Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_H18
(444 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P43619|NADC_YEAST Nicotinate-nucleotide pyrophosphorylas... 138 6e-33
sp|Q91X91|NADC_MOUSE Nicotinate-nucleotide pyrophosphorylas... 128 6e-30
sp|Q15274|NADC_HUMAN Nicotinate-nucleotide pyrophosphorylas... 123 2e-28
sp|P74301|NADC_SYNY3 Probable nicotinate-nucleotide pyropho... 92 7e-19
sp|O28439|NADC_ARCFU Probable nicotinate-nucleotide pyropho... 89 6e-18
sp|P77938|NADC_RHORU Probable nicotinate-nucleotide pyropho... 88 7e-18
sp|O27860|NADC_METTH Probable nicotinate-nucleotide pyropho... 84 2e-16
sp|P39666|NADC_BACSU Probable nicotinate-nucleotide pyropho... 79 6e-15
sp|Q57916|NADC_METJA Probable nicotinate-nucleotide pyropho... 77 2e-14
sp|P30819|NADC_PSEAE Nicotinate-nucleotide pyrophosphorylas... 77 2e-14
>sp|P43619|NADC_YEAST Nicotinate-nucleotide pyrophosphorylase [carboxylating]
(Quinolinate phosphoribosyltransferase
[decarboxylating]) (QAPRTase)
Length = 295
Score = 138 bits (347), Expect = 6e-33
Identities = 70/137 (51%), Positives = 96/137 (70%), Gaps = 7/137 (5%)
Frame = +2
Query: 5 GLPFAEAVFKYFDCVVEWKNVEGSFI------AKPTVIGMVKGPANKILMAERTSLNILT 166
G+PFA+ VF + VEW EGSF+ + V+ + GPA IL+AERT+LNIL+
Sbjct: 55 GVPFAQEVFNQCELQVEWLFKEGSFLEPSKNDSGKIVVAKITGPAKNILLAERTALNILS 114
Query: 167 RACGVATVANRLSSKLKPT-WKGELTGSRKTTPGFRIVEKYAMYIGGISTHRYDLSSMVM 343
R+ G+AT ++++ S + T +KG + G+RKTTPG R +EKY+M +GG THRYDLSSMVM
Sbjct: 115 RSSGIATASHKIISLARSTGYKGTIAGTRKTTPGLRRLEKYSMLVGGCDTHRYDLSSMVM 174
Query: 344 VKDNHVKANGSIENPLK 394
+KDNH+ A GSI N +K
Sbjct: 175 LKDNHIWATGSITNAVK 191
>sp|Q91X91|NADC_MOUSE Nicotinate-nucleotide pyrophosphorylase [carboxylating]
(Quinolinate phosphoribosyltransferase
[decarboxylating]) (QAPRTase) (QPRTase)
Length = 299
Score = 128 bits (321), Expect = 6e-30
Identities = 63/128 (49%), Positives = 82/128 (64%), Gaps = 1/128 (0%)
Frame = +2
Query: 2 AGLPFAEAVFKYFDCVVEWKNVEGSFIAKPTVIGMVKGPANKILMAERTSLNILTRACGV 181
AG PF +A+F +C V W EGS + + VKGPA+ +L+ ER +LN L R G+
Sbjct: 55 AGRPFFDAIFTQLNCQVSWFLPEGSKLVPVVKVAEVKGPAHHLLLGERVALNTLARCSGI 114
Query: 182 ATVANRLSSKLKPT-WKGELTGSRKTTPGFRIVEKYAMYIGGISTHRYDLSSMVMVKDNH 358
A+ A + T W G + G+RKTTPGFR+VEKY + +GG + HRYDL MVMVKDNH
Sbjct: 115 ASAAATAVEVARSTGWTGHVAGTRKTTPGFRLVEKYGLQVGGAACHRYDLGGMVMVKDNH 174
Query: 359 VKANGSIE 382
V A GS+E
Sbjct: 175 VVAAGSME 182
>sp|Q15274|NADC_HUMAN Nicotinate-nucleotide pyrophosphorylase [carboxylating]
(Quinolinate phosphoribosyltransferase
[decarboxylating]) (QAPRTase) (QPRTase)
Length = 297
Score = 123 bits (309), Expect = 2e-28
Identities = 59/132 (44%), Positives = 83/132 (62%), Gaps = 1/132 (0%)
Frame = +2
Query: 2 AGLPFAEAVFKYFDCVVEWKNVEGSFIAKPTVIGMVKGPANKILMAERTSLNILTRACGV 181
AG PF +A+F +C V W EGS + + V+GPA+ +L+ ER +LN L R G+
Sbjct: 55 AGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGI 114
