Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_K24
(821 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y2G4|ANKR6_HUMAN Ankyrin repeat domain protein 6 127 3e-29
sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyr... 96 9e-20
sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G) 96 1e-19
sp|Q92625|ANKS1_HUMAN Ankyrin repeat and SAM domain-contain... 96 2e-19
sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin) 95 2e-19
sp|Q9WV06|ANR2_MOUSE Ankyrin repeat domain protein 2 (Skele... 95 3e-19
sp|Q59H18|TNI3K_HUMAN Serine/threonine-protein kinase TNNI3... 93 1e-18
sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4... 92 2e-18
sp|Q5RF15|TNI3K_PONPY Serine/threonine-protein kinase TNNI3... 91 3e-18
sp|Q80YE7|DAPK1_MOUSE Death-associated protein kinase 1 (DA... 90 7e-18
>sp|Q9Y2G4|ANKR6_HUMAN Ankyrin repeat domain protein 6
Length = 692
Score = 127 bits (320), Expect = 3e-29
Identities = 63/152 (41%), Positives = 96/152 (63%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
GNT LHEA+W G+SQ+ + L + G N + T LHLA Q H+Q+TR L+ G+
Sbjct: 108 GNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRA 167
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
+ +N GDT LH RY H + R+L++ ++++NQ GDT+LH+AAAL +K+ K+L+
Sbjct: 168 DLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILL 227
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
E+GA+ I N +TPL+ A N+ E+ +L
Sbjct: 228 EAGADTTIVNNAGQTPLETARYHNNPEVALLL 259
Score = 90.9 bits (224), Expect = 4e-18
Identities = 51/163 (31%), Positives = 92/163 (56%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
HG TPLH AA KG+ V+ L + G ++ + T LH A G+ + LI G
Sbjct: 41 HGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCA 100
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
++ Q++ G+T LH +G + +++L+ +++ +N+ G+T+LH+A + T++L
Sbjct: 101 LDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVL 160
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQK 504
+ +G+ D++N +T L VA + NH II +L + CS ++K
Sbjct: 161 LLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEK 203
Score = 51.2 bits (121), Expect = 3e-06
Identities = 34/115 (29%), Positives = 51/115 (44%)
Frame = +1
Query: 130 LHLAVQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQN 309
L +A G + LI GA + A + G TPLH GH V +IL+ D++ Q+
Sbjct: 14 LLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQD 72
Query: 310 QNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
T+LH A + +I L+ G LD ++ T L A S+ +L
Sbjct: 73 DGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLL 127
Score = 34.3 bits (77), Expect = 0.42
Identities = 18/65 (27%), Positives = 39/65 (60%)
Frame = +1
Query: 310 QNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSIC 489
++G T LH+AA + ++L+++G +LD+++ ++T L A ++EII L C
Sbjct: 40 KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGC 99
Query: 490 SSNQK 504
+ +++
Sbjct: 100 ALDRQ 104
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
Length = 1881
Score = 96.3 bits (238), Expect = 9e-20
Identities = 55/177 (31%), Positives = 91/177 (51%), Gaps = 1/177 (0%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G TPLH A K + + +E L + G + V S TPLH+A GH +NL++ GA
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
N N +TPLH R GH V++ L+ + +N + ++ T LH AA + + KLL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSE-IIDILKMSICSSNQKTVSFLPENIRENF 543
+E+ AN ++ TPL +A ++ H E ++ +L+ + F P ++ +
Sbjct: 490 LENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKY 546
Score = 95.9 bits (237), Expect = 1e-19
Identities = 63/187 (33%), Positives = 96/187 (51%), Gaps = 6/187 (3%)
Frame = +1
Query: 7 DSTHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKC 186
+S G TPLH AA +G+++ V L NL N S TPLHL Q GH LIK
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 187 GADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKIT 366
G ++A R G TPLH YG+ + + L+ +D+N + + G + LH AA I
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 750
Query: 367 KLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKM------SICSSNQKTVSFLPEN 528
LL+++GA+ + + TPL +A + + + D+LK+ + S++ +SF PE
Sbjct: 751 TLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSF-PET 809
Query: 529 IRENFSV 549
+ E V
Sbjct: 810 VDEILDV 816
Score = 90.9 bits (224), Expect = 4e-18
Identities = 51/152 (33%), Positives = 80/152 (52%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G TPLH A++ G+ V+ L Q G PN+ N + TPLH+A + GH + + L++ A +
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
NA+ + TPLH R GH + ++L+ +++ N G T LHIAA + L+
Sbjct: 464 NAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALL 523
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
E A+ + TPL VA K + ++L
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 87.8 bits (216), Expect = 3e-17
Identities = 49/163 (30%), Positives = 84/163 (51%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G +P+H AA + V L Q + + TPLH+A GH++ + L+ GA
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
N++ G TPLH + H V +L+ + I+ ++G T LH+A+ + I K L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQK 504
++ GA+ ++ N++ ETPL +A + H+E+ L + N K
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Score = 87.0 bits (214), Expect = 6e-17
Identities = 50/163 (30%), Positives = 83/163 (50%)
Frame = +1
Query: 25 TPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINA 204
TPLH AA G+ + + L G PN + FTPLH+A + H + L+K GA I+A
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 205 QNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVES 384
G TPLH GH + + L+ + N N +T LH+AA ++ K L+++
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 385 GANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVS 513
A ++ + ++TPL A + H+ ++ +L + + N T +
Sbjct: 460 KAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 502
Score = 86.3 bits (212), Expect = 9e-17
Identities = 52/168 (30%), Positives = 85/168 (50%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G TPLH A+ +G V L G TPLH A + GH + + L+ GA
