Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_I24
(817 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q7TMR0|PCP_MOUSE Lysosomal Pro-X carboxypeptidase precur... 190 5e-48
sp|Q5RBU7|PCP_PONPY Lysosomal Pro-X carboxypeptidase precur... 181 3e-45
sp|P42785|PCP_HUMAN Lysosomal Pro-X carboxypeptidase precur... 180 5e-45
sp|P34676|YO26_CAEEL Putative serine protease Z688.6 precursor 165 1e-40
sp|Q9EPB1|DPP2_RAT Dipeptidyl-peptidase II precursor (DPP I... 160 3e-39
sp|Q9UHL4|DPP2_HUMAN Dipeptidyl-peptidase II precursor (DPP... 155 1e-37
sp|Q9ET22|DPP2_MOUSE Dipeptidyl-peptidase II precursor (DPP... 154 2e-37
sp|P34610|PCP1_CAEEL Putative serine protease pcp-1 precursor 137 4e-32
sp|Q9NQE7|TSSP_HUMAN Thymus-specific serine protease precursor 80 9e-15
sp|Q9QXE5|TSSP_MOUSE Thymus-specific serine protease precursor 75 3e-13
>sp|Q7TMR0|PCP_MOUSE Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase)
Length = 491
Score = 190 bits (482), Expect = 5e-48
Identities = 96/223 (43%), Positives = 137/223 (61%), Gaps = 2/223 (0%)
Frame = +2
Query: 155 QYETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFVE-GNPILFYCGNEGSIELFANNSGF 331
+Y YF +DHF + D F +YL++ K++ G ILFY GNEG I F NN+GF
Sbjct: 45 KYSVLYFEQKVDHFGFA-DMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGF 103
Query: 332 VWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNL 511
+W++ E+L A++VFAEHR+YG +LPFG+ S+ +Q+ +L SEQ + +
Sbjct: 104 MWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTI 163
Query: 512 PGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKA 691
PGA PVIA GGSYGGMLAAWFR KYP+IV G+LAASAP+ + + C +++T
Sbjct: 164 PGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTND 223
Query: 692 YQTKGSDACVSNVRNVWPVIQQMNDS-LHLVNLSRIFHTCQPL 817
++ K C ++R W VI +++ S L +L+ I H C PL
Sbjct: 224 FR-KSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPL 265
>sp|Q5RBU7|PCP_PONPY Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase)
Length = 496
Score = 181 bits (458), Expect = 3e-45
Identities = 92/222 (41%), Positives = 132/222 (59%), Gaps = 2/222 (0%)
Frame = +2
Query: 158 YETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFVE-GNPILFYCGNEGSIELFANNSGFV 334
Y YF +DHF + N F +YL++ K + + G ILFY GNEG I F NN+GF+
Sbjct: 48 YSVLYFQQKVDHFGF-NTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFM 106
Query: 335 WELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNLP 514
W++ E+L A++VFAEHR+YG +LPFG ++ +++ +L SEQ K +P
Sbjct: 107 WDVAEELKAMLVFAEHRYYGESLPFGDNTFKDSRHLNFLTSEQALADFAELIKHLKRTIP 166
Query: 515 GASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKAY 694
GA + PVIA GGSYGGMLAAWFR KYP++V G+LAASAP+ ++ C +++T +
Sbjct: 167 GAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDF 226
Query: 695 QTKGSDACVSNVRNVWPVIQQM-NDSLHLVNLSRIFHTCQPL 817
+ G C ++R W I ++ N L L+ H C PL
Sbjct: 227 RKSGPH-CSESIRRSWDAINRLSNTGSGLQWLTGALHLCSPL 267
>sp|P42785|PCP_HUMAN Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase) (Angiotensinase C)
(Lysosomal carboxypeptidase C)
Length = 496
Score = 180 bits (456), Expect = 5e-45
Identities = 92/222 (41%), Positives = 131/222 (59%), Gaps = 2/222 (0%)
Frame = +2
Query: 158 YETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFVE-GNPILFYCGNEGSIELFANNSGFV 334
Y YF +DHF + N F +YL++ K + + G ILFY GNEG I F NN+GF+
Sbjct: 48 YSVLYFQQKVDHFGF-NTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFM 106
Query: 335 WELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNLP 514
W++ E+L A++VFAEHR+YG +LPFG S+ +++ +L SEQ K +P
Sbjct: 107 WDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIP 166
