Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_I23
(572 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 69 8e-12
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 69 8e-12
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 69 8e-12
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 65 9e-11
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 65 2e-10
sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Eps... 64 2e-10
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 63 6e-10
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 63 6e-10
sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 62 8e-10
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 62 8e-10
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 68.9 bits (167), Expect = 8e-12
Identities = 38/116 (32%), Positives = 66/116 (56%), Gaps = 8/116 (6%)
Frame = +3
Query: 84 GEFEWKIENFAQQRRRT------NIYSESFYSHKNGYKMCLSVKIGNDDYA--DYVSVYF 239
G+ WK+ ++ ++R +I+S+SFY+ + GY++C + D ++S+YF
Sbjct: 404 GKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYF 463
Query: 240 HLMRGEFDNDLLWPFKHAVTIDMINQMSGGAYESKTRKYDDDDPNHKGWNKPTTEI 407
+MRGEFD+ L WPF+ VT+ +++Q SG +T K DPN + +P E+
Sbjct: 464 VVMRGEFDSLLQWPFRQRVTLMLLDQ-SGKKNIMETFK---PDPNSSSFKRPDGEM 515
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 68.9 bits (167), Expect = 8e-12
Identities = 39/116 (33%), Positives = 63/116 (54%), Gaps = 8/116 (6%)
Frame = +3
Query: 84 GEFEWKIENFAQQRRRT------NIYSESFYSHKNGYKMCLSVKIGNDDYAD--YVSVYF 239
G WKI ++ ++++ ++YS+ FY+ GYKMC V + D ++S++F
Sbjct: 416 GVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFF 475
Query: 240 HLMRGEFDNDLLWPFKHAVTIDMINQMSGGAYESKTRKYDDDDPNHKGWNKPTTEI 407
+MRGE+D L WPFK VT+ +++Q S + K DPN + KPT E+
Sbjct: 476 VIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFK---PDPNSSSFKKPTGEM 528
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 68.9 bits (167), Expect = 8e-12
Identities = 39/116 (33%), Positives = 63/116 (54%), Gaps = 8/116 (6%)
Frame = +3
Query: 84 GEFEWKIENFAQQRRRT------NIYSESFYSHKNGYKMCLSVKIGNDDYAD--YVSVYF 239
G WKI ++ ++++ ++YS+ FY+ GYKMC V + D ++S++F
Sbjct: 415 GVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFF 474
Query: 240 HLMRGEFDNDLLWPFKHAVTIDMINQMSGGAYESKTRKYDDDDPNHKGWNKPTTEI 407
+MRGE+D L WPFK VT+ +++Q S + K DPN + KPT E+
Sbjct: 475 VIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFK---PDPNSSSFKKPTGEM 527
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 65.5 bits (158), Expect = 9e-11
Identities = 34/116 (29%), Positives = 64/116 (55%), Gaps = 8/116 (6%)
Frame = +3
Query: 84 GEFEWKIENFAQQRRRT------NIYSESFYSHKNGYKMCLSVKIGNDDYAD--YVSVYF 239
G+ WK+ ++ ++R +++S+ FY+ + GY++C + D ++S+YF
Sbjct: 404 GKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYF 463
Query: 240 HLMRGEFDNDLLWPFKHAVTIDMINQMSGGAYESKTRKYDDDDPNHKGWNKPTTEI 407
+MRGEFD+ L WPF+ VT+ +++Q + +T K DPN + +P E+
Sbjct: 464 VVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNHIVETFK---ADPNSSSFKRPDGEM 516
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 64.7 bits (156), Expect = 2e-10
Identities = 37/104 (35%), Positives = 60/104 (57%), Gaps = 8/104 (7%)
Frame = +3
Query: 30 NLQIKTIEMERITEKINFGEFEWKIENFAQQRRRT------NIYSESFYSHKNGYKMCLS 191
+L+ K +EME T G F WKI +FA++R+ I+S +FY+ + GYKMCL
Sbjct: 337 DLEQKVLEMEASTYD---GVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLR 393
Query: 192 VKIGND--DYADYVSVYFHLMRGEFDNDLLWPFKHAVTIDMINQ 317
+ + D ++S++F +M+G D L WPF VT+ +++Q
Sbjct: 394 IYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQ 437
>sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced
protein 6)
Length = 416
Score = 64.3 bits (155), Expect = 2e-10
Identities = 38/129 (29%), Positives = 70/129 (54%), Gaps = 26/129 (20%)
Frame = +3
Query: 9 IDNEKINNLQIKTIEME-----------------RITEKINF-GEFEWKIENFAQQ---- 122
+D E+I +L+ + +E++ R+ E+ +F G F WKI N ++
Sbjct: 224 LDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASFDGTFLWKITNVTRRCHES 283
Query: 123 --RRRTNIYSESFYSHKNGYKMCLSVKIGNDDYAD--YVSVYFHLMRGEFDNDLLWPFKH 290
R +++S +FY+ K GYK+CL + + D ++S++ +MRGE+D L WPF++
Sbjct: 284 ACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRN 343
Query: 291 AVTIDMINQ 317
VT +++Q
Sbjct: 344 KVTFMLLDQ 352
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 62.8 bits (151), Expect = 6e-10
Identities = 39/129 (30%), Positives = 65/129 (50%), Gaps = 12/129 (9%)
Frame = +3
Query: 51 EMERITEKINFGE---FEWKIENF------AQQRRRTNIYSESFYSHKNGYKMCLSVKIG 203
E+ R E+++ G WKI ++ A+ + +S +FY+HK GYK+ +S +
Sbjct: 294 ELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLN 353
Query: 204 NDDYAD--YVSVYFHLMRGEFDNDLLWPFKHAVTIDMINQMSGG-AYESKTRKYDDDDPN 374
+ + ++S+Y ++ G FDN L WPF VT +++Q G A + DPN
Sbjct: 354 GNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPN 413
Query: 375 HKGWNKPTT 401
K + KP T
Sbjct: 414 WKNFQKPGT 422
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 62.8 bits (151), Expect = 6e-10
Identities = 38/129 (29%), Positives = 64/129 (49%), Gaps = 12/129 (9%)
Frame = +3
Query: 51 EMERITEKINFGE---FEWKIENF------AQQRRRTNIYSESFYSHKNGYKMCLSVKIG 203
E+ R E+++ G WKI ++ A+ + +S +FY+HK GYK+ +S +
Sbjct: 294 ELRRELEELSIGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSASLN 353
Query: 204 NDDYAD--YVSVYFHLMRGEFDNDLLWPFKHAVTIDMINQMSGG-AYESKTRKYDDDDPN 374
+ + ++S+Y ++ G FDN L WP VT +++Q G A + DPN
Sbjct: 354 GNGSGEGTHLSIYIRVLPGAFDNLLEWPLARRVTFSLLDQSDPGLAKPQHVTETFHPDPN 413
Query: 375 HKGWNKPTT 401
K + KP T
Sbjct: 414 WKNFQKPGT 422
>sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1
Length = 409
Score = 62.4 bits (150), Expect = 8e-10
Identities = 37/129 (28%), Positives = 69/129 (53%), Gaps = 26/129 (20%)
Frame = +3
Query: 9 IDNEKINNLQIKTIEME-----------------RITEKINF-GEFEWKIENFAQQ---- 122
+D E + +L+ + +E++ R+ E+ +F G F WKI N ++
Sbjct: 217 LDREHLLSLEQRVVELQQTLAQKDQVLGKLEHSLRLMEEASFDGTFLWKITNVTKRCHES 276
Query: 123 --RRRTNIYSESFYSHKNGYKMCLSVKIGNDDYAD--YVSVYFHLMRGEFDNDLLWPFKH 290
R +++S +FY+ K GYK+CL + + D ++S++ +MRGE+D L WPF++
Sbjct: 277 VCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRN 336
Query: 291 AVTIDMINQ 317
VT +++Q
Sbjct: 337 KVTFMLLDQ 345
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 62.4 bits (150), Expect = 8e-10
Identities = 39/134 (29%), Positives = 69/134 (51%), Gaps = 9/134 (6%)
Frame = +3
Query: 24 INNLQIKTIEMERITEKINFGEFEWKIENFA------QQRRRTNIYSESFYSHKNGYKMC 185
I L+ K E+E ++ N G + WKI NF ++ + I+S FY+ K GYK+C
Sbjct: 334 IRTLEDKVAEIE--AQQCN-GIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLC 390
Query: 186 LSVKIG---NDDYADYVSVYFHLMRGEFDNDLLWPFKHAVTIDMINQMSGGAYESKTRKY 356
+ + + A+Y+S++ H M+GE+D+ L WPF+ + + +++Q S +
Sbjct: 391 MRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQ-SEAPVRQNHEEI 449
Query: 357 DDDDPNHKGWNKPT 398
D P + +PT
Sbjct: 450 MDAKPELLAFQRPT 463
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,739,590
Number of Sequences: 369166
Number of extensions: 906003
Number of successful extensions: 2516
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2421
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2503
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4226258440
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)