Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_E24
(884 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (En... 141 2e-33
sp|P91953|HE_HEMPU 50 kDa hatching enzyme precursor (HE) (H... 135 1e-31
sp|Q9Y5R2|MMP24_HUMAN Matrix metalloproteinase-24 precursor... 135 2e-31
sp|Q9R0S2|MMP24_MOUSE Matrix metalloproteinase-24 precursor... 135 2e-31
sp|Q99PW6|MMP24_RAT Matrix metalloproteinase-24 precursor (... 135 2e-31
sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metal... 132 2e-30
sp|P45452|MMP13_HUMAN Collagenase 3 precursor (Matrix metal... 131 2e-30
sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor... 131 3e-30
sp|Q9WTR0|MMP16_MOUSE Matrix metalloproteinase-16 precursor... 131 3e-30
sp|O35548|MMP16_RAT Matrix metalloproteinase-16 precursor (... 131 3e-30
>sp|P22757|HE_PARLI Hatching enzyme precursor (HE) (HEZ) (Envelysin)
(Sea-urchin-hatching proteinase) [Contains: Hatching
enzyme 18 kDa form]
Length = 587
Score = 141 bits (356), Expect = 2e-33
Identities = 90/232 (38%), Positives = 120/232 (51%), Gaps = 2/232 (0%)
Frame = +1
Query: 94 YDESSGNFEDSIKELQKMAGIEQDGELSDEVLSHMNKGRCGGKDREKKNKRYVASGAKWD 273
+ E++ N+ +I + Q+ GI Q G L + ++ RCG D +V S W
Sbjct: 120 FGEANLNYTSAILDFQEHGGINQTGILDADTAELLSTPRCGVPDVLP----FVTSSITWS 175
Query: 274 RG--VTYKYYLHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLGFSESRDKVGCKFSISFS 447
R VTY + + + + E+RRAF+V W VS L F E D I F
Sbjct: 176 RNQPVTYSFGALTSDLNQNDVKDEIRRAFRV----WDDVSGLSFREVPDTTSVDIRIKFG 231
Query: 448 GKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPRNGNLHCDNAETWTEGKDSGINLR 627
DH D D GGVLAHA+ PRNG+ H D++ETWTEG SG NL
Sbjct: 232 SYDH------------GDGISFDG-RGGVLAHAFLPRNGDAHFDDSETWTEGTRSGTNLF 278
Query: 628 IVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGA 783
VAAHE GH++GL+HS SALM P+Y GY+ +RL NDD G +S+YG+
Sbjct: 279 QVAAHEFGHSLGLYHSTVRSALMYPYYQGYV--PNFRLDNDDIAGIRSLYGS 328
>sp|P91953|HE_HEMPU 50 kDa hatching enzyme precursor (HE) (HEZ) (Envelysin)
(Sea-urchin-hatching proteinase) [Contains: 38 kDa
hatching enzyme; 32 kDa hatching enzyme non-specific; 15
kDa peptide]
Length = 591
Score = 135 bits (341), Expect = 1e-31
Identities = 89/231 (38%), Positives = 119/231 (51%), Gaps = 2/231 (0%)
Frame = +1
Query: 94 YDESSGNFEDSIKELQKMAGIEQDGELSDEVLSHMNKGRCGGKDREKKNKRYVASGAKWD 273
+ E++ N+ +I E Q+ GI Q G L E + ++ RCG D YV G W
Sbjct: 123 FGEANINYTSAILEYQQNGGINQTGILDAETAALLDTPRCGVPDILP----YVTGGIAWP 178
Query: 274 RGV--TYKYYLHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLGFSESRDKVGCKFSISFS 447
R V TY + + + +T + E+RRAF+V W VS+L F E D I F
Sbjct: 179 RNVAVTYSFGTLSNDLSQTAIKNELRRAFQV----WDDVSSLTFREVVDSSSVDIRIKFG 234
Query: 448 GKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPRNGNLHCDNAETWTEGKDSGINLR 627
+H +F Q GGVLAHA+ PRNG+ H D++E WT G +SG NL
Sbjct: 235 SYEH---GDGISFDGQ----------GGVLAHAFLPRNGDAHFDDSERWTIGTNSGTNLF 281
Query: 628 IVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYG 780
VAAHE GH++GL+HS SALM P+Y GY + L DD G S+YG
Sbjct: 282 QVAAHEFGHSLGLYHSDVQSALMYPYYRGY--NPNFNLDRDDIAGITSLYG 330
>sp|Q9Y5R2|MMP24_HUMAN Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP)
Length = 645
Score = 135 bits (340), Expect = 2e-31