Query: 515 GASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKAY 694
GA + PVIA GGSYGGMLAAWFR KYP++V G+LAASAP+ ++ C +++T +
Sbjct: 167 GAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDF 226
Query: 695 QTKGSDACVSNVRNVWPVIQQM-NDSLHLVNLSRIFHTCQPL 817
+ G C ++ W I ++ N L L+ H C PL
Sbjct: 227 RKSGPH-CSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPL 267
>sp|P34676|YO26_CAEEL Putative serine protease Z688.6 precursor
Length = 507
Score = 165 bits (418), Expect = 1e-40
Identities = 87/189 (46%), Positives = 119/189 (62%), Gaps = 3/189 (1%)
Frame = +2
Query: 149 EFQYETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFVEGNPILFYCGNEGSIELFANNSG 328
+++YE Y +D F + ND +F ++Y ++ ++ G PILFY GNEGS+E FA N+G
Sbjct: 38 KYKYEEGYLKAPIDPFAFTNDL-EFDLRYFLNIDHYETGGPILFYTGNEGSLEAFAENTG 96
Query: 329 FVWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXK-Y 505
F+W+L +L A VVF EHRFYG + PF +SY ++ GYL+S+Q K
Sbjct: 97 FMWDLAPELKAAVVFVEHRFYGKSQPFKNESYTDIRHLGYLSSQQALADFALSVQFFKNE 156
Query: 506 NLPGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV--GNIENCSYPFQV 679
+ GA S VIAFGGSYGGML+AWFR KYP+IV G++AASAPV NI Y F +
Sbjct: 157 KIKGAQKSAVIAFGGSYGGMLSAWFRIKYPHIVDGAIAASAPVFWFTDSNIPEDVYDF-I 215
Query: 680 LTKAYQTKG 706
+T+A+ G
Sbjct: 216 VTRAFLDAG 224
>sp|Q9EPB1|DPP2_RAT Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 500
Score = 160 bits (406), Expect = 3e-39
Identities = 97/228 (42%), Positives = 133/228 (58%), Gaps = 2/228 (0%)
Frame = +2
Query: 140 SNLEFQYETKYFPTYLDHFTYKNDSNK-FLMKYLISTKNFVEGN-PILFYCGNEGSIELF 313
S L+ + YF Y+DHF +++ SNK F ++L+S K + G PI FY GNEG I
Sbjct: 35 SVLDPDFRENYFEQYMDHFNFESFSNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSL 94
Query: 314 ANNSGFVWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXX 493
ANNSGF+ EL Q A++VFAEHR+YG +LPFG +S Y L EQ
Sbjct: 95 ANNSGFIVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRG-YTQLLTVEQALADFAVLLQ 153
Query: 494 XXKYNLPGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPF 673
++NL G +P IAFGGSYGGML+A+ R KYP++VAG+LAASAPV+ V + N F
Sbjct: 154 ALRHNL-GVQDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVIAVAGLGNPDQFF 212
Query: 674 QVLTKAYQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPL 817
+ +T + + S C VR+ + I+ + +S+ F TCQ L
Sbjct: 213 RDVTADFYGQ-SPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSL 259
>sp|Q9UHL4|DPP2_HUMAN Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 492
Score = 155 bits (393), Expect = 1e-37
Identities = 92/222 (41%), Positives = 131/222 (59%), Gaps = 2/222 (0%)
Frame = +2
Query: 158 YETKYFPTYLDHFTYKNDSNK-FLMKYLISTKNFVEGN-PILFYCGNEGSIELFANNSGF 331
++ ++F LDHF ++ NK F ++L+S + +V G PI FY GNEG + FANNSGF
Sbjct: 31 FQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSGF 90
Query: 332 VWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNL 511
V EL + A++VFAEHR+YG +LPFG +S + L EQ + +L
Sbjct: 91 VAELAAERGALLVFAEHRYYGKSLPFGAQSTQRG-HTELLTVEQALADFAELLRALRRDL 149
Query: 512 PGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKA 691
GA +P IAFGGSYGGML+A+ R KYP++VAG+LAASAPVL V + + + F+ +T
Sbjct: 150 -GAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTAD 208
Query: 692 YQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPL 817
++ + S C VR + I+ + + F TCQPL
Sbjct: 209 FEGQ-SPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPL 249
>sp|Q9ET22|DPP2_MOUSE Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 506
Score = 154 bits (390), Expect = 2e-37
Identities = 94/226 (41%), Positives = 131/226 (57%), Gaps = 2/226 (0%)
Frame = +2
Query: 146 LEFQYETKYFPTYLDHFTYKNDSNK-FLMKYLISTKNFVEGN-PILFYCGNEGSIELFAN 319