Query: 182 ATVANRLSSKLKPT-WKGELTGSRKTTPGFRIVEKYAMYIGGISTHRYDLSSMVMVKDNH 358
A+ A + W G + G+RKTTPGFR+VEKY + +GG ++HRYDL +VMVKDNH
Sbjct: 115 ASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNH 174
Query: 359 VKANGSIENPLK 394
V A G +E ++
Sbjct: 175 VVAAGGVEKAVR 186
>sp|P74301|NADC_SYNY3 Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]
(Quinolinate phosphoribosyltransferase
[decarboxylating]) (QAPRTase)
Length = 295
Score = 91.7 bits (226), Expect = 7e-19
Identities = 50/138 (36%), Positives = 76/138 (55%), Gaps = 2/138 (1%)
Frame = +2
Query: 2 AGLPFAEAVFKYFDCVVEWKNV--EGSFIAKPTVIGMVKGPANKILMAERTSLNILTRAC 175
AGLP A +F+ D +E++ + EG + TV+ + G +L ER +LN++
Sbjct: 62 AGLPMAARIFQLLDPSMEFQVLAGEGQAVTASTVVATMAGNLGSLLTGERVALNLVMGLS 121
Query: 176 GVATVANRLSSKLKPTWKGELTGSRKTTPGFRIVEKYAMYIGGISTHRYDLSSMVMVKDN 355
G+AT+ + + + +RKTTPG R++EKYA +GG HR L VMVKDN
Sbjct: 122 GIATMTRQYVQAIAD-YPTRFVDTRKTTPGLRVLEKYASRLGGAMNHRLGLDDAVMVKDN 180
Query: 356 HVKANGSIENPLKF*NQN 409
H++A GSI ++ QN
Sbjct: 181 HIQAAGSITKAVQTLRQN 198
>sp|O28439|NADC_ARCFU Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]
(Quinolinate phosphoribosyltransferase
[decarboxylating]) (QAPRTase)
Length = 258
Score = 88.6 bits (218), Expect = 6e-18
Identities = 49/132 (37%), Positives = 75/132 (56%), Gaps = 1/132 (0%)
Frame = +2
Query: 2 AGLPFAEAVFKYFDCVVEWKNVEGSFIAKPTVIGMVKGPANKILMAERTSLNILTRACGV 181
AG+ + +F + VV +G I V+ ++G ++ IL ER ++NIL R G+
Sbjct: 27 AGVGVVKILFDLAEIVVMESKKDGEPIKPGDVVMRLRGKSDSILATERLAINILMRMSGI 86
Query: 182 ATVANRLSSKLKPTW-KGELTGSRKTTPGFRIVEKYAMYIGGISTHRYDLSSMVMVKDNH 358
AT ++ + + K + +RKTTPGFRI EK A+ IGG HR+ LS +M+KDNH
Sbjct: 87 ATATAKMVERARRVNPKVVVAATRKTTPGFRIFEKMAVEIGGGDAHRFSLSDCLMLKDNH 146
Query: 359 VKANGSIENPLK 394
+ GS+E +K
Sbjct: 147 IAVAGSLERAMK 158
>sp|P77938|NADC_RHORU Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]
(Quinolinate phosphoribosyltransferase
[decarboxylating]) (QAPRTase)
Length = 296
Score = 88.2 bits (217), Expect = 7e-18
Identities = 53/132 (40%), Positives = 70/132 (53%), Gaps = 2/132 (1%)
Frame = +2
Query: 2 AGLPFAEAVFKYFDCVVEWKNV--EGSFIAKPTVIGMVKGPANKILMAERTSLNILTRAC 175
AGL A + F D V + +G+ IA + V G A IL AERT+LN L
Sbjct: 58 AGLGCARSAFALLDDTVTFTTPLEDGAEIAAGQTVAEVAGAARTILAAERTALNFLGHLS 117
Query: 176 GVATVANRLSSKLKPTWKGELTGSRKTTPGFRIVEKYAMYIGGISTHRYDLSSMVMVKDN 355
G+AT R + T + LT +RKTTPG R +EKYA+ GG S HR+ L V++KDN
Sbjct: 118 GIATRTRRFGDAIAHT-RARLTCTRKTTPGLRGLEKYAVRCGGGSNHRFGLDDAVLIKDN 176
Query: 356 HVKANGSIENPL 391
H+ G + L
Sbjct: 177 HIAVAGGVSAAL 188
>sp|O27860|NADC_METTH Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]
(Quinolinate phosphoribosyltransferase
[decarboxylating]) (QAPRTase)
Length = 279
Score = 83.6 bits (205), Expect = 2e-16
Identities = 46/133 (34%), Positives = 78/133 (58%), Gaps = 2/133 (1%)
Frame = +2
Query: 2 AGLPFAEAVFKYFDC-VVEWKNVEGSFIAKPTVIGMVKGPANKILMAERTSLNILTRACG 178
AG+ AE + + F ++ WK+ +G ++ + ++G A ILM ERT LN++ + G
