Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_F01
(633 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 108 1e-23
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 108 1e-23
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 106 6e-23
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 106 6e-23
sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 63 7e-10
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 57 4e-08
sp|P81013|GRN1_CYPCA Granulin-1 52 1e-06
sp|P81014|GRN2_CYPCA Granulin-2 49 8e-06
sp|P81015|GRN3_CYPCA Granulin-3 45 2e-04
sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (... 43 8e-04
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 108 bits (270), Expect = 1e-23
Identities = 54/157 (34%), Positives = 72/157 (45%)
Frame = +2
Query: 47 ITPAFLERSNIINACQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTC 226
+ PA L S I C + ++ C D TCC+ SG + CC PNA+CC D +HCCP+ T C
Sbjct: 197 LLPAALPTSVI---CPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVC 253
Query: 227 DLVNKRCIHQSNEPIEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCP 406
DL RC+ Q+ ++P +T VW+ C CP
Sbjct: 254 DLRQSRCLSQNK----------AKTLLTKLPSWT------------VWDVE-CDQEVSCP 290
Query: 407 NSFPCCLLVPGQYFCCPFPGGVCCSSPPGCVPSGQQC 517
CC L G++ CCPFP VCC C P +C
Sbjct: 291 EGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRC 327
Score = 103 bits (257), Expect = 4e-22
Identities = 55/149 (36%), Positives = 70/149 (46%), Gaps = 6/149 (4%)
Frame = +2
Query: 89 CQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQ-SNE 265
C G+ C D TCC G CC P A CC D++HCCP G +CDLV+ RC+ +
Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHIRCVTALGSH 171
Query: 266 PIEWPVVKIVDPAKIEIPKYT-VERNPLRE---FIIKVWNKSTCPDG-SLCPNSFPCCLL 430
P+ + PA + YT E P+ + CPD S CP+ CCLL
Sbjct: 172 PLTTKL-----PA--QRTNYTGAEGTPVVSPGLLPAALPTSVICPDSRSQCPDDTTCCLL 224
Query: 431 VPGQYFCCPFPGGVCCSSPPGCVPSGQQC 517
G+Y CCP P +CCS C P C
Sbjct: 225 ASGEYGCCPMPNAICCSDHLHCCPQDTVC 253
Score = 90.5 bits (223), Expect = 3e-18
Identities = 47/140 (33%), Positives = 59/140 (42%)
Frame = +2
Query: 104 ALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPV 283
A C ++TCC GG CCQ P+AVCC D HCCP G TC++ + C
Sbjct: 445 ASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTCNVKARSC------------ 492
Query: 284 VKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFCCPFP 463
K D A + P + + C D C + CC G + CCPF
Sbjct: 493 EKAADGAHLAAPLAVGSTGGVMDV--------ACGDRHFCHDEQTCCRDSRGGWACCPFH 544
Query: 464 GGVCCSSPPGCVPSGQQCVS 523
GVCC C P+G C S
Sbjct: 545 QGVCCKDQRHCCPAGFHCES 564
Score = 73.2 bits (178), Expect = 5e-13
Identities = 40/144 (27%), Positives = 54/144 (37%), Gaps = 1/144 (0%)
Frame = +2
Query: 89 CQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEP 268
CQ+ A C +C ++ +G CC + A+ CGD HCCP G C CI + +
Sbjct: 47 CQS-PANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTCIQRPD-- 103
Query: 269 IEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSL-CPNSFPCCLLVPGQY 445
I + CP G CP+S CC ++ G +
Sbjct: 104 ------------------------------IHLLGAVQCPGGEFECPDSSTCCHMLDGSW 133
Query: 446 FCCPFPGGVCCSSPPGCVPSGQQC 517
CCP P CC C P G C
Sbjct: 134 GCCPMPQASCCEDRVHCCPHGASC 157
Score = 71.6 bits (174), Expect = 2e-12
Identities = 41/135 (30%), Positives = 54/135 (40%), Gaps = 6/135 (4%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C + +TCC +SG CC +P AVCC D +HCCPE C C Q + W
Sbjct: 289 CPEGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRCHTEKDTC-EQGLLQVPWAQKT 347
