Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_P04
(406 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma p... 71 7e-13
sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Pol... 71 9e-13
sp|Q9BYE2|TMPSD_HUMAN Transmembrane protease, serine 13 (Mo... 70 1e-12
sp|P15120|UROK_CHICK Urokinase-type plasminogen activator p... 70 2e-12
sp|Q6BEA2|PRS27_RAT Protease serine 27 precursor (Marapsin)... 70 2e-12
sp|Q8BJR6|PRS27_MOUSE Protease serine 27 precursor (Marapsi... 69 4e-12
sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Pol... 69 5e-12
sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polys... 69 5e-12
sp|P29598|UROK_RAT Urokinase-type plasminogen activator pre... 68 6e-12
sp|Q05589|UROK_BOVIN Urokinase-type plasminogen activator p... 68 8e-12
>sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 71.2 bits (173), Expect = 7e-13
Identities = 37/110 (33%), Positives = 58/110 (52%)
Frame = -1
Query: 406 TKTYGQISRYLLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPL 227
+K G+I L K+++ +++ +C++ Y +I +C K+ACKGDSGGPL
Sbjct: 525 SKEKGEIQNILQKVNIPLVTNEECQK--RYQDYKITQRMVCAGYKEGGKDACKGDSGGPL 582
Query: 226 ICKVNNKDIQTGIVSYGSVYCHHGHIPGIYTNVSSVYQWINQHANNND*K 77
+CK N GI S+G C PG+YT V+ WI + ++D K
Sbjct: 583 VCKHNGMWRLVGITSWGE-GCARREQPGVYTKVAEYMDWILEKTQSSDGK 631
>sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Polyserase-1) (Polyserase-I)
(Polyserine protease-1) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1059
Score = 70.9 bits (172), Expect = 9e-13
Identities = 35/100 (35%), Positives = 57/100 (57%), Gaps = 1/100 (1%)
Frame = -1
Query: 394 GQISRYLLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLICKV 215
G ++R L K V +LS+ CR++ + ++I +C ++C GD+GGPL C+
Sbjct: 961 GSMARQLQKAAVRLLSEQTCRRF---YPVQISSRMLCAGFPQGGVDSCSGDAGGPLACRE 1017
Query: 214 -NNKDIQTGIVSYGSVYCHHGHIPGIYTNVSSVYQWINQH 98
+ + + TG+ S+G C H PG+YT V++V WI QH
Sbjct: 1018 PSGRWVLTGVTSWG-YGCGRPHFPGVYTRVAAVRGWIGQH 1056
Score = 52.4 bits (124), Expect = 3e-07
Identities = 29/91 (31%), Positives = 47/91 (51%), Gaps = 1/91 (1%)
Frame = -1
Query: 376 LLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLIC-KVNNKDI 200
L K V +L Q+ C + + + D +C ++C+GDSGGPL+C + + +
Sbjct: 345 LQKATVELLDQALC---ASLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFF 401
Query: 199 QTGIVSYGSVYCHHGHIPGIYTNVSSVYQWI 107
GIVS+G + C PG+Y V+ + WI
Sbjct: 402 LAGIVSWG-IGCAEARRPGVYARVTRLRDWI 431
Score = 50.4 bits (119), Expect = 1e-06
Identities = 30/91 (32%), Positives = 43/91 (47%), Gaps = 1/91 (1%)
Frame = -1
Query: 376 LLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLIC-KVNNKDI 200
L K V I+ Q C + + D IC ++C+GDSGGPL C +
Sbjct: 645 LQKASVGIIDQKTC---SVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFY 701
Query: 199 QTGIVSYGSVYCHHGHIPGIYTNVSSVYQWI 107
GIVS+G + C PG+YT ++ + WI
Sbjct: 702 LAGIVSWG-IGCAQVKKPGVYTRITRLKGWI 731
>sp|Q9BYE2|TMPSD_HUMAN Transmembrane protease, serine 13 (Mosaic serine protease)
(Membrane-type mosaic serine protease)
Length = 581
Score = 70.5 bits (171), Expect = 1e-12
Identities = 34/99 (34%), Positives = 56/99 (56%)
Frame = -1
Query: 403 KTYGQISRYLLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLI 224
+T + S +L ++ VN++ +C Y Y P +C H +++C+GDSGGPL+
Sbjct: 453 ETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTP-RMMCAGDLHGGRDSCQGDSGGPLV 511
