Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_F04
(601 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q5G265|NETR_SAGLB Neurotrypsin precursor 119 8e-27
sp|Q5G268|NETR_HYLLE Neurotrypsin precursor 115 8e-26
sp|P56730|NETR_HUMAN Neurotrypsin precursor (Motopsin) (Ley... 115 1e-25
sp|Q5G266|NETR_TRAPH Neurotrypsin precursor 115 1e-25
sp|Q5G269|NETR_PONPY Neurotrypsin precursor 115 1e-25
sp|Q5G271|NETR_PANTR Neurotrypsin precursor 115 1e-25
sp|Q5G267|NETR_MACMU Neurotrypsin precursor 115 1e-25
sp|Q5G270|NETR_GORGO Neurotrypsin precursor 114 2e-25
sp|O08762|NETR_MOUSE Neurotrypsin precursor (Motopsin) (Bra... 107 2e-23
sp|O15393|TMPS2_HUMAN Transmembrane protease, serine 2 prec... 99 6e-21
>sp|Q5G265|NETR_SAGLB Neurotrypsin precursor
Length = 875
Score = 119 bits (297), Expect = 8e-27
Identities = 63/195 (32%), Positives = 103/195 (52%), Gaps = 5/195 (2%)
Frame = +1
Query: 19 GEHKCTHKEDIGVICGLXXXXXXXXXXXXXVKVDAGGDSKCGKRPIVQKRGRVVGGFEAV 198
G H C H ED GVIC + S CG R + +++ R++GG ++
Sbjct: 585 GRHNCRHSEDAGVICDYFGKKASGNSNKESLS------SVCGLRLLHRRQKRIIGGKNSL 638
Query: 199 YGGFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKNE---YRVRTGDWDNS 366
GG+PWQV +R K D CGA++LS W++ AAHC+ R N Y VR GD+
Sbjct: 639 RGGWPWQVSLRLKSSHRDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRNYAVRVGDYHTL 698
Query: 367 ADNNDKYEQVFEIEELILHPNWNNANYDYDLALIKIERNDGVGIKFNNYVQPVCLPKLGM 546
+++E+ ++E+++H + + DYD+AL++++ + +FN++V P CLP
Sbjct: 699 VP--EEFEEEIGVQEIVIHREYRPDSSDYDIALVRLQGPEEQCARFNSHVLPACLPLWRE 756
Query: 547 MPDPN-TKCYVSGLG 588
P + CY++G G
Sbjct: 757 RPQKTASNCYITGWG 771
Score = 39.7 bits (91), Expect = 0.006
Identities = 14/21 (66%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
CP WGEH C HKED GV C
Sbjct: 359 CPKSSWGEHNCGHKEDAGVSC 379
Score = 35.4 bits (80), Expect = 0.11
Identities = 10/21 (47%), Positives = 15/21 (71%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
C +WG H C+H+ED+G+ C
Sbjct: 465 CSRRQWGRHDCSHREDVGIAC 485
>sp|Q5G268|NETR_HYLLE Neurotrypsin precursor
Length = 875
Score = 115 bits (288), Expect = 8e-26
Identities = 61/195 (31%), Positives = 103/195 (52%), Gaps = 5/195 (2%)
Frame = +1
Query: 19 GEHKCTHKEDIGVICGLXXXXXXXXXXXXXVKVDAGGDSKCGKRPIVQKRGRVVGGFEAV 198
G H C H ED GVIC + S CG R + +++ R++GG ++
Sbjct: 585 GRHNCRHSEDAGVICDYFGKKASGNSNKESLS------SVCGLRLLHRRQKRIIGGKNSL 638
Query: 199 YGGFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKNE---YRVRTGDWDNS 366
GG+PWQV +R K D CGA++LS W++ AAHC+ R N Y VR GD+
Sbjct: 639 RGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRNYAVRVGDYHTL 698
Query: 367 ADNNDKYEQVFEIEELILHPNWNNANYDYDLALIKIERNDGVGIKFNNYVQPVCLPKLGM 546
