Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_G16
(778 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9BW91|NUDT9_HUMAN ADP-ribose pyrophosphatase, mitochond... 271 1e-72
sp|Q5XIG0|NUDT9_RAT ADP-ribose pyrophosphatase, mitochondri... 270 2e-72
sp|Q8BVU5|NUDT9_MOUSE ADP-ribose pyrophosphatase, mitochond... 270 3e-72
sp|Q09297|NDX6_CAEEL Putative nudix hydrolase 6 187 2e-47
sp|Q91YD4|TRPM2_MOUSE Transient receptor potential cation c... 165 1e-40
sp|O94759|TRPM2_HUMAN Transient receptor potential cation c... 164 3e-40
sp|Q8N2Z3|NUD9P_HUMAN Hypothetical nucleoside diphosphate-l... 121 2e-27
sp|Q58549|ADPP_METJA ADP-ribose pyrophosphatase (ADP-ribose... 40 0.007
sp|P35942|RRPO_ROTGI RNA-directed RNA polymerase subunit VP... 38 0.027
sp|P34641|CED11_CAEEL Ced-11 protein 38 0.035
>sp|Q9BW91|NUDT9_HUMAN ADP-ribose pyrophosphatase, mitochondrial precursor (ADP-ribose
diphosphatase) (Adenosine diphosphoribose
pyrophosphatase) (ADPR-PPase) (ADP-ribose
phosphohydrolase) (Nucleoside diphosphate-linked moiety
X motif 9) (Nudix motif 9)
Length = 350
Score = 271 bits (693), Expect = 1e-72
Identities = 129/229 (56%), Positives = 168/229 (73%), Gaps = 1/229 (0%)
Frame = +3
Query: 24 DDDILKNPFADINFNELDGKIDRRSHHGMYDIVDGLPRNPYGRTGIVGRGCLYYWGPNHA 203
D I ++ F+ FNE DG ++R+S +G+Y+I +G PRNP GRTG+VGRG L WGPNHA
Sbjct: 112 DPQISESNFSP-KFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHA 170
Query: 204 ADPVVTTWKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKRE 383
ADP++T WKRD + I VS K IL+FV I RK EWA+PGGMVDPGE ++AT+KRE
Sbjct: 171 ADPIITRWKRDSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKRE 230
Query: 384 FSEEALNTLIKTTQEKKELYEKIDYLF-VNGTTIYTGYVDDPRNTDNAWIETVAVNFHDK 560
F EEALN+L KT+ EK+E+ EK+ LF + IY GYVDDPRNTDNAW+ET AVN+HD+
Sbjct: 231 FGEEALNSLQKTSAEKREIEEKLHKLFSQDHLVIYKGYVDDPRNTDNAWMETEAVNYHDE 290
Query: 561 DGDSLAQIKLEAGDDAAAIRWIDLNKELKLYASHLSILSDLVDKHGAHW 707
G+ + + LEAGDDA ++W+D+N +LKLYASH + + +K AHW
Sbjct: 291 TGEIMDNLMLEAGDDAGKVKWVDINDKLKLYASHSQFIKLVAEKRDAHW 339
>sp|Q5XIG0|NUDT9_RAT ADP-ribose pyrophosphatase, mitochondrial precursor (ADP-ribose
diphosphatase) (Adenosine diphosphoribose
pyrophosphatase) (ADPR-PPase) (ADP-ribose
phosphohydrolase) (Nucleoside diphosphate-linked moiety
X motif 9) (Nudix motif 9)
Length = 350
Score = 270 bits (691), Expect = 2e-72
Identities = 128/229 (55%), Positives = 169/229 (73%), Gaps = 1/229 (0%)
Frame = +3
Query: 24 DDDILKNPFADINFNELDGKIDRRSHHGMYDIVDGLPRNPYGRTGIVGRGCLYYWGPNHA 203
D I ++ F+ FNE DG ++R+S +G+Y+I +G PRNP GRTG+VGRG L WGPNHA
Sbjct: 112 DPQISESSFSP-RFNEKDGHVERKSQNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHA 170
Query: 204 ADPVVTTWKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKRE 383
