Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_L13
(834 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 52 3e-06
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 51 3e-06
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 49 2e-05
sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6 47 6e-05
sp|P36044|MNN4_YEAST Protein MNN4 47 8e-05
sp|Q13111|CAF1A_HUMAN Chromatin assembly factor 1 subunit A... 45 3e-04
sp|O67825|IF2_AQUAE Translation initiation factor IF-2 44 4e-04
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 44 7e-04
sp|Q12315|GLE1_YEAST Nucleoporin GLE1 (Nuclear pore protein... 43 0.001
sp|Q922B6|TRAF7_MOUSE E3 ubiquitin protein ligase TRAF7 (TN... 42 0.002
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 51.6 bits (122), Expect = 3e-06
Identities = 34/129 (26%), Positives = 59/129 (45%), Gaps = 6/129 (4%)
Frame = +2
Query: 116 CKDELISNNQVDHRRNMKISKVVMKCPEE--MCSHECAII----NMEEHVRVCEKKSVKC 277
CK +++ N +H N+ CPE C + CA I ++EH+ VC + C
Sbjct: 171 CKKDVVVINLQNHEENL--------CPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDC 222
Query: 278 PLANVGCDGKKIAREMLNDHCQSANFNHCKILIEMIDNMRNEIDILKANDEKNQLKIENL 457
P + GC R L H SA H ++++E + +I L + E+ + KI+ L
Sbjct: 223 PFKHYGC-AVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQL 281
Query: 458 EKNLKSKDE 484
+ +K ++
Sbjct: 282 AETIKKLEK 290
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 51.2 bits (121), Expect = 3e-06
Identities = 26/92 (28%), Positives = 46/92 (50%), Gaps = 2/92 (2%)
Frame = +2
Query: 11 LINAYCVPCGCSYCCDCVNEMVNNGVENCPGKTEDCKDELISNNQV--DHRRNMKISKVV 184
L A PCG +C C+ + + + CP +E++ NQ+ D+ +I ++
Sbjct: 77 LREAVQTPCGHRFCKACIIKSIRDAGHKCP-----VDNEILLENQLFPDNFAKREILSLM 131
Query: 185 MKCPEEMCSHECAIINMEEHVRVCEKKSVKCP 280
+KCP E C H+ + ++E+H CE + CP
Sbjct: 132 VKCPNEGCLHKMELRHLEDHQAHCEFALMDCP 163
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/130 (24%), Positives = 58/130 (44%)
Frame = +2
Query: 116 CKDELISNNQVDHRRNMKISKVVMKCPEEMCSHECAIINMEEHVRVCEKKSVKCPLANVG 295
CK +++ N DH N + CP C + EH+ VC + CP + G
Sbjct: 171 CKRDIVVTNLQDHEEN-SCPAYPVSCPNR-CVQTIPRARVNEHLTVCPEAEQDCPFKHYG 228
Query: 296 CDGKKIAREMLNDHCQSANFNHCKILIEMIDNMRNEIDILKANDEKNQLKIENLEKNLKS 475
C K R L +H ++A +H +++E + I L + E+ + KI+ L + +K
Sbjct: 229 CTVKG-KRGNLLEHERAALQDHMLLVLEKNYQLEQRISDLYQSLEQKESKIQQLAETVKK 287
Query: 476 KDEIIDKINQ 505
++ + + Q
Sbjct: 288 FEKELKQFTQ 297
Score = 37.0 bits (84), Expect = 0.067
Identities = 26/117 (22%), Positives = 50/117 (42%), Gaps = 4/117 (3%)
Frame = +2
Query: 5 NILINAYCVPCGCSYCCDCVNEMVN-NGVENCPGKTEDCKDELISNNQVDHRRNMKISKV 181
++L N + CG +C C+ + N V CP E K + + + R + +
Sbjct: 50 SVLHNPHQTGCGHRFCQQCIRSLRELNSVPICPVDKEVIKPQEVFKDNCCKREVLNLHVY 109
Query: 182 VMKCPEEMCSHECAIINMEEHVRVCEKKSVKCPLANVGCDG---KKIAREMLNDHCQ 343
P C+ + ++H++ C ++V CP N C +K +E L+ +C+
Sbjct: 110 CKNAPG--CNARIILGRFQDHLQHCSFQAVPCP--NESCREAMLRKDVKEHLSAYCR 162
>sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6
Length = 530
Score = 47.0 bits (110), Expect = 6e-05
Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 2/92 (2%)
Frame = +2
Query: 11 LINAYCVPCGCSYCCDCVNEMVNNGVENCPGKTEDCKDELISNNQV--DHRRNMKISKVV 184
L A PCG +C C+ + + + CP +E++ NQ+ D+ +I +
