Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_F02
(820 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P05094|ACTN1_CHICK Alpha-actinin 1 (Alpha-actinin cytosk... 244 2e-64
sp|Q9Z1P2|ACTN1_RAT Alpha-actinin 1 (Alpha-actinin cytoskel... 243 4e-64
sp|P18091|ACTN_DROME Alpha-actinin, sarcomeric (F-actin cro... 243 5e-64
sp|P12814|ACTN1_HUMAN Alpha-actinin 1 (Alpha-actinin cytosk... 242 8e-64
sp|Q7TPR4|ACTN1_MOUSE Alpha-actinin 1 (Alpha-actinin cytosk... 242 1e-63
sp|O43707|ACTN4_HUMAN Alpha-actinin 4 (Non-muscle alpha-act... 239 5e-63
sp|P57780|ACTN4_MOUSE Alpha-actinin 4 (Non-muscle alpha-act... 239 5e-63
sp|Q9QXQ0|ACTN4_RAT Alpha-actinin 4 (Non-muscle alpha-actin... 239 9e-63
sp|Q08043|ACTN3_HUMAN Alpha-actinin 3 (Alpha actinin skelet... 234 2e-61
sp|O88990|ACTN3_MOUSE Alpha-actinin 3 (Alpha actinin skelet... 233 6e-61
>sp|P05094|ACTN1_CHICK Alpha-actinin 1 (Alpha-actinin cytoskeletal isoform) (Non-muscle
alpha-actinin 1) (F-actin cross linking protein)
Length = 893
Score = 244 bits (623), Expect = 2e-64
Identities = 119/261 (45%), Positives = 183/261 (70%), Gaps = 1/261 (0%)
Frame = +3
Query: 39 NLNQISENPYTLLSQTALSVEWNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKL 218
++N NPYT ++ ++ +W + L+P RD+ L +E ++Q +NE+LR+ FG+ AN +
Sbjct: 584 HVNMAGTNPYTTITPQEINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVI 643
Query: 219 GPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEINEYRKLAMEVDKCSQELQQNMIF 398
GPWI K + I +S E TLE Q + + E I Y+ +++ Q++Q+ +IF
Sbjct: 644 GPWIQTKMEEIGRISI-EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIF 702
Query: 399 ETPNCRYSMETLRVSWEQLQSSMRRSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKN 578
+ + Y+ME +RV WEQL +++ R+ +E+E+QILTRD+KGISQ QM+EFR FNHFD++
Sbjct: 703 DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRD 762
Query: 579 KTRTLEPKEFKACLVSLGCNL-KEEKGEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETT 755
+ TL P+EFKACL+SLG ++ + +GEA+FA+IMS VDPNR GVVTF AFID+M++ET
Sbjct: 763 HSGTLGPEEFKACLISLGYDIGNDAQGEAEFARIMSIVDPNRMGVVTFQAFIDFMSRETA 822
Query: 756 EQDTLEQILQSFKVLCQDRDY 818
+ DT +Q++ SFK+L D++Y
Sbjct: 823 DTDTADQVMASFKILAGDKNY 843
Score = 33.9 bits (76), Expect = 0.55
Identities = 22/131 (16%), Positives = 57/131 (43%), Gaps = 1/131 (0%)
Frame = +3
Query: 102 WNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLS-SGENV 278
W L +E+L E+ + + + L E F A+ W D K+ + +
Sbjct: 369 WGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQKDYETATL 428
Query: 279 STLESQKSQIEHLETEINEYRKLAMEVDKCSQELQQNMIFETPNCRYSMETLRVSWEQLQ 458
S +++ + E E+++ ++ ++ +QEL + +++P+ + + W+ L
Sbjct: 429 SEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLG 488
Query: 459 SSMRRSKSEIE 491
+ ++ + +E
Sbjct: 489 ALTQKRREALE 499
Score = 31.6 bits (70), Expect = 2.7
Identities = 22/85 (25%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Frame = +3
Query: 150 KELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEI 329
K L+ +NE+L E++ LA+ L WI ++ I +L + +T+++ + ++E +
Sbjct: 265 KVLAVNQENEQLMEDYEKLASDLLEWI---RRTIPWLENRAPENTMQAMQQKLE----DF 317