Query: 223 CKVNNKDIQTGIVSYGSVYCHHGHIPGIYTNVSSVYQWI 107
C+ NN+ G+ S+G+ C + PG+YT V+ V WI
Sbjct: 512 CEQNNRWYLAGVTSWGT-GCGQRNKPGVYTKVTEVLPWI 549
>sp|P15120|UROK_CHICK Urokinase-type plasminogen activator precursor (uPA) (U-plasminogen
activator) [Contains: Urokinase-type plasminogen
activator chain A; Urokinase-type plasminogen activator
chain B]
Length = 434
Score = 70.1 bits (170), Expect = 2e-12
Identities = 35/95 (36%), Positives = 53/95 (55%)
Frame = -1
Query: 376 LLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLICKVNNKDIQ 197
L+ VN++SQ C+ Y R+ D+ +C +ACKGDSGGP++C+ N +
Sbjct: 329 LMSATVNLISQDDCKNK-YYDSTRVTDNMVCAGDPLWETDACKGDSGGPMVCEHNGRMTL 387
Query: 196 TGIVSYGSVYCHHGHIPGIYTNVSSVYQWINQHAN 92
GIVS+G C + PG+YT V+ WI+ + N
Sbjct: 388 YGIVSWGD-GCAKKNKPGVYTRVTRYLNWIDSNMN 421
>sp|Q6BEA2|PRS27_RAT Protease serine 27 precursor (Marapsin) (Pancreasin)
Length = 328
Score = 70.1 bits (170), Expect = 2e-12
Identities = 38/100 (38%), Positives = 58/100 (58%), Gaps = 6/100 (6%)
Frame = -1
Query: 382 RYLLKLDVNILSQSQC-----RQYGAYFKIR-IPDHNICGKSSHRNKNACKGDSGGPLIC 221
R L KL V ++ +C + A +++ I D +C + K+ACKGDSGGPL+C
Sbjct: 179 RILQKLAVPLIDTPKCNLLYSKDAEADIQLKTIKDDMLCAGFAEGKKDACKGDSGGPLVC 238
Query: 220 KVNNKDIQTGIVSYGSVYCHHGHIPGIYTNVSSVYQWINQ 101
V+ +Q G++S+G C + PG+Y V+S YQWI+Q
Sbjct: 239 LVDQSWVQAGVISWGE-GCARRNRPGVYIRVASHYQWIHQ 277
>sp|Q8BJR6|PRS27_MOUSE Protease serine 27 precursor (Marapsin) (Pancreasin)
Length = 328
Score = 68.9 bits (167), Expect = 4e-12
Identities = 37/100 (37%), Positives = 59/100 (59%), Gaps = 6/100 (6%)
Frame = -1
Query: 382 RYLLKLDVNILSQSQC-----RQYGAYFKIR-IPDHNICGKSSHRNKNACKGDSGGPLIC 221
R L KL V I+ +C + + F+++ I D +C + K+ACKGDSGGPL+C
Sbjct: 179 RVLQKLAVPIIDTPKCNLLYNKDVESDFQLKTIKDDMLCAGFAEGKKDACKGDSGGPLVC 238
Query: 220 KVNNKDIQTGIVSYGSVYCHHGHIPGIYTNVSSVYQWINQ 101
V+ +Q G++S+G C + PG+Y V+S ++WI+Q
Sbjct: 239 LVDQSWVQAGVISWGE-GCARRNRPGVYIRVTSHHKWIHQ 277
>sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1065
Score = 68.6 bits (166), Expect = 5e-12
Identities = 34/100 (34%), Positives = 57/100 (57%), Gaps = 1/100 (1%)
Frame = -1
Query: 394 GQISRYLLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLICK- 218
G ++R L K V +LS+ CR++ + ++I +C ++C GD+GGPL C+
Sbjct: 967 GSMARQLQKAAVRVLSEQTCRRF---YPVQISSRMLCAGFPQGGVDSCSGDAGGPLACRE 1023
Query: 217 VNNKDIQTGIVSYGSVYCHHGHIPGIYTNVSSVYQWINQH 98
+ + + TG+ S+G C H PG+YT V++V WI Q+
Sbjct: 1024 PSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1062
Score = 55.5 bits (132), Expect = 4e-08
Identities = 31/91 (34%), Positives = 48/91 (52%), Gaps = 1/91 (1%)
Frame = -1
Query: 376 LLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLIC-KVNNKDI 200
L K V +L QS C + + + D +C ++C+GDSGGPL+C + + +
Sbjct: 347 LQKATVELLDQSLC---SSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFF 403
Query: 199 QTGIVSYGSVYCHHGHIPGIYTNVSSVYQWI 107
GIVS+G + C PG+YT V+ + WI
Sbjct: 404 LAGIVSWG-IGCAEARRPGVYTRVTRLRDWI 433
Score = 53.9 bits (128), Expect = 1e-07
Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 1/91 (1%)
Frame = -1
Query: 376 LLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLIC-KVNNKDI 200
L K V I+ Q C GA + + D +C ++C+GDSGGPL C +
Sbjct: 647 LQKASVGIIEQKMC---GALYNFSLTDRMLCAGFLEGRVDSCQGDSGGPLACEETPGVFY 703
Query: 199 QTGIVSYGSVYCHHGHIPGIYTNVSSVYQWI 107
GIVS+G + C PG+Y ++ + WI