+++E+ ++++++H + + DYD+AL++++ + +F+++V P CLP
Sbjct: 699 VP--EEFEEEIGVQQIVIHREYRPDSSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRE 756
Query: 547 MPDPN-TKCYVSGLG 588
P + CY++G G
Sbjct: 757 RPQKTASNCYITGWG 771
Score = 39.7 bits (91), Expect = 0.006
Identities = 14/21 (66%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
CP WGEH C HKED GV C
Sbjct: 359 CPKSSWGEHNCGHKEDAGVSC 379
Score = 33.1 bits (74), Expect = 0.55
Identities = 9/21 (42%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
C +WG H C+H+ED+ + C
Sbjct: 465 CSRRQWGRHDCSHREDVSIAC 485
>sp|P56730|NETR_HUMAN Neurotrypsin precursor (Motopsin) (Leydin)
Length = 875
Score = 115 bits (287), Expect = 1e-25
Identities = 61/195 (31%), Positives = 102/195 (52%), Gaps = 5/195 (2%)
Frame = +1
Query: 19 GEHKCTHKEDIGVICGLXXXXXXXXXXXXXVKVDAGGDSKCGKRPIVQKRGRVVGGFEAV 198
G H C H ED GVIC + S CG R + +++ R++GG ++
Sbjct: 585 GRHNCRHSEDAGVICDYFGKKASGNSNKESLS------SVCGLRLLHRRQKRIIGGKNSL 638
Query: 199 YGGFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKNE---YRVRTGDWDNS 366
GG+PWQV +R K D CGA++LS W++ AAHC+ R N Y VR GD+
Sbjct: 639 RGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTL 698
Query: 367 ADNNDKYEQVFEIEELILHPNWNNANYDYDLALIKIERNDGVGIKFNNYVQPVCLPKLGM 546
+++E+ ++++++H + DYD+AL++++ + +F+++V P CLP
Sbjct: 699 VP--EEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRE 756
Query: 547 MPDPN-TKCYVSGLG 588
P + CY++G G
Sbjct: 757 RPQKTASNCYITGWG 771
Score = 39.7 bits (91), Expect = 0.006
Identities = 14/21 (66%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
CP WGEH C HKED GV C
Sbjct: 359 CPKSSWGEHNCGHKEDAGVSC 379
Score = 33.1 bits (74), Expect = 0.55
Identities = 9/21 (42%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
C +WG H C+H+ED+ + C
Sbjct: 465 CSRRQWGRHDCSHREDVSIAC 485
>sp|Q5G266|NETR_TRAPH Neurotrypsin precursor
Length = 875
Score = 115 bits (287), Expect = 1e-25
Identities = 61/195 (31%), Positives = 103/195 (52%), Gaps = 5/195 (2%)
Frame = +1
Query: 19 GEHKCTHKEDIGVICGLXXXXXXXXXXXXXVKVDAGGDSKCGKRPIVQKRGRVVGGFEAV 198
G H C H ED GVIC + S CG R + +++ R++GG ++
Sbjct: 585 GRHNCRHSEDAGVICDYFGKKASGNSNKESLS------SVCGLRLLHRRQKRIIGGKNSL 638
Query: 199 YGGFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKNE---YRVRTGDWDNS 366
GG+PWQV +R K D CGA++LS W++ AAHC+ R N Y VR GD+
Sbjct: 639 RGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRNYAVRVGDYHTL 698
Query: 367 ADNNDKYEQVFEIEELILHPNWNNANYDYDLALIKIERNDGVGIKFNNYVQPVCLPKLGM 546
+++E+ ++++++H + + DYD+AL++++ + +F+++V P CLP
Sbjct: 699 VP--EEFEEEIGVQQIVIHREYRPDSSDYDIALVRLQGPEEQCARFSSHVLPACLPFWRE 756