ADP++T WKRDE+ I VS K IL+FV I RK EWA+PGGMVDPGE ++AT+KRE
Sbjct: 171 ADPIITRWKRDESGNKITHPVSGKCILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKRE 230
Query: 384 FSEEALNTLIKTTQEKKELYEKIDYLF-VNGTTIYTGYVDDPRNTDNAWIETVAVNFHDK 560
F EEALN+L K++ EK+E+ EK+ LF IY GYVDDPRNTDNAW+ET AVN+HD+
Sbjct: 231 FGEEALNSLQKSSAEKREIEEKLHALFSQEHLVIYKGYVDDPRNTDNAWMETEAVNYHDE 290
Query: 561 DGDSLAQIKLEAGDDAAAIRWIDLNKELKLYASHLSILSDLVDKHGAHW 707
G+++ + LEAGDDA ++W+D++ +LKLYASH + + +K AHW
Sbjct: 291 TGETMDNLTLEAGDDAGKVKWVDISDQLKLYASHSQFIKLVAEKRDAHW 339
>sp|Q8BVU5|NUDT9_MOUSE ADP-ribose pyrophosphatase, mitochondrial precursor (ADP-ribose
diphosphatase) (Adenosine diphosphoribose
pyrophosphatase) (ADPR-PPase) (ADP-ribose
phosphohydrolase) (Nucleoside diphosphate-linked moiety
X motif 9) (Nudix motif 9)
Length = 350
Score = 270 bits (690), Expect = 3e-72
Identities = 128/229 (55%), Positives = 169/229 (73%), Gaps = 1/229 (0%)
Frame = +3
Query: 24 DDDILKNPFADINFNELDGKIDRRSHHGMYDIVDGLPRNPYGRTGIVGRGCLYYWGPNHA 203
D I ++ F+ FNE DG ++R+S +G+Y+I +G PRNP GRTG+VGRG L WGPNHA
Sbjct: 112 DPQISESNFSP-KFNEKDGHVERKSQNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHA 170
Query: 204 ADPVVTTWKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKRE 383
ADP++T WKRDE+ I VS K IL+FV I RK EWA+PGGMVDPGE ++AT+KRE
Sbjct: 171 ADPIITRWKRDESGNKITHPVSGKCILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKRE 230
Query: 384 FSEEALNTLIKTTQEKKELYEKIDYLF-VNGTTIYTGYVDDPRNTDNAWIETVAVNFHDK 560
F EEALN+L K++ EK+E+ EK+ LF IY GYVDDPRNTDNAW+ET AVN+HD+
Sbjct: 231 FGEEALNSLQKSSAEKREIEEKLHALFSQEHLVIYKGYVDDPRNTDNAWMETEAVNYHDE 290
Query: 561 DGDSLAQIKLEAGDDAAAIRWIDLNKELKLYASHLSILSDLVDKHGAHW 707
G+++ + LEAGDDA ++W+D++ +LKLYASH + + +K AHW
Sbjct: 291 TGETMDNLTLEAGDDAGKVKWVDISDQLKLYASHSQFIKLVAEKRDAHW 339
>sp|Q09297|NDX6_CAEEL Putative nudix hydrolase 6
Length = 260
Score = 187 bits (476), Expect = 2e-47
Identities = 101/214 (47%), Positives = 136/214 (63%), Gaps = 2/214 (0%)
Frame = +3
Query: 60 NFNELDGKIDRRSHHGMY--DIVDGLPRNPYGRTGIVGRGCLYYWGPNHAADPVVTTWKR 233
++N +DGKI+R S+ Y D V P NP GRTG+ GRG L WGPNHAADP+V+ +
Sbjct: 67 SWNAIDGKINRVSYVCQYSFDPVTLRPLNPIGRTGLSGRGLLGRWGPNHAADPIVS--RT 124
Query: 234 DENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKREFSEEALNTLI 413
++N + L+FV + R + EWA+PGGMVD GE V+ T++REF+EEA++ ++
Sbjct: 125 NDNGD-----------LEFVAVQRHDNGEWAIPGGMVDAGEHVSQTLRREFAEEAMHGIV 173
Query: 414 KTTQEKKELYEKIDYLFVNGTTIYTGYVDDPRNTDNAWIETVAVNFHDKDGDSLAQIKLE 593
+ E +D L+ NG +Y GYVDDPRNTDNAW+ETV NFHD G L + L+
Sbjct: 174 DS--------ENLDELWNNGKELYRGYVDDPRNTDNAWMETVVFNFHDSKG-LLKNVALQ 224
Query: 594 AGDDAAAIRWIDLNKELKLYASHLSILSDLVDKH 695
AGDDA A+RWI +N LYASH + L + H