Query: 330 NEYRKL---AMEVDKCSQELQQNMI 395
+YR+L +KC E+ N +
Sbjct: 318 RDYRRLHKPPKVQEKCQLEINFNTL 342
>sp|Q9Z1P2|ACTN1_RAT Alpha-actinin 1 (Alpha-actinin cytoskeletal isoform) (Non-muscle
alpha-actinin 1) (F-actin cross linking protein)
Length = 892
Score = 243 bits (621), Expect = 4e-64
Identities = 121/261 (46%), Positives = 182/261 (69%), Gaps = 1/261 (0%)
Frame = +3
Query: 39 NLNQISENPYTLLSQTALSVEWNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKL 218
++N NPYT ++ ++ +W+ + L+P RD+ L +E S+Q NE+LR+ FG+ AN +
Sbjct: 583 HVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHSRQQHNERLRKQFGAQANVI 642
Query: 219 GPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEINEYRKLAMEVDKCSQELQQNMIF 398
GPWI K + I +S E TLE Q S + E I Y+ +++ Q +Q+ +IF
Sbjct: 643 GPWIQTKMEEIGRISI-EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF 701
Query: 399 ETPNCRYSMETLRVSWEQLQSSMRRSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKN 578
+ + Y+ME +RV WEQL +++ R+ +E+E+QILTRD+KGISQ QM+EFR FNHFD++
Sbjct: 702 DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRD 761
Query: 579 KTRTLEPKEFKACLVSLGCNL-KEEKGEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETT 755
+ TL P+EFKACL+SLG ++ + +GEA+FA+IMS VDPNR GVVTF AFID+M++ET
Sbjct: 762 HSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETA 821
Query: 756 EQDTLEQILQSFKVLCQDRDY 818
+ DT +Q++ SFK+L D++Y
Sbjct: 822 DTDTADQVMASFKILAGDKNY 842
Score = 33.5 bits (75), Expect = 0.72
Identities = 22/131 (16%), Positives = 57/131 (43%), Gaps = 1/131 (0%)
Frame = +3
Query: 102 WNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLS-SGENV 278
W L +E+L E+ + + + L E F A+ W D K+ + +
Sbjct: 368 WGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATL 427
Query: 279 STLESQKSQIEHLETEINEYRKLAMEVDKCSQELQQNMIFETPNCRYSMETLRVSWEQLQ 458
S +++ + E E+++ ++ ++ +QEL + +++P+ + + W+ L
Sbjct: 428 SEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLG 487
Query: 459 SSMRRSKSEIE 491
+ ++ + +E
Sbjct: 488 ALTQKRREALE 498
Score = 31.2 bits (69), Expect = 3.6
Identities = 22/85 (25%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Frame = +3
Query: 150 KELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEI 329
K L+ +NE+L E++ LA+ L WI ++ I +L + +T+++ + ++E +
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWI---RRTIPWLENRVPENTMQAMQQKLE----DF 316
Query: 330 NEYRKL---AMEVDKCSQELQQNMI 395
+YR+L +KC E+ N +
Sbjct: 317 RDYRRLHKPPKVQEKCQLEINFNTL 341
>sp|P18091|ACTN_DROME Alpha-actinin, sarcomeric (F-actin cross linking protein)
Length = 924
Score = 243 bits (620), Expect = 5e-64
Identities = 122/273 (44%), Positives = 180/273 (65%), Gaps = 1/273 (0%)
Frame = +3
Query: 3 VDSQIKNRALENNLNQISENPYTLLSQTALSVEWNKLSDLLPLRDEFLQKELSQQTKNEK 182
V+S +K + L ENPYT L+ ++ +W+ + L+P RD+ L EL +Q NE
Sbjct: 607 VESIVKQHQIPGGL----ENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEM 662
Query: 183 LRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEINEYRKLAMEVD 362
LR F AN +GPWI+ + + + G S LE Q +++ E + Y+ E++
Sbjct: 663 LRRQFAEKANIVGPWIERQMDAVTAIGMGLQGS-LEDQLHRLKEYEQAVYAYKPNIEELE 721
