Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_G19
(869 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q7TMR0|PCP_MOUSE Lysosomal Pro-X carboxypeptidase precur... 206 9e-53
sp|Q5RBU7|PCP_PONPY Lysosomal Pro-X carboxypeptidase precur... 195 1e-49
sp|P42785|PCP_HUMAN Lysosomal Pro-X carboxypeptidase precur... 194 2e-49
sp|P34676|YO26_CAEEL Putative serine protease Z688.6 precursor 181 2e-45
sp|Q9EPB1|DPP2_RAT Dipeptidyl-peptidase II precursor (DPP I... 181 2e-45
sp|Q9UHL4|DPP2_HUMAN Dipeptidyl-peptidase II precursor (DPP... 174 4e-43
sp|Q9ET22|DPP2_MOUSE Dipeptidyl-peptidase II precursor (DPP... 173 6e-43
sp|P34610|PCP1_CAEEL Putative serine protease pcp-1 precursor 150 6e-36
sp|Q9NQE7|TSSP_HUMAN Thymus-specific serine protease precursor 80 1e-14
sp|Q9QXE5|TSSP_MOUSE Thymus-specific serine protease precursor 75 3e-13
>sp|Q7TMR0|PCP_MOUSE Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase)
Length = 491
Score = 206 bits (523), Expect = 9e-53
Identities = 106/256 (41%), Positives = 153/256 (59%), Gaps = 4/256 (1%)
Frame = +1
Query: 112 QYETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFVE-GNPILFYCGNEGSIELFANNSGF 288
+Y YF +DHF + D F +YL++ K++ G ILFY GNEG I F NN+GF
Sbjct: 45 KYSVLYFEQKVDHFGFA-DMRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGF 103
Query: 289 VWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNL 468
+W++ E+L A++VFAEHR+YG +LPFG+ S+ +Q+ +L SEQ + +
Sbjct: 104 MWDVAEELKAMLVFAEHRYYGESLPFGQDSFKDSQHLNFLTSEQALADFAELIRHLEKTI 163
Query: 469 PGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKA 648
PGA PVIA GGSYGGMLAAWFR KYP+IV G+LAASAP+ + + C +++T
Sbjct: 164 PGAQGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMVPCGEFMKIVTND 223
Query: 649 YQTKGSDACVSNVRNVWPVIQQMNDS-LHLVNLSRIFHTCQPL--KNVDDLIAVLTDGLF 819
++ K C ++R W VI +++ S L +L+ I H C PL + + L + +
Sbjct: 224 FR-KSGPYCSESIRKSWNVIDKLSGSGSGLQSLTNILHLCSPLTSEKIPTLKGWIAETWV 282
Query: 820 DMGMANYPYPANFLGP 867
++ M NYPY NFL P
Sbjct: 283 NLAMVNYPYACNFLQP 298
>sp|Q5RBU7|PCP_PONPY Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase)
Length = 496
Score = 195 bits (496), Expect = 1e-49
Identities = 101/255 (39%), Positives = 151/255 (59%), Gaps = 4/255 (1%)
Frame = +1
Query: 115 YETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFVE-GNPILFYCGNEGSIELFANNSGFV 291
Y YF +DHF + N F +YL++ K + + G ILFY GNEG I F NN+GF+
Sbjct: 48 YSVLYFQQKVDHFGF-NTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFM 106
Query: 292 WELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNLP 471
W++ E+L A++VFAEHR+YG +LPFG ++ +++ +L SEQ K +P
Sbjct: 107 WDVAEELKAMLVFAEHRYYGESLPFGDNTFKDSRHLNFLTSEQALADFAELIKHLKRTIP 166
Query: 472 GASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKAY 651
GA + PVIA GGSYGGMLAAWFR KYP++V G+LAASAP+ ++ C +++T +
Sbjct: 167 GAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDF 226
Query: 652 QTKGSDACVSNVRNVWPVIQQM-NDSLHLVNLSRIFHTCQPL--KNVDDLIAVLTDGLFD 822
+ G C ++R W I ++ N L L+ H C PL +++ L +++ +