Sbjct: 225 AGDDAKALRWIAVNSNEPLYASHSHFIDLLKESH 258
>sp|Q91YD4|TRPM2_MOUSE Transient receptor potential cation channel subfamily M member 2
(Long transient receptor potential channel 2) (LTrpC2)
(LTrpC-2) (Transient receptor potential channel 7)
(TrpC7)
Length = 1507
Score = 165 bits (418), Expect = 1e-40
Identities = 88/232 (37%), Positives = 129/232 (55%), Gaps = 11/232 (4%)
Frame = +3
Query: 45 PFADINFNELDGKIDRRSHHGMYDIVDGLPRNPYGRTGIVGRGCLYYWGPNHAADPVVTT 224
P + I++N +DG DRRS HG+Y + G P NP GRTG+ GRG L ++GPNH PVVT
Sbjct: 1292 PLSKISYNVVDGPTDRRSFHGVYVVEYGFPLNPMGRTGLRGRGSLSWFGPNHTLQPVVTR 1351
Query: 225 WKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKREFSEEALN 404
WKR++ I + S + +L+ + + WALPGG +PGE++ +KR
Sbjct: 1352 WKRNQGGAIC--RKSVRKMLEVLVMKLPRSEHWALPGGSREPGEMLPRKLKRVL------ 1403
Query: 405 TLIKTTQEKKELYEKIDYLFVNGTTIYTGYVDDPRNTDNAWIETVAVNFHDKDGDSLAQI 584
++E + + L + GT +Y GYVDDPRNTDNAWIETVAV+ H +D + +
Sbjct: 1404 --------RQEFWVAFETLLMQGTEVYKGYVDDPRNTDNAWIETVAVSIHFQDQNDMELK 1455
Query: 585 KLEAG-----------DDAAAIRWIDLNKELKLYASHLSILSDLVDKHGAHW 707
+LE D + W +++ + LYA+H +IL + GAH+
Sbjct: 1456 RLEENLHTHDPKELTRDLKLSTEWQVVDRRIPLYANHKTILQKVASLFGAHF 1507
>sp|O94759|TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2
(Long transient receptor potential channel 2) (LTrpC2)
(LTrpC-2) (Transient receptor potential channel 7)
(TrpC7) (Estrogen-responsive element associated gene
protein 1)
Length = 1503
Score = 164 bits (414), Expect = 3e-40
Identities = 89/225 (39%), Positives = 128/225 (56%), Gaps = 4/225 (1%)
Frame = +3
Query: 45 PFADINFNELDGKIDRRSHHGMYDIVDGLPRNPYGRTGIVGRGCLYYWGPNHAADPVVTT 224
P + I +N +DG DRRS HG Y + GLP NP GRTG+ GRG L +GPNH P+VT
Sbjct: 1295 PLSTIQYNVVDGLRDRRSFHGPYTVQAGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTR 1354
Query: 225 WKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELVTATIKREFSEEALN 404
W+R+E+ I + S K +L+ + + WALPGG +PGE++ +KR
Sbjct: 1355 WRRNEDGAIC--RKSIKKMLEVLVVKLPLSEHWALPGGSREPGEMLPRKLKRIL------ 1406
Query: 405 TLIKTTQEKKELYEKIDYLFVNGTTIYTGYVDDPRNTDNAWIETVAVNFHDKDGDSL--- 575
++E + + L G +Y GY+DDPRNTDNAWIETVAV+ H +D + +
Sbjct: 1407 --------RQEHWPSFENLLKCGMEVYKGYMDDPRNTDNAWIETVAVSVHFQDQNDVELN 1458
Query: 576 -AQIKLEAGDDAAAIRWIDLNKELKLYASHLSILSDLVDKHGAHW 707
L A D A+IRW +++ + LYA+H ++L + GAH+
Sbjct: 1459 RLNSNLHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFGAHY 1503
>sp|Q8N2Z3|NUD9P_HUMAN Hypothetical nucleoside diphosphate-linked moiety X motif 9P1
Length = 120
Score = 121 bits (303), Expect = 2e-27
Identities = 62/123 (50%), Positives = 84/123 (68%), Gaps = 1/123 (0%)
Frame = +3
Query: 339 MVDPGELVTATIKREFSEEALNTLIKTTQEKKELYEKIDYLFVNGT-TIYTGYVDDPRNT 515
MVDPGE ++AT+KREF EEA+N+L K+ +E +EL ++ L +Y GYVDD RNT