Query: 363 KCSQELQQNMIFETPNCRYSMETLRVSWEQLQSSMRRSKSEIEDQILTRDSKGISQSQMD 542
K Q +Q++MIFE Y+METLRV WEQL +S+ R+ +E+E+QILTRDSKGISQ Q++
Sbjct: 722 KIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLN 781
Query: 543 EFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNL-KEEKGEADFAKIMSEVDPNRSGVVTF 719
EFR FNHFDKN+T L P+EFK+CLVSLG ++ K+ +G+ DF +I++ VDPN +G V F
Sbjct: 782 EFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILAVVDPNNTGYVHF 841
Query: 720 GAFIDYMAKETTEQDTLEQILQSFKVLCQDRDY 818
AF+D+M +E+T+ DT EQ++ SF++L D+ Y
Sbjct: 842 DAFLDFMTRESTDTDTAEQVIDSFRILAADKPY 874
Score = 31.2 bits (69), Expect = 3.6
Identities = 35/196 (17%), Positives = 81/196 (41%), Gaps = 15/196 (7%)
Frame = +3
Query: 150 KELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQI-----EH 314
K L +NE+L E + LA+ L WI ++N + +++ ++ + + +H
Sbjct: 296 KVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKH 355
Query: 315 LETEINEYRKLAMEVDKCSQELQ-QNMIFETPNCRYSMETLRVSWEQLQSSMRRSKSEIE 491
+ + KL + +L+ N P ++ + SW+ L+ ++ E
Sbjct: 356 KPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLE----LAEKAFE 411
Query: 492 DQILTRDSKGISQSQMDEFRRCFNH-------FDKNKTRTLEPKEFKACLVS--LGCNLK 644
+ +L ++ + +++ + F H + + K L+ ++F+ C ++ K
Sbjct: 412 EWLL---AETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKK 468
Query: 645 EEKGEADFAKIMSEVD 692
E E+D A V+
Sbjct: 469 HEAFESDLAAHQDRVE 484
>sp|P12814|ACTN1_HUMAN Alpha-actinin 1 (Alpha-actinin cytoskeletal isoform) (Non-muscle
alpha-actinin 1) (F-actin cross linking protein)
Length = 892
Score = 242 bits (618), Expect = 8e-64
Identities = 120/261 (45%), Positives = 182/261 (69%), Gaps = 1/261 (0%)
Frame = +3
Query: 39 NLNQISENPYTLLSQTALSVEWNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKL 218
++N NPYT ++ ++ +W+ + L+P RD+ L +E ++Q NE+LR+ FG+ AN +
Sbjct: 583 HVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVI 642
Query: 219 GPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEINEYRKLAMEVDKCSQELQQNMIF 398
GPWI K + I +S E TLE Q S + E I Y+ +++ Q +Q+ +IF
Sbjct: 643 GPWIQTKMEEIGRISI-EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIF 701
Query: 399 ETPNCRYSMETLRVSWEQLQSSMRRSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKN 578
+ + Y+ME +RV WEQL +++ R+ +E+E+QILTRD+KGISQ QM+EFR FNHFD++
Sbjct: 702 DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRD 761
Query: 579 KTRTLEPKEFKACLVSLGCNL-KEEKGEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETT 755
+ TL P+EFKACL+SLG ++ + +GEA+FA+IMS VDPNR GVVTF AFID+M++ET
Sbjct: 762 HSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETA 821
Query: 756 EQDTLEQILQSFKVLCQDRDY 818
+ DT +Q++ SFK+L D++Y
Sbjct: 822 DTDTADQVMASFKILAGDKNY 842
Score = 34.3 bits (77), Expect = 0.42
Identities = 22/131 (16%), Positives = 58/131 (44%), Gaps = 1/131 (0%)
Frame = +3
Query: 102 WNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLS-SGENV 278
W L + +E+L E+ + + + L E F A+ W D K+ + +
Sbjct: 368 WGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATL 427
Query: 279 STLESQKSQIEHLETEINEYRKLAMEVDKCSQELQQNMIFETPNCRYSMETLRVSWEQLQ 458