Sbjct: 227 RKSGPH-CSESIRRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVN 285
Query: 823 MGMANYPYPANFLGP 867
+ M +YPY +NFL P
Sbjct: 286 LAMVDYPYASNFLQP 300
>sp|P42785|PCP_HUMAN Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase)
(PRCP) (Proline carboxypeptidase) (Angiotensinase C)
(Lysosomal carboxypeptidase C)
Length = 496
Score = 194 bits (494), Expect = 2e-49
Identities = 101/255 (39%), Positives = 150/255 (58%), Gaps = 4/255 (1%)
Frame = +1
Query: 115 YETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFVE-GNPILFYCGNEGSIELFANNSGFV 291
Y YF +DHF + N F +YL++ K + + G ILFY GNEG I F NN+GF+
Sbjct: 48 YSVLYFQQKVDHFGF-NTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFM 106
Query: 292 WELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNLP 471
W++ E+L A++VFAEHR+YG +LPFG S+ +++ +L SEQ K +P
Sbjct: 107 WDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIP 166
Query: 472 GASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKAY 651
GA + PVIA GGSYGGMLAAWFR KYP++V G+LAASAP+ ++ C +++T +
Sbjct: 167 GAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDF 226
Query: 652 QTKGSDACVSNVRNVWPVIQQM-NDSLHLVNLSRIFHTCQPL--KNVDDLIAVLTDGLFD 822
+ G C ++ W I ++ N L L+ H C PL +++ L +++ +
Sbjct: 227 RKSGPH-CSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVN 285
Query: 823 MGMANYPYPANFLGP 867
+ M +YPY +NFL P
Sbjct: 286 LAMVDYPYASNFLQP 300
>sp|P34676|YO26_CAEEL Putative serine protease Z688.6 precursor
Length = 507
Score = 181 bits (459), Expect = 2e-45
Identities = 104/261 (39%), Positives = 148/261 (56%), Gaps = 9/261 (3%)
Frame = +1
Query: 106 EFQYETKYFPTYLDHFTYKNDSNKFLMKYLISTKNFVEGNPILFYCGNEGSIELFANNSG 285
+++YE Y +D F + ND +F ++Y ++ ++ G PILFY GNEGS+E FA N+G
Sbjct: 38 KYKYEEGYLKAPIDPFAFTNDL-EFDLRYFLNIDHYETGGPILFYTGNEGSLEAFAENTG 96
Query: 286 FVWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXK-Y 462
F+W+L +L A VVF EHRFYG + PF +SY ++ GYL+S+Q K
Sbjct: 97 FMWDLAPELKAAVVFVEHRFYGKSQPFKNESYTDIRHLGYLSSQQALADFALSVQFFKNE 156
Query: 463 NLPGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV--GNIENCSYPFQV 636
+ GA S VIAFGGSYGGML+AWFR KYP+IV G++AASAPV NI Y F +
Sbjct: 157 KIKGAQKSAVIAFGGSYGGMLSAWFRIKYPHIVDGAIAASAPVFWFTDSNIPEDVYDF-I 215
Query: 637 LTKAYQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQP---LKNVDD---LIA 798
+T+A+ G + + W + ++ S + + P L+N DD L
Sbjct: 216 VTRAFLDAGCNR--KAIEKGWIALDELAKSDSGRQYLNVLYKLDPKSKLENKDDIGFLKQ 273
Query: 799 VLTDGLFDMGMANYPYPANFL 861
+ + + M M NYPYP +FL
Sbjct: 274 YIRESMEAMAMVNYPYPTSFL 294
>sp|Q9EPB1|DPP2_RAT Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 500
Score = 181 bits (459), Expect = 2e-45
Identities = 109/262 (41%), Positives = 150/262 (57%), Gaps = 5/262 (1%)
Frame = +1
Query: 97 SNLEFQYETKYFPTYLDHFTYKNDSNK-FLMKYLISTKNFVEGN-PILFYCGNEGSIELF 270
S L+ + YF Y+DHF +++ SNK F ++L+S K + G PI FY GNEG I
Sbjct: 35 SVLDPDFRENYFEQYMDHFNFESFSNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSL 94
Query: 271 ANNSGFVWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXX 450
ANNSGF+ EL Q A++VFAEHR+YG +LPFG +S Y L EQ