Sbjct: 704 LAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
>sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1061
Score = 68.6 bits (166), Expect = 5e-12
Identities = 34/100 (34%), Positives = 57/100 (57%), Gaps = 1/100 (1%)
Frame = -1
Query: 394 GQISRYLLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLICK- 218
G ++R L K V +LS+ CR++ + ++I +C ++C GD+GGPL C+
Sbjct: 963 GSMARQLQKAAVRVLSEQTCRRF---YPVQISSRMLCAGFPQGGVDSCSGDAGGPLACRE 1019
Query: 217 VNNKDIQTGIVSYGSVYCHHGHIPGIYTNVSSVYQWINQH 98
+ + + TG+ S+G C H PG+YT V++V WI Q+
Sbjct: 1020 PSGQWVLTGVTSWG-YGCGRPHFPGVYTRVAAVLGWIGQN 1058
Score = 54.7 bits (130), Expect = 7e-08
Identities = 30/99 (30%), Positives = 52/99 (52%), Gaps = 1/99 (1%)
Frame = -1
Query: 376 LLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLIC-KVNNKDI 200
L K V +L Q+ C + + + D +C ++C+GDSGGPL+C + + +
Sbjct: 347 LQKATVELLDQNLC---SSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFF 403
Query: 199 QTGIVSYGSVYCHHGHIPGIYTNVSSVYQWINQHANNND 83
G+VS+G + C PG+YT V+ + WI + ++ D
Sbjct: 404 LAGVVSWG-IGCAEARRPGVYTRVTRLRDWILEVTSSAD 441
Score = 53.9 bits (128), Expect = 1e-07
Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 1/91 (1%)
Frame = -1
Query: 376 LLKLDVNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLIC-KVNNKDI 200
L K V I+ Q C GA + + D +C ++C+GDSGGPL C +
Sbjct: 647 LQKASVGIIEQKMC---GALYNFSLTDRMLCAGFLEGRVDSCQGDSGGPLACEETPGVFY 703
Query: 199 QTGIVSYGSVYCHHGHIPGIYTNVSSVYQWI 107
GIVS+G + C PG+Y ++ + WI
Sbjct: 704 LAGIVSWG-IGCAQAKKPGVYARITRLKDWI 733
>sp|P29598|UROK_RAT Urokinase-type plasminogen activator precursor (uPA) (U-plasminogen
activator) [Contains: Urokinase-type plasminogen
activator long chain A; Urokinase-type plasminogen
activator short chain A; Urokinase-type plasminogen
activator chain B]
Length = 432
Score = 68.2 bits (165), Expect = 6e-12
Identities = 35/88 (39%), Positives = 48/88 (54%)
Frame = -1
Query: 361 VNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLICKVNNKDIQTGIVS 182
V I+S QC+Q Y+ I +C ++C GDSGGPLIC ++ + +GIVS
Sbjct: 338 VKIISHEQCKQ-PHYYGSEINYKMLCAADPEWKTDSCSGDSGGPLICNIDGRPTLSGIVS 396
Query: 181 YGSVYCHHGHIPGIYTNVSSVYQWINQH 98
+GS C + PG+YT VS WI H
Sbjct: 397 WGS-GCAEKNKPGVYTRVSYFLNWIQSH 423
>sp|Q05589|UROK_BOVIN Urokinase-type plasminogen activator precursor (uPA) (U-plasminogen
activator) [Contains: Urokinase-type plasminogen
activator chain A; Urokinase-type plasminogen activator
chain B]
Length = 433
Score = 67.8 bits (164), Expect = 8e-12
Identities = 33/88 (37%), Positives = 49/88 (55%)
Frame = -1
Query: 361 VNILSQSQCRQYGAYFKIRIPDHNICGKSSHRNKNACKGDSGGPLICKVNNKDIQTGIVS 182
V+++S C+Q Y+ + D +C ++C+GDSGGPL+C + + TGIVS
Sbjct: 339 VSLVSHEVCQQ-PHYYGAEVTDKMLCAADPQWETDSCQGDSGGPLVCTIQGRLTLTGIVS 397
Query: 181 YGSVYCHHGHIPGIYTNVSSVYQWINQH 98
+G C + PG+YT VS WIN H
Sbjct: 398 WGR-DCAMKYKPGVYTRVSKFLPWINTH 424
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,263,982
Number of Sequences: 369166
Number of extensions: 951226
Number of successful extensions: 2924
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2499
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2558
length of database: 68,354,980
effective HSP length: 98
effective length of database: 50,250,950
effective search space used: 1809034200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)