Sbjct: 238 NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
I A+ + G +P+H + H R+L+ ++I+ + T LH+AA ++ K+L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVSFL 519
++ GA + R + TPL +A KKNH ++++L + S + T S L
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
Score = 85.9 bits (211), Expect = 1e-16
Identities = 54/162 (33%), Positives = 80/162 (49%)
Frame = +1
Query: 25 TPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINA 204
TPLH AA G++ V+ L + PNL + TPLH+A + GH +T L++ A
Sbjct: 472 TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
Query: 205 QNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVES 384
+ G TPLH +YG V+ +L+ + N +NG T LH+A I KLL+
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 591
Query: 385 GANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTV 510
G + TPL +A K+N E+ L S+N ++V
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV 633
Score = 85.9 bits (211), Expect = 1e-16
Identities = 49/163 (30%), Positives = 87/163 (53%)
Frame = +1
Query: 10 STHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCG 189
+T G+TPLH AA +G+ +TV L + + FTPLH+A + G + L++
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 190 ADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITK 369
A NA + G TPLH V + + + ++L+ + NG T LHIAA + ++ +
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 370 LLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSN 498
L++ G + + ++Q TPL +A ++ H+E++ +L + N
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Score = 84.7 bits (208), Expect = 3e-16
Identities = 51/162 (31%), Positives = 83/162 (51%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G TPLH AA + + L Q G N + TPLHLA Q GH + L+ A+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
N N+ G TPLH + GH V+ +LI ++ + G T LH+A+ K+ K L
Sbjct: 661 GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFL 720
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQ 501
++ A+++ + +PL A ++ H++I+ +L + S N+
Sbjct: 721 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Score = 82.0 bits (201), Expect = 2e-15
Identities = 56/203 (27%), Positives = 98/203 (48%), Gaps = 7/203 (3%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G TPLH A V+ L G P+ ++ +TPLH+A + + R+L++ G
Sbjct: 568 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGS 627
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
NA++ G TPLH + GHA + +L+S ++ N N++G T LH+ A + +L
Sbjct: 628 ANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKT-VSFLP------ENIR 534
++ G +D TPL VA + +++ L N KT + + P +
Sbjct: 688 IKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
Query: 535 ENFSVQSRHVSIPNEMCSVVNTP 603
+ ++ ++ + PNE+ S TP
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTP 770
Score = 78.6 bits (192), Expect = 2e-14
Identities = 54/184 (29%), Positives = 85/184 (46%), Gaps = 29/184 (15%)
Frame = +1
Query: 10 STHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCG 189
S G TPL+ AA + + + V++L + G N+ FTPL +A+Q GH +LI G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 190 A---------DINAQN--------------------RFGDTPLHTGVRYGHAGVSRILIS 282
I A+N + G TPLH Y + V+++L++
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 283 VSSDINQQNQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEI 462
+ +N QNG T LHIA+ + +LL++ GA ++ + TPL A + H I
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 463 IDIL 474
+IL
Sbjct: 288 SEIL 291
Score = 74.3 bits (181), Expect = 4e-13
Identities = 46/152 (30%), Positives = 71/152 (46%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G TPLH AA G + E L + PN + TPLH+AV + + L+ G
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
++ G TPLH + V+R L+ N ++ G T LH+AA ++ LL+
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
AN ++ N TPL + ++ H + D+L
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVL 687
Score = 70.5 bits (171), Expect = 5e-12
Identities = 52/184 (28%), Positives = 89/184 (48%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
GNT LH AA G + V L G N + FTPL++A Q H + + L++ GA+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
N G TPL ++ GH V LI+ + + + +LHIAA + +L+
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLL 193
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVSFLPENIRENFSVQSR 558
++ N D+ + TPL +A H E +++ ++ + + +V+F P+N + SR
Sbjct: 194 QNDPNPDVLSKTGFTPLHIAA---HYENLNVAQLLL--NRGASVNFTPQNGITPLHIASR 248
Query: 559 HVSI 570
++
Sbjct: 249 RGNV 252
Score = 67.8 bits (164), Expect = 3e-11
Identities = 37/122 (30%), Positives = 63/122 (51%)
Frame = +1
Query: 100 NLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILI 279
N N + LHLA + GH + L+ + + G+T LH G V R L+
Sbjct: 39 NTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 280 SVSSDINQQNQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSE 459
+ +++N Q+Q G T L++AA ++ K L+E+GAN ++ TPL VA+++ H
Sbjct: 99 NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 158
Query: 460 II 465
++
Sbjct: 159 VV 160
Score = 67.8 bits (164), Expect = 3e-11
Identities = 41/148 (27%), Positives = 78/148 (52%)
Frame = +1
Query: 31 LHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINAQN 210
LH AA ++T L Q P++++ + FTPLH+A + + L+ GA +N
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 211 RFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVESGA 390
+ G TPLH R G+ + R+L+ + I + ++ T LH AA +I+++L++ GA
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Query: 391 NLDIRNIQNETPLDVAIKKNHSEIIDIL 474
+ + +P+ +A + +H + + +L
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 59.7 bits (143), Expect = 9e-09
Identities = 35/123 (28%), Positives = 64/123 (52%)
Frame = +1
Query: 139 AVQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNG 318
A + G+ + ++ G DIN N+ G LH + GH + L+ + + G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 319 DTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSN 498
+T+LHIAA + ++ + LV GAN++ ++ + TPL +A ++NH E++ L + + N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 499 QKT 507
T
Sbjct: 139 VAT 141
>sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G)
