Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_F15
(846 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Z2S9|FLOT2_RAT Flotillin-2 (Reggie-1) (REG-1) 333 4e-91
sp|O61492|FLOT2_DROME Flotillin-2 332 1e-90
sp|Q98TZ8|FLT2_BRARE Flotillin-2a (Reggie-1a) (REG-1) 331 2e-90
sp|O42305|FLOT2_CARAU Flotillin-2 (Reggie-1) (REG-1) 327 3e-89
sp|Q60634|FLOT2_MOUSE Flotillin-2 (Epidermal surface antige... 271 2e-72
sp|Q14254|FLOT2_HUMAN Flotillin-2 (Epidermal surface antige... 271 2e-72
sp|O61491|FLOT1_DROME Flotillin-1 214 2e-55
sp|O75955|FLOT1_HUMAN Flotillin-1 207 2e-53
sp|Q7YR41|FLOT1_PANTR Flotillin-1 207 2e-53
sp|O08917|FLOT1_MOUSE Flotillin-1 204 2e-52
>sp|Q9Z2S9|FLOT2_RAT Flotillin-2 (Reggie-1) (REG-1)
Length = 428
Score = 333 bits (854), Expect = 4e-91
Identities = 164/250 (65%), Positives = 195/250 (78%)
Frame = +3
Query: 3 PNEALAISGGCCGTGSMKTIIGGWGWAWWLVSQVQKISLEVMTLNPTCEHVETKEGVPLT 182
PNEAL +SGGCCG+ + + GGW WAWW +S Q+ISLE+MTL P CE VET EGV LT
Sbjct: 9 PNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGVALT 68
Query: 183 VTGVAQVKVMTEPSLLATACEQFLGRRRSEIEETILQTLDGHLRAILGTLTVEAIYQDRD 362
VTGVAQVK+MTE LLA ACEQFLG+ +I+ +LQTL+GHLR+ILGTLTVE IYQDRD
Sbjct: 69 VTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRD 128
Query: 363 QFAHQVREVAAPDVAKMGIEILSFTIKDVYDKVEYLNSLGRAQTAIVKRDADIGVAEAER 542
QFA VREVAAPDV +MGIEILSFTIKDVYDKV+YL+SLG+ QTA+V+RDADIGVAEAER
Sbjct: 129 QFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAER 188
Query: 543 DAGIREAECEKARMDVRYEADTEIANATRGFQLQKASFDAEVFKVRXXXXXXXXXXXXXX 722
DAGIREAEC+K +DV++ ADT+IA++ R F+LQK++F EV
Sbjct: 189 DAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGARE 248
Query: 723 XQKIRSEEIQ 752
QKIR EEI+
Sbjct: 249 QQKIRQEEIE 258
>sp|O61492|FLOT2_DROME Flotillin-2
Length = 438
Score = 332 bits (850), Expect = 1e-90
Identities = 168/263 (63%), Positives = 199/263 (75%), Gaps = 13/263 (4%)
Frame = +3
Query: 3 PNEALAISGGCCGTGSMKTIIGGWGWAWWLVSQVQKISLEVMTLNPTCEHVETKEGVPLT 182
PNEAL +SGGCCG+ +TI+GGW WAWWLV+ VQ++SL VMTLNP CE+VET +GVPLT
Sbjct: 9 PNEALIVSGGCCGSTKKRTIVGGWAWAWWLVTDVQRLSLNVMTLNPMCENVETSQGVPLT 68
Query: 183 VTGVAQVKVMTEPS-------------LLATACEQFLGRRRSEIEETILQTLDGHLRAIL 323
VTGVAQ K+M S LL TA EQFLG+ EI++TILQTL+GHLRAIL
Sbjct: 69 VTGVAQCKIMKSSSYKQTDYHNDEADELLGTASEQFLGKSVKEIKQTILQTLEGHLRAIL 128
Query: 324 GTLTVEAIYQDRDQFAHQVREVAAPDVAKMGIEILSFTIKDVYDKVEYLNSLGRAQTAIV 503
GTLTVE +Y+DRDQFA VREVAAPDV +MGIEILSFTIKDVYD V+YL SLG+AQTA+V
Sbjct: 129 GTLTVEEVYKDRDQFAALVREVAAPDVGRMGIEILSFTIKDVYDDVQYLASLGKAQTAVV 188
Query: 504 KRDADIGVAEAERDAGIREAECEKARMDVRYEADTEIANATRGFQLQKASFDAEVFKVRX 683
KRDAD GVAEA RDAGIREAECEK+ MDV+Y DT+I + TR ++LQKA+FD E+ +
Sbjct: 189 KRDADAGVAEANRDAGIREAECEKSAMDVKYSTDTKIEDNTRMYKLQKANFDQEINTAKA 248
Query: 684 XXXXXXXXXXXXXXQKIRSEEIQ 752
Q+IR+EEIQ
Sbjct: 249 ESQLAYELQAAKIRQRIRNEEIQ 271
>sp|Q98TZ8|FLT2_BRARE Flotillin-2a (Reggie-1a) (REG-1)
Length = 428
Score = 331 bits (848), Expect = 2e-90
Identities = 162/250 (64%), Positives = 198/250 (79%)
Frame = +3
Query: 3 PNEALAISGGCCGTGSMKTIIGGWGWAWWLVSQVQKISLEVMTLNPTCEHVETKEGVPLT 182
PNEAL +SGGCCG+ +GGW WAWWL++ +QKI+LE+MTL P CE VET EGV +T
Sbjct: 9 PNEALVVSGGCCGSDGKTYTVGGWAWAWWLITDIQKITLEIMTLQPKCEDVETAEGVAIT 68
Query: 183 VTGVAQVKVMTEPSLLATACEQFLGRRRSEIEETILQTLDGHLRAILGTLTVEAIYQDRD 362
VTGVAQVKVMT+ LL ACEQFLG+ +EI+ ILQTL+GHLR+ILGTLTVE IYQDRD
Sbjct: 69 VTGVAQVKVMTDNELLGYACEQFLGKTVTEIKSVILQTLEGHLRSILGTLTVEQIYQDRD 128
Query: 363 QFAHQVREVAAPDVAKMGIEILSFTIKDVYDKVEYLNSLGRAQTAIVKRDADIGVAEAER 542
QFA VREVAAPDV +MGIEILSFTIKDVYDKV+YL+SLG++QTA V+RDADIGVAEAER
Sbjct: 129 QFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKSQTAAVQRDADIGVAEAER 188
Query: 543 DAGIREAECEKARMDVRYEADTEIANATRGFQLQKASFDAEVFKVRXXXXXXXXXXXXXX 722
DAGIREAEC+K MD++++ADT++A++ R ++QKA+F+ EV +
Sbjct: 189 DAGIREAECKKEMMDIKFQADTKMADSKRELEMQKAAFNQEVNTKKAEAQLAYELQAAKE 248
Query: 723 XQKIRSEEIQ 752
QKIR EEI+
Sbjct: 249 QQKIRLEEIE 258
>sp|O42305|FLOT2_CARAU Flotillin-2 (Reggie-1) (REG-1)
Length = 428
Score = 327 bits (838), Expect = 3e-89
Identities = 161/250 (64%), Positives = 195/250 (78%)
Frame = +3
Query: 3 PNEALAISGGCCGTGSMKTIIGGWGWAWWLVSQVQKISLEVMTLNPTCEHVETKEGVPLT 182
PNEAL +SG CCG+ + ++GGW WAWWL+S Q+I+LE+MTL P CE VET EGV +T
Sbjct: 9 PNEALVVSGACCGSDAKTYVVGGWAWAWWLISDTQRITLEIMTLQPKCEDVETAEGVAIT 68
Query: 183 VTGVAQVKVMTEPSLLATACEQFLGRRRSEIEETILQTLDGHLRAILGTLTVEAIYQDRD 362
VTGVAQVKVMT+ LLA ACEQFLG+ EI+ +LQTL+GHLR+ILGTLTVE IYQDRD
Sbjct: 69 VTGVAQVKVMTDQDLLAVACEQFLGKSVMEIKAVVLQTLEGHLRSILGTLTVEQIYQDRD 128
Query: 363 QFAHQVREVAAPDVAKMGIEILSFTIKDVYDKVEYLNSLGRAQTAIVKRDADIGVAEAER 542
+FA VREVAAPDV +MGIEILSFTIKDVYDK++YL+SLG+ QTA V+RDADIGVAEAER
Sbjct: 129 EFARLVREVAAPDVGRMGIEILSFTIKDVYDKLDYLSSLGKTQTAAVQRDADIGVAEAER 188
Query: 543 DAGIREAECEKARMDVRYEADTEIANATRGFQLQKASFDAEVFKVRXXXXXXXXXXXXXX 722
DAGIREAEC+K MDV++ ADT +A++ R +LQKA+F+ EV +
Sbjct: 189 DAGIREAECKKEMMDVKFLADTRMADSKRELELQKAAFNQEVNTKKAESQLAYELEAAKE 248
Query: 723 XQKIRSEEIQ 752
QKIR EEI+
Sbjct: 249 QQKIRLEEIE 258
>sp|Q60634|FLOT2_MOUSE Flotillin-2 (Epidermal surface antigen) (ESA)
Length = 379
Score = 271 bits (693), Expect = 2e-72
Identities = 140/209 (66%), Positives = 164/209 (78%)
Frame = +3
Query: 126 MTLNPTCEHVETKEGVPLTVTGVAQVKVMTEPSLLATACEQFLGRRRSEIEETILQTLDG 305
MTL P CE VET EGV LTVTGVAQVK+MTE LLA ACEQFLG+ +I+ +LQTL+G
Sbjct: 1 MTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEG 60
Query: 306 HLRAILGTLTVEAIYQDRDQFAHQVREVAAPDVAKMGIEILSFTIKDVYDKVEYLNSLGR 485
HLR+ILGTLTVE IYQDRDQFA VREVAAPDV +MGIEILSFTIKDVYDKV+YL+SLG+
Sbjct: 61 HLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGK 120
Query: 486 AQTAIVKRDADIGVAEAERDAGIREAECEKARMDVRYEADTEIANATRGFQLQKASFDAE 665
QTA+V+RDADIGVAEAERDAGIREAEC+K +DV++ ADT+IA++ R F+LQK++F E
Sbjct: 121 TQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEE 180
Query: 666 VFKVRXXXXXXXXXXXXXXXQKIRSEEIQ 752
V QKIR EEI+
Sbjct: 181 VNIKTAEAQLAYELQGAREQQKIRQEEIE 209
>sp|Q14254|FLOT2_HUMAN Flotillin-2 (Epidermal surface antigen) (ESA)
Length = 379
Score = 271 bits (693), Expect = 2e-72
Identities = 140/209 (66%), Positives = 164/209 (78%)
Frame = +3
Query: 126 MTLNPTCEHVETKEGVPLTVTGVAQVKVMTEPSLLATACEQFLGRRRSEIEETILQTLDG 305
MTL P CE VET EGV LTVTGVAQVK+MTE LLA ACEQFLG+ +I+ +LQTL+G
Sbjct: 1 MTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEG 60
Query: 306 HLRAILGTLTVEAIYQDRDQFAHQVREVAAPDVAKMGIEILSFTIKDVYDKVEYLNSLGR 485
HLR+ILGTLTVE IYQDRDQFA VREVAAPDV +MGIEILSFTIKDVYDKV+YL+SLG+
Sbjct: 61 HLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGK 120
Query: 486 AQTAIVKRDADIGVAEAERDAGIREAECEKARMDVRYEADTEIANATRGFQLQKASFDAE 665
QTA+V+RDADIGVAEAERDAGIREAEC+K +DV++ ADT+IA++ R F+LQK++F E
Sbjct: 121 TQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEE 180
Query: 666 VFKVRXXXXXXXXXXXXXXXQKIRSEEIQ 752
V QKIR EEI+
Sbjct: 181 VNIKTAEAQLAYELQGAREQQKIRQEEIE 209
>sp|O61491|FLOT1_DROME Flotillin-1
Length = 426
Score = 214 bits (545), Expect = 2e-55
Identities = 123/253 (48%), Positives = 166/253 (65%), Gaps = 3/253 (1%)
Frame = +3
Query: 3 PNEALAISGGCCGTGSMKTII--GGWGWAWWLVSQVQKISLEVMTLNPTCEHVETKEGVP 176
PNEAL +SG CC MK ++ GG + W + QVQ+ISL MTL V T +GVP
Sbjct: 10 PNEALVVSG-CC---YMKPLLVPGGRAFVWPVGQQVQRISLNTMTLQVESPCVYTSQGVP 65
Query: 177 LTVTGVAQVKVMTE-PSLLATACEQFLGRRRSEIEETILQTLDGHLRAILGTLTVEAIYQ 353
++VTG+AQVKV + +L TACEQFLG+ +EI L TL+GH RAI+G++TVE IY+
Sbjct: 66 ISVTGIAQVKVQGQNEDMLLTACEQFLGKSEAEINHIALVTLEGHQRAIMGSMTVEEIYK 125
Query: 354 DRDQFAHQVREVAAPDVAKMGIEILSFTIKDVYDKVEYLNSLGRAQTAIVKRDADIGVAE 533
DR +F+ QV EVA+ D+A MGI ++S+TIKD+ D+ YL SLG A+TA VKRDA IG AE
Sbjct: 126 DRKKFSKQVFEVASSDLANMGITVVSYTIKDLRDEEGYLRSLGMARTAEVKRDARIGEAE 185
Query: 534 AERDAGIREAECEKARMDVRYEADTEIANATRGFQLQKASFDAEVFKVRXXXXXXXXXXX 713
A +A I+EA E+ RM R+ DT+IA A R F+L+KA++D EV +
Sbjct: 186 ARAEAHIKEAIAEEQRMAARFLNDTDIAKAQRDFELKKAAYDVEVQTKKAEAEMAYELQA 245
Query: 714 XXXXQKIRSEEIQ 752
Q+I+ E++Q
Sbjct: 246 AKTKQRIKEEQMQ 258
>sp|O75955|FLOT1_HUMAN Flotillin-1
Length = 427
Score = 207 bits (528), Expect = 2e-53
Identities = 108/251 (43%), Positives = 166/251 (66%), Gaps = 1/251 (0%)
Frame = +3
Query: 3 PNEALAISGGCCGTGSMKTIIGGWGWAWWLVSQVQKISLEVMTLNPTCEHVETKEGVPLT 182
PNEA+ +SG C M + GG + + Q+Q+ISL +TLN E V T+ GVP++
Sbjct: 7 PNEAMVVSGFCRSPPVM--VAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPIS 64
Query: 183 VTGVAQVKVMTE-PSLLATACEQFLGRRRSEIEETILQTLDGHLRAILGTLTVEAIYQDR 359
VTG+AQVK+ + +LA AC+ FLG+ +EI L+TL+GH RAI+ +TVE IY+DR
Sbjct: 65 VTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDR 124
Query: 360 DQFAHQVREVAAPDVAKMGIEILSFTIKDVYDKVEYLNSLGRAQTAIVKRDADIGVAEAE 539
+F+ QV +VA+ D+ MGI ++S+T+KD++D +YL+SLG+A+TA V++DA IG AEA+
Sbjct: 125 QKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAK 184
Query: 540 RDAGIREAECEKARMDVRYEADTEIANATRGFQLQKASFDAEVFKVRXXXXXXXXXXXXX 719
RDAGIREA+ ++ ++ +Y ++ E+A A R ++L+KA++D EV R
Sbjct: 185 RDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAK 244
Query: 720 XXQKIRSEEIQ 752
Q+I + +Q
Sbjct: 245 TKQQIEEQRVQ 255
>sp|Q7YR41|FLOT1_PANTR Flotillin-1
Length = 427
Score = 207 bits (528), Expect = 2e-53
Identities = 108/251 (43%), Positives = 166/251 (66%), Gaps = 1/251 (0%)
Frame = +3
Query: 3 PNEALAISGGCCGTGSMKTIIGGWGWAWWLVSQVQKISLEVMTLNPTCEHVETKEGVPLT 182
PNEA+ +SG C M + GG + + Q+Q+ISL +TLN E V T+ GVP++
Sbjct: 7 PNEAMVVSGFCRSPPVM--VAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPIS 64
Query: 183 VTGVAQVKVMTE-PSLLATACEQFLGRRRSEIEETILQTLDGHLRAILGTLTVEAIYQDR 359
VTG+AQVK+ + +LA AC+ FLG+ +EI L+TL+GH RAI+ +TVE IY+DR
Sbjct: 65 VTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDR 124
Query: 360 DQFAHQVREVAAPDVAKMGIEILSFTIKDVYDKVEYLNSLGRAQTAIVKRDADIGVAEAE 539
+F+ QV +VA+ D+ MGI ++S+T+KD++D +YL+SLG+A+TA V++DA IG AEA+
Sbjct: 125 QKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAK 184
Query: 540 RDAGIREAECEKARMDVRYEADTEIANATRGFQLQKASFDAEVFKVRXXXXXXXXXXXXX 719
RDAGIREA+ ++ ++ +Y ++ E+A A R ++L+KA++D EV R
Sbjct: 185 RDAGIREAKAKQEKVSAQYLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAK 244
Query: 720 XXQKIRSEEIQ 752
Q+I + +Q
Sbjct: 245 TKQQIEEQRVQ 255
>sp|O08917|FLOT1_MOUSE Flotillin-1
Length = 428
Score = 204 bits (519), Expect = 2e-52
Identities = 107/251 (42%), Positives = 165/251 (65%), Gaps = 1/251 (0%)
Frame = +3
Query: 3 PNEALAISGGCCGTGSMKTIIGGWGWAWWLVSQVQKISLEVMTLNPTCEHVETKEGVPLT 182
PNEA+ +SG C M + GG + + Q+Q+ISL +TLN E V T+ GVP++
Sbjct: 7 PNEAMVVSGFCRSPPVM--VAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPIS 64
Query: 183 VTGVAQVKVMTE-PSLLATACEQFLGRRRSEIEETILQTLDGHLRAILGTLTVEAIYQDR 359
VTG+AQVK+ + +LA AC+ FLG+ +EI L+TL+GH RAI+ +TVE IY+DR
Sbjct: 65 VTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDR 124
Query: 360 DQFAHQVREVAAPDVAKMGIEILSFTIKDVYDKVEYLNSLGRAQTAIVKRDADIGVAEAE 539
+F+ QV +VA+ D+ MGI ++S+T+KD++D +YL+SLG+A+TA V++DA IG AEA+
Sbjct: 125 QKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAK 184
Query: 540 RDAGIREAECEKARMDVRYEADTEIANATRGFQLQKASFDAEVFKVRXXXXXXXXXXXXX 719
RDAGIREA+ ++ ++ + ++ E+A A R ++L+KA++D EV R
Sbjct: 185 RDAGIREAKAKQEKVSAQCLSEIEMAKAQRDYELKKATYDIEVNTRRAQADLAYQLQVAK 244
Query: 720 XXQKIRSEEIQ 752
Q+I + +Q
Sbjct: 245 TKQQIEEQRVQ 255
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,711,460
Number of Sequences: 369166
Number of extensions: 1530023
Number of successful extensions: 5284
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4989
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5259
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)