Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_E12
(293 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q07954|LRP1_HUMAN Low-density lipoprotein receptor-relat... 39 0.004
sp|P56677|ST14_MOUSE Suppressor of tumorigenicity 14 (Epithin) 35 0.069
sp|Q9Y5Y6|ST14_HUMAN Suppressor of tumorigenicity 14 (Matri... 33 0.26
sp|P35953|VLDLR_RABIT Very low-density lipoprotein receptor... 32 0.45
sp|Q00996|CD59_SHV21 Surface glycoprotein CD59 homolog prec... 31 0.76
sp|P98165|VLDLR_CHICK Very low-density lipoprotein receptor... 30 1.3
sp|P82771|LC57_ARATH Putative low-molecular-weight cysteine... 30 1.7
sp|Q8TC27|ADA32_HUMAN ADAM 32 precursor (A disintegrin and ... 30 1.7
sp|Q9NZR2|LRP1B_HUMAN Low-density lipoprotein receptor-rela... 30 1.7
sp|P98155|VLDLR_HUMAN Very low-density lipoprotein receptor... 30 2.2
>sp|Q07954|LRP1_HUMAN Low-density lipoprotein receptor-related protein 1 precursor (LRP)
(Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E
receptor) (APOER) (CD91)
Length = 4544
Score = 38.9 bits (89), Expect = 0.004
Identities = 23/68 (33%), Positives = 30/68 (44%)
Frame = +3
Query: 51 ALKCYECDHCEGKAGSPSKDSCDYCLEEATKDGINRRCGKGGCLSIGNLRCCNNKDLCND 230
+L C HC+ K S + YC K R+C G C+S N+ CN D C D
Sbjct: 2541 SLTCDGVPHCKDK----SDEKPSYCNSRRCKKTF-RQCSNGRCVS--NMLWCNGADDCGD 2593
Query: 231 GK*NLDCN 254
G + CN
Sbjct: 2594 GSDEIPCN 2601
Score = 29.3 bits (64), Expect = 2.9
Identities = 21/67 (31%), Positives = 28/67 (41%), Gaps = 2/67 (2%)
Frame = +3
Query: 66 ECDHCEGKAGSPSKDSCDYCLEEAT--KDGINRRCGKGGCLSIGNLRCCNNKDLCNDGK* 239
+CD + ++ C+ T KD C CLS +LRC N D C DG
Sbjct: 3715 QCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLS-SSLRC-NMFDDCGDGSD 3772
Query: 240 NLDCNFD 260
DC+ D
Sbjct: 3773 EEDCSID 3779
Score = 27.7 bits (60), Expect = 8.4
Identities = 20/65 (30%), Positives = 27/65 (41%), Gaps = 10/65 (15%)
Frame = +3
Query: 66 ECDHCEGKAGSPSKDSC---DYCLEEATKDGINRRCGKG-------GCLSIGNLRCCNNK 215
E HCEGK PS SC C+ E ++ C G GCL N C + +
Sbjct: 2765 EAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLY--NSTCDDRE 2822
Query: 216 DLCND 230
+C +
Sbjct: 2823 FMCQN 2827
Score = 27.7 bits (60), Expect = 8.4
Identities = 20/59 (33%), Positives = 23/59 (38%), Gaps = 1/59 (1%)
Frame = +3
Query: 57 KCYECDHCEGKA-GSPSKDSCDYCLEEATKDGINRRCGKGGCLSIGNLRCCNNKDLCND 230
K + CDH A GS C+Y T RC G CLS C D C+D
Sbjct: 2833 KHFVCDHDRDCADGSDESPECEY----PTCGPSEFRCANGRCLSSRQWECDGEND-CHD 2886
>sp|P56677|ST14_MOUSE Suppressor of tumorigenicity 14 (Epithin)