S +++ + E E+++ ++ ++ +QEL + +++P+ + + W+ L
Sbjct: 428 SEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLG 487
Query: 459 SSMRRSKSEIE 491
+ ++ + +E
Sbjct: 488 ALTQKRREALE 498
Score = 30.4 bits (67), Expect = 6.1
Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Frame = +3
Query: 150 KELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEI 329
K L+ +NE+L E++ LA+ L WI ++ I +L + +T+ + + ++E +
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWI---RRTIPWLENRVPENTMHAMQQKLE----DF 316
Query: 330 NEYRKL---AMEVDKCSQELQQNMI 395
+YR+L +KC E+ N +
Sbjct: 317 RDYRRLHKPPKVQEKCQLEINFNTL 341
>sp|Q7TPR4|ACTN1_MOUSE Alpha-actinin 1 (Alpha-actinin cytoskeletal isoform) (Non-muscle
alpha-actinin 1) (F-actin cross linking protein)
Length = 892
Score = 242 bits (617), Expect = 1e-63
Identities = 120/261 (45%), Positives = 182/261 (69%), Gaps = 1/261 (0%)
Frame = +3
Query: 39 NLNQISENPYTLLSQTALSVEWNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKL 218
++N NPYT ++ ++ +W+ + L+P RD+ L +E ++Q NE+LR+ FG+ AN +
Sbjct: 583 HVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVI 642
Query: 219 GPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEINEYRKLAMEVDKCSQELQQNMIF 398
GPWI K + I +S E TLE Q S + E I Y+ +++ Q +Q+ +IF
Sbjct: 643 GPWIQTKMEEIGRISI-EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLECDHQLIQEALIF 701
Query: 399 ETPNCRYSMETLRVSWEQLQSSMRRSKSEIEDQILTRDSKGISQSQMDEFRRCFNHFDKN 578
+ + Y+ME +RV WEQL +++ R+ +E+E+QILTRD+KGISQ QM+EFR FNHFD++
Sbjct: 702 DNKHTNYNMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRD 761
Query: 579 KTRTLEPKEFKACLVSLGCNL-KEEKGEADFAKIMSEVDPNRSGVVTFGAFIDYMAKETT 755
+ TL P+EFKACL+SLG ++ + +GEA+FA+IMS VDPNR GVVTF AFID+M++ET
Sbjct: 762 HSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETA 821
Query: 756 EQDTLEQILQSFKVLCQDRDY 818
+ DT +Q++ SFK+L D++Y
Sbjct: 822 DTDTADQVMASFKILAGDKNY 842
Score = 33.5 bits (75), Expect = 0.72
Identities = 22/131 (16%), Positives = 57/131 (43%), Gaps = 1/131 (0%)
Frame = +3
Query: 102 WNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLS-SGENV 278
W L +E+L E+ + + + L E F A+ W D K+ + +
Sbjct: 368 WGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATL 427
Query: 279 STLESQKSQIEHLETEINEYRKLAMEVDKCSQELQQNMIFETPNCRYSMETLRVSWEQLQ 458
S +++ + E E+++ ++ ++ +QEL + +++P+ + + W+ L
Sbjct: 428 SEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLG 487
Query: 459 SSMRRSKSEIE 491
+ ++ + +E
Sbjct: 488 ALTQKRREALE 498
Score = 30.4 bits (67), Expect = 6.1
Identities = 22/85 (25%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Frame = +3
Query: 150 KELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEI 329
K L+ +NE+L E++ LA+ L WI ++ I +L + +T+ + + ++E +
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWI---RRTIPWLENRVPENTMHAMQQKLE----DF 316
Query: 330 NEYRKL---AMEVDKCSQELQQNMI 395
+YR+L +KC E+ N +
Sbjct: 317 RDYRRLHKPPKVQEKCQLEINFNTL 341
>sp|O43707|ACTN4_HUMAN Alpha-actinin 4 (Non-muscle alpha-actinin 4) (F-actin cross linking
protein)
Length = 911