Identities = 89/253 (35%), Positives = 128/253 (50%), Gaps = 17/253 (6%)
Frame = +1
Query: 103 SSGNFEDSIKELQKMAGIEQDGELSDEVLSHMNKGRCGGKD-----REKKNKRYVASGAK 267
S+ + ++ +Q+ GI G L + M K RCG D R ++NKRY +G K
Sbjct: 103 SAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQK 162
Query: 268 W-DRGVTYKYYLHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLGFSE------SRDKVGC 426
W + +TY + ++ P+ + E + R+A + A D W +V+ L F E D+
Sbjct: 163 WRQKHITYSIH---NYTPK-VGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEA 218
Query: 427 KFSISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWT 597
I F+ H D SP D GG LAHAYFP G+ H D+ E WT
Sbjct: 219 DIMIFFASGFH------------GDSSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWT 265
Query: 598 EGKDS--GINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQS 771
G + G +L +VA HE+GHA+GL HS DPSA+MAP+Y Y+ ++LP DD G Q
Sbjct: 266 LGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFY-QYMETHNFKLPQDDLQGIQK 324
Query: 772 IYGARGKRALPSK 810
IYG + P++
Sbjct: 325 IYGPPAEPLEPTR 337
>sp|Q9R0S2|MMP24_MOUSE Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP) (MMP-21)
Length = 618
Score = 135 bits (339), Expect = 2e-31
Identities = 88/248 (35%), Positives = 126/248 (50%), Gaps = 17/248 (6%)
Frame = +1
Query: 118 EDSIKELQKMAGIEQDGELSDEVLSHMNKGRCGGKD-----REKKNKRYVASGAKW-DRG 279
+ ++ +Q+ GI G L + M K RCG D R ++NKRY +G KW +
Sbjct: 81 QSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKH 140
Query: 280 VTYKYYLHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLGFSE------SRDKVGCKFSIS 441
+TY + ++ P+ + E + R+A + A D W +V+ L F E D+ I
Sbjct: 141 ITYSIH---NYTPK-VGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIF 196
Query: 442 FSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGKDS 612
F+ H D SP D GG LAHAYFP G+ H D+ E WT G +
Sbjct: 197 FASGFH------------GDSSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNAN 243
Query: 613 --GINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGAR 786
G +L +VA HE+GHA+GL HS DPSA+MAP+Y Y+ ++LP DD G Q IYG
Sbjct: 244 HDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFY-QYMETHNFKLPQDDLQGIQKIYGPP 302
Query: 787 GKRALPSK 810
+ P++
Sbjct: 303 AEPLEPTR 310
>sp|Q99PW6|MMP24_RAT Matrix metalloproteinase-24 precursor (MMP-24) (Membrane-type
matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5
matrix metalloproteinase) (MT5-MMP)
Length = 618
Score = 135 bits (339), Expect = 2e-31
Identities = 88/248 (35%), Positives = 126/248 (50%), Gaps = 17/248 (6%)
Frame = +1
Query: 118 EDSIKELQKMAGIEQDGELSDEVLSHMNKGRCGGKD-----REKKNKRYVASGAKW-DRG 279
+ ++ +Q+ GI G L + M K RCG D R ++NKRY +G KW +
Sbjct: 81 QSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKH 140
Query: 280 VTYKYYLHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLGFSE------SRDKVGCKFSIS 441
+TY + ++ P+ + E + R+A + A D W +V+ L F E D+ I
Sbjct: 141 ITYSIH---NYTPK-VGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIF 196
Query: 442 FSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGKDS 612
F+ H D SP D GG LAHAYFP G+ H D+ E WT G +
Sbjct: 197 FASGFH------------GDSSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNAN 243
Query: 613 --GINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGAR 786