Query: 290 IVDPAKIEIPK------YTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFC 451
P++ P PLR I +C + C CC L G++ C
Sbjct: 348 PAQPSRPSQPSPPGPPGPPSPPGPLRSEI-------SCDEVVSCRPGNICCRLASGEWGC 400
Query: 452 CPFPGGVCCSSPPGC 496
CP G C + C
Sbjct: 401 CPSSEGYLCMAGERC 415
Score = 66.2 bits (160), Expect = 6e-11
Identities = 23/62 (37%), Positives = 34/62 (54%)
Frame = +2
Query: 77 IINACQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQ 256
+++ + C D++TCC GG CC + VCC DQ HCCP G C+ RC+H+
Sbjct: 513 VMDVACGDRHFCHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQGTRCVHK 572
Query: 257 SN 262
+
Sbjct: 573 KS 574
Score = 42.0 bits (97), Expect = 0.001
Identities = 16/45 (35%), Positives = 20/45 (44%)
Frame = +2
Query: 383 CPDGSLCPNSFPCCLLVPGQYFCCPFPGGVCCSSPPGCVPSGQQC 517
C + CP CC + G + CC P VCC C P+G C
Sbjct: 441 CDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTC 485
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 108 bits (270), Expect = 1e-23
Identities = 49/143 (34%), Positives = 65/143 (45%)
Frame = +2
Query: 89 CQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEP 268
C + K C D TCC +G + CC PNA+CC D +HCCP+ T CDL+ +CI +
Sbjct: 206 CPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCISKD--- 262
Query: 269 IEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYF 448
++P Y V N+ C CP+ + CC L G +
Sbjct: 263 -------YTTDLMTKLPGYPV-------------NEVKCDLEVSCPDGYTCCRLNTGAWG 302
Query: 449 CCPFPGGVCCSSPPGCVPSGQQC 517
CCPF VCC C P+G QC
Sbjct: 303 CCPFTKAVCCEDHIHCCPAGFQC 325
Score = 103 bits (257), Expect = 4e-22
Identities = 51/144 (35%), Positives = 66/144 (45%), Gaps = 1/144 (0%)
Frame = +2
Query: 89 CQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEP 268
C + C D TCC+ G CC P A CC D++HCCP G +CDLV+ RCI +
Sbjct: 125 CPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCISPTG-- 182
Query: 269 IEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDG-SLCPNSFPCCLLVPGQY 445
P++K K+ +R V CPD + CP+ CC L G+Y
Sbjct: 183 -THPLLK----------KFPAQRTNRAVASFSV----VCPDAKTQCPDDSTCCELPTGKY 227
Query: 446 FCCPFPGGVCCSSPPGCVPSGQQC 517
CCP P +CCS C P C
Sbjct: 228 GCCPMPNAICCSDHLHCCPQDTVC 251
Score = 90.5 bits (223), Expect = 3e-18
Identities = 47/141 (33%), Positives = 63/141 (44%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C D TCC +G CC + AVCC D +HCCP G C C ++ P +K
Sbjct: 287 CPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTC---ELGVLQVPWMK 343
Query: 290 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFCCPFPGG 469
V A + +P + +N + C D S CP++ CC L G + CCP P
Sbjct: 344 KV-TASLSLPDPQILKNDV-----------PCDDFSSCPSNNTCCRLSSGDWGCCPMPEA 391
Query: 470 VCCSSPPGCVPSGQQCVSG*Y 532
VCC C P G +C+ Y
Sbjct: 392 VCCLDHQHCCPQGFKCMDEGY 412
Score = 84.3 bits (207), Expect = 2e-16
Identities = 46/136 (33%), Positives = 59/136 (43%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C +TCC S G CCQ P+AVCC D+ HCCP G TC++ + C
Sbjct: 447 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-------------- 492
Query: 290 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFCCPFPGG 469
E +V+ + F KV N C G C ++ CC G + CCP+ G
Sbjct: 493 -------EKDAGSVQPSMDLTFGSKVGNVE-CGAGHFCHDNQSCCKDSQGGWACCPYVKG 544
Query: 470 VCCSSPPGCVPSGQQC 517
VCC C P G C
Sbjct: 545 VCCRDGRHCCPIGFHC 560
Score = 79.7 bits (195), Expect = 6e-15
Identities = 39/136 (28%), Positives = 55/136 (40%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C TCC SG CC P AVCC D HCCP+G C +++ + + +