Sbjct: 77 LREAVQTPCGHRFCKACIIKSIRDAGHKCP-----VDNEILLENQLFPDNFAKREILSLT 131
Query: 185 MKCPEEMCSHECAIINMEEHVRVCEKKSVKCP 280
+KCP + C + + ++E+H CE V CP
Sbjct: 132 VKCPNKGCLQKMELRHLEDHQVHCEFALVNCP 163
>sp|P36044|MNN4_YEAST Protein MNN4
Length = 1178
Score = 46.6 bits (109), Expect = 8e-05
Identities = 25/80 (31%), Positives = 48/80 (60%)
Frame = +3
Query: 579 EKETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDEDKRECDKINEINLERKTKEI 758
EK+ ++E KE+ E+K +E +KMK E+E K +DE+K++ ++ + E K K+
Sbjct: 1089 EKKKQEEEEKKKKEEEEKKKQEEGEKMKNEDEENKKNEDEEKKKNEEEEKKKQEEKNKKN 1148
Query: 759 FAEMQKEKQERIESINDERK 818
E +K+++E + N+E +
Sbjct: 1149 EDEEKKKQEEEEKKKNEEEE 1168
Score = 45.8 bits (107), Expect = 1e-04
Identities = 24/78 (30%), Positives = 48/78 (61%)
Frame = +3
Query: 579 EKETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDEDKRECDKINEINLERKTKEI 758
EK+ ++E KE+ E+K +E ++K K+E E K +++E+K++ ++ + E + K+
Sbjct: 1041 EKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKQEEEEKKK 1100
Query: 759 FAEMQKEKQERIESINDE 812
E +K+KQE E + +E
Sbjct: 1101 KEEEEKKKQEEGEKMKNE 1118
Score = 43.1 bits (100), Expect = 0.001
Identities = 25/83 (30%), Positives = 51/83 (61%), Gaps = 3/83 (3%)
Frame = +3
Query: 579 EKETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDEDKR---ECDKINEINLERKT 749
EK+ ++E KE+ E+K +E ++K K+E E K +++E+K+ E +K + E+K
Sbjct: 1049 EKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKQEEEEKKKKEEEEKKK 1108
Query: 750 KEIFAEMQKEKQERIESINDERK 818
+E +M+ E +E ++ ++E+K
Sbjct: 1109 QEEGEKMKNEDEENKKNEDEEKK 1131
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/83 (30%), Positives = 45/83 (54%)
Frame = +3
Query: 579 EKETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDEDKRECDKINEINLERKTKEI 758
EK+ ++E KE+ E+K +E ++K K+E E K +++E+K++ ++ E K K+
Sbjct: 1057 EKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKQEEEEKKKKEE------EEKKKQE 1110
Query: 759 FAEMQKEKQERIESINDERKSIN 827
E K + E + DE K N
Sbjct: 1111 EGEKMKNEDEENKKNEDEEKKKN 1133
Score = 41.2 bits (95), Expect = 0.004
Identities = 25/89 (28%), Positives = 51/89 (57%), Gaps = 9/89 (10%)
Frame = +3
Query: 579 EKETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDEDKREC---------DKINEI 731
EK+ ++E KE+ E+K +E ++K K+E E K +++E+K++ D+ N+
Sbjct: 1065 EKKKKEEEEKKKKEEEEKKKKEEEEKKKQEEEEKKKKEEEEKKKQEEGEKMKNEDEENKK 1124
Query: 732 NLERKTKEIFAEMQKEKQERIESINDERK 818
N + + K+ E +K+++E+ + DE K
Sbjct: 1125 NEDEEKKKNEEEEKKKQEEKNKKNEDEEK 1153
Score = 40.4 bits (93), Expect = 0.006
Identities = 25/84 (29%), Positives = 48/84 (57%), Gaps = 1/84 (1%)
Frame = +3
Query: 579 EKETVKQEFDSLKEDLERKIEEIDDKMKR-ENERMKIEKDEDKRECDKINEINLERKTKE 755
EK+ ++E +E+ E+K +E ++K K+ E E+MK E +E+K+ D+ + N E + K+
Sbjct: 1081 EKKKKEEEEKKKQEEEEKKKKEEEEKKKQEEGEKMKNEDEENKKNEDEEKKKNEEEEKKK 1140
Query: 756 IFAEMQKEKQERIESINDERKSIN 827
+ +K + E + +E K N
Sbjct: 1141 QEEKNKKNEDEEKKKQEEEEKKKN 1164
Score = 39.3 bits (90), Expect = 0.014
Identities = 22/76 (28%), Positives = 43/76 (56%)
Frame = +3
Query: 585 ETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDEDKRECDKINEINLERKTKEIFA 764
E K+ KE+ E+K +E ++K K+E E K +++E+K++ ++ + E + K+
Sbjct: 1035 EERKRREKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKQE 1094