G +L +VA HE+GHA+GL HS DPSA+MAP+Y Y+ ++LP DD G Q IYG
Sbjct: 244 HDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFY-QYMETHNFKLPQDDLQGIQKIYGPP 302
Query: 787 GKRALPSK 810
+ P++
Sbjct: 303 AEPLEPTR 310
>sp|O62806|MMP13_RABIT Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 132 bits (331), Expect = 2e-30
Identities = 96/279 (34%), Positives = 138/279 (49%), Gaps = 19/279 (6%)
Frame = +1
Query: 1 ILLSVLFIYSVQSFKSSEEKD--------AEKYLTDFYD--------YDESSGNFEDSIK 132
+LLS +S+ S+E+ D AE YL +Y ++G+ D ++
Sbjct: 10 LLLSWTHCWSLPLLNSNEDDDLSEEDFQFAESYLRSYYHPLNPAGILKKNAAGSMVDRLR 69
Query: 133 ELQKMAGIEQDGELSDEVLSHMNKGRCGGKDREKKNKRYVASGAKWDRGVTYKYYLHLDW 312
E+Q G+E G+L D L+ M + RCG D + N KW + T Y +++
Sbjct: 70 EMQSFFGLEVTGKLDDNTLAIMKQPRCGVPDVGEYN--VFPRTLKWSQ--TNLTYRIVNY 125
Query: 313 MPRTMSEAEVRRAFKVALDYWVRVSNLGFSESRDKVGCKFSISFSGKDHLMYNVDNNFQS 492
P ++ +EV +AFK A W V+ L F+ + ISF K+H
Sbjct: 126 TP-DLTHSEVEKAFKKAFKVWSDVTPLNFTRIHNGTA-DIMISFGTKEH----------- 172
Query: 493 QRDPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGKDSGINLRIVAAHEMGHAIG 663
D P D P G+LAHA+ P G+ H D+ ETWT G NL +VAAHE GH++G
Sbjct: 173 -GDFYPFDG-PSGLLAHAFPPGPNYGGDAHFDDDETWTSSS-KGYNLFLVAAHEFGHSLG 229
Query: 664 LHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYG 780
L HS+DP ALM P Y Y ++ + LP+DD G QS+YG
Sbjct: 230 LDHSKDPGALMFPIY-TYTGKSHFMLPDDDVQGIQSLYG 267
>sp|P45452|MMP13_HUMAN Collagenase 3 precursor (Matrix metalloproteinase-13) (MMP-13)
Length = 471
Score = 131 bits (330), Expect = 2e-30
Identities = 90/251 (35%), Positives = 129/251 (51%), Gaps = 12/251 (4%)
Frame = +1
Query: 64 AEKYLTDFYD--------YDESSGNFEDSIKELQKMAGIEQDGELSDEVLSHMNKGRCGG 219
AE+YL +Y + ++ + + ++E+Q G+E G+L D L M K RCG
Sbjct: 39 AERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGV 98
Query: 220 KDREKKNKRYVASGAKWDR-GVTYKYYLHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLG 396
D + N KW + +TY+ +++ P M+ +EV +AFK A W V+ L
Sbjct: 99 PDVGEYN--VFPRTLKWSKMNLTYRI---VNYTP-DMTHSEVEKAFKKAFKVWSDVTPLN 152
Query: 397 FSESRDKVGCKFSISFSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPR---NGN 567
F+ D + ISF K+H D P D P G+LAHA+ P G+
Sbjct: 153 FTRLHDGIA-DIMISFGIKEH------------GDFYPFDG-PSGLLAHAFPPGPNYGGD 198
Query: 568 LHCDNAETWTEGKDSGINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPN 747
H D+ ETWT G NL +VAAHE GH++GL HS+DP ALM P Y Y ++ + LP+
Sbjct: 199 AHFDDDETWTSSS-KGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY-TYTGKSHFMLPD 256
Query: 748 DDTLGAQSIYG 780
DD G QS+YG
Sbjct: 257 DDVQGIQSLYG 267
>sp|Q9JHI0|MMP19_MOUSE Matrix metalloproteinase-19 precursor (MMP-19) (Matrix
metalloproteinase RASI)
Length = 527
Score = 131 bits (329), Expect = 3e-30
Identities = 82/224 (36%), Positives = 121/224 (54%), Gaps = 2/224 (0%)
Frame = +1
Query: 121 DSIKELQKMAGIEQDGELSDEVLSHMNKGRCGGKDR-EKKNKRYVASGAKWDRGVTYKYY 297
++++ Q+ +G+ G++ D + M + RCG +D +K+ +Y+ G + +T++ +
Sbjct: 56 EALRTFQEASGLPISGQMDDATRARMKQPRCGLEDPFNQKSLKYLLLGHWRKKNLTFRIF 115
Query: 298 LHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLGFSESRDKVG-CKFSISFSGKDHLMYNV 474
+P T+S VR A A YW V+ L F E K G +SF G+ L +
Sbjct: 116 N----VPSTLSLPRVRAALHQAFKYWSSVAPLTFREV--KAGWADIRLSFHGRQSLYCS- 168