Sbjct: 369 CPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKC--MDEGYCQKGDRMVAG---- 422
Query: 290 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFCCPFPGG 469
+E+ P+R+ + C + CP CC + G + CC P
Sbjct: 423 -------------LEKMPVRQTTLLQHGDIGCDQHTSCPVGQTCCPSLKGSWACCQLPHA 469
Query: 470 VCCSSPPGCVPSGQQC 517
VCC C P+G C
Sbjct: 470 VCCEDRQHCCPAGYTC 485
Score = 74.3 bits (181), Expect = 2e-13
Identities = 37/136 (27%), Positives = 50/136 (36%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C D +C ++ SG CC + V C D HCCP G C K C S+ +
Sbjct: 67 CPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQISDSLL------ 120
Query: 290 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFCCPFPGG 469
++ P E CP+S CC+++ G + CCP P
Sbjct: 121 ----GAVQCPGSQFE----------------------CPDSATCCIMIDGSWGCCPMPQA 154
Query: 470 VCCSSPPGCVPSGQQC 517
CC C P G C
Sbjct: 155 SCCEDRVHCCPHGASC 170
Score = 58.5 bits (140), Expect = 1e-08
Identities = 24/65 (36%), Positives = 32/65 (49%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C D ++CC GG CC Y VCC D HCCP G C +C+ + W ++
Sbjct: 522 CHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGTKCLRKKTP--RWDIL- 578
Query: 290 IVDPA 304
+ DPA
Sbjct: 579 LRDPA 583
Score = 43.9 bits (102), Expect = 3e-04
Identities = 18/46 (39%), Positives = 21/46 (45%)
Frame = +2
Query: 380 TCPDGSLCPNSFPCCLLVPGQYFCCPFPGGVCCSSPPGCVPSGQQC 517
+C CP+ + C L V G CCPF GV C C P G C
Sbjct: 60 SCQIRDHCPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHC 105
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 106 bits (264), Expect = 6e-23
Identities = 48/143 (33%), Positives = 69/143 (48%)
Frame = +2
Query: 89 CQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEP 268
C + K C D TCC +G + CC PNA+CC D +HCCP+ T CDL+ +C+ ++
Sbjct: 207 CPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCLSKN--- 263
Query: 269 IEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYF 448
++P Y V+ +K + +CP+G + CC L G +
Sbjct: 264 -------YTTDLLTKLPGYPVKE-------VKCDMEVSCPEG------YTCCRLNTGAWG 303
Query: 449 CCPFPGGVCCSSPPGCVPSGQQC 517
CCPF VCC C P+G QC
Sbjct: 304 CCPFAKAVCCEDHIHCCPAGFQC 326
Score = 101 bits (251), Expect = 2e-21
Identities = 48/144 (33%), Positives = 62/144 (43%), Gaps = 1/144 (0%)
Frame = +2
Query: 89 CQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEP 268
C + C D TCC+ G CC P A CC D++HCCP G +CDLV+ RC+ +
Sbjct: 125 CPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCVSPTG-- 182
Query: 269 IEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDG-SLCPNSFPCCLLVPGQY 445
+ P R F + CPD + CP+ CC L G+Y
Sbjct: 183 --------THTLLKKFPAQKTNRAVSLPFSV------VCPDAKTQCPDDSTCCELPTGKY 228
Query: 446 FCCPFPGGVCCSSPPGCVPSGQQC 517
CCP P +CCS C P C
Sbjct: 229 GCCPMPNAICCSDHLHCCPQDTVC 252
Score = 92.0 bits (227), Expect = 1e-18
Identities = 45/141 (31%), Positives = 61/141 (43%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C + TCC +G CC + AVCC D +HCCP G C C + W + K
Sbjct: 288 CPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHTEKGTC-EMGILQVPW-MKK 345
Query: 290 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFCCPFPGG 469
++ P ++ P+ P C D + CP + CC L G + CCP P
Sbjct: 346 VIAPLRLPDPQILKSDTP-------------CDDFTRCPTNNTCCKLNSGDWGCCPIPEA 392
Query: 470 VCCSSPPGCVPSGQQCVSG*Y 532
VCCS C P G C++ Y
Sbjct: 393 VCCSDNQHCCPQGFTCLAQGY 413
Score = 89.7 bits (221), Expect = 5e-18