Score = 239 bits (611), Expect = 5e-63
Identities = 122/273 (44%), Positives = 182/273 (66%), Gaps = 1/273 (0%)
Frame = +3
Query: 3 VDSQIKNRALENNLNQISENPYTLLSQTALSVEWNKLSDLLPLRDEFLQKELSQQTKNEK 182
+ + + A N++ NPYT ++ ++ +W K+ L+P RD L +E S+Q NE
Sbjct: 590 IHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 649
Query: 183 LRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEINEYRKLAMEVD 362
LR F S AN +GPWI K + I +S N TLE Q S ++ E I +Y+ ++
Sbjct: 650 LRRQFASQANVVGPWIQTKMEEIGRISIEMN-GTLEDQLSHLKQYERSIVDYKPNLDLLE 708
Query: 363 KCSQELQQNMIFETPNCRYSMETLRVSWEQLQSSMRRSKSEIEDQILTRDSKGISQSQMD 542
+ Q +Q+ +IF+ + Y+ME +RV WEQL +++ R+ +E+E+QILTRD+KGISQ QM
Sbjct: 709 QQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQ 768
Query: 543 EFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEEK-GEADFAKIMSEVDPNRSGVVTF 719
EFR FNHFDK+ L P+EFKACL+SLG +++ ++ GEA+F +IMS VDPN SG+VTF
Sbjct: 769 EFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTF 828
Query: 720 GAFIDYMAKETTEQDTLEQILQSFKVLCQDRDY 818
AFID+M++ETT+ DT +Q++ SFKVL D+++
Sbjct: 829 QAFIDFMSRETTDTDTADQVIASFKVLAGDKNF 861
Score = 33.9 bits (76), Expect = 0.55
Identities = 35/173 (20%), Positives = 74/173 (42%), Gaps = 8/173 (4%)
Frame = +3
Query: 102 WNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLSSGENVS 281
W L +E+L E+ + + + L E F A+ W D K+ + + +
Sbjct: 387 WQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDY--ETA 444
Query: 282 TLESQKSQI---EHLETEINEYRKLAMEVDKCSQELQQNMIFETPNCRYSMETLRVSWEQ 452
TL K+ I E E+++ ++ ++ +QEL + +++ N + + W+
Sbjct: 445 TLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDA 504
Query: 453 LQS---SMRRSKSEIEDQILTRDSKGISQSQMDEFRRC--FNHFDKNKTRTLE 596
L S S R + + E Q+ + I Q ++ +R FN++ ++ L+
Sbjct: 505 LGSLTHSRREALEKTEKQL-----EAIDQLHLEYAKRAAPFNNWMESAMEDLQ 552
>sp|P57780|ACTN4_MOUSE Alpha-actinin 4 (Non-muscle alpha-actinin 4) (F-actin cross linking
protein)
Length = 912
Score = 239 bits (611), Expect = 5e-63
Identities = 121/273 (44%), Positives = 182/273 (66%), Gaps = 1/273 (0%)
Frame = +3
Query: 3 VDSQIKNRALENNLNQISENPYTLLSQTALSVEWNKLSDLLPLRDEFLQKELSQQTKNEK 182
+ + + A N++ NPYT ++ ++ +W K+ L+P RD L +E S+Q NE
Sbjct: 591 IHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 650
Query: 183 LRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEINEYRKLAMEVD 362
LR F S AN +GPWI K + I +S N TLE Q S ++ E I +Y+ ++
Sbjct: 651 LRRQFASQANMVGPWIQTKMEEIGRISIEMN-GTLEDQLSHLKQYERSIVDYKPSLDLLE 709
Query: 363 KCSQELQQNMIFETPNCRYSMETLRVSWEQLQSSMRRSKSEIEDQILTRDSKGISQSQMD 542
+ Q +Q+ +IF+ + Y+ME +RV WEQL +++ R+ +E+E+QILTRD+KGISQ QM
Sbjct: 710 QQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQ 769
Query: 543 EFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEEK-GEADFAKIMSEVDPNRSGVVTF 719
EFR FNHFDK+ L P+EFKACL+SLG +++ ++ G+A+F +IMS VDPN SG+VTF
Sbjct: 770 EFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGDAEFNRIMSVVDPNHSGLVTF 829
Query: 720 GAFIDYMAKETTEQDTLEQILQSFKVLCQDRDY 818
AFID+M++ETT+ DT +Q++ SFKVL D+++
Sbjct: 830 QAFIDFMSRETTDTDTADQVIASFKVLAGDKNF 862
Score = 34.7 bits (78), Expect = 0.32