Sbjct: 95 ANNSGFIVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRG-YTQLLTVEQALADFAVLLQ 153
Query: 451 XXKYNLPGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPF 630
++NL G +P IAFGGSYGGML+A+ R KYP++VAG+LAASAPV+ V + N F
Sbjct: 154 ALRHNL-GVQDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVIAVAGLGNPDQFF 212
Query: 631 QVLTKAYQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPL---KNVDDLIAV 801
+ +T + + S C VR+ + I+ + +S+ F TCQ L K++ L
Sbjct: 213 RDVTADFYGQ-SPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGF 271
Query: 802 LTDGLFDMGMANYPYPANFLGP 867
+ + M +YPYP NFLGP
Sbjct: 272 ARNAFTVLAMMDYPYPTNFLGP 293
>sp|Q9UHL4|DPP2_HUMAN Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 492
Score = 174 bits (440), Expect = 4e-43
Identities = 103/256 (40%), Positives = 148/256 (57%), Gaps = 5/256 (1%)
Frame = +1
Query: 115 YETKYFPTYLDHFTYKNDSNK-FLMKYLISTKNFVEGN-PILFYCGNEGSIELFANNSGF 288
++ ++F LDHF ++ NK F ++L+S + +V G PI FY GNEG + FANNSGF
Sbjct: 31 FQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSGF 90
Query: 289 VWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNL 468
V EL + A++VFAEHR+YG +LPFG +S + L EQ + +L
Sbjct: 91 VAELAAERGALLVFAEHRYYGKSLPFGAQSTQRG-HTELLTVEQALADFAELLRALRRDL 149
Query: 469 PGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQVLTKA 648
GA +P IAFGGSYGGML+A+ R KYP++VAG+LAASAPVL V + + + F+ +T
Sbjct: 150 -GAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTAD 208
Query: 649 YQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPL---KNVDDLIAVLTDGLF 819
++ + S C VR + I+ + + F TCQPL K++ L +
Sbjct: 209 FEGQ-SPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFT 267
Query: 820 DMGMANYPYPANFLGP 867
+ M +YPYP +FLGP
Sbjct: 268 VLAMMDYPYPTDFLGP 283
>sp|Q9ET22|DPP2_MOUSE Dipeptidyl-peptidase II precursor (DPP II) (Dipeptidyl
aminopeptidase II) (Quiescent cell proline dipeptidase)
(Dipeptidyl peptidase 7)
Length = 506
Score = 173 bits (438), Expect = 6e-43
Identities = 105/260 (40%), Positives = 148/260 (56%), Gaps = 5/260 (1%)
Frame = +1
Query: 103 LEFQYETKYFPTYLDHFTYKNDSNK-FLMKYLISTKNFVEGN-PILFYCGNEGSIELFAN 276
L+ + YF Y+DHF +++ NK F ++L+S K + G PI FY GNEG I FAN
Sbjct: 37 LDPDFHENYFEQYMDHFNFESFGNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSFAN 96
Query: 277 NSGFVWELGEQLSAIVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXX 456
NSGF+ EL Q A++VFAEHR+YG +LPFG +S Y L EQ
Sbjct: 97 NSGFMVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRG-YTQLLTVEQALADFAVLLQAL 155
Query: 457 KYNLPGASHSPVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMVGNIENCSYPFQV 636
+ +L G +P IAFGGSYGGML+A+ R KYP++VAG+LAASAPV+ V + + F+
Sbjct: 156 RQDL-GVHDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVVAVAGLGDSYQFFRD 214
Query: 637 LTKAYQTKGSDACVSNVRNVWPVIQQMNDSLHLVNLSRIFHTCQPL---KNVDDLIAVLT 807
+T + + S C VR+ + I+ + +S+ F TCQ L K++ L
Sbjct: 215 VTADFYGQ-SPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFAR 273
Query: 808 DGLFDMGMANYPYPANFLGP 867
+ + M +YPYP +FLGP