Length = 4377
Score = 95.9 bits (237), Expect = 1e-19
Identities = 53/150 (35%), Positives = 79/150 (52%)
Frame = +1
Query: 25 TPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINA 204
TPLH +A G + V+ L Q G PN S +TPLHL+ + GH L+ GA ++
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
Query: 205 QNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVES 384
+ G TPLH +YG V+ +L+ S+ + ++G T LH+AA +K+ LL++
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 385 GANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
GA+ TPL +A KKN +I L
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTL 650
Score = 88.6 bits (218), Expect = 2e-17
Identities = 50/152 (32%), Positives = 76/152 (50%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G TP+H AA+ G+ V L G PN N T LH+A + G + R L++ GA +
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
A+ + TPLH R G A + + L+ + N +G T LH++A + L+
Sbjct: 493 EAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL 552
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
+ GA+L I + TPL VA K E+ ++L
Sbjct: 553 DHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 87.8 bits (216), Expect = 3e-17
Identities = 57/192 (29%), Positives = 89/192 (46%), Gaps = 6/192 (3%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G +H AA +G+ V L NL N S TPLHLA Q L+ GA +
Sbjct: 664 GIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHV 723
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
+AQ + G TPLH G YG+ + L+ S+ +N + +NG T LH AA I +L+
Sbjct: 724 DAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDILK------MSICSSNQKTVSFLPENIREN 540
++ A+ + + T L +A + + ++D LK M+ + +K +PE + E
Sbjct: 784 QNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEV 843
Query: 541 FSVQSRHVSIPN 576
+ V N
Sbjct: 844 LDMSDDEVRKAN 855
Score = 87.4 bits (215), Expect = 4e-17
Identities = 50/166 (30%), Positives = 80/166 (48%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G TPLH AA K L + G N V +HLA Q GH L+ A+
Sbjct: 630 NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
+N N+ G TPLH + V+ +L++ + ++ Q + G T LH+ KI L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVS 513
++ A ++ + TPL A ++ H+ II++L + S N+ TV+
Sbjct: 750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVN 795
Score = 86.7 bits (213), Expect = 7e-17
Identities = 50/163 (30%), Positives = 80/163 (49%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G TPLH AA + L G P+ + +TPLH+A + L++ GAD
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA 657
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
NA R G +H + GH + +L+ ++++N N++G T LH+AA R + ++LV
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKT 507
GA++D + TPL V + +I++ L N KT
Sbjct: 718 NQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT 760
Score = 83.6 bits (205), Expect = 6e-16
Identities = 49/163 (30%), Positives = 80/163 (49%)
Frame = +1
Query: 25 TPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINA 204
T LH AA G+ + + L PN + FTPLH+A + + L+K GA I A
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 205 QNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVES 384
G TP+H GH + L+ + N N G+T+LH+AA + ++ + LV+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
Query: 385 GANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVS 513
GA ++ + ++TPL ++ + ++I+ L S N T S
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS 531
Score = 80.9 bits (198), Expect = 4e-15
Identities = 39/125 (31%), Positives = 74/125 (59%)
Frame = +1
Query: 100 NLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILI 279
N+ N + LHLA + GH + L++ A+++A + G+T LH G A V ++L+
Sbjct: 68 NICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLV 127
Query: 280 SVSSDINQQNQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSE 459
+ +++N Q+QNG T L++AA ++ K L+++GA+ + TPL VA+++ H +
Sbjct: 128 TNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQ 187
Query: 460 IIDIL 474
++ +L
Sbjct: 188 VVSLL 192
Score = 80.9 bits (198), Expect = 4e-15
Identities = 48/153 (31%), Positives = 75/153 (49%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G TPLH A K + +E L + G V S TP+H+A GH L+ GA
Sbjct: 399 NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
N N G+T LH R G A V R L+ + + + ++ T LHI+A L + I + L
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
++ GA+ + TPL ++ ++ H ++ L
Sbjct: 519 LQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Score = 78.2 bits (191), Expect = 3e-14
Identities = 43/150 (28%), Positives = 77/150 (51%)
Frame = +1
Query: 25 TPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINA 204
TPLH A+ +G + V+ L G + TPLH + GH Q L+ A I +
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 205 QNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVES 384
+ + G +PLH + H ++L+ + ++ + T+LH+AA K+ K+L++
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 385 GANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
AN + + + TPL +A KKN +++++L
Sbjct: 390 KANPNAKALNGFTPLHIACKKNRIKVMELL 419
Score = 77.8 bits (190), Expect = 3e-14
Identities = 51/184 (27%), Positives = 89/184 (48%), Gaps = 29/184 (15%)
Frame = +1
Query: 10 STHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLI--- 180
S +G TPL+ AA + + + V++L G +L FTPL +A+Q GH+Q L+
Sbjct: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEND 196
Query: 181 -------------------KCGA-----DINA--QNRFGDTPLHTGVRYGHAGVSRILIS 282
K A D NA +++ G TPLH YG+ V+ +L++
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256
Query: 283 VSSDINQQNQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEI 462
++ ++ +N T LH+A+ + KLL++ GA +D + TPL + H ++
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQV 316
Query: 463 IDIL 474
+++L
Sbjct: 317 VEML 320
Score = 77.8 bits (190), Expect = 3e-14
Identities = 45/155 (29%), Positives = 78/155 (50%)
Frame = +1
Query: 10 STHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCG 189
+T G TPLH +A +G+ +L G ++ FTPLH+A + G + L++
Sbjct: 529 TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588
