Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_G12
(844 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chrom... 213 4e-55
sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein 106 7e-23
sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regul... 105 2e-22
sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regul... 104 3e-22
sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein) 103 8e-22
sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein 95 2e-19
sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-rela... 95 3e-19
sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein) 94 4e-19
sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-relate... 94 5e-19
sp|Q9UN36|NDRG2_HUMAN NDRG2 protein (Syld709613 protein) 90 9e-18
>sp|O02485|YDJ1_CAEEL Hypothetical protein ZK1073.1 in chromosome X
Length = 325
Score = 213 bits (543), Expect = 4e-55
Identities = 107/279 (38%), Positives = 176/279 (63%), Gaps = 4/279 (1%)
Frame = +3
Query: 6 CGNVNIFIQGN--RSSNEIIIFTIHDLGCNHKEYVQFIDHISMRHLKNRCVWIHLDIPGQ 179
CG +++++QGN + II T+HD+G NHK +V+F++H SM +K + +++H+ +PGQ
Sbjct: 16 CGVLHVYVQGNLEERGGKTIILTVHDIGTNHKSFVRFVNHPSMATVKEKAIFLHVCVPGQ 75
Query: 180 GDNEDELKLKEFPTMQEIADDVKIIFDELSIQHAVLFGEGAGANILARFAMSYDEKVLGI 359
DN + +FPT+ I DD+ + D+ ++ A+ FGEG GANI+ RFAM + +++GI
Sbjct: 76 EDNSADF-FGDFPTLDGIGDDLSAVLDKFEVKSAIAFGEGVGANIICRFAMGHPNRIMGI 134
Query: 360 VLIHCTGTTAGIKEAIRDKLITWKLNTSGMNPVAESYLVVHRFGEQINTNNENEFREMIN 539
VL+HCT TTAGI E ++K++ +L S M+ A YL+ H+FG + + E
Sbjct: 135 VLVHCTSTTAGIIEYCKEKVMNMRLENSIMSDGAWDYLLAHKFGGESKSRQE-------- 186
Query: 540 GFKKNLQSSINPKNLNKFILSFMNRTNIAEKINQL--KCPALFVTGTLASHNHTVMTLYN 713
+ + L++++NPKNL+K++++F RT+++ I AL VTG+ ASH HTV T +
Sbjct: 187 -YLEELKATLNPKNLSKYLVAFTKRTDLSSTIGTKLETVDALLVTGSKASHLHTVYTTHK 245
Query: 714 TLQKFVKDNPERLKKLELVQVNGVANVLKEKPEKIAESL 830
++ K KK L+ V+ VA+V++E P+K+A SL
Sbjct: 246 SMNK---------KKTTLLVVDNVADVMQEAPDKLARSL 275
>sp|Q9UGV2|NDRG3_HUMAN NDRG3 protein
Length = 375
Score = 106 bits (265), Expect = 7e-23
Identities = 81/291 (27%), Positives = 134/291 (46%), Gaps = 13/291 (4%)
Frame = +3
Query: 9 GNVNIFIQGNRSSNEIIIFTIHDLGCNHKE-YVQFIDHISMRHLKNRCVWIHLDIPGQGD 185
G V++ I+G N +I T HD+G NHK + F + M+ + H+D PGQ +
Sbjct: 40 GVVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNAFFNFEDMQEITQHFAVCHVDAPGQQE 99
Query: 186 NEDELKLK-EFPTMQEIADDVKIIFDELSIQHAVLFGEGAGANILARFAMSYDEKVLGIV 362
++PTM E+A+ + + LS++ + G GAGA IL+RFA+++ E V G+V
Sbjct: 100 GAPSFPTGYQYPTMDELAEMLPPVLTHLSLKSIIGIGVGAGAYILSRFALNHPELVEGLV 159
Query: 363 LIHCTGTTAGIKEAIRDKLITWKLNTSGMNPVAESYLVVHRFG-EQINTNNENEFREMIN 539