Query: 547 MPDPN-TKCYVSGLG 588
P + CY++G G
Sbjct: 757 RPQKTASNCYITGWG 771
Score = 39.7 bits (91), Expect = 0.006
Identities = 14/21 (66%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
CP WGEH C HKED GV C
Sbjct: 359 CPKSSWGEHNCGHKEDAGVSC 379
Score = 33.1 bits (74), Expect = 0.55
Identities = 9/21 (42%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
C +WG H C+H+ED+ + C
Sbjct: 465 CSRRQWGRHDCSHREDVSIAC 485
>sp|Q5G269|NETR_PONPY Neurotrypsin precursor
Length = 877
Score = 115 bits (287), Expect = 1e-25
Identities = 61/195 (31%), Positives = 103/195 (52%), Gaps = 5/195 (2%)
Frame = +1
Query: 19 GEHKCTHKEDIGVICGLXXXXXXXXXXXXXVKVDAGGDSKCGKRPIVQKRGRVVGGFEAV 198
G H C H ED GVIC + S CG R + +++ R++GG ++
Sbjct: 587 GRHNCRHSEDAGVICDYFGKKASGNSNKESLS------SVCGLRLLHRRQKRIIGGKNSL 640
Query: 199 YGGFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKNE---YRVRTGDWDNS 366
GG+PWQV +R K D CGA++LS W++ AAHC+ R N Y VR GD+
Sbjct: 641 RGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRNYAVRVGDYHTL 700
Query: 367 ADNNDKYEQVFEIEELILHPNWNNANYDYDLALIKIERNDGVGIKFNNYVQPVCLPKLGM 546
+++E+ ++++++H + + DYD+AL++++ + +F+++V P CLP
Sbjct: 701 VP--EEFEEEVGVQQIVIHREYRPDSSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRE 758
Query: 547 MPDPN-TKCYVSGLG 588
P + CY++G G
Sbjct: 759 RPQKTASNCYITGWG 773
Score = 39.7 bits (91), Expect = 0.006
Identities = 14/21 (66%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
CP WGEH C HKED GV C
Sbjct: 361 CPKSSWGEHNCGHKEDAGVSC 381
Score = 33.1 bits (74), Expect = 0.55
Identities = 9/21 (42%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
C +WG H C+H+ED+ + C
Sbjct: 467 CSRRQWGRHDCSHREDVSIAC 487
>sp|Q5G271|NETR_PANTR Neurotrypsin precursor
Length = 875
Score = 115 bits (287), Expect = 1e-25
Identities = 61/195 (31%), Positives = 102/195 (52%), Gaps = 5/195 (2%)
Frame = +1
Query: 19 GEHKCTHKEDIGVICGLXXXXXXXXXXXXXVKVDAGGDSKCGKRPIVQKRGRVVGGFEAV 198
G H C H ED GVIC + S CG R + +++ R++GG ++
Sbjct: 585 GRHNCRHSEDAGVICDYFGKKASGNSNKESLS------SVCGLRLLHRRQKRIIGGKNSL 638
Query: 199 YGGFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKNE---YRVRTGDWDNS 366
GG+PWQV +R K D CGA++LS W++ AAHC+ R N Y VR GD+
Sbjct: 639 RGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTL 698
Query: 367 ADNNDKYEQVFEIEELILHPNWNNANYDYDLALIKIERNDGVGIKFNNYVQPVCLPKLGM 546
+++E+ ++++++H + DYD+AL++++ + +F+++V P CLP
Sbjct: 699 VP--EEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRE 756
Query: 547 MPDPN-TKCYVSGLG 588
P + CY++G G
Sbjct: 757 RPQKTASNCYITGWG 771
Score = 39.7 bits (91), Expect = 0.006
Identities = 14/21 (66%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