Sbjct: 1 MVDPGEKISATLKREFGEEAMNSLQKSRKEMQELERQLHKLLSQEHFEVYKGYVDDSRNT 60
Query: 516 DNAWIETVAVNFHDKDGDSLAQIKLEAGDDAAAIRWIDLNKELKLYASHLSILSDLVDKH 695
DN WIET AVN+ D+ D L LEAGDDA ++W+D+N +L+LYAS + + +K
Sbjct: 61 DNCWIETEAVNYRDEIMDHL---PLEAGDDAKKVKWVDINDKLELYASLSQFIQLVAEKR 117
Query: 696 GAH 704
GAH
Sbjct: 118 GAH 120
>sp|Q58549|ADPP_METJA ADP-ribose pyrophosphatase (ADP-ribose diphosphatase) (Adenosine
diphosphoribose pyrophosphatase) (ADPR-PPase)
(ADP-ribose phosphohydrolase)
Length = 169
Score = 40.0 bits (92), Expect = 0.007
Identities = 48/167 (28%), Positives = 67/167 (40%), Gaps = 1/167 (0%)
Frame = +3
Query: 183 YWGPNHAADPVVTTWKRDENNEIIFDKVSQKPILKFVGIFRKHDNEWALPGGMVDPGELV 362
Y P A D ++ +++N+I+ K P F G F ALPGG V+ GE V
Sbjct: 38 YLHPAVAVDGII-----EKDNKILLIKRKNNP---FKGCF-------ALPGGFVECGETV 82
Query: 363 TATIKREFSEEALNTLIKTTQEKKELYEKIDYLFVNGTTIYTGYVDDPRNTDNAWIETVA 542
+ RE EE L K+ L +Y+ DPR ++
Sbjct: 83 EEAVVREIKEET------------GLIPKVKSLL----GVYSSPDRDPRG------HVIS 120
Query: 543 VNF-HDKDGDSLAQIKLEAGDDAAAIRWIDLNKELKLYASHLSILSD 680
+ F D G +L+AGDDA + DLN KL H I+ D
Sbjct: 121 IVFILDVIGG-----ELKAGDDAKEAEFFDLNNLPKLAFDHEKIIKD 162
>sp|P35942|RRPO_ROTGI RNA-directed RNA polymerase subunit VP1 (Inner layer protein VP1)
(Core protein VP1)
Length = 1159
Score = 38.1 bits (87), Expect = 0.027
Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 1/69 (1%)
Frame = +3
Query: 393 EALNTLIKTTQEKKELYEKIDYLF-VNGTTIYTGYVDDPRNTDNAWIETVAVNFHDKDGD 569
E L TL KT E L EKI+ L + T+Y G D RN +W+ T + ++
Sbjct: 56 ELLLTLKKTLDECSTLDEKIETLLRIRYFTVYVGDKSDKRNIIRSWLSTTINRLNVEEYA 115
Query: 570 SLAQIKLEA 596
S+ +I+L+A
Sbjct: 116 SIQEIELQA 124
>sp|P34641|CED11_CAEEL Ced-11 protein
Length = 1418
Score = 37.7 bits (86), Expect = 0.035
Identities = 40/145 (27%), Positives = 60/145 (41%), Gaps = 9/145 (6%)
Frame = +3
Query: 126 GLPRNPYGRTGIVGRGCLYYWGPNHAADPVVTTWKRDENNEIIFDKVSQKPILKFVGIFR 305
G P NP GRTG+ GRG +G N VV + + +++ D SQK I
Sbjct: 1245 GFPLNPNGRTGMAGRGNHPRFGANRRCYYVVLSGGVEAKCQVLVD--SQKNI-------- 1294
Query: 306 KHDNEWALPGGMVDPGELVTATIK---------REFSEEALNTLIKTTQEKKELYEKIDY 458
NEW L D E +T+ +K FS L++ I T ++I
Sbjct: 1295 --PNEWHLENSSKD--EHLTSILKMIGISDSDAHMFSMRRLDSSIITAD------KRIPS 1344
Query: 459 LFVNGTTIYTGYVDDPRNTDNAWIE 533
+ + + ++ +TDNAW E
Sbjct: 1345 NDTSPAHLASEVAENENDTDNAWTE 1369
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,093,837
Number of Sequences: 369166
Number of extensions: 1718215
Number of successful extensions: 5392
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5164
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5375
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7260540000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)