Query: 190 ADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITK 369
A +A + G TPLH Y + V+ +L+ + + +NG T LHIAA + I
Sbjct: 589 ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIAT 648
Query: 370 LLVESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
L+E GA+ + Q + +A ++ H +++ +L
Sbjct: 649 TLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Score = 74.3 bits (181), Expect = 4e-13
Identities = 50/164 (30%), Positives = 74/164 (45%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G TPLH A G+ Q VE L + +PLH+A QG H + L++ +
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV 360
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
+ T LH GH V+++L+ ++ N + NG T LHIA R K+ +LL+
Sbjct: 361 DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL 420
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTV 510
+ GA++ TP+ VA H I+ L S N V
Sbjct: 421 KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNV 464
Score = 72.8 bits (177), Expect = 1e-12
Identities = 37/112 (33%), Positives = 65/112 (58%)
Frame = +1
Query: 139 AVQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNG 318
A + GH + + IK G DIN N+ G LH + GH V L+ ++++ + G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 319 DTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
+T+LHIA+ + ++ K+LV +GAN++ ++ TPL +A ++NH E++ L
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159
Score = 69.3 bits (168), Expect = 1e-11
Identities = 43/158 (27%), Positives = 75/158 (47%)
Frame = +1
Query: 1 IQDSTHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLI 180
+ + +G +PLH A + V+ L Q + V T LH+A GH + + L+
Sbjct: 328 LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387
Query: 181 KCGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRK 360
A+ NA+ G TPLH + V +L+ + I ++G T +H+AA +
Sbjct: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
Query: 361 ITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
I L+ GA+ + N++ ET L +A + +E++ L
Sbjct: 448 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Score = 65.5 bits (158), Expect = 2e-10
Identities = 44/152 (28%), Positives = 74/152 (48%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
GNT LH A+ G ++ V+ L G N + + FTPL++A Q H + + L+ GA
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
+ G TPL ++ GH V +L+ + + + + +LHIAA K LL+
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLL----ENDTKGKVRLPALHIAARKDDTKAAALLL 222
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
++ N D+ + TPL +A + + +L
Sbjct: 223 QNDNNADVESKSGFTPLHIAAHYGNINVATLL 254
Score = 30.8 bits (68), Expect = 4.7
Identities = 16/47 (34%), Positives = 27/47 (57%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGH 156
+G TPLH+AA +G++ + L Q PN + + T L +A + G+
Sbjct: 762 NGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGY 808
>sp|Q92625|ANKS1_HUMAN Ankyrin repeat and SAM domain-containing protein 1 (Odin)
Length = 1134
Score = 95.5 bits (236), Expect = 2e-19
Identities = 59/170 (34%), Positives = 86/170 (50%), Gaps = 3/170 (1%)
Frame = +1
Query: 7 DSTHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKC 186
DST G TPLH AA G+ VE L + L N+ + PLHLA G Q R LI
Sbjct: 77 DST-GYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVRLLIHQ 135
Query: 187 GAD---INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRR 357
G +N QN +T LH +YGH V ++L+ +D +N +T L +AA R
Sbjct: 136 GPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRL 195
Query: 358 KITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKT 507
++ K+L+ + NL N + TPL +A + H ++ +L + SN +T
Sbjct: 196 EVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQT 245
Score = 70.9 bits (172), Expect = 4e-12
Identities = 46/144 (31%), Positives = 73/144 (50%), Gaps = 5/144 (3%)
Frame = +1
Query: 58 SQTVEYLCQIGRLPNL--VNYSLFTPLHLAVQGGHNQTTRNLIKCGADINAQNRFGDTPL 231
S + L + R PN+ V+ + +TPLH A GH L++ A N + G PL
Sbjct: 58 SHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPL 117
Query: 232 HTGVRYGHAGVSRILISVSSD---INQQNQNGDTSLHIAAALKRRKITKLLVESGANLDI 402
H G A + R+LI +N+QN + +T+LH AA ++ K+L+E + +
Sbjct: 118 HLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTM 177
Query: 403 RNIQNETPLDVAIKKNHSEIIDIL 474
RN + ETPLD+A E++ +L
Sbjct: 178 RNNKFETPLDLAALYGRLEVVKML 201
Score = 68.2 bits (165), Expect = 3e-11
Identities = 41/143 (28%), Positives = 72/143 (50%)
Frame = +1
Query: 4 QDSTHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIK 183
+ + T LH AA G+++ V+ L + P + N TPL LA G + + L+
Sbjct: 144 EQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKFETPLDLAALYGRLEVVKMLLN 203
Query: 184 CGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKI 363
++ + N TPLH R GH V ++L+ D N Q + G ++LH AA + +
Sbjct: 204 AHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDV 262
Query: 364 TKLLVESGANLDIRNIQNETPLD 432
++L+ +G +++I++ T LD
Sbjct: 263 VQILLAAGTDVNIKDNHGLTALD 285
Score = 51.6 bits (122), Expect = 3e-06
Identities = 31/113 (27%), Positives = 53/113 (46%), Gaps = 3/113 (2%)
Frame = +1
Query: 187 GADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKIT 366
G ++N + G TPLH GH V +L+ + N + G LH+AA +I
Sbjct: 70 GPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIV 129
Query: 367 KLLVESGAN---LDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVSF 516
+LL+ G + ++ +N NET L A + H+E++ +L + + F
Sbjct: 130 RLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNKF 182
>sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin)
Length = 1862
Score = 95.1 bits (235), Expect = 2e-19
Identities = 62/186 (33%), Positives = 93/186 (50%), Gaps = 5/186 (2%)
Frame = +1
Query: 7 DSTHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKC 186
+S G TPLH AA +G+++ V L NL N S TPLHL Q GH LIK
Sbjct: 627 ESVQGVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVLVADVLIKH 686
Query: 187 GADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKIT 366
G ++A R G TPLH YG+ + + L+ +D+N + + G + LH AA I
Sbjct: 687 GVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIV 746
Query: 367 KLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKM-----SICSSNQKTVSFLPENI 531