CP WGEH C HKED GV C
Sbjct: 359 CPKSSWGEHNCGHKEDAGVSC 379
Score = 33.1 bits (74), Expect = 0.55
Identities = 9/21 (42%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
C +WG H C+H+ED+ + C
Sbjct: 465 CSRRQWGRHDCSHREDVSIAC 485
>sp|Q5G267|NETR_MACMU Neurotrypsin precursor
Length = 875
Score = 115 bits (287), Expect = 1e-25
Identities = 61/195 (31%), Positives = 103/195 (52%), Gaps = 5/195 (2%)
Frame = +1
Query: 19 GEHKCTHKEDIGVICGLXXXXXXXXXXXXXVKVDAGGDSKCGKRPIVQKRGRVVGGFEAV 198
G H C H ED GVIC + S CG R + +++ R++GG ++
Sbjct: 585 GRHNCRHSEDAGVICDYFGKKASGNSNKESLS------SVCGLRLLHRRQKRIIGGKNSL 638
Query: 199 YGGFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKNE---YRVRTGDWDNS 366
GG+PWQV +R K D CGA++LS W++ AAHC+ R N Y VR GD+
Sbjct: 639 RGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRNYAVRVGDYHTL 698
Query: 367 ADNNDKYEQVFEIEELILHPNWNNANYDYDLALIKIERNDGVGIKFNNYVQPVCLPKLGM 546
+++E+ ++++++H + + DYD+AL++++ + +F+++V P CLP
Sbjct: 699 VP--EEFEEEIGVQQIVIHREYRPDSSDYDIALVRLQGPEEQCARFSSHVLPACLPFWRE 756
Query: 547 MPDPN-TKCYVSGLG 588
P + CY++G G
Sbjct: 757 RPQKTASNCYITGWG 771
Score = 39.7 bits (91), Expect = 0.006
Identities = 14/21 (66%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
CP WGEH C HKED GV C
Sbjct: 359 CPKSSWGEHNCGHKEDAGVSC 379
Score = 32.7 bits (73), Expect = 0.72
Identities = 9/21 (42%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
C +WG+H C+H ED+ + C
Sbjct: 465 CSRRQWGQHDCSHHEDVSIAC 485
>sp|Q5G270|NETR_GORGO Neurotrypsin precursor
Length = 876
Score = 114 bits (285), Expect = 2e-25
Identities = 61/195 (31%), Positives = 103/195 (52%), Gaps = 5/195 (2%)
Frame = +1
Query: 19 GEHKCTHKEDIGVICGLXXXXXXXXXXXXXVKVDAGGDSKCGKRPIVQKRGRVVGGFEAV 198
G H C H ED GVIC + S CG R + +++ R++GG ++
Sbjct: 586 GRHNCRHSEDAGVICDYFGKKASGNSNKESLS------SVCGLRLLHRRQKRIIGGKNSL 639
Query: 199 YGGFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKNE---YRVRTGDWDNS 366
GG+PWQV +R K D CGA++LS W++ AAHC+ R N Y VR GD+
Sbjct: 640 RGGWPWQVSLRLKSYHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRNYAVRVGDYHTL 699
Query: 367 ADNNDKYEQVFEIEELILHPNWNNANYDYDLALIKIERNDGVGIKFNNYVQPVCLPKLGM 546
+++E+ ++++++H + + DYD+AL++++ + +F+++V P CLP
Sbjct: 700 VP--EEFEEEIGVQQIVIHREYRPDSSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRE 757
Query: 547 MPDPN-TKCYVSGLG 588
P + CY++G G
Sbjct: 758 RPQKTASNCYITGWG 772
Score = 39.7 bits (91), Expect = 0.006
Identities = 14/21 (66%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
CP WGEH C HKED GV C
Sbjct: 360 CPKSSWGEHNCGHKEDAGVSC 380
Score = 33.1 bits (74), Expect = 0.55
Identities = 9/21 (42%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