Identities = 47/136 (34%), Positives = 63/136 (46%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C +TCC S G CCQ P+AVCC D+ HCCP G TC++ + C + + I+ PV+
Sbjct: 448 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-EKDVDFIQPPVLL 506
Query: 290 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFCCPFPGG 469
+ P KV N C +G C ++ CC G + CCP+ G
Sbjct: 507 TLGP--------------------KVGNVE-CGEGHFCHDNQTCCKDSAGVWACCPYLKG 545
Query: 470 VCCSSPPGCVPSGQQC 517
VCC C P G C
Sbjct: 546 VCCRDGRHCCPGGFHC 561
Score = 82.0 bits (201), Expect = 1e-15
Identities = 47/136 (34%), Positives = 58/136 (42%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C TCC SG CC P AVCC D HCCP+G TC L C Q + + + K
Sbjct: 370 CPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTC-LAQGYC--QKGDTMVAGLEK 426
Query: 290 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFCCPFPGG 469
I PA+ + PL+ I C + CP CC + G + CC P
Sbjct: 427 I--PAR--------QTTPLQIGDI------GCDQHTSCPVGQTCCPSLKGSWACCQLPHA 470
Query: 470 VCCSSPPGCVPSGQQC 517
VCC C P+G C
Sbjct: 471 VCCEDRQHCCPAGYTC 486
Score = 80.5 bits (197), Expect = 3e-15
Identities = 39/136 (28%), Positives = 52/136 (38%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C +C ++ SG CC + V CGD HCCP+G C K C S+ P+
Sbjct: 67 CPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSCFQMSDNPL------ 120
Query: 290 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFCCPFPGG 469
++ P E CP+S CC++V G + CCP P
Sbjct: 121 ----GAVQCPGSQFE----------------------CPDSATCCIMVDGSWGCCPMPQA 154
Query: 470 VCCSSPPGCVPSGQQC 517
CC C P G C
Sbjct: 155 SCCEDRVHCCPHGASC 170
Score = 55.1 bits (131), Expect = 1e-07
Identities = 20/49 (40%), Positives = 25/49 (51%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQ 256
C D +TCC +G CC Y VCC D HCCP G C +C+ +
Sbjct: 523 CHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKCLRK 571
Score = 43.1 bits (100), Expect = 6e-04
Identities = 18/46 (39%), Positives = 20/46 (43%)
Frame = +2
Query: 380 TCPDGSLCPNSFPCCLLVPGQYFCCPFPGGVCCSSPPGCVPSGQQC 517
+C CP + C L V G CCPF GV C C P G C
Sbjct: 60 SCQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHC 105
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 106 bits (264), Expect = 6e-23
Identities = 49/143 (34%), Positives = 69/143 (48%)
Frame = +2
Query: 89 CQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEP 268
C + ++ C D TCC SG + CC PNA CC D +HCCP+ T CDL+ +C+ + N
Sbjct: 208 CPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENAT 267
Query: 269 IEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYF 448
+ ++P +TV +K + +CPDG + CC L G +
Sbjct: 268 TD---------LLTKLPAHTVGD-------VKCDMEVSCPDG------YTCCRLQSGAWG 305
Query: 449 CCPFPGGVCCSSPPGCVPSGQQC 517
CCPF VCC C P+G C
Sbjct: 306 CCPFTQAVCCEDHIHCCPAGFTC 328
Score = 103 bits (258), Expect = 3e-22
Identities = 51/144 (35%), Positives = 64/144 (44%), Gaps = 1/144 (0%)
Frame = +2
Query: 89 CQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEP 268
C + + C D TCCV G CC P A CC D++HCCP G CDLV+ RCI +
Sbjct: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTG-- 183
Query: 269 IEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDG-SLCPNSFPCCLLVPGQY 445
P ++P R + + + CPD S CP+ CC L G+Y
Sbjct: 184 --------THPLAKKLPAQRTNR------AVALSSSVMCPDARSRCPDGSTCCELPSGKY 229
Query: 446 FCCPFPGGVCCSSPPGCVPSGQQC 517
CCP P CCS C P C
Sbjct: 230 GCCPMPNATCCSDHLHCCPQDTVC 253
Score = 101 bits (252), Expect = 1e-21
Identities = 50/138 (36%), Positives = 63/138 (45%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C D TCC +SG CC + AVCC D +HCCP G TCD C Q + W