LL+++GA+ + + TPL +A + + + D+LK+ S+ + K PE +
Sbjct: 747 TLLLKNGASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVSDKHRMSYPETV 806
Query: 532 RENFSV 549
E V
Sbjct: 807 DEILDV 812
Score = 90.9 bits (224), Expect = 4e-18
Identities = 51/146 (34%), Positives = 78/146 (53%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G TPLH A K + + +E L + G + V S TPLH+A GH +NL++ GA
Sbjct: 366 NGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 425
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
N N +TPLH R GH V++ L+ + N + ++ T LH AA + + KLL
Sbjct: 426 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLL 485
Query: 376 VESGANLDIRNIQNETPLDVAIKKNH 453
+E+GA+ ++ TPL A ++ H
Sbjct: 486 LENGASPNLATTAGHTPLHTAAREGH 511
Score = 89.0 bits (219), Expect = 1e-17
Identities = 49/163 (30%), Positives = 85/163 (52%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G +P+H AA + V L Q + + TPLH+A GH++ + L+ GA
Sbjct: 300 NGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 359
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
N++ G TPLH + H V +L+ + I+ ++G T LH+A+ + I K L
Sbjct: 360 PNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 419
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQK 504
++ GA+ ++ N++ ETPL +A + H+E+ L + +N K
Sbjct: 420 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAK 462
Score = 87.8 bits (216), Expect = 3e-17
Identities = 51/152 (33%), Positives = 76/152 (50%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G TPLH A++ G+ V+ L Q G PN+ N + TPLH+A + GH + + L++ A
Sbjct: 400 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKA 459
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
NA+ + TPLH R GH G+ ++L+ + N G T LH AA L+
Sbjct: 460 NAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALL 519
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
E A+ + TPL VA K + ++L
Sbjct: 520 EKEASQACMTKKGFTPLHVAAKYGKVRLAELL 551
Score = 86.3 bits (212), Expect = 9e-17
Identities = 52/168 (30%), Positives = 86/168 (51%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G TPLH A+ +G V L G TPLH A + GH + + L+ GA
Sbjct: 234 NGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAP 293
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
I A+ + G +P+H + H R+L+ +++I+ + T LH+AA ++ K+L
Sbjct: 294 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVL 353
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVSFL 519
++ GA + R + TPL +A KKNH ++++L + S + T S L
Sbjct: 354 LDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGL 401
Score = 86.3 bits (212), Expect = 9e-17
Identities = 51/163 (31%), Positives = 82/163 (50%)
Frame = +1
Query: 25 TPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINA 204
TPLH AA G+ + + L G PN + FTPLH+A + H + L+K GA I+A
Sbjct: 336 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASIDA 395
Query: 205 QNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVES 384
G TPLH GH + + L+ + N N +T LH+AA ++ K L+++
Sbjct: 396 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQN 455
Query: 385 GANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVS 513
A + + ++TPL A + H+ ++ +L + S N T +
Sbjct: 456 KAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTA 498
Score = 84.7 bits (208), Expect = 3e-16
Identities = 54/162 (33%), Positives = 79/162 (48%)
Frame = +1
Query: 25 TPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINA 204
TPLH AA G++ V+ L + G PNL + TPLH A + GH T L++ A
Sbjct: 468 TPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALLEKEASQAC 527
Query: 205 QNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVES 384
+ G TPLH +YG ++ +L+ + N +NG T LH+A I KLL+
Sbjct: 528 MTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 587
Query: 385 GANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTV 510
G + TPL +A K+N E+ L S+N ++V
Sbjct: 588 GGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESV 629
Score = 84.7 bits (208), Expect = 3e-16
Identities = 51/162 (31%), Positives = 83/162 (51%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G TPLH AA + + L Q G N + TPLHLA Q GH + L+ A+
Sbjct: 597 NGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQAN 656
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
N N+ G TPLH + GH V+ +LI ++ + G T LH+A+ K+ K L
Sbjct: 657 GNLGNKSGLTPLHLVSQEGHVLVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFL 716
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQ 501
++ A+++ + +PL A ++ H++I+ +L + S N+
Sbjct: 717 LQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 758
Score = 84.0 bits (206), Expect = 5e-16
Identities = 48/163 (29%), Positives = 85/163 (52%)
Frame = +1
Query: 10 STHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCG 189
+T G+TPLH AA +G+ T L + + FTPLH+A + G + L++
Sbjct: 496 TTAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHD 555
Query: 190 ADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITK 369
A NA + G TPLH V + + + ++L+ + NG T LHIAA + ++ +
Sbjct: 556 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVAR 615
Query: 370 LLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSN 498
L++ G + + ++Q TPL +A ++ H+E++ +L + N
Sbjct: 616 SLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQANGN 658
Score = 79.7 bits (195), Expect = 9e-15
Identities = 55/184 (29%), Positives = 85/184 (46%), Gaps = 29/184 (15%)
Frame = +1
Query: 10 STHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCG 189
S G TPL+ AA + + + V++L + G N+ FTPL +A+Q GH +LI G
Sbjct: 104 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 163
Query: 190 A---------DINAQN--------------------RFGDTPLHTGVRYGHAGVSRILIS 282
I A+N + G TPLH Y + V+++L++
Sbjct: 164 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 223
Query: 283 VSSDINQQNQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEI 462
+ +N QNG T LHIA+ + +LL++ GA ++ R TPL A + H I
Sbjct: 224 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRI 283
Query: 463 IDIL 474
+IL
Sbjct: 284 SEIL 287
Score = 79.7 bits (195), Expect = 9e-15