LI+ G + KL SG+ ++ H FG E++ N ++I
Sbjct: 160 LINVDPCAKGWIDWAASKL-------SGLTTNVVDIILAHHFGQEELQAN-----LDLIQ 207
Query: 540 GFKKNLQSSINPKNLNKFILSFMNRTNIA----------EKINQLKCPALFVTGTLASHN 689
++ ++ IN NL F+ S+ R ++ K LKC L V G +
Sbjct: 208 TYRMHIAQDINQDNLQLFLNSYNGRRDLEIERPILGQNDNKSKTLKCSTLLVVGDNSPAV 267
Query: 690 HTVMTLYNTLQKFVKDNPERLKKLELVQVNGVANVLKEKPEKIAESLQYFL 842
V+ + L NP L++ G+ V+ +P K+ E+ +YFL
Sbjct: 268 EAVVECNSRL------NPINTTLLKMADCGGLPQVV--QPGKLTEAFKYFL 310
>sp|Q92597|NDRG1_HUMAN NDRG1 protein (N-myc downstream regulated gene 1 protein)
(Differentiation-related gene 1 protein) (DRG1)
(Reducing agents and tunicamycin-responsive protein)
(RTP) (Nickel-specific induction protein Cap43) (Rit42)
Length = 394
Score = 105 bits (261), Expect = 2e-22
Identities = 74/287 (25%), Positives = 137/287 (47%), Gaps = 9/287 (3%)
Frame = +3
Query: 9 GNVNIFIQGNRSSNEIIIFTIHDLGCNHKE-YVQFIDHISMRHLKNRCVWIHLDIPGQGD 185
G+V++ + G N +I T HD+G NHK Y ++ M+ + H+D PGQ D
Sbjct: 42 GSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQD 101
Query: 186 NEDELKLKE-FPTMQEIADDVKIIFDELSIQHAVLFGEGAGANILARFAMSYDEKVLGIV 362
+P+M ++A+ + + + ++ + G GAGA IL RFA++ E V G+V
Sbjct: 102 GAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLV 161
Query: 363 LIHCTGTTAGIKEAIRDKLITWKLNTSGMNPVAESYLVVHRFGEQINTNNENEFREMING 542
LI+ G + K+ SG +V H FG++ +N E+++
Sbjct: 162 LINVNPCAEGWMDWAASKI-------SGWTQALPDMVVSHLFGKEEMQSNV----EVVHT 210
Query: 543 FKKNLQSSINPKNLNKFILSFMNRTNI-------AEKINQLKCPALFVTGTLASHNHTVM 701
+++++ + +NP NL+ FI ++ +R ++ L+CPAL V G + V+
Sbjct: 211 YRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVV 270
Query: 702 TLYNTLQKFVKDNPERLKKLELVQVNGVANVLKEKPEKIAESLQYFL 842
+ L +P + L++ G+ + +P K+AE+ +YF+
Sbjct: 271 ECNSKL------DPTKTTLLKMADCGGLPQI--SQPAKLAEAFKYFV 309
>sp|Q62433|NDRG1_MOUSE NDRG1 protein (N-myc downstream regulated gene 1 protein) (Protein
Ndr1)
Length = 394
Score = 104 bits (260), Expect = 3e-22
Identities = 73/287 (25%), Positives = 137/287 (47%), Gaps = 9/287 (3%)
Frame = +3
Query: 9 GNVNIFIQGNRSSNEIIIFTIHDLGCNHKE-YVQFIDHISMRHLKNRCVWIHLDIPGQGD 185
G++++ + G N +I T HD+G NHK Y + M+ + H+D PGQ D
Sbjct: 42 GSLHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNSEDMQEITQHFAVCHVDAPGQQD 101
Query: 186 NEDELKLKE-FPTMQEIADDVKIIFDELSIQHAVLFGEGAGANILARFAMSYDEKVLGIV 362
+ +P+M ++A+ + + + ++ + G GAGA IL RFA++ E V G+V
Sbjct: 102 GAPSFPVGYMYPSMDQLAEMLPGVLHQFGLKSVIGMGTGAGAYILTRFALNNPEMVEGLV 161
Query: 363 LIHCTGTTAGIKEAIRDKLITWKLNTSGMNPVAESYLVVHRFGEQINTNNENEFREMING 542
L++ G + K+ SG +V H FG++ NN E+++