Sbjct: 43 AGVEVAEMMAREFSISIIRWKD-DGDPLSGGERVLTLEGDAMDILMVERTMLNLMMKMSG 101
Query: 179 VATVANRLSSKLKPTWKG-ELTGSRKTTPGFRIVEKYAMYIGGISTHRYDLSSMVMVKDN 355
+AT+ + + + +G + +RKTTPG + EK A+ IGG THR+ L M+KDN
Sbjct: 102 IATLTRSMLQRARAVNEGIRIAATRKTTPGLQWFEKQAVRIGGGDTHRFRLDDCAMIKDN 161
Query: 356 HVKANGSIENPLK 394
H+ G+IE+ ++
Sbjct: 162 HIAIVGNIEDAVR 174
>sp|P39666|NADC_BACSU Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]
(Quinolinate phosphoribosyltransferase
[decarboxylating]) (QAPRTase) (General stress protein
70) (GSP70)
Length = 289
Score = 78.6 bits (192), Expect = 6e-15
Identities = 42/104 (40%), Positives = 63/104 (60%)
Frame = +2
Query: 68 EGSFIAKPTVIGMVKGPANKILMAERTSLNILTRACGVATVANRLSSKLKPTWKGELTGS 247
+G + K VI + GPA +L ER LN++ R G+AT+ R + + + ++ +
Sbjct: 71 DGDMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMT-REAVRCLDDEQIKICDT 129
Query: 248 RKTTPGFRIVEKYAMYIGGISTHRYDLSSMVMVKDNHVKANGSI 379
RKTTPG R++EKYA+ GG HR+ L +M+KDNH+ A GSI
Sbjct: 130 RKTTPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSI 173
>sp|Q57916|NADC_METJA Probable nicotinate-nucleotide pyrophosphorylase [carboxylating]
(Quinolinate phosphoribosyltransferase
[decarboxylating]) (QAPRTase)
Length = 283
Score = 77.0 bits (188), Expect = 2e-14
Identities = 40/89 (44%), Positives = 55/89 (61%), Gaps = 1/89 (1%)
Frame = +2
Query: 110 KGPANKILMAERTSLNILTRACGVATVANRLSSKLKPTWKG-ELTGSRKTTPGFRIVEKY 286
+G A ILM ERT+LN+L G+AT+ NR+ K K K + +RKT P ++KY
Sbjct: 82 EGDARTILMLERTALNLLMHLSGIATMTNRIVKKAKSVNKNVRVACTRKTLPLLSPLQKY 141
Query: 287 AMYIGGISTHRYDLSSMVMVKDNHVKANG 373
A+YIGG THR+ L V++KDNH+ G
Sbjct: 142 AVYIGGGDTHRFRLDDCVLIKDNHIAIVG 170
>sp|P30819|NADC_PSEAE Nicotinate-nucleotide pyrophosphorylase [carboxylating]
(Quinolinate phosphoribosyltransferase
[decarboxylating]) (QAPRTase)
Length = 282
Score = 77.0 bits (188), Expect = 2e-14
Identities = 43/132 (32%), Positives = 70/132 (53%), Gaps = 2/132 (1%)
Frame = +2
Query: 2 AGLPFAEAVFKYFD--CVVEWKNVEGSFIAKPTVIGMVKGPANKILMAERTSLNILTRAC 175
AG + + VF+ D +V W+ +G + ++ +KGPA +L ER++LN L
Sbjct: 54 AGRAWVDEVFRQVDPRVLVTWQVEDGQRVEPNQMLFQLKGPARALLTGERSALNFLQLLS 113
Query: 176 GVATVANRLSSKLKPTWKGELTGSRKTTPGFRIVEKYAMYIGGISTHRYDLSSMVMVKDN 355
G AT + + + T +L +RKT PG R+ +KYA+ GG HR L ++K+N
Sbjct: 114 GTATRSQHYADLVAGT-AVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKEN 172
Query: 356 HVKANGSIENPL 391
H+ A G I+ +
Sbjct: 173 HIAACGGIDRAI 184
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,368,287
Number of Sequences: 369166
Number of extensions: 908605
Number of successful extensions: 2207
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2166
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2189
length of database: 68,354,980
effective HSP length: 100
effective length of database: 49,881,480
effective search space used: 2344429560
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)