L+ + YF Y+DHF +++ NK F ++L+S K + G PI FY GNEG I FAN
Sbjct: 37 LDPDFHENYFEQYMDHFNFESFGNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSFAN 96
Query: 320 NSGFVWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXX 499
NSGF+ EL Q A++VFAEHR+YG +LPFG +S Y L EQ
Sbjct: 97 NSGFMVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRG-YTQLLTVEQALADFAVLLQAL 155
Query: 500 KYNLPGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQV 679
+ +L G +P IAFGGSYGGML+A+ R KYP++VAG+LAASAPV+ V + + F+
Sbjct: 156 RQDL-GVHDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVVAVAGLGDSYQFFRD 214
Query: 680 LTKAYQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPL 817
+T + + S C VR+ + I+ + +S+ F TCQ L
Sbjct: 215 VTADFYGQ-SPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSL 259
>sp|P34610|PCP1_CAEEL Putative serine protease pcp-1 precursor
Length = 565
Score = 137 bits (345), Expect = 4e-32
Identities = 75/193 (38%), Positives = 111/193 (57%), Gaps = 7/193 (3%)
Frame = +2
Query: 185 LDHFTYKNDSNKFLMKYLISTKNFVEGNPILFYCGNEGSIELFANNSGFVWELGEQLSAI 364
LDHFT+ D+ F M+ + + + G PI FY GNEG +E F +G +++L +A
Sbjct: 51 LDHFTW-GDTRTFDMRVMWNNTFYKPGGPIFFYTGNEGGLESFVTATGMMFDLAPMFNAS 109
Query: 365 VVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXK-----YNLPGASHS 529
++FAEHRFYG T PFG +SY S GYL SEQ K + + + +
Sbjct: 110 IIFAEHRFYGQTQPFGNQSYASLANVGYLTSEQALADYAELLTELKRDNNQFKMTFPAAT 169
Query: 530 PVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV--GNIENCSYPFQVLTKAYQTK 703
VI+FGGSYGGML+AWFRQKYP+IV G+ A SAP++ + G ++ ++ + ++ Y
Sbjct: 170 QVISFGGSYGGMLSAWFRQKYPHIVKGAWAGSAPLIYMNGGGVDPGAFD-HITSRTYIDN 228
Query: 704 GSDACVSNVRNVW 742
G + + + N W
Sbjct: 229 GCNRFI--LANAW 239
>sp|Q9NQE7|TSSP_HUMAN Thymus-specific serine protease precursor
Length = 514
Score = 79.7 bits (195), Expect = 9e-15
Identities = 54/154 (35%), Positives = 79/154 (51%), Gaps = 1/154 (0%)
Frame = +2
Query: 185 LDHFTYKNDSNKFLMKYLISTKNFV-EGNPILFYCGNEGSIELFANNSGFVWELGEQLSA 361
LD F +D FL +Y ++ +++V + PI + G EGS+ + G L A
Sbjct: 66 LDPFNV-SDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAPAWGA 124
Query: 362 IVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNLPGASHSPVIA 541
+V+ EHRFYG ++P G + AQ +L+S +S SP I
Sbjct: 125 LVISLEHRFYGLSIPAG--GLEMAQ-LRFLSSRLALADVVSARLALSRLFNISSSSPWIC 181
Query: 542 FGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV 643
FGGSY G LAAW R K+P+++ S+A+SAPV V
Sbjct: 182 FGGSYAGSLAAWARLKFPHLIFASVASSAPVRAV 215
>sp|Q9QXE5|TSSP_MOUSE Thymus-specific serine protease precursor
Length = 509
Score = 74.7 bits (182), Expect = 3e-13
Identities = 52/154 (33%), Positives = 77/154 (50%), Gaps = 1/154 (0%)
Frame = +2
Query: 185 LDHFTYKNDSNKFLMKYLISTKNFV-EGNPILFYCGNEGSIELFANNSGFVWELGEQLSA 361
LD F +D FL +Y ++ ++ + P+ + G EGS+ + +G L A
Sbjct: 65 LDPFN-ASDRRTFLQRYWVNDQHRTGQDVPVFLHIGGEGSLGPGSVMAGHPAALAPAWGA 123
Query: 362 IVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNLPGASHSPVIA 541
+V+ EHRFYG ++P G D A YL+S L +S SP I
Sbjct: 124 LVISLEHRFYGLSMPAG--GLDLA-LLRYLSSRHALADVASARQALSGLLNVSSSSPWIC 180
Query: 542 FGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV 643
FGGSY G LA W R K+P++V ++A+SAP+ V
Sbjct: 181 FGGSYAGSLATWARLKFPHLVFAAVASSAPLSAV 214
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,783,416
Number of Sequences: 369166
Number of extensions: 1726794
Number of successful extensions: 4377
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4247
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4363
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7811456130
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)