Sbjct: 162 LMNVNPCAEGWMDWAASKI-------SGWTQALPDMVVSHLFGKEEIHNNV----EVVHT 210
Query: 543 FKKNLQSSINPKNLNKFILSFMNRTNI-------AEKINQLKCPALFVTGTLASHNHTVM 701
+++++ + +NP NL+ FI ++ +R ++ L+CPAL V G + V+
Sbjct: 211 YRQHILNDMNPSNLHLFISAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDNSPAVDAVV 270
Query: 702 TLYNTLQKFVKDNPERLKKLELVQVNGVANVLKEKPEKIAESLQYFL 842
+ L +P + L++ G+ + +P K+AE+ +YF+
Sbjct: 271 ECNSKL------DPTKTTLLKMADCGGLPQI--SQPAKLAEAFKYFV 309
>sp|Q9QYF9|NDRG3_MOUSE NDRG3 protein (Ndr3 protein)
Length = 375
Score = 103 bits (256), Expect = 8e-22
Identities = 79/291 (27%), Positives = 135/291 (46%), Gaps = 13/291 (4%)
Frame = +3
Query: 9 GNVNIFIQGNRSSNEIIIFTIHDLGCNHKE-YVQFIDHISMRHLKNRCVWIHLDIPGQGD 185
G V++ I+G N +I T HD+G NHK + F + M+ + H+D PGQ +
Sbjct: 40 GMVHVTIRGLPKGNRPVILTYHDIGLNHKSCFNTFFNFEDMQEITQHFAVCHVDAPGQQE 99
Query: 186 NEDELKLK-EFPTMQEIADDVKIIFDELSIQHAVLFGEGAGANILARFAMSYDEKVLGIV 362
++PTM E+A+ + + LS++ + G GAGA IL+RFA+++ E V G+V
Sbjct: 100 AAPSFPTGYQYPTMDELAEMLPPVLTHLSMKSIIGIGVGAGAYILSRFALNHPELVEGLV 159
Query: 363 LIHCTGTTAGIKEAIRDKLITWKLNTSGMNPVAESYLVVHRFG-EQINTNNENEFREMIN 539
LI+ G + KL SG ++ H FG E++ N ++I
Sbjct: 160 LINIDPCAKGWIDWAASKL-------SGFTTNIVDIILAHHFGQEELQAN-----LDLIQ 207
Query: 540 GFKKNLQSSINPKNLNKFILSFMNRTNIA----------EKINQLKCPALFVTGTLASHN 689
++ ++ IN +NL F+ S+ R ++ ++ LKC L V G +
Sbjct: 208 TYRLHIAQDINQENLQLFLGSYNGRRDLEIERPILGQNDNRLKTLKCSTLLVVGDNSPAV 267
Query: 690 HTVMTLYNTLQKFVKDNPERLKKLELVQVNGVANVLKEKPEKIAESLQYFL 842
V+ + L +P L++ G+ V+ +P K+ E+ +YFL
Sbjct: 268 EAVVECNSRL------DPINTTLLKMADCGGLPQVV--QPGKLTEAFKYFL 310
>sp|Q8BTG7|NDRG4_MOUSE NDRG4 protein
Length = 352
Score = 95.1 bits (235), Expect = 2e-19
Identities = 71/287 (24%), Positives = 129/287 (44%), Gaps = 9/287 (3%)
Frame = +3
Query: 9 GNVNIFIQGNRSSNEIIIFTIHDLGCNHKE-YVQFIDHISMRHLKNRCVWIHLDIPGQGD 185
G +++ I+G+ N I T HD+G NHK + F + M+ + V H+D PGQ
Sbjct: 16 GLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQV 75
Query: 186 NEDELKLK-EFPTMQEIADDVKIIFDELSIQHAVLFGEGAGANILARFAMSYDEKVLGIV 362
+ +FP+M+++A + + ++ + G GAGA +LA+FA+ + + V G+V
Sbjct: 76 GASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLV 135
Query: 363 LIHCTGTTAGIKEAIRDKLITWKLNTSGMNPVAESYLVVHRFGEQINTNNENEFREMING 542
L++ G + KL SG+ ++ H F ++ NN E++
Sbjct: 136 LMNIDPNGKGWIDWAATKL-------SGLTSTLPDTVLSHLFSQEELVNN----TELVQS 184
Query: 543 FKKNLQSSINPKNLNKFILSF-------MNRTNIAEKINQLKCPALFVTGTLASHNHTVM 701
+++ + + +N NL F + +NR L+CP + V G A V+
Sbjct: 185 YRQQISNVVNQANLQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEEGVV 244
Query: 702 TLYNTLQKFVKDNPERLKKLELVQVNGVANVLKEKPEKIAESLQYFL 842
+ L +P L++ G+ V +P K+ E+ +YFL
Sbjct: 245 ECNSKL------DPTTTTFLKMADSGGLPQV--TQPGKLTEAFKYFL 283
>sp|Q9ULP0|NDRG4_HUMAN NDRG4 protein (Brain development-related molecule 1) (Vascular
smooth muscle cell associated protein 8) (SMAP-8)
Length = 352
Score = 94.7 bits (234), Expect = 3e-19
Identities = 71/287 (24%), Positives = 129/287 (44%), Gaps = 9/287 (3%)
Frame = +3
Query: 9 GNVNIFIQGNRSSNEIIIFTIHDLGCNHKE-YVQFIDHISMRHLKNRCVWIHLDIPGQGD 185
G +++ I+G+ N I T HD+G NHK + F + M+ + V H+D PGQ
Sbjct: 16 GLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQV 75
Query: 186 NEDELKLK-EFPTMQEIADDVKIIFDELSIQHAVLFGEGAGANILARFAMSYDEKVLGIV 362
+ +FP+M+++A + + ++ + G GAGA +LA+FA+ + + V G+V
Sbjct: 76 GASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLV 135
Query: 363 LIHCTGTTAGIKEAIRDKLITWKLNTSGMNPVAESYLVVHRFGEQINTNNENEFREMING 542
L++ G + KL SG+ ++ H F ++ NN E++
Sbjct: 136 LVNIDPNGKGWIDWAATKL-------SGLTSTLPDTVLSHLFSQEELVNN----TELVQS 184
Query: 543 FKKNLQSSINPKNLNKFILSF-------MNRTNIAEKINQLKCPALFVTGTLASHNHTVM 701
+++ + + +N NL F + +NR L+CP + V G A V+
Sbjct: 185 YRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGVV 244
Query: 702 TLYNTLQKFVKDNPERLKKLELVQVNGVANVLKEKPEKIAESLQYFL 842
+ L +P L++ G+ V +P K+ E+ +YFL
Sbjct: 245 ECNSKL------DPTTTTFLKMADSGGLPQV--TQPGKLTEAFKYFL 283
>sp|Q9QYG0|NDRG2_MOUSE NDRG2 protein (Ndr2 protein)
Length = 371
Score = 94.4 bits (233), Expect = 4e-19
Identities = 72/283 (25%), Positives = 131/283 (46%), Gaps = 5/283 (1%)
Frame = +3
Query: 9 GNVNIFIQGNRSSNEIIIFTIHDLGCNHKEYVQFIDHIS-MRHLKNRCVWIHLDIPGQGD 185
G+V + G IFT HD+G N+K Q + M+ + V +H+D PG +
Sbjct: 48 GSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFRFGDMQEIIQNFVRVHVDAPGMEE 107
Query: 186 NEDELKLK-EFPTMQEIADDVKIIFDELSIQHAVLFGEGAGANILARFAMSYDEKVLGIV 362
L ++P++ ++AD + I L+ + G GAGA IL+R+A+++ + V G+V
Sbjct: 108 GAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGVGVGAGAYILSRYALNHPDTVEGLV 167
Query: 363 LIHCTGTTAGIKEAIRDKLITWKLNTSGMNPVAESYLVVHRFGEQINTNNENEFREMING 542
LI+ G + KL +G+ ++ H F ++ + N E+I
Sbjct: 168 LINIDPNAKGWMDWAAHKL-------TGLTSSIPDMILGHLFSQEELSGNS----ELIQK 216
Query: 543 FKKNLQSSINPKNLNKFILSFMNRTNIAEK---INQLKCPALFVTGTLASHNHTVMTLYN 713
++ +Q + N +N+ + S+ NR ++ + LKCP + V G A H V+ +
Sbjct: 217 YRGIIQHAPNLENIELYWNSYNNRRDLNFERGGETTLKCPVMLVVGDQAPHEDAVVECNS 276
Query: 714 TLQKFVKDNPERLKKLELVQVNGVANVLKEKPEKIAESLQYFL 842
L +P + L++ G + +P K+ E+ +YFL
Sbjct: 277 KL------DPTQTSFLKMADSGGQPQL--TQPGKLTEAFKYFL 311
>sp|Q9Z2L9|NDRG4_RAT NDRG4 protein (Brain development-related molecule 1)
Length = 352
Score = 94.0 bits (232), Expect = 5e-19
