Sbjct: 441 VVQKKDGCDWIRCTVCHTEICW 462
Score = 55.5 bits (132), Expect = 2e-07
Identities = 25/110 (22%), Positives = 52/110 (47%), Gaps = 11/110 (10%)
Frame = +3
Query: 516 QMKNNAYIPNSESFECGICNSFILpreGLIIRNCFHCYCKSCFEETLKNVN--------F 671
Q++ + + N+E EC +C S + P E +++R C H +C+ C + T++N
Sbjct: 255 QLEQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFI 314
Query: 672 TSNFKCPKCGIEINNQEIIKAVGVEKLIGMACKEAAPK---MFCCKYPDC 812
+ + CP +E + ++ ++ + + A + + CK PDC
Sbjct: 315 DNTYSCPGKLLEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDC 364
>sp|Q8IWT3|PARC_HUMAN p53-associated parkin-like cytoplasmic protein (UbcH7 associated
protein 1)
Length = 2517
Score = 55.5 bits (132), Expect = 2e-07
Identities = 51/229 (22%), Positives = 81/229 (35%), Gaps = 19/229 (8%)
Frame = +3
Query: 33 AQFIVI*MSICMKCKGTGIVDDSFTLRLCNHMFCHKCLCEYIKFHI------NCKIKCPV 194
AQ + + C C DD C H C C EY+ I NC CP+
Sbjct: 2060 AQAVPVRPDHCPVCVSPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNC--TCPI 2117
Query: 195 ENCNKNISDQIIRKCLSNPEIALYEQMSLCKSTKSARKCLT-----SNCSAIMFIEDNKA 359
+C + IR +S+PE+ + +L + + LT C I+ +
Sbjct: 2118 ADCPAQPTGAFIRAIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGC 2177
Query: 360 IFQCQFCDQPNCLKCE--KRHYPNQCGDLNHNED---AIEAAAKVAMSRHRREALEEQMK 524
C C +C C + HYP CG ++ D + + A S+H + + ++
Sbjct: 2178 GTTCSKCGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKR-- 2235
Query: 525 NNAYIPNSESFECGICNSFILpreGLIIRNCFHC---YCKSCFEETLKN 662
C C + I EG + C C +C C + N
Sbjct: 2236 ------------CPSCQAPIEKNEGCLHMTCAKCNHGFCWRCLKSWKPN 2272
>sp|Q80TT8|PARC_MOUSE p53-associated parkin-like cytoplasmic protein
Length = 1865
Score = 55.1 bits (131), Expect = 2e-07
Identities = 48/204 (23%), Positives = 79/204 (38%), Gaps = 19/204 (9%)
Frame = +3
Query: 93 DDSFTLRLCNHMFCHKCLCEYI------KFHINCKIKCPVENCNKNISDQIIRKCLSNPE 254
DDS +L C H C C EY+ F +NC CP+ +C + IR +S+PE
Sbjct: 1420 DDSPSL-CCLHCCCKSCWNEYLTTRIEQNFVLNCT--CPIADCPAQPTGAFIRNIVSSPE 1476
Query: 255 IALYEQMSLCKSTKSARKCLT-----SNCSAIMFIEDNKAIFQCQFCDQPNCLKCE--KR 413
+ + +L + + LT C I+ + + C C +C C +
Sbjct: 1477 VISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGSGTTCSKCGWASCFSCSFPEA 1536
Query: 414 HYPNQCGDLNHNED---AIEAAAKVAMSRHRREALEEQMKNNAYIPNSESFECGICNSFI 584
HYP CG ++ D + + A S+H + + ++ C C + I
Sbjct: 1537 HYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKR--------------CPSCQAPI 1582
Query: 585 LpreGLIIRNCFHC---YCKSCFE 647
EG + C C +C C +
Sbjct: 1583 EKNEGCLHMTCARCNHGFCWRCLK 1606
Score = 35.4 bits (80), Expect = 0.19
Identities = 17/48 (35%), Positives = 23/48 (47%), Gaps = 3/48 (6%)
Frame = +3
Query: 558 ECGICNSFILpreGLIIRNCFHCYCKSCFEETLK---NVNFTSNFKCP 692
+C +C + + P + C HC CKSC+ E L NF N CP
Sbjct: 1408 QCPVCVTPLGPHDDSPSLCCLHCCCKSCWNEYLTTRIEQNFVLNCTCP 1455
>sp|Q925F3|UB7I4_MOUSE Ubiquitin-conjugating enzyme 7-interacting protein 4
(UbcM4-interacting protein 4) (RING finger protein 144)
Length = 292
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/212 (23%), Positives = 80/212 (37%), Gaps = 17/212 (8%)
Frame = +3
Query: 63 CMKCKGTGIVDDSFTLRLCNHMFCHKCLCEY----IKFHINCKIKCPVENCNK--NISDQ 224
C C G + T+ C +FC CL +Y IK + I CP C K ++ +
Sbjct: 20 CKLCLGEYPAEQMTTIAQCQCIFCTLCLKQYVELLIKEGLETAISCPDAACPKQGHLQEN 79
Query: 225 IIRKCLSNPEIALYEQMSLCKST---KSARKCLTSNCSAIMFIED----NKAIFQCQFCD 383
I ++ + Y+++ + C S C A+ ++D + QC+ CD
Sbjct: 80 EIECMVAAEIMQRYKKLQFEREVLFDPCRTWCPASTCQAVCQLQDIGLQTPQLVQCKACD 139
Query: 384 QPNCLKCEKRHYPNQ-CGDLNHNEDAIEAAAKVAMSRHRREALEEQMKNNAYIPNSESFE 560
C C+ R +P Q C + I S + E + +K
Sbjct: 140 MEFCSACKARWHPGQGCPETM----PITFLPGETSSAFKMEEGDAPIK-----------R 184
Query: 561 CGICNSFILpreG---LIIRNCFHCYCKSCFE 647
C C +I EG ++ +NC H +C C E