Identities = 54/203 (26%), Positives = 97/203 (47%), Gaps = 7/203 (3%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G TPLH A V+ L G P+ ++ +TPLH+A + + R+L++ G
Sbjct: 564 NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGS 623
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
NA++ G TPLH + GH + +L+S ++ N N++G T LH+ + + +L
Sbjct: 624 ANAESVQGVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVLVADVL 683
Query: 376 VESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKT-VSFLP------ENIR 534
++ G +D TPL VA + +++ L N KT + + P +
Sbjct: 684 IKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 743
Query: 535 ENFSVQSRHVSIPNEMCSVVNTP 603
+ ++ ++ + PNE+ S TP
Sbjct: 744 DIVTLLLKNGASPNEVSSNGTTP 766
Score = 72.4 bits (176), Expect = 1e-12
Identities = 46/152 (30%), Positives = 71/152 (46%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G TPLH AA G + E L + PN + TPLH+AV + + L+ G
Sbjct: 532 GFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 591
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
++ G TPLH + V+R L+ N ++ G T LH+AA ++ LL+
Sbjct: 592 HSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLL 651
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
AN ++ N TPL + ++ H + D+L
Sbjct: 652 SKQANGNLGNKSGLTPLHLVSQEGHVLVADVL 683
Score = 70.5 bits (171), Expect = 5e-12
Identities = 52/184 (28%), Positives = 89/184 (48%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
GNT LH AA G + V L G N + FTPL++A Q H + + L++ GA+
Sbjct: 74 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 133
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
N G TPL ++ GH V LI+ + + + +LHIAA + +L+
Sbjct: 134 NVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIAARNDDTRTAAVLL 189
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVSFLPENIRENFSVQSR 558
++ N D+ + TPL +A H E +++ ++ + + +V+F P+N + SR
Sbjct: 190 QNDPNPDVLSKTGFTPLHIAA---HYENLNVAQLLL--NRGASVNFTPQNGITPLHIASR 244
Query: 559 HVSI 570
++
Sbjct: 245 RGNV 248
Score = 67.8 bits (164), Expect = 3e-11
Identities = 37/122 (30%), Positives = 63/122 (51%)
Frame = +1
Query: 100 NLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILI 279
N N + LHLA + GH + L+ + + G+T LH G V R L+
Sbjct: 35 NTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 94
Query: 280 SVSSDINQQNQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSE 459
+ +++N Q+Q G T L++AA ++ K L+E+GAN ++ TPL VA+++ H
Sbjct: 95 NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 154
Query: 460 II 465
++
Sbjct: 155 VV 156
Score = 67.8 bits (164), Expect = 3e-11
Identities = 41/148 (27%), Positives = 78/148 (52%)
Frame = +1
Query: 31 LHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINAQN 210
LH AA ++T L Q P++++ + FTPLH+A + + L+ GA +N
Sbjct: 173 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 232
Query: 211 RFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVESGA 390
+ G TPLH R G+ + R+L+ + I + ++ T LH AA +I+++L++ GA
Sbjct: 233 QNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGA 292
Query: 391 NLDIRNIQNETPLDVAIKKNHSEIIDIL 474
+ + +P+ +A + +H + + +L
Sbjct: 293 PIQAKTKNGLSPIHMAAQGDHLDCVRLL 320
Score = 59.7 bits (143), Expect = 9e-09
Identities = 35/123 (28%), Positives = 64/123 (52%)
Frame = +1
Query: 139 AVQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNG 318
A + G+ + ++ G DIN N+ G LH + GH + L+ + + G
Sbjct: 15 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 74
Query: 319 DTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSN 498
+T+LHIAA + ++ + LV GAN++ ++ + TPL +A ++NH E++ L + + N
Sbjct: 75 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 134
Query: 499 QKT 507
T
Sbjct: 135 VAT 137
>sp|Q9WV06|ANR2_MOUSE Ankyrin repeat domain protein 2 (Skeletal muscle ankyrin repeat
protein) (mArpp)
Length = 328
Score = 94.7 bits (234), Expect = 3e-19
Identities = 50/137 (36%), Positives = 79/137 (57%)
Frame = +1
Query: 25 TPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINA 204
T LH A+ +G+ + +E L + G + + T +H A +GGH + R L GAD N
Sbjct: 152 TALHRASLEGHMEILEKLLENGATVDFQDRLDCTAMHWACRGGHLEVVRLLQSRGADTNV 211
Query: 205 QNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVES 384
+++ TPLH VR GH + +S+ DIN +++ GD++LH A L R KI KLL+
Sbjct: 212 RDKLLSTPLHVAVRTGHVEIVEHFLSLGLDINAKDREGDSALHDAVRLNRYKIIKLLLLH 271
Query: 385 GANLDIRNIQNETPLDV 435
GA++ +N+ +TP D+
Sbjct: 272 GADMMAKNLAGKTPTDL 288
Score = 47.0 bits (110), Expect = 6e-05
Identities = 37/142 (26%), Positives = 68/142 (47%), Gaps = 3/142 (2%)
Frame = +1
Query: 124 TPLHLAVQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQ 303
T L AV+G + L G + + F T LH GH + L+ + ++
Sbjct: 120 TFLKAAVEGKMKVIDKYLAD-GGSADTCDEFRRTALHRASLEGHMEILEKLLENGATVDF 178
Query: 304 QNQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIID---IL 474
Q++ T++H A ++ +LL GA+ ++R+ TPL VA++ H EI++ L
Sbjct: 179 QDRLDCTAMHWACRGGHLEVVRLLQSRGADTNVRDKLLSTPLHVAVRTGHVEIVEHFLSL 238
Query: 475 KMSICSSNQKTVSFLPENIREN 540
+ I + +++ S L + +R N
Sbjct: 239 GLDINAKDREGDSALHDAVRLN 260
>sp|Q59H18|TNI3K_HUMAN Serine/threonine-protein kinase TNNI3K (TNNI3-interacting kinase)
(Cardiac ankyrin repeat kinase)
Length = 936
Score = 92.8 bits (229), Expect = 1e-18
Identities = 54/158 (34%), Positives = 80/158 (50%), Gaps = 2/158 (1%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G T LH A +K ++ + L G V Y T LH+A GH + L++ GA+
Sbjct: 201 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 260
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
+N Q+ TPLH YGH V+R+L+ +D+N + GD LH+A+A I KLL
Sbjct: 261 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL 320
Query: 376 VESGANLDIRNIQNE--TPLDVAIKKNHSEIIDILKMS 483
+E G+ D+ NE PL + H +I+ L S
Sbjct: 321 MEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQS 358
Score = 69.7 bits (169), Expect = 9e-12
Identities = 58/194 (29%), Positives = 84/194 (43%), Gaps = 41/194 (21%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G T LH A G+ + + L Q G N+ + FTPLH+A GH Q TR L+K GAD+
Sbjct: 235 GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADV 294