C +WG H C+H+ED+ + C
Sbjct: 466 CSRRQWGRHDCSHREDVSIAC 486
>sp|O08762|NETR_MOUSE Neurotrypsin precursor (Motopsin) (Brain-specific serine protease 3)
(BSSP-3)
Length = 761
Score = 107 bits (267), Expect = 2e-23
Identities = 60/200 (30%), Positives = 101/200 (50%), Gaps = 10/200 (5%)
Frame = +1
Query: 19 GEHKCTHKEDIGVICGLXXXXXXXXXXXXXVKVDAGGD-----SKCGKRPIVQKRGRVVG 183
G H C H ED GVIC K + G+ S CG R + +++ R++G
Sbjct: 471 GRHNCRHSEDAGVICDYLEK-----------KASSSGNKEMLSSGCGLRLLHRRQKRIIG 519
Query: 184 GFEAVYGGFPWQVGVRQKVDDYDSHW-CGASILSEDWIIGAAHCYARPKNE---YRVRTG 351
G ++ G +PWQ +R + D CGA++LS W++ AAHC+ R N Y VR G
Sbjct: 520 GNNSLRGAWPWQASLRLRSAHGDGRLLCGATLLSSCWVLTAAHCFKRYGNNSRSYAVRVG 579
Query: 352 DWDNSADNNDKYEQVFEIEELILHPNWNNANYDYDLALIKIERNDGVGIKFNNYVQPVCL 531
D+ +++EQ ++++++H N+ DYD+AL++++ + + +V P CL
Sbjct: 580 DYHTLVP--EEFEQEIGVQQIVIHRNYRPDRSDYDIALVRLQGPGEQCARLSTHVLPACL 637
Query: 532 PKLGMMPDPN-TKCYVSGLG 588
P P + C+++G G
Sbjct: 638 PLWRERPQKTASNCHITGWG 657
Score = 39.7 bits (91), Expect = 0.006
Identities = 14/21 (66%), Positives = 14/21 (66%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
CP WGEH C HKED GV C
Sbjct: 245 CPKSSWGEHNCGHKEDAGVSC 265
Score = 34.7 bits (78), Expect = 0.19
Identities = 10/21 (47%), Positives = 15/21 (71%)
Frame = +1
Query: 1 CPSFKWGEHKCTHKEDIGVIC 63
C +WG H C+H+ED+G+ C
Sbjct: 351 CSRRQWGRHDCSHREDVGLTC 371
>sp|O15393|TMPS2_HUMAN Transmembrane protease, serine 2 precursor [Contains: Transmembrane
protease, serine 2 non-catalytic chain; Transmembrane
protease, serine 2 catalytic chain]
Length = 492
Score = 99.4 bits (246), Expect = 6e-21
Identities = 52/150 (34%), Positives = 85/150 (56%)
Frame = +1
Query: 139 CGKRPIVQKRGRVVGGFEAVYGGFPWQVGVRQKVDDYDSHWCGASILSEDWIIGAAHCYA 318
CG ++ R+VGG A+ G +PWQV + + + H CG SI++ +WI+ AAHC
Sbjct: 244 CGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQ----NVHVCGGSIITPEWIVTAAHCVE 299
Query: 319 RPKNEYRVRTGDWDNSADNNDKYEQVFEIEELILHPNWNNANYDYDLALIKIERNDGVGI 498
+P N T + Y +++E++I HPN+++ + D+AL+K+++ +
Sbjct: 300 KPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKP----L 355
Query: 499 KFNNYVQPVCLPKLGMMPDPNTKCYVSGLG 588
FN+ V+PVCLP GMM P C++SG G
Sbjct: 356 TFNDLVKPVCLPNPGMMLQPEQLCWISGWG 385
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,605,597
Number of Sequences: 369166
Number of extensions: 1337405
Number of successful extensions: 4259
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3509
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3628
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4602033670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)