Query: 765 EMQKEKQERIESINDE 812
E +K+K+E E E
Sbjct: 1095 EEEKKKKEEEEKKKQE 1110
Score = 35.4 bits (80), Expect = 0.20
Identities = 20/67 (29%), Positives = 41/67 (61%), Gaps = 3/67 (4%)
Frame = +3
Query: 627 ERKIEEIDDKMKRENERMKIEKDEDK---RECDKINEINLERKTKEIFAEMQKEKQERIE 797
E+K +E ++K K+E E K +++E+K E +K + E+K KE + ++E++E+ +
Sbjct: 1041 EKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKQEEEEKKK 1100
Query: 798 SINDERK 818
+E+K
Sbjct: 1101 KEEEEKK 1107
Score = 32.7 bits (73), Expect = 1.3
Identities = 15/58 (25%), Positives = 36/58 (62%)
Frame = +3
Query: 645 IDDKMKRENERMKIEKDEDKRECDKINEINLERKTKEIFAEMQKEKQERIESINDERK 818
++++ +RE ++ + E+ + K E +K + E+K KE + +KE++E+ + +E+K
Sbjct: 1034 LEERKRREKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKKKKEEEEKK 1091
Score = 31.2 bits (69), Expect = 3.7
Identities = 20/71 (28%), Positives = 41/71 (57%), Gaps = 1/71 (1%)
Frame = +3
Query: 579 EKETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDEDKRECDKINE-INLERKTKE 755
E+E KQE ++ + + ++ +D+ K++NE + +K E+K + ++ E E + K+
Sbjct: 1103 EEEKKKQEEGEKMKNEDEENKKNEDEEKKKNEEEEKKKQEEKNKKNEDEEKKKQEEEEKK 1162
Query: 756 IFAEMQKEKQE 788
E +K+KQE
Sbjct: 1163 KNEEEEKKKQE 1173
>sp|Q13111|CAF1A_HUMAN Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin
assembly factor I p150 subunit) (CAF-I 150 kDa subunit)
(CAF-Ip150)
Length = 938
Score = 44.7 bits (104), Expect = 3e-04
Identities = 28/86 (32%), Positives = 51/86 (59%), Gaps = 2/86 (2%)
Frame = +3
Query: 579 EKETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDE-DKRECDKINEINLERKTKE 755
EKE +K+E KE+ ++K EE + ++K + R K EKDE +K E ++ E + + +
Sbjct: 338 EKEKLKEEAKRAKEEAKKKKEE-EKELKEKERREKREKDEKEKAEKQRLKEERRKERQEA 396
Query: 756 IFAEM-QKEKQERIESINDERKSINA 830
+ A++ +K K+E + + +E K I A
Sbjct: 397 LEAKLEEKRKKEEEKRLREEEKRIKA 422
Score = 30.8 bits (68), Expect = 4.8
Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 5/86 (5%)
Frame = +3
Query: 582 KETVKQEFDSLKEDLERKIEEIDDKMK-----RENERMKIEKDEDKRECDKINEINLERK 746
K+ VK + K L+R E + ++K E E++K E K E K E E K
Sbjct: 305 KKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELK 364
Query: 747 TKEIFAEMQKEKQERIESINDERKSI 824
KE ++EK+E+ E E++ +
Sbjct: 365 EKE-----RREKREKDEKEKAEKQRL 385
>sp|O67825|IF2_AQUAE Translation initiation factor IF-2
Length = 805
Score = 44.3 bits (103), Expect = 4e-04
Identities = 25/80 (31%), Positives = 49/80 (61%)
Frame = +3
Query: 579 EKETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDEDKRECDKINEINLERKTKEI 758
++E K+E + K+ +E I+EI +K ++E E+ K+EK E K E ++ E+ E + +E
Sbjct: 113 KEEEEKKEEEKPKKSVEELIKEILEKKEKEKEKKKVEK-ERKEEKVRVVEVKKEERKEEK 171
Query: 759 FAEMQKEKQERIESINDERK 818
E ++E++ +I+ ER+
Sbjct: 172 KEEKKEEEKPKIKMSKKERE 191
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/78 (28%), Positives = 41/78 (52%)
Frame = +3
Query: 585 ETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDEDKRECDKINEINLERKTKEIFA 764
E + +E + KE+ E+K EE K E + +EK E ++E K+ + E K + +
Sbjct: 103 EVIVEEIEEKKEEEEKKEEEKPKKSVEELIKEILEKKEKEKEKKKVEKERKEEKVRVVEV 162
Query: 765 EMQKEKQERIESINDERK 818
+ ++ K+E+ E +E K
Sbjct: 163 KKEERKEEKKEEKKEEEK 180
Score = 32.7 bits (73), Expect = 1.3
Identities = 18/80 (22%), Positives = 44/80 (55%)