Length = 855
Score = 34.7 bits (78), Expect = 0.069
Identities = 21/58 (36%), Positives = 28/58 (48%), Gaps = 8/58 (13%)
Frame = +3
Query: 105 KDSCDYCLEEATKDGIN--------RRCGKGGCLSIGNLRCCNNKDLCNDGK*NLDCN 254
KD+C +EA+ D +N RC G CLS GN C D C+DG +C+
Sbjct: 547 KDNCGDGSDEASCDSVNVVSCTKYTYRCQNGLCLSKGNPECDGKTD-CSDGSDEKNCD 603
Score = 28.9 bits (63), Expect = 3.8
Identities = 17/58 (29%), Positives = 27/58 (46%), Gaps = 5/58 (8%)
Frame = +3
Query: 108 DSCDYCLEEATKDGINR-----RCGKGGCLSIGNLRCCNNKDLCNDGK*NLDCNFDNL 266
DS + C + + ++G + +C G CL + CN KD C DG C+ N+
Sbjct: 509 DSVNDCGDGSDEEGCSCPAGSFKCSNGKCLP--QSQKCNGKDNCGDGSDEASCDSVNV 564
>sp|Q9Y5Y6|ST14_HUMAN Suppressor of tumorigenicity 14 (Matriptase) (Membrane-type serine
protease 1) (MT-SP1) (Prostamin) (Serine protease
TADG-15) (Tumor associated differentially-expressed
gene-15 protein)
Length = 855
Score = 32.7 bits (73), Expect = 0.26
Identities = 21/58 (36%), Positives = 28/58 (48%), Gaps = 8/58 (13%)
Frame = +3
Query: 105 KDSCDYCLEEATKDGIN--------RRCGKGGCLSIGNLRCCNNKDLCNDGK*NLDCN 254
KD C +EA+ +N RC G CLS GN C+ K+ C+DG DC+
Sbjct: 547 KDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPE-CDGKEDCSDGSDEKDCD 603
Score = 30.4 bits (67), Expect = 1.3
Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 5/53 (9%)
Frame = +3
Query: 108 DSCDYCLEEATKDGINR-----RCGKGGCLSIGNLRCCNNKDLCNDGK*NLDC 251
DS + C + + + G + RC G CLS + CN KD C DG C
Sbjct: 509 DSVNDCGDNSDEQGCSCPAQTFRCSNGKCLS--KSQQCNGKDDCGDGSDEASC 559
>sp|P35953|VLDLR_RABIT Very low-density lipoprotein receptor precursor (VLDL receptor)
Length = 873
Score = 32.0 bits (71), Expect = 0.45
Identities = 18/58 (31%), Positives = 27/58 (46%)
Frame = +3
Query: 78 CEGKAGSPSKDSCDYCLEEATKDGINRRCGKGGCLSIGNLRCCNNKDLCNDGK*NLDC 251
C+G++ S + + C T C G C+S + CN +D C+DG LDC
Sbjct: 134 CDGESDCDSGEDEENC-GNVTCSSDEFTCSSGRCISRNFV--CNGQDDCSDGSDELDC 188
>sp|Q00996|CD59_SHV21 Surface glycoprotein CD59 homolog precursor
Length = 121
Score = 31.2 bits (69), Expect = 0.76
Identities = 22/91 (24%), Positives = 33/91 (36%), Gaps = 13/91 (14%)
Frame = +3
Query: 3 LLFVVSVVLTIISEYEALKCYECDH--CEGKAGSPSKDSCDYCLEEATKDGINRRCGKGG 176
+LF + + +L+CY C H + + + D CL G+ RC K
Sbjct: 3 ILFTLVLTFVFCKPIHSLQCYNCSHSTMQCTTSTSCTSNLDSCLIAKAGSGVYYRCWKFD 62
Query: 177 CLSIGNL-----------RCCNNKDLCNDGK 236
S + CC K+LCN K
Sbjct: 63 DCSFKRISNQLSETQLKYHCC-KKNLCNVNK 92
>sp|P98165|VLDLR_CHICK Very low-density lipoprotein receptor precursor (VLDL receptor)
(Vitellogenin receptor) (VTG receptor)
Length = 863
Score = 30.4 bits (67), Expect = 1.3
Identities = 17/58 (29%), Positives = 26/58 (44%)
Frame = +3
Query: 78 CEGKAGSPSKDSCDYCLEEATKDGINRRCGKGGCLSIGNLRCCNNKDLCNDGK*NLDC 251
C+G+ S + + C T C G C+S + CN +D C+DG L+C
Sbjct: 152 CDGEKDCDSGEDEENC-GNVTCSAAEFTCSSGQCISKSFV--CNGQDDCSDGSDELEC 206
>sp|P82771|LC57_ARATH Putative low-molecular-weight cysteine-rich protein LCR57 precursor
Length = 120
Score = 30.0 bits (66), Expect = 1.7
Identities = 23/107 (21%), Positives = 36/107 (33%), Gaps = 39/107 (36%)
Frame = +3
Query: 3 LLFVVSVVLTIISEYEALKCYECDH-----------CEGKAGSPSKDSC----------- 116
LLF++S+++ S ++ CD C+ K G S C
Sbjct: 8 LLFLLSLLIIFASAVNQIRAQTCDENLSSCENCDQRCKAKHGPSSVSKCNGPDGTCGCAS 67
Query: 117 -----------DYCLEEATKDGINRRC------GKGGCLSIGNLRCC 206
D C ++ +R+C GKGGC+ R C
Sbjct: 68 FKPAKLCIGATDMCTDKCPTSCCDRQCAIKYKNGKGGCVDYAGYRMC 114
>sp|Q8TC27|ADA32_HUMAN ADAM 32 precursor (A disintegrin and metalloprotease domain 32)
Length = 787
Score = 30.0 bits (66), Expect = 1.7
Identities = 25/76 (32%), Positives = 32/76 (42%), Gaps = 6/76 (7%)
Frame = +3
Query: 45 YEALKCYECD------HCEGKAGSPSKDSCDYCLEEATKDGINRRCGKGGCLSIGNLRCC 206
Y+ L C +C C KA P D + C +G + CG L I L C
Sbjct: 433 YKGLCCKDCQILQSGVECRPKA-HPECDIAENC------NGSSPECGPDITL-INGLSCK 484
Query: 207 NNKDLCNDGK*NLDCN 254
NNK +C DG DC+
Sbjct: 485 NNKFICYDG----DCH 496
>sp|Q9NZR2|LRP1B_HUMAN Low-density lipoprotein receptor-related protein 1B precursor
(Low-density lipoprotein receptor-related protein-deleted
in tumor) (LRP-DIT)
Length = 4599
Score = 30.0 bits (66), Expect = 1.7
Identities = 13/33 (39%), Positives = 18/33 (54%)
Frame = +3
Query: 162 CGKGGCLSIGNLRCCNNKDLCNDGK*NLDCNFD 260
C G C+ G L C+NKD C DG +C+ +
Sbjct: 2898 CKNGRCIPSGGL--CDNKDDCGDGSDERNCHIN 2928
Score = 28.5 bits (62), Expect = 4.9
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Frame = +3
Query: 51 ALKCYECDHCEGKAGSPSKD-SCD--YCLEEATKDGINRRCGKGGCLSIGNLRCCNNKDL 221
AL + CD E G S + +CD CL K N++C + + NLRC N +D
Sbjct: 3370 ALPAFICDG-ENDCGDNSDELNCDTHVCLSGQFKCTKNQKC-----IPV-NLRC-NGQDD 3421
Query: 222 CNDGK*NLDCNFDNLDYSYYQ 284
C D + DC ++ Y+Q
Sbjct: 3422 CGDEEDERDCPENSCSPDYFQ 3442
Score = 28.1 bits (61), Expect = 6.5
Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 4/70 (5%)
Frame = +3
Query: 54 LKCYECDHCEGKAGSPSKDSCDYCLEEATKDGI----NRRCGKGGCLSIGNLRCCNNKDL 221
L C HC+ K S + YC + + G NRRC G + C+ ++
Sbjct: 2528 LTCDGIPHCKDK----SDEKLLYCENRSCRRGFKPCