Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_F22
(261 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 76 3e-14
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 75 4e-14
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 75 5e-14
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 75 6e-14
sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 64 1e-10
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 59 3e-09
sp|P81013|GRN1_CYPCA Granulin-1 54 1e-07
sp|P81014|GRN2_CYPCA Granulin-2 50 2e-06
sp|P81015|GRN3_CYPCA Granulin-3 46 3e-05
sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (... 43 3e-04
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 75.9 bits (185), Expect = 3e-14
Identities = 28/58 (48%), Positives = 36/58 (62%)
Frame = +3
Query: 33 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQS 206
IC + ++ C D TCC SG + CC NA+CC D LHCCP+ T CDL RC+ Q+
Sbjct: 207 ICPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVCDLRQSRCLSQN 264
Score = 67.4 bits (163), Expect = 1e-11
Identities = 23/61 (37%), Positives = 34/61 (55%)
Frame = +3
Query: 27 LNICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQS 206
+++ + C D++TCC GG CC + VCC DQ HCCP G C+ RC+H+
Sbjct: 514 MDVACGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQGTRCVHKK 573
Query: 207 N 209
+
Sbjct: 574 S 574
Score = 67.0 bits (162), Expect = 1e-11
Identities = 25/54 (46%), Positives = 31/54 (57%)
Frame = +3
Query: 36 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 197
C G+ C D TCC G CC A CC D++HCCP G +CDLV+ RC+
Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHIRCV 165
Score = 59.7 bits (143), Expect = 2e-09
Identities = 23/48 (47%), Positives = 29/48 (60%)
Frame = +3
Query: 51 ALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRC 194
A C ++TCC GG CCQ +AVCC D HCCP G TC++ + C
Sbjct: 445 ASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTCNVKARSC 492
Score = 53.9 bits (128), Expect = 1e-07
Identities = 20/46 (43%), Positives = 25/46 (54%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRC 194
C + +TCC +SG CC + AVCC D +HCCPE C C
Sbjct: 289 CPEGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRCHTEKDTC 334
Score = 46.2 bits (108), Expect = 2e-05
Identities = 21/56 (37%), Positives = 28/56 (50%)
Frame = +3
Query: 36 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 203
CQ+ A C +C + +G CC +S A+ CGD HCCP G C CI +
Sbjct: 47 CQS-PANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTCIQR 101
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 75.5 bits (184), Expect = 4e-14
Identities = 26/55 (47%), Positives = 34/55 (61%)
Frame = +3
Query: 33 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 197
+C + K C D TCC +G + CC NA+CC D LHCCP+ T CDL+ +CI
Sbjct: 205 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCI 259
Score = 65.5 bits (158), Expect = 4e-11
Identities = 25/54 (46%), Positives = 30/54 (55%)
Frame = +3
Query: 36 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 197
C + C D TCC G CC A CC D++HCCP G +CDLV+ RCI
Sbjct: 125 CPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCI 178
Score = 58.2 bits (139), Expect = 6e-09
Identities = 22/46 (47%), Positives = 28/46 (60%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRC 194
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C
Sbjct: 447 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC 492
Score = 57.0 bits (136), Expect = 1e-08
Identities = 20/49 (40%), Positives = 25/49 (51%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 203
C D ++CC GG CC Y VCC D HCCP G C +C+ +
Sbjct: 522 CHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGTKCLRK 570
Score = 55.1 bits (131), Expect = 5e-08
Identities = 20/46 (43%), Positives = 24/46 (52%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRC 194
C D TCC +G CC ++ AVCC D +HCCP G C C
Sbjct: 287 CPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTC 332
Score = 50.8 bits (120), Expect = 9e-07
Identities = 19/39 (48%), Positives = 20/39 (51%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTC 173
C TCC SG CC AVCC D HCCP+G C
Sbjct: 369 CPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKC 407
Score = 49.3 bits (116), Expect = 3e-06
Identities = 24/66 (36%), Positives = 30/66 (45%), Gaps = 2/66 (3%)
Frame = +3
Query: 3 NTW--IVERNLNICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCD 176
+TW I R L+ + C D +C + SG CC +S V C D HCCP G C
Sbjct: 47 DTWPIITSRRLDGSCQIRDHCPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCS 106
Query: 177 LVNKRC 194
K C
Sbjct: 107 ADGKSC 112
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 75.1 bits (183), Expect = 5e-14
Identities = 25/58 (43%), Positives = 36/58 (62%)
Frame = +3
Query: 33 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQS 206
+C + K C D TCC +G + CC NA+CC D LHCCP+ T CDL+ +C+ ++
Sbjct: 206 VCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCLSKN 263
Score = 65.5 bits (158), Expect = 4e-11
Identities = 24/54 (44%), Positives = 30/54 (55%)
Frame = +3
Query: 36 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 197
C + C D TCC G CC A CC D++HCCP G +CDLV+ RC+
Sbjct: 125 CPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCV 178
Score = 58.9 bits (141), Expect = 3e-09
Identities = 26/62 (41%), Positives = 37/62 (59%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEWPVVE 236
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C + + I+ PV+
Sbjct: 448 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-EKDVDFIQPPVLL 506
Query: 237 TI 242
T+
Sbjct: 507 TL 508
Score = 55.5 bits (132), Expect = 4e-08
Identities = 20/49 (40%), Positives = 25/49 (51%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 203
C D +TCC +G CC Y VCC D HCCP G C +C+ +
Sbjct: 523 CHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKCLRK 571
Score = 54.3 bits (129), Expect = 8e-08
Identities = 21/54 (38%), Positives = 27/54 (50%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPI 218
C +C + SG CC +S V CGD HCCP+G C K C S+ P+
Sbjct: 67 CPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSCFQMSDNPL 120
Score = 54.3 bits (129), Expect = 8e-08
Identities = 20/39 (51%), Positives = 21/39 (53%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTC 173
C TCC SG CC AVCC D HCCP+G TC
Sbjct: 370 CPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTC 408
Score = 53.5 bits (127), Expect = 1e-07
Identities = 19/46 (41%), Positives = 24/46 (52%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRC 194
C + TCC +G CC ++ AVCC D +HCCP G C C
Sbjct: 288 CPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHTEKGTC 333
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 74.7 bits (182), Expect = 6e-14
Identities = 26/59 (44%), Positives = 36/59 (61%)
Frame = +3
Query: 33 ICQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSN 209
+C + ++ C D TCC SG + CC NA CC D LHCCP+ T CDL+ +C+ + N
Sbjct: 207 MCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKEN 265
Score = 64.7 bits (156), Expect = 6e-11
Identities = 25/54 (46%), Positives = 30/54 (55%)
Frame = +3
Query: 36 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 197
C + + C D TCC G CC A CC D++HCCP G CDLV+ RCI
Sbjct: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCI 179
Score = 62.8 bits (151), Expect = 2e-10
Identities = 25/56 (44%), Positives = 30/56 (53%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQSNEPIEW 224
C D TCC +SG CC ++ AVCC D +HCCP G TCD C Q + W
Sbjct: 290 CPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTC-EQGPHQVPW 344
Score = 58.2 bits (139), Expect = 6e-09
Identities = 22/46 (47%), Positives = 28/46 (60%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRC 194
C +TCC S G CCQ +AVCC D+ HCCP G TC++ + C
Sbjct: 450 CPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC 495
Score = 57.4 bits (137), Expect = 1e-08
Identities = 20/49 (40%), Positives = 25/49 (51%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQ 203
C D +TCC G CC Y VCC D+ HCCP G C +C+ +
Sbjct: 527 CHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRR 575
Score = 53.9 bits (128), Expect = 1e-07
Identities = 22/46 (47%), Positives = 24/46 (52%)
Frame = +3
Query: 36 CQNGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTC 173
C N + C TCC SG CC AVCC D HCCP+G TC
Sbjct: 366 CDNVSS-CPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTC 410
Score = 49.3 bits (116), Expect = 3e-06
Identities = 20/52 (38%), Positives = 25/52 (48%)
Frame = +3
Query: 51 ALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCIHQS 206
A C +C + SG CC + AV CGD HCCP G C + C +S
Sbjct: 65 AHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRS 116
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1)
Length = 54
Score = 63.5 bits (153), Expect = 1e-10
Identities = 23/47 (48%), Positives = 28/47 (59%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 197
C +TCC + G CC Y VCC D +HCCP GT CD ++RCI
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVCDEDHRRCI 53
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 59.3 bits (142), Expect = 3e-09
Identities = 21/36 (58%), Positives = 23/36 (63%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEG 164
C D +TCC + GG CC YS VCC DQ HCCP G
Sbjct: 10 CHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVG 45
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 53.5 bits (127), Expect = 1e-07
Identities = 20/48 (41%), Positives = 25/48 (52%)
Frame = +3
Query: 54 LCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 197
+C D TCC S G CC +S CC D +HCC G CD + C+
Sbjct: 9 ICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHCDSTSTHCL 56
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 50.1 bits (118), Expect = 2e-06
Identities = 19/52 (36%), Positives = 24/52 (46%)
Frame = +3
Query: 42 NGKALCGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 197
N + C + TCC S G CC + CC D HCC G CD + C+
Sbjct: 5 NARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTLCL 56
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 45.8 bits (107), Expect = 3e-05
Identities = 18/47 (38%), Positives = 21/47 (44%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQCCQYSNAVCCGDQLHCCPEGTTCDLVNKRCI 197
C TCC S G CC + CC D HCC G CD + C+
Sbjct: 10 CPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDSTSTLCL 56
>sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (RD21)
Length = 462
Score = 42.7 bits (99), Expect = 3e-04
Identities = 21/59 (35%), Positives = 23/59 (38%), Gaps = 6/59 (10%)
Frame = +3
Query: 57 CGDQKTCCASKSGGHQC-----CQYSNAVCCGDQLHCCP-EGTTCDLVNKRCIHQSNEP 215
C + TCC G C C A CC D CCP E CDL C+ N P
Sbjct: 381 CPESNTCCCLFEYGKYCFAWGCCPLEAATCCDDNYSCCPHEYPVCDLDQGTCLLSKNSP 439
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,285,458
Number of Sequences: 369166
Number of extensions: 606301
Number of successful extensions: 2314
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1951
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2251
length of database: 68,354,980
effective HSP length: 57
effective length of database: 57,825,085
effective search space used: 1676927465
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)