Identities = 71/287 (24%), Positives = 129/287 (44%), Gaps = 9/287 (3%)
Frame = +3
Query: 9 GNVNIFIQGNRSSNEIIIFTIHDLGCNHKEYVQFIDHIS-MRHLKNRCVWIHLDIPGQGD 185
G +++ I+G+ N I T HD+G NHK + ++ M+ + V H+D PGQ
Sbjct: 16 GLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTLFNLEDMQEITKHFVVCHVDAPGQQV 75
Query: 186 NEDELKLK-EFPTMQEIADDVKIIFDELSIQHAVLFGEGAGANILARFAMSYDEKVLGIV 362
+ +FP+M+++A + + ++ + G GAGA +LA+FA+ + + V G+V
Sbjct: 76 GASQFPQGYQFPSMEQLATMLPNVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLV 135
Query: 363 LIHCTGTTAGIKEAIRDKLITWKLNTSGMNPVAESYLVVHRFGEQINTNNENEFREMING 542
L++ G + KL SG+ ++ H F ++ NN E++
Sbjct: 136 LMNIDPNGKGWIDWAATKL-------SGLTSTLPDTVLSHLFSQEELVNN----TELVQS 184
Query: 543 FKKNLQSSINPKNLNKFILSF-------MNRTNIAEKINQLKCPALFVTGTLASHNHTVM 701
+++ + S +N NL F + +NR L+CP + V G A V+
Sbjct: 185 YRQQISSVVNQANLQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGVV 244
Query: 702 TLYNTLQKFVKDNPERLKKLELVQVNGVANVLKEKPEKIAESLQYFL 842
+ L +P L++ G+ V +P K+ E+ +YFL
Sbjct: 245 ECNSKL------DPTTTTFLKMADSGGLPQV--TQPGKLTEAFKYFL 283
>sp|Q9UN36|NDRG2_HUMAN NDRG2 protein (Syld709613 protein)
Length = 371
Score = 89.7 bits (221), Expect = 9e-18
Identities = 69/283 (24%), Positives = 127/283 (44%), Gaps = 5/283 (1%)
Frame = +3
Query: 9 GNVNIFIQGNRSSNEIIIFTIHDLGCNHKEYVQ-FIDHISMRHLKNRCVWIHLDIPGQGD 185
G+V + G I T HD+G N+K Q M+ + V +H+D PG +
Sbjct: 48 GSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEE 107
Query: 186 NEDELKLK-EFPTMQEIADDVKIIFDELSIQHAVLFGEGAGANILARFAMSYDEKVLGIV 362
L ++P++ ++AD + + L+ + G GAGA ILAR+A+++ + V G+V
Sbjct: 108 GAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLV 167
Query: 363 LIHCTGTTAGIKEAIRDKLITWKLNTSGMNPVAESYLVVHRFGEQINTNNENEFREMING 542
LI+ G + KL +G+ ++ H F ++ + N E+I
Sbjct: 168 LINIDPNAKGWMDWAAHKL-------TGLTSSIPEMILGHLFSQEELSGNS----ELIQK 216
Query: 543 FKKNLQSSINPKNLNKFILSFMNRTNIAEKIN---QLKCPALFVTGTLASHNHTVMTLYN 713
++ + + N N+ + S+ NR ++ + L+CP + V G A H V+ +
Sbjct: 217 YRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNS 276
Query: 714 TLQKFVKDNPERLKKLELVQVNGVANVLKEKPEKIAESLQYFL 842
L +P + L++ G + +P K+ E+ +YFL
Sbjct: 277 KL------DPTQTSFLKMADSGGQPQL--TQPGKLTEAFKYFL 311
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,384,252
Number of Sequences: 369166
Number of extensions: 1803552
Number of successful extensions: 5323
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5132
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5303
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8245425915
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)