Query: 199 NAQNRFGDTPLHTG-----------------------------------VRYGHAGVSRI 273
N GD PLH R+GH + +
Sbjct: 295 NVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKY 354
Query: 274 LISVSSDINQQ----NQNGDTSLHIAAALKRRKITKLLVE-SGA-NLDIRNIQNETPLDV 435
L+ SD+ Q N GDT LH+A + ++ K +++ SG +L NI +ET
Sbjct: 355 LL--QSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHS 412
Query: 436 AIKKNHSEIIDILK 477
A + + ID++K
Sbjct: 413 AC--TYGKSIDLVK 424
Score = 52.8 bits (125), Expect = 1e-06
Identities = 36/116 (31%), Positives = 56/116 (48%), Gaps = 1/116 (0%)
Frame = +1
Query: 130 LHLA-VQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQ 306
LHL + GG R L+ G + R G T LH V +A + L+ +DI Q
Sbjct: 172 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQV 231
Query: 307 NQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
G T+LHIA + +L++ GAN++I++ TPL +A H ++ +L
Sbjct: 232 GYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 287
Score = 43.9 bits (102), Expect = 5e-04
Identities = 48/206 (23%), Positives = 82/206 (39%), Gaps = 7/206 (3%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLF--TPLHLAVQGGHNQTTRNLIKCG 189
+G+TPLH A + G + + + QI +L ++F T H A G + +L+K
Sbjct: 370 YGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI---DLVKFL 426
Query: 190 AD-----INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKR 354
D IN Q R G T LH+ +GH + + L+ +D+N
Sbjct: 427 LDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN------------------ 468
Query: 355 RKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVSFLPENIR 534
LV + +T L A +K H I+ +LK ++ LP N
Sbjct: 469 ------LVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLK-----HYKRPQDELPCNEY 517
Query: 535 ENFSVQSRHVSIPNEMCSVVNTPEQK 612
+VS+P+ + + + ++K
Sbjct: 518 SQPGGDGSYVSVPSPLGKIKSMTKEK 543
>sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4 (Receptor-interacting
serine/threonine-protein kinase 4) (Ankyrin repeat domain
protein 3) (PKC-delta-interacting protein kinase)
Length = 832
Score = 91.7 bits (226), Expect = 2e-18
Identities = 55/150 (36%), Positives = 76/150 (50%), Gaps = 1/150 (0%)
Frame = +1
Query: 28 PLHEAAWKGYSQTVEYLC-QIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINA 204
PLH AAW+G+ V+ L Q G N TPLHLA Q GH + R LI +D+N
Sbjct: 621 PLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNV 680
Query: 205 QNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVES 384
+ TPLH GH +R+L+ + +G T+LH+AA KLLVE
Sbjct: 681 CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 740
Query: 385 GANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
A++ R N+T L +A HSE+++ L
Sbjct: 741 KADVLARGPLNQTALHLAAAHGHSEVVEEL 770
Score = 79.7 bits (195), Expect = 9e-15
Identities = 48/166 (28%), Positives = 82/166 (49%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G TPLH AA +G+ + L + N+ + TPLH+A + GH T R L+ GA
Sbjct: 652 GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGK 711
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
A G T LH R GH ++L+ +D+ + T+LH+AAA ++ + LV
Sbjct: 712 EAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV 771
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVSF 516
+ +D+ + Q + L +A + H++ ++ L N +++ F
Sbjct: 772 SADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKF 816
Score = 68.2 bits (165), Expect = 3e-11
Identities = 38/115 (33%), Positives = 62/115 (53%)
Frame = +1
Query: 130 LHLAVQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQN 309
LHLAV+ G + + L+ A+ N NR G TPLH V GV +L++ +N ++
Sbjct: 490 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 549
Query: 310 QNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
++ T+LH AA T+LL+E A+++ + + TP+ VA + I+ IL
Sbjct: 550 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 604
Score = 66.6 bits (161), Expect = 8e-11
Identities = 51/192 (26%), Positives = 82/192 (42%), Gaps = 34/192 (17%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAV------------------ 144
G + LH A G + ++L PNL N TPLH+AV
Sbjct: 486 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 545
Query: 145 ---------------QGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILI 279
Q G +TR L++ A +N + G TP+H ++G + RIL+
Sbjct: 546 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 605
Query: 280 SVSSDINQQNQNGDTSLHIAAALKRRKITKLLV-ESGANLDIRNIQNETPLDVAIKKNHS 456
D++ Q ++ LH AA I KLL + G +++ + + TPL +A ++ H
Sbjct: 606 RRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHY 665
Query: 457 EIIDILKMSICS 492
+ IL + +CS
Sbjct: 666 RVARIL-IDLCS 676
Score = 35.4 bits (80), Expect = 0.19
Identities = 18/71 (25%), Positives = 38/71 (53%)
Frame = +1
Query: 292 DINQQNQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDI 471
D++ +G + LH+A + + K L+ + AN ++ N + TPL +A+++ ++++
Sbjct: 478 DVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVEL 537
Query: 472 LKMSICSSNQK 504
L S N K
Sbjct: 538 LLARKISVNAK 548
>sp|Q5RF15|TNI3K_PONPY Serine/threonine-protein kinase TNNI3K (TNNI3-interacting kinase)
Length = 618
Score = 91.3 bits (225), Expect = 3e-18
Identities = 53/155 (34%), Positives = 79/155 (50%), Gaps = 2/155 (1%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
+G T LH A +K ++ + L G V Y T LH+A GH + L++ GA+
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHGGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGAN 159
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLL 375
+N Q+ TPLH YGH V+R+L+ +D+N + GD LH+A+A I KLL
Sbjct: 160 VNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLL 219
Query: 376 VESGANLDIRNIQNE--TPLDVAIKKNHSEIIDIL 474
+E G+ D+ NE PL + H +I+ L
Sbjct: 220 MEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYL 254
Score = 69.3 bits (168), Expect = 1e-11
Identities = 55/192 (28%), Positives = 82/192 (42%), Gaps = 39/192 (20%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G T LH A G+ + + L Q G N+ + FTPLH+A GH Q TR L+K GAD+
Sbjct: 134 GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADV 193
Query: 199 NAQNRFGDTPLHTG-----------------------------------VRYGHAGVSRI 273
N GD PLH R+GH + +