Sbjct: 290 CPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTC-EQGPHQVPWMEKA 348
Query: 290 IVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYFCCPFPGG 469
PA + +P + + C + S CP+S CC L G++ CCP P
Sbjct: 349 ---PAHLSLPDPQALKRDV-----------PCDNVSSCPSSDTCCQLTSGEWGCCPIPEA 394
Query: 470 VCCSSPPGCVPSGQQCVS 523
VCCS C P G CV+
Sbjct: 395 VCCSDHQHCCPQGYTCVA 412
Score = 83.6 bits (205), Expect = 4e-16
Identities = 47/139 (33%), Positives = 64/139 (46%), Gaps = 1/139 (0%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVK 289
C +TCC S G CCQ P+AVCC D+ HCCP G TC++ + C E VV
Sbjct: 450 CPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC--------EKEVVS 501
Query: 290 IVDPAKIEIPKYTVERNPLREFIIKVWNKST-CPDGSLCPNSFPCCLLVPGQYFCCPFPG 466
P + R+P V K C +G C ++ CC + CCP+
Sbjct: 502 AQ-------PATFLARSP------HVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQ 548
Query: 467 GVCCSSPPGCVPSGQQCVS 523
GVCC+ C P+G +C +
Sbjct: 549 GVCCADRRHCCPAGFRCAA 567
Score = 82.0 bits (201), Expect = 1e-15
Identities = 46/143 (32%), Positives = 58/143 (40%)
Frame = +2
Query: 89 CQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCIHQSNEP 268
C N + C TCC SG CC P AVCC D HCCP+G TC + +C S
Sbjct: 366 CDNVSS-CPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTC-VAEGQCQRGS--- 420
Query: 269 IEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVWNKSTCPDGSLCPNSFPCCLLVPGQYF 448
+IV +E+ P R + C + CP CC + G +
Sbjct: 421 ------EIVAG---------LEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWA 465
Query: 449 CCPFPGGVCCSSPPGCVPSGQQC 517
CC P VCC C P+G C
Sbjct: 466 CCQLPHAVCCEDRQHCCPAGYTC 488
Score = 79.7 bits (195), Expect = 6e-15
Identities = 48/170 (28%), Positives = 63/170 (37%), Gaps = 1/170 (0%)
Frame = +2
Query: 11 CCAMILVQYIVSITPAFLERSNIINACQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCG 190
CC +L ++ P L R ++ CQ A C +C + SG CC +P AV CG
Sbjct: 41 CCRPLLDKW-----PTTLSR-HLGGPCQVD-AHCSAGHSCIFTVSGTSSCCPFPEAVACG 93
Query: 191 DQMHCCPEGTTCDLVNKRCIHQSNEPIEWPVVKIVDPAKIEIPKYTVERNPLREFIIKVW 370
D HCCP G C + C +S +
Sbjct: 94 DGHHCCPRGFHCSADGRSCFQRSGNNSVGAI----------------------------- 124
Query: 371 NKSTCPDGSL-CPNSFPCCLLVPGQYFCCPFPGGVCCSSPPGCVPSGQQC 517
CPD CP+ CC++V G + CCP P CC C P G C
Sbjct: 125 ---QCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFC 171
Score = 60.5 bits (145), Expect = 4e-09
Identities = 35/94 (37%), Positives = 43/94 (45%), Gaps = 5/94 (5%)
Frame = +2
Query: 38 IVSITPA-FLERSNIINA----CQNGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMH 202
+VS PA FL RS + C G C D +TCC G CC Y VCC D+ H
Sbjct: 499 VVSAQPATFLARSPHVGVKDVECGEGH-FCHDNQTCCRDNRQGWACCPYRQGVCCADRRH 557
Query: 203 CCPEGTTCDLVNKRCIHQSNEPIEWPVVKIVDPA 304
CCP G C +C+ + E W + DPA
Sbjct: 558 CCPAGFRCAARGTKCLRR--EAPRWD-APLRDPA 588
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1)
Length = 54
Score = 62.8 bits (151), Expect = 7e-10
Identities = 23/47 (48%), Positives = 28/47 (59%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCI 250
C +TCC + G CC Y VCC D +HCCP GT CD ++RCI
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVCDEDHRRCI 53
Score = 44.7 bits (104), Expect = 2e-04
Identities = 17/39 (43%), Positives = 20/39 (51%)
Frame = +2
Query: 401 CPNSFPCCLLVPGQYFCCPFPGGVCCSSPPGCVPSGQQC 517
CP + CC G+ CCP+ GVCC C PSG C
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVC 45
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 57.0 bits (136), Expect = 4e-08