Frame = +3
Query: 576 MEKETVKQEFDSLKEDLERKIEEIDDKMKRENERMKIEKDEDKRECDKINEINLERKTKE 755
++++ ++ +D+ E + EE+ + + ++ +K+E+K+E + E+ +E K E
Sbjct: 45 LDEQALEMIYDAFGIKEEEEKEEVVTEQAQAPAEVEEKKEEEKKEEVIVEEV-VEEKKPE 103
Query: 756 IFAEMQKEKQERIESINDER 815
+ E +EK+E E +E+
Sbjct: 104 VIVEEIEEKKEEEEKKEEEK 123
Score = 31.6 bits (70), Expect = 2.8
Identities = 24/92 (26%), Positives = 47/92 (51%), Gaps = 12/92 (13%)
Frame = +3
Query: 579 EKETVKQEFDSLKEDLERKIEE-------IDDKMKRENERMKIEKDEDKRECDKINEINL 737
EKE V E ++E K EE +++ ++ + + +E+ E+K+E ++ E
Sbjct: 64 EKEEVVTEQAQAPAEVEEKKEEEKKEEVIVEEVVEEKKPEVIVEEIEEKKEEEEKKEEEK 123
Query: 738 ERKT-----KEIFAEMQKEKQERIESINDERK 818
+K+ KEI + +KEK+++ + ERK
Sbjct: 124 PKKSVEELIKEILEKKEKEKEKK--KVEKERK 153
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 43.5 bits (101), Expect = 7e-04
Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 2/95 (2%)
Frame = +2
Query: 95 CPGKTEDCK--DELISNNQVDHRRNMKISKVVMKCPEEMCSHECAIINMEEHVRVCEKKS 268
CP +C L+ ++ +H + K + C + C C+ +++E H VC K
Sbjct: 129 CPFLLTECPACKGLVRLSEKEHHTEQECPKRSLSC--QHCRAPCSHVDLEVHYEVCPKFP 186
Query: 269 VKCPLANVGCDGKKIAREMLNDHCQSANFNHCKIL 373
+ C GC KKI RE DH ++ + C++L
Sbjct: 187 LTCD----GCGKKKIpreTFQDHVRAC--SKCRVL 215
Score = 37.0 bits (84), Expect = 0.067
Identities = 23/95 (24%), Positives = 42/95 (44%)
Frame = +2
Query: 236 EEHVRVCEKKSVKCPLANVGCDGKKIAREMLNDHCQSANFNHCKILIEMIDNMRNEIDIL 415
++HVR C K V C VGC + + E L DH H +L+ + L
Sbjct: 203 QDHVRACSKCRVLCRFHTVGC-SEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTL 261
Query: 416 KANDEKNQLKIENLEKNLKSKDEIIDKINQEIELI 520
+ + + LE+ + + + I+ +N+E+E +
Sbjct: 262 NQVGPELLQRCQILEQKIATFENIVCVLNREVERV 296
>sp|Q12315|GLE1_YEAST Nucleoporin GLE1 (Nuclear pore protein GLE1) (RNA export factor
GLE1)
Length = 538
Score = 42.7 bits (99), Expect = 0.001
Identities = 26/74 (35%), Positives = 43/74 (58%), Gaps = 4/74 (5%)
Frame = +3
Query: 615 KEDLERKIEEIDDKMKRENERMKIEKDEDKRECDKINEINLERKTKEIFAEMQKEKQE-- 788
KE+ ERK +E ++K KRE E ++ +KDE+ ERK KE A++ ++KQE
Sbjct: 163 KEEEERKRKEAEEKAKREQELLRQKKDEE------------ERKRKEAEAKLAQQKQEEE 210
Query: 789 --RIESINDERKSI 824
+IE N++ + +
Sbjct: 211 RKKIEEQNEKERQL 224
>sp|Q922B6|TRAF7_MOUSE E3 ubiquitin protein ligase TRAF7 (TNF receptor-associated factor
7)
Length = 594
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/117 (23%), Positives = 54/117 (46%), Gaps = 13/117 (11%)
Frame = +2
Query: 185 MKCPEEMCSHECAIINMEEHVRVCEKKSVKCPLANVGCD--GKKIAREMLNDHCQSANFN 358
++CP +N+E H++ CE +KCP + GC G ++ H ++ F
Sbjct: 155 VRCPNNPSCPPLLKMNLEAHLKECE--HIKCPHSKYGCTFIGN---QDTYETHLETCRFE 209
Query: 359 HCKILIEMIDNMRNEIDILKANDE-----------KNQLKIENLEKNLKSKDEIIDK 496
K ++ D+ +E+ + A + K KI+ LEK+L+ K +++D+
Sbjct: 210 GLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDE 266
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,217,137
Number of Sequences: 369166
Number of extensions: 1348076
Number of successful extensions: 10864
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 8297
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 10450
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8100769320
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)