Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_G13
(588 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 201 1e-51
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 201 1e-51
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 198 7e-51
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 197 2e-50
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 194 1e-49
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 192 4e-49
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 191 9e-49
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 191 9e-49
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 189 4e-48
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 188 8e-48
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 201 bits (511), Expect = 1e-51
Identities = 100/174 (57%), Positives = 116/174 (66%), Gaps = 2/174 (1%)
Frame = +1
Query: 4 LISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSK 180
L+S SEQ LVDCS LMDNAFRYIKD G I++E YPY D +C N +
Sbjct: 166 LVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKAT 225
Query: 181 IVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDH 360
I TGF DI +E + AVAT+GPVSVAIDA H SFQLY G+YNE C LDH
Sbjct: 226 IGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDH 285
Query: 361 GVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 519
GVL VGYGT + G YW+VKNSW TWGE GYIKM++++ NQCGIAT +SYP V
Sbjct: 286 GVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 201 bits (511), Expect = 1e-51
Identities = 99/174 (56%), Positives = 118/174 (67%), Gaps = 2/174 (1%)
Frame = +1
Query: 4 LISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSK 180
L+S SEQ LVDCS LMDNAFRYIKD G I++E YPY A D +C N
Sbjct: 168 LVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGT 227
Query: 181 IVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDH 360
+ GFTDI +E +A AVATVGPVSVAIDA H SFQ Y G+YNE C LDH
Sbjct: 228 VGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDH 287
Query: 361 GVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 519
GVL VG+GT + G+ YW+VKNSW TWG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 288 GVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 198 bits (504), Expect = 7e-51
Identities = 93/173 (53%), Positives = 124/173 (71%), Gaps = 1/173 (0%)
Frame = +1
Query: 4 LISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIK-DQGIESEGDYPYTATDGTCKRNPSK 180
LIS +EQQLVDCS M++AF YIK + GI++E YPY A DG+C+ + +
Sbjct: 151 LISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNS 210
Query: 181 IVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDH 360
+ C+G T+I S +ET L AV +GP+SV IDA H+SFQ Y SG+Y E SCS + LDH
Sbjct: 211 VAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDH 270
Query: 361 GVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 519
VLAVGYG++ G+ +W+VKNSW +WG++GYIKMS+++ N CGIAT+ASYPLV
Sbjct: 271 AVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 197 bits (501), Expect = 2e-50
Identities = 101/175 (57%), Positives = 117/175 (66%), Gaps = 2/175 (1%)
Frame = +1
Query: 1 RLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPS 177
+L+S SEQ LVD S LMDNAF+YIK+ G ++SE YPY ATD +C P
Sbjct: 44 KLVSLSEQNLVDSSRPQGNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPE 103
Query: 178 KIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLD 357
K TGF DI Q E L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LD
Sbjct: 104 YSAAKDTGFVDIP-QREKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLD 162
Query: 358 HGVLAVGYGTQ-IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 519
HGVL VGYG + K+WIVKNSW WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 163 HGVLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 194 bits (494), Expect = 1e-49
Identities = 100/178 (56%), Positives = 117/178 (65%), Gaps = 5/178 (2%)
Frame = +1
Query: 1 RLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPS 177
RLIS SEQ LVDCS LMD AF+Y++D G ++SE YPY AT+ +CK NP
Sbjct: 157 RLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPK 216
Query: 178 KIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLD 357
V TGF DI Q E L AVATVGP+SVAIDAGH SF YK GIY E CS+ +D
Sbjct: 217 YSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMD 275
Query: 358 HGVLAVGYGTQI----GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 519
HGVL VGYG + KYW+VKNSW WG GY+KM+KD++N CGIA+ ASYP V
Sbjct: 276 HGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 192 bits (489), Expect = 4e-49
Identities = 102/179 (56%), Positives = 116/179 (64%), Gaps = 6/179 (3%)
Frame = +1
Query: 1 RLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATD-GTCKRNP 174
+L+S SEQ LVDCS LMDNAF+YIKD G ++SE YPY ATD +C P
Sbjct: 157 KLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKP 216
Query: 175 SKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQL 354
TGF DI Q E L AVATVGP+SVAIDAGH SFQ YKSGIY + CS L
Sbjct: 217 ECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDL 275
Query: 355 DHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 519
DHGVL VGYG + K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 276 DHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 334
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 191 bits (486), Expect = 9e-49
Identities = 96/178 (53%), Positives = 113/178 (63%), Gaps = 5/178 (2%)
Frame = +1
Query: 1 RLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPS 177
+L+S SEQ LVDCS M AF+Y+K+ G ++SE YPY A D CK P
Sbjct: 157 KLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPE 216
Query: 178 KIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLD 357
V TGFT + E L AVATVGP+SVA+DAGH+SFQ YKSGIY E CS+ LD
Sbjct: 217 NSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLD 276
Query: 358 HGVLAVGYG----TQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 519
HGVL VGYG KYW+VKNSW WG +GY+K++KDK N CGIAT ASYP V
Sbjct: 277 HGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 191 bits (486), Expect = 9e-49
Identities = 100/178 (56%), Positives = 115/178 (64%), Gaps = 5/178 (2%)
Frame = +1
Query: 1 RLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDG-TCKRNP 174
+L+S SEQ LVDCS LMDNAFRY+KD G ++SE YPY D TC P
Sbjct: 157 KLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKP 216
Query: 175 SKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQL 354
TGF D+ Q E L AVAT+GP+SVAIDAGH SFQ YKSGIY + CS+ L
Sbjct: 217 ECSAANDTGFVDLP-QREKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDL 275
Query: 355 DHGVLAVGY---GTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 519
DHGVL VGY GT K+WIVKNSW WG +GY+KM+KD+ N CGIAT ASYP V
Sbjct: 276 DHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 189 bits (480), Expect = 4e-48
Identities = 94/173 (54%), Positives = 118/173 (68%), Gaps = 1/173 (0%)
Frame = +1
Query: 4 LISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSK 180
L+S SEQQLVDCS M +AF YIKD G I++E YPY A D +C+ + +
Sbjct: 150 LVSLSEQQLVDCSTDYGNDGCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANS 209
Query: 181 IVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDH 360
I CTG ++Q E L AV+ VGP+SVAIDA H SFQ Y SG+Y E++CS T LDH
Sbjct: 210 IGAICTGSVEVQHTEEA-LQEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDH 268
Query: 361 GVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 519
GVLAVGYGT+ K YW+VKNSW +WG++GYIKMS+++ N CGIA+ SYP V
Sbjct: 269 GVLAVGYGTESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 188 bits (478), Expect = 8e-48
Identities = 100/178 (56%), Positives = 116/178 (65%), Gaps = 5/178 (2%)
Frame = +1
Query: 1 RLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPS 177
+LIS SEQ LVDCS LMD AF+YIK+ G ++SE YPY A DG+CK
Sbjct: 157 KLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAE 216
Query: 178 KIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLD 357
V TGF DI Q E L AVATVGP+SVA+DA H S Q Y SGIY E +CS+ LD
Sbjct: 217 YAVANDTGFVDIPQQ-EKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLD 275
Query: 358 HGVLAVGY---GTQIGK-KYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 519
HGVL VGY GT K KYW+VKNSW WG GYIK++KD+ N CG+AT ASYP+V
Sbjct: 276 HGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,787,451
Number of Sequences: 369166
Number of extensions: 1255882
Number of successful extensions: 3897
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3431
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3508
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4406202450
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)