Sbjct: 185 CPKCRVYIERDEGCAQMMCKNCKHAFCWYCLE 216
>sp|P50876|UB7I4_HUMAN Ubiquitin-conjugating enzyme 7-interacting protein 4
(UbcM4-interacting protein 4) (RING finger protein 144)
Length = 292
Score = 46.6 bits (109), Expect = 8e-05
Identities = 46/211 (21%), Positives = 77/211 (36%), Gaps = 16/211 (7%)
Frame = +3
Query: 63 CMKCKGTGIVDDSFTLRLCNHMFCHKCLCEY----IKFHINCKIKCPVENCNK--NISDQ 224
C C G V+ T+ C +FC CL +Y IK + I CP C K ++ +
Sbjct: 20 CKLCLGEYPVEQMTTIAQCQCIFCTLCLKQYVELLIKEGLETAISCPDAACPKQGHLQEN 79
Query: 225 IIRKCLSNPEIALYEQMSLCKST---KSARKCLTSNCSAIMFIED----NKAIFQCQFCD 383
I ++ + Y+++ + C S C A+ ++D QC+ C
Sbjct: 80 EIECMVAAEIMQRYKKLQFEREVLFDPCRTWCPASTCQAVCQLQDVGLQTPQPVQCKACR 139
Query: 384 QPNCLKCEKRHYPNQCGDLNHNEDAIEAAAKVAMSRHRREALEEQMKNNAYIPNSESFEC 563
C C+ +P Q + A + +++A I C
Sbjct: 140 MEFCSTCKASWHPGQ---------GCPETMPITFLPGETSAAFKMEEDDAPIK-----RC 185
Query: 564 GICNSFILpreG---LIIRNCFHCYCKSCFE 647
C +I EG ++ +NC H +C C E
Sbjct: 186 PKCKVYIERDEGCAQMMCKNCKHAFCWYCLE 216
>sp|O76924|ARI2_DROME Ariadne-2 protein (Ari-2)
Length = 509
Score = 44.7 bits (104), Expect = 3e-04
Identities = 35/136 (25%), Positives = 57/136 (41%), Gaps = 12/136 (8%)
Frame = +3
Query: 60 ICMKCKGTGIVDDSFTLRLCNHMFCHKCLCEYIKFH----INCKIKCPVENCNKNISDQI 227
+C C + + D ++L C H FC C Y + I+ +I C + CN + + +
Sbjct: 152 MCPVCASSQLGDKFYSLA-CGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDL 210
Query: 228 IRKCLSNPEIA-LYEQMSL---CKSTKSARKCLTSNCSAIM---FIEDNKAIFQCQFCDQ 386
+ ++ P + Y+Q + KS R C NC I+ I +AI C+ C
Sbjct: 211 VLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRAI--CKACHT 268
Query: 387 PNCLKC-EKRHYPNQC 431
C +C H P C
Sbjct: 269 GFCFRCGMDYHAPTDC 284
>sp|O95376|ARI2_HUMAN Ariadne-2 protein homolog (ARI-2) (Triad1 protein)
Length = 493
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/118 (21%), Positives = 49/118 (41%), Gaps = 10/118 (8%)
Frame = +3
Query: 117 CNHMFCHKCLCEY----IKFHINCKIKCPVENCNKNISDQIIRKCLSNPEIA----LYEQ 272
C H FC C ++ +K + + C ++C + + L N E+ Y
Sbjct: 156 CQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLF 215
Query: 273 MSLCKSTKSARKCLTSNCSAIMFIEDNKAI-FQCQFCDQPNCLKCEKR-HYPNQCGDL 440
+S + C ++C ++ +++ +A QC C++ C KC + H P C +
Sbjct: 216 RDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATI 273
Score = 31.6 bits (70), Expect = 2.7
Identities = 14/46 (30%), Positives = 25/46 (54%), Gaps = 1/46 (2%)
Frame = +3
Query: 516 QMKNNAYIPNSES-FECGICNSFILpreGLIIRNCFHCYCKSCFEE 650
Q + ++P S C +C F+ +E L+ C H +C+SC+E+
Sbjct: 123 QPNPSKHVPTSHPPHHCAVCMQFVR-KENLLSLACQHQFCRSCWEQ 167
>sp|Q9Y4X5|ARI1_HUMAN Ariadne-1 protein homolog (ARI-1) (Ubiquitin-conjugating enzyme
E2-binding protein 1) (UbcH7-binding protein)
(UbcM4-interacting protein) (HHARI) (H7-AP2) (MOP-6)
Length = 557
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/122 (24%), Positives = 56/122 (45%), Gaps = 12/122 (9%)
Frame = +3
Query: 102 FTLRLCNHMFCHKCLCEYIKFHI-----NCKIKCPVENCNKNISDQIIRKCLSNPEIAL- 263
FT C H FC +C EY+ I I CP C+ + D + + +++ ++ L
Sbjct: 198 FTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLK 257
Query: 264 YEQM---SLCKSTKSARKCLTSNCSAIMFIE--DNKAIFQCQFCDQPNCLKC-EKRHYPN 425
Y+ + S + + + C +C ++ ++ D K + +C+ C + C C E H P
Sbjct: 258 YQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPV-RCK-CGRQFCFNCGENWHDPV 315
Query: 426 QC 431
+C
Sbjct: 316 KC 317
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,759,316
Number of Sequences: 369166
Number of extensions: 1776163
Number of successful extensions: 5873
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5369
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5843
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7763237265
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)