Identities = 31/143 (21%), Positives = 60/143 (41%), Gaps = 6/143 (4%)
Frame = +3
Query: 102 WNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLSSGENVS 281
W L +E+L E+ + + + L E F A+ W D K+ + +
Sbjct: 388 WQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK--QRDYETA 445
Query: 282 TLESQKSQI---EHLETEINEYRKLAMEVDKCSQELQQNMIFETPNCRYSMETLRVSWEQ 452
TL K+ I E E+++ ++ ++ +QEL + +++ N + + W+
Sbjct: 446 TLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDN 505
Query: 453 LQS---SMRRSKSEIEDQILTRD 512
L S S R + + E Q+ T D
Sbjct: 506 LGSLTHSRREALEKTEKQLETID 528
>sp|Q9QXQ0|ACTN4_RAT Alpha-actinin 4 (Non-muscle alpha-actinin 4) (F-actin cross linking
protein)
Length = 911
Score = 239 bits (609), Expect = 9e-63
Identities = 122/273 (44%), Positives = 181/273 (66%), Gaps = 1/273 (0%)
Frame = +3
Query: 3 VDSQIKNRALENNLNQISENPYTLLSQTALSVEWNKLSDLLPLRDEFLQKELSQQTKNEK 182
+ + + A N++ NPYT ++ ++ +W K+ L+P RD L +E S+Q NE
Sbjct: 590 IHKEAQRIAESNHIKLSGSNPYTSVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 649
Query: 183 LRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEINEYRKLAMEVD 362
LR F S AN +GPWI K + I +S N TLE Q S ++ E I +Y+ ++
Sbjct: 650 LRRQFASQANMVGPWIQTKMEEIGRISIEMN-GTLEDQLSHLKQYERSIVDYKPNLDLLE 708
Query: 363 KCSQELQQNMIFETPNCRYSMETLRVSWEQLQSSMRRSKSEIEDQILTRDSKGISQSQMD 542
+ Q +Q+ +IF+ + Y+ME LRV WEQL +++ R+ +E+E+QILTRD+KGISQ QM
Sbjct: 709 QQHQLIQEALIFDNKHTNYTMEHLRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQ 768
Query: 543 EFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEEK-GEADFAKIMSEVDPNRSGVVTF 719
EFR FNHFDK+ L P+EFK CL+SLG +++ ++ G+A+F +IMS VDPN SG+VTF
Sbjct: 769 EFRASFNHFDKDHGGALGPEEFKGCLISLGYDVENDRQGDAEFNRIMSVVDPNHSGLVTF 828
Query: 720 GAFIDYMAKETTEQDTLEQILQSFKVLCQDRDY 818
AFID+M+KETT+ DT +Q++ SFKVL D+++
Sbjct: 829 QAFIDFMSKETTDTDTADQVIGSFKVLAGDKNF 861
Score = 35.4 bits (80), Expect = 0.19
Identities = 31/143 (21%), Positives = 61/143 (42%), Gaps = 6/143 (4%)
Frame = +3
Query: 102 WNKLSDLLPLRDEFLQKELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLSSGENVS 281
W L +E+L E+ + + + L E F A+ W D K+ + + +
Sbjct: 387 WQHLEQAEKGYEEWLLNEIPRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDY--ETA 444
Query: 282 TLESQKSQI---EHLETEINEYRKLAMEVDKCSQELQQNMIFETPNCRYSMETLRVSWEQ 452
TL K+ I E E+++ ++ ++ +QEL + +++ N + + W+
Sbjct: 445 TLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDN 504
Query: 453 LQS---SMRRSKSEIEDQILTRD 512
L S S R + + E Q+ T D
Sbjct: 505 LGSLTHSRREALEKTEKQLETID 527
>sp|Q08043|ACTN3_HUMAN Alpha-actinin 3 (Alpha actinin skeletal muscle isoform 3) (F-actin
cross linking protein)
Length = 901
Score = 234 bits (598), Expect = 2e-61
Identities = 116/272 (42%), Positives = 179/272 (65%)
Frame = +3
Query: 3 VDSQIKNRALENNLNQISENPYTLLSQTALSVEWNKLSDLLPLRDEFLQKELSQQTKNEK 182
+ +I+ L S NPY LS ++ +W+ + L+P RD+ LQ+EL++Q NE+
Sbjct: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNER 644
Query: 183 LRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEINEYRKLAMEVD 362
LR F + AN +GPWI K + + L++G +LE Q + + E I Y+ ++
Sbjct: 645 LRRQFAAQANAIGPWIQAKVEEVGRLAAGL-AGSLEEQMAGLRQQEQNIINYKTNIDRLE 703
Query: 363 KCSQELQQNMIFETPNCRYSMETLRVSWEQLQSSMRRSKSEIEDQILTRDSKGISQSQMD 542
Q LQ++++F+ + YSME +RV WEQL +S+ R+ +E+E+Q+LTRD+KG+SQ Q++
Sbjct: 704 GDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLN 763
Query: 543 EFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEEKGEADFAKIMSEVDPNRSGVVTFG 722
EFR FNHFD+ + +EP +F+ACL+S+G +L GE +FA+IM+ VDPN +GVVTF
Sbjct: 764 EFRASFNHFDRKRNGMMEPDDFRACLISMGYDL----GEVEFARIMTMVDPNAAGVVTFQ 819
Query: 723 AFIDYMAKETTEQDTLEQILQSFKVLCQDRDY 818
AFID+M +ET E DT EQ++ SFK+L D++Y
Sbjct: 820 AFIDFMTRETAETDTTEQVVASFKILAGDKNY 851
Score = 30.0 bits (66), Expect = 8.0
Identities = 21/85 (24%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Frame = +3
Query: 150 KELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEI 329
K L+ +NEKL E + LA++L WI ++ + +L + ++ + + ++E +
Sbjct: 278 KVLAVNQENEKLMEEYEKLASELLEWI---RRTVPWLENRVGEPSMSAMQRKLE----DF 330
Query: 330 NEYRKLAME---VDKCSQELQQNMI 395
+YR+L +KC E+ N +
Sbjct: 331 RDYRRLHKPPRIQEKCQLEINFNTL 355
>sp|O88990|ACTN3_MOUSE Alpha-actinin 3 (Alpha actinin skeletal muscle isoform 3) (F-actin
cross linking protein)
Length = 900
Score = 233 bits (593), Expect = 6e-61
Identities = 116/272 (42%), Positives = 179/272 (65%)
Frame = +3
Query: 3 VDSQIKNRALENNLNQISENPYTLLSQTALSVEWNKLSDLLPLRDEFLQKELSQQTKNEK 182
+ +I+ L S NPY LS ++ +W+ + L+P RD+ LQ+EL++Q NE+
Sbjct: 584 IQGEIQKICQTYGLRPKSGNPYITLSSQDINNKWDTVRKLVPSRDQTLQEELARQQVNER 643
Query: 183 LRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEINEYRKLAMEVD 362
LR F + AN +GPWI K + + L++G +LE Q + + E I Y+ ++
Sbjct: 644 LRRQFAAQANAIGPWIQGKVEEVGRLAAGL-AGSLEEQMAGLRQQEQNIINYKSNIDRLE 702
Query: 363 KCSQELQQNMIFETPNCRYSMETLRVSWEQLQSSMRRSKSEIEDQILTRDSKGISQSQMD 542
Q LQ++++F+ + YSME +RV WEQL +S+ R+ +E+E+Q+LTRD+KG+SQ Q++
Sbjct: 703 GDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLN 762
Query: 543 EFRRCFNHFDKNKTRTLEPKEFKACLVSLGCNLKEEKGEADFAKIMSEVDPNRSGVVTFG 722
EFR FNHFD+ + +EP +F+ACL+S+G +L GE +FA+IM+ VDPN +GVVTF
Sbjct: 763 EFRASFNHFDRKRNGMMEPDDFRACLISMGYDL----GEVEFARIMTMVDPNAAGVVTFQ 818
Query: 723 AFIDYMAKETTEQDTLEQILQSFKVLCQDRDY 818
AFID+M +ET E DT EQ++ SFK+L D++Y
Sbjct: 819 AFIDFMTRETAETDTAEQVVASFKILAGDKNY 850
Score = 30.0 bits (66), Expect = 8.0
Identities = 21/85 (24%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Frame = +3
Query: 150 KELSQQTKNEKLRENFGSLANKLGPWIDEKQQFINYLSSGENVSTLESQKSQIEHLETEI 329
K L+ +NEKL E + LA++L WI ++ + +L + ++ + + ++E +
Sbjct: 277 KVLAVNQENEKLMEEYEKLASELLEWI---RRTVPWLENRVGEPSMSAMQRKLE----DF 329
Query: 330 NEYRKL---AMEVDKCSQELQQNMI 395
+YR+L +KC E+ N +
Sbjct: 330 RDYRRLHKPPRVQEKCQLEINFNTL 354
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,099,088
Number of Sequences: 369166
Number of extensions: 1498638
Number of successful extensions: 5922
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5401
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5793
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7859674995
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)