Query: 475 DNNFQSQRDPSPLDNVPGGVLAHAYFPRNGNLHCDNAETWTEGKDSGINLRIVAAHEMGH 654
N F PG VLAHA P G++H D E WTEG G+NLRI+AAHE+GH
Sbjct: 169 -NTFDG----------PGKVLAHADIPELGSIHFDKDELWTEGTYQGVNLRIIAAHEVGH 217
Query: 655 AIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGAR 786
A+GL HS+ ALMAP Y GY + ++L DD G Q++YG R
Sbjct: 218 ALGLGHSRYTQALMAPVYAGY--QPFFKLHPDDVAGIQALYGKR 259
>sp|Q9WTR0|MMP16_MOUSE Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 131 bits (329), Expect = 3e-30
Identities = 86/249 (34%), Positives = 126/249 (50%), Gaps = 13/249 (5%)
Frame = +1
Query: 103 SSGNFEDSIKELQKMAGIEQDGELSDEVLSHMNKGRCGGKDREK-------KNKRYVASG 261
S+ + ++ +Q+ GI G++ + M K RCG D+ + + KRY +G
Sbjct: 65 SAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFNIRRKRYALTG 124
Query: 262 AKWD-RGVTYKYYLHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLGFSESRDKVGCKFSI 438
KW + +TY + + + + E RRA + A D W V+ L F E +S
Sbjct: 125 QKWQHKHITYS----IKNVTPKVGDPETRRAIRRAFDVWQNVTPLTFEE------VPYSE 174
Query: 439 SFSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGKD 609
+GK + + D SP D GG LAHAYFP G+ H D+ E WT G
Sbjct: 175 LENGKRDVDITIIFASGFHGDRSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNP 233
Query: 610 S--GINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGA 783
+ G +L +VA HE+GHA+GL HS DP+A+MAP+Y Y+ ++LPNDD G Q IYG
Sbjct: 234 NHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFY-QYMETDNFKLPNDDLQGIQKIYGP 292
Query: 784 RGKRALPSK 810
K P++
Sbjct: 293 PDKIPPPTR 301
>sp|O35548|MMP16_RAT Matrix metalloproteinase-16 precursor (MMP-16) (Membrane-type
matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3)
(Membrane-type-3 matrix metalloproteinase) (MT3-MMP)
(MT3MMP)
Length = 607
Score = 131 bits (329), Expect = 3e-30
Identities = 86/249 (34%), Positives = 126/249 (50%), Gaps = 13/249 (5%)
Frame = +1
Query: 103 SSGNFEDSIKELQKMAGIEQDGELSDEVLSHMNKGRCGGKDREK-------KNKRYVASG 261
S+ + ++ +Q+ GI G++ + M K RCG D+ + + KRY +G
Sbjct: 65 SAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFNIRRKRYALTG 124
Query: 262 AKWD-RGVTYKYYLHLDWMPRTMSEAEVRRAFKVALDYWVRVSNLGFSESRDKVGCKFSI 438
KW + +TY + + + + E RRA + A D W V+ L F E +S
Sbjct: 125 QKWQHKHITYS----IKNVTPKVGDPETRRAIRRAFDVWQNVTPLTFEE------VPYSE 174
Query: 439 SFSGKDHLMYNVDNNFQSQRDPSPLDNVPGGVLAHAYFPR---NGNLHCDNAETWTEGKD 609
+GK + + D SP D GG LAHAYFP G+ H D+ E WT G
Sbjct: 175 LENGKRDVDITIIFASGFHGDRSPFDG-EGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNP 233
Query: 610 S--GINLRIVAAHEMGHAIGLHHSQDPSALMAPWYGGYISEAEYRLPNDDTLGAQSIYGA 783
+ G +L +VA HE+GHA+GL HS DP+A+MAP+Y Y+ ++LPNDD G Q IYG
Sbjct: 234 NHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFY-QYMETDNFKLPNDDLQGIQKIYGP 292
Query: 784 RGKRALPSK 810
K P++
Sbjct: 293 PDKIPPPTR 301
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.316 0.134 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 109,015,114
Number of Sequences: 369166
Number of extensions: 2398523
Number of successful extensions: 7716
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7240
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7516
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8838279920
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)