Sbjct: 194 NVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKY 253
Query: 274 LISVSSDINQQ--NQNGDTSLHIAAALKRRKITKLLVE-SGA-NLDIRNIQNETPLDVAI 441
L+ ++ N GDT LH+A + ++ K +++ SG +L NI +ET A
Sbjct: 254 LLQNDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSAC 313
Query: 442 KKNHSEIIDILK 477
+ + ID++K
Sbjct: 314 --TYGKSIDLVK 323
Score = 53.1 bits (126), Expect = 9e-07
Identities = 36/116 (31%), Positives = 57/116 (49%), Gaps = 1/116 (0%)
Frame = +1
Query: 130 LHLA-VQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQ 306
LHL + GG+ R L+ G + R G T LH V +A + L+ +DI Q
Sbjct: 71 LHLCCICGGNKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHGGADIQQV 130
Query: 307 NQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
G T+LHIA + +L++ GAN++I++ TPL +A H ++ +L
Sbjct: 131 GYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLL 186
Score = 43.9 bits (102), Expect = 5e-04
Identities = 48/206 (23%), Positives = 82/206 (39%), Gaps = 7/206 (3%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLF--TPLHLAVQGGHNQTTRNLIKCG 189
+G+TPLH A + G + + + QI +L ++F T H A G + +L+K
Sbjct: 269 YGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSI---DLVKFL 325
Query: 190 AD-----INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKR 354
D IN Q R G T LH+ +GH + + L+ +D+N
Sbjct: 326 LDQNVININHQGRDGHTGLHSACYHGHIHLVQFLLDNGADMN------------------ 367
Query: 355 RKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICSSNQKTVSFLPENIR 534
LV + +T L A +K H I+ +LK ++ LP N
Sbjct: 368 ------LVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLK-----HYKRPQDELPCNEY 416
Query: 535 ENFSVQSRHVSIPNEMCSVVNTPEQK 612
+VS+P+ + + + ++K
Sbjct: 417 SQPGGDGSYVSVPSPLGKIKSMTKEK 442
>sp|Q80YE7|DAPK1_MOUSE Death-associated protein kinase 1 (DAP kinase 1)
Length = 1442
Score = 90.1 bits (222), Expect = 7e-18
Identities = 49/158 (31%), Positives = 82/158 (51%)
Frame = +1
Query: 19 GNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADI 198
G T LH AA G++ V+ LC G P+ + TPLH A G+ + L + G ++
Sbjct: 445 GETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHCAAWHGYYSVAKALCEVGCNV 504
Query: 199 NAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLV 378
N +NR G+TPL T G+ + L +D+N +++G +LH+A + ++ K L+
Sbjct: 505 NIKNREGETPLLTASARGYHDIVECLAEHGADLNASDKDGHIALHLAVRRCQMEVIKTLL 564
Query: 379 ESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSICS 492
G+ +D ++ TPL VA K + I+ L + C+
Sbjct: 565 GHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCEASCN 602
Score = 88.2 bits (217), Expect = 2e-17
Identities = 52/150 (34%), Positives = 76/150 (50%)
Frame = +1
Query: 25 TPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGADINA 204
TPLH AAW GY + LC++G N+ N TPL A G++ L + GAD+NA
Sbjct: 480 TPLHCAAWHGYYSVAKALCEVGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNA 539
Query: 205 QNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKITKLLVES 384
++ G LH VR V + L+ S ++ Q+++G+T LH+A I L E+
Sbjct: 540 SDKDGHIALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCEA 599
Query: 385 GANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
NLDI N TPL +A +++ L
Sbjct: 600 SCNLDISNKYGRTPLHLAANNGILDVVRYL 629
Score = 81.3 bits (199), Expect = 3e-15
Identities = 49/157 (31%), Positives = 84/157 (53%)
Frame = +1
Query: 4 QDSTHGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIK 183
Q + HG PL AA G Q ++ L + G ++ + ++ A + GH T + L +
Sbjct: 374 QPNKHGTPPLLIAAGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGHVDTLKFLNE 433
Query: 184 CGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQNQNGDTSLHIAAALKRRKI 363
++ +++ G+T LH RYGHA V ++L S S+ + Q++ +T LH AA +
Sbjct: 434 NKCPLDVKDKSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHCAAWHGYYSV 493
Query: 364 TKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDIL 474
K L E G N++I+N + ETPL A + + +I++ L
Sbjct: 494 AKALCEVGCNVNIKNREGETPLLTASARGYHDIVECL 530
Score = 62.0 bits (149), Expect = 2e-09
Identities = 36/126 (28%), Positives = 65/126 (51%)
Frame = +1
Query: 127 PLHLAVQGGHNQTTRNLIKCGADINAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQQ 306
PL +A G+ Q + LIK G+ I+ Q++ G ++ R+GH + L ++ +
Sbjct: 382 PLLIAAGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGHVDTLKFLNENKCPLDVK 441
Query: 307 NQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDVAIKKNHSEIIDILKMSI 486
+++G+T+LH+AA + +LL G+N D ++ + ETPL A + + L
Sbjct: 442 DKSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHCAAWHGYYSVAKALCEVG 501
Query: 487 CSSNQK 504
C+ N K
Sbjct: 502 CNVNIK 507
Score = 46.6 bits (109), Expect = 8e-05
Identities = 31/96 (32%), Positives = 42/96 (43%)
Frame = +1
Query: 16 HGNTPLHEAAWKGYSQTVEYLCQIGRLPNLVNYSLFTPLHLAVQGGHNQTTRNLIKCGAD 195
HGNTPLH A G + V LC+ ++ N TPLHLA G R L GA+
Sbjct: 576 HGNTPLHVACKDGSAPIVVALCEASCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGAN 635
Query: 196 INAQNRFGDTPLHTGVRYGHAGVSRILISVSSDINQ 303
+ A G T H V+ +L + D ++
Sbjct: 636 VEALTSDGKTAEDLAKAEQHEHVAGLLARLRKDTHR 671
Score = 42.0 bits (97), Expect = 0.002
Identities = 31/126 (24%), Positives = 61/126 (48%), Gaps = 1/126 (0%)
Frame = +1
Query: 259 GVSRILISVSS-DINQQNQNGDTSLHIAAALKRRKITKLLVESGANLDIRNIQNETPLDV 435
G+ +L S+SS D+NQ N++G L IAA ++ +LL++ G+ +D+++ +
Sbjct: 359 GLQHLLGSLSSYDVNQPNKHGTPPLLIAAGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYW 418
Query: 436 AIKKNHSEIIDILKMSICSSNQKTVSFLPENIRENFSVQSRHVSIPNEMCSVVNTPEQKP 615
A + H + + L + C + K S + + + H + +CS + P+
Sbjct: 419 ASRHGHVDTLKFLNENKCPLDVKDKS---GETALHVAARYGHADVVQLLCSFGSNPD--- 472
Query: 616 FRAKSE 633
F+ K E
Sbjct: 473 FQDKEE 478
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.315 0.130 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,496,270
Number of Sequences: 369166
Number of extensions: 1880834
Number of successful extensions: 7203
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4629
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6065
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7907893860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)