Identities = 20/36 (55%), Positives = 22/36 (61%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEG 217
C D +TCC + GG CC Y VCC DQ HCCP G
Sbjct: 10 CHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVG 45
Score = 42.4 bits (98), Expect = 0.001
Identities = 16/42 (38%), Positives = 20/42 (47%)
Frame = +2
Query: 383 CPDGSLCPNSFPCCLLVPGQYFCCPFPGGVCCSSPPGCVPSG 508
C +G C + CC G CCP+ GVCC+ C P G
Sbjct: 4 CGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVG 45
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 52.0 bits (123), Expect = 1e-06
Identities = 19/48 (39%), Positives = 25/48 (52%)
Frame = +2
Query: 107 LCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCI 250
+C D TCC+S G CC + CC D +HCC G CD + C+
Sbjct: 9 ICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHCDSTSTHCL 56
Score = 46.2 bits (108), Expect = 7e-05
Identities = 18/47 (38%), Positives = 23/47 (48%)
Frame = +2
Query: 383 CPDGSLCPNSFPCCLLVPGQYFCCPFPGGVCCSSPPGCVPSGQQCVS 523
C ++CP+ CCL G ++CCPF G CC C G C S
Sbjct: 4 CDAATICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHCDS 50
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 49.3 bits (116), Expect = 8e-06
Identities = 19/52 (36%), Positives = 24/52 (46%)
Frame = +2
Query: 95 NGKALCGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCI 250
N + C + TCC S G CC + CC D HCC G CD + C+
Sbjct: 5 NARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTLCL 56
Score = 40.8 bits (94), Expect = 0.003
Identities = 17/47 (36%), Positives = 22/47 (46%)
Frame = +2
Query: 383 CPDGSLCPNSFPCCLLVPGQYFCCPFPGGVCCSSPPGCVPSGQQCVS 523
C + CP+ CC G ++CCPF G CC C G +C S
Sbjct: 4 CNARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDS 50
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 45.1 bits (105), Expect = 2e-04
Identities = 18/47 (38%), Positives = 21/47 (44%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQCCQYPNAVCCGDQMHCCPEGTTCDLVNKRCI 250
C TCC S G CC + CC D HCC G CD + C+
Sbjct: 10 CPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDSTSTLCL 56
Score = 43.1 bits (100), Expect = 6e-04
Identities = 18/47 (38%), Positives = 21/47 (44%)
Frame = +2
Query: 383 CPDGSLCPNSFPCCLLVPGQYFCCPFPGGVCCSSPPGCVPSGQQCVS 523
C G CP+ CC G ++CCPF G CC C G C S
Sbjct: 4 CDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDS 50
>sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (RD21)
Length = 462
Score = 42.7 bits (99), Expect = 8e-04
Identities = 22/66 (33%), Positives = 25/66 (37%), Gaps = 6/66 (9%)
Frame = +2
Query: 110 CGDQKTCCVSKSGGHQC-----CQYPNAVCCGDQMHCCP-EGTTCDLVNKRCIHQSNEPI 271
C + TCC G C C A CC D CCP E CDL C+ N P
Sbjct: 381 CPESNTCCCLFEYGKYCFAWGCCPLEAATCCDDNYSCCPHEYPVCDLDQGTCLLSKNSPF 440
Query: 272 EWPVVK 289
+K
Sbjct: 441 SVKALK 446
Score = 36.2 bits (82), Expect = 0.072
Identities = 16/45 (35%), Positives = 19/45 (42%), Gaps = 4/45 (8%)
Frame = +2
Query: 380 TCPDGSLCPNSFPCCLLVPGQYF----CCPFPGGVCCSSPPGCVP 502
TCP+ + C CCL G+Y CCP CC C P
Sbjct: 380 TCPESNTC-----CCLFEYGKYCFAWGCCPLEAATCCDDNYSCCP 419
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,853,239
Number of Sequences: 369166
Number of extensions: 1860581
Number of successful extensions: 6037
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5139
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5906
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5072399280
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)