Sbjct: 274 NAFTVLAMMDYPYPTDFLGP 293
>sp|P34610|PCP1_CAEEL Putative serine protease pcp-1 precursor
Length = 565
Score = 150 bits (378), Expect = 6e-36
Identities = 91/255 (35%), Positives = 137/255 (53%), Gaps = 13/255 (5%)
Frame = +1
Query: 142 LDHFTYKNDSNKFLMKYLISTKNFVEGNPILFYCGNEGSIELFANNSGFVWELGEQLSAI 321
LDHFT+ D+ F M+ + + + G PI FY GNEG +E F +G +++L +A
Sbjct: 51 LDHFTW-GDTRTFDMRVMWNNTFYKPGGPIFFYTGNEGGLESFVTATGMMFDLAPMFNAS 109
Query: 322 VVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXK-----YNLPGASHS 486
++FAEHRFYG T PFG +SY S GYL SEQ K + + + +
Sbjct: 110 IIFAEHRFYGQTQPFGNQSYASLANVGYLTSEQALADYAELLTELKRDNNQFKMTFPAAT 169
Query: 487 PVIAFGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV--GNIENCSYPFQVLTKAYQTK 660
VI+FGGSYGGML+AWFRQKYP+IV G+ A SAP++ + G ++ ++ + ++ Y
Sbjct: 170 QVISFGGSYGGMLSAWFRQKYPHIVKGAWAGSAPLIYMNGGGVDPGAFD-HITSRTYIDN 228
Query: 661 GSDACV-SNVRNVWPVIQQMNDSLHLVNLSRIF--HTCQPLKNVDD---LIAVLTDGLFD 822
G + + +N N + + +N + +F ++N D L A L + +
Sbjct: 229 GCNRFILANAWNATLNLSSTDAGRQWLNNNTVFKLDPRTKIRNQTDGWNLNAYLREAIEY 288
Query: 823 MGMANYPYPANFLGP 867
M M +YPYP FL P
Sbjct: 289 MAMVDYPYPTGFLEP 303
>sp|Q9NQE7|TSSP_HUMAN Thymus-specific serine protease precursor
Length = 514
Score = 79.7 bits (195), Expect = 1e-14
Identities = 54/154 (35%), Positives = 79/154 (51%), Gaps = 1/154 (0%)
Frame = +1
Query: 142 LDHFTYKNDSNKFLMKYLISTKNFV-EGNPILFYCGNEGSIELFANNSGFVWELGEQLSA 318
LD F +D FL +Y ++ +++V + PI + G EGS+ + G L A
Sbjct: 66 LDPFNV-SDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAPAWGA 124
Query: 319 IVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNLPGASHSPVIA 498
+V+ EHRFYG ++P G + AQ +L+S +S SP I
Sbjct: 125 LVISLEHRFYGLSIPAG--GLEMAQ-LRFLSSRLALADVVSARLALSRLFNISSSSPWIC 181
Query: 499 FGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV 600
FGGSY G LAAW R K+P+++ S+A+SAPV V
Sbjct: 182 FGGSYAGSLAAWARLKFPHLIFASVASSAPVRAV 215
>sp|Q9QXE5|TSSP_MOUSE Thymus-specific serine protease precursor
Length = 509
Score = 74.7 bits (182), Expect = 3e-13
Identities = 52/154 (33%), Positives = 77/154 (50%), Gaps = 1/154 (0%)
Frame = +1
Query: 142 LDHFTYKNDSNKFLMKYLISTKNFV-EGNPILFYCGNEGSIELFANNSGFVWELGEQLSA 318
LD F +D FL +Y ++ ++ + P+ + G EGS+ + +G L A
Sbjct: 65 LDPFN-ASDRRTFLQRYWVNDQHRTGQDVPVFLHIGGEGSLGPGSVMAGHPAALAPAWGA 123
Query: 319 IVVFAEHRFYGSTLPFGKKSYDSAQYFGYLNSEQXXXXXXXXXXXXKYNLPGASHSPVIA 498
+V+ EHRFYG ++P G D A YL+S L +S SP I
Sbjct: 124 LVISLEHRFYGLSMPAG--GLDLA-LLRYLSSRHALADVASARQALSGLLNVSSSSPWIC 180
Query: 499 FGGSYGGMLAAWFRQKYPNIVAGSLAASAPVLMV 600
FGGSY G LA W R K+P++V ++A+SAP+ V
Sbjct: 181 FGGSYAGSLATWARLKFPHLVFAAVASSAPLSAV 214
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,002,160
Number of Sequences: 369166
Number of extensions: 1805783
Number of successful extensions: 4584
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4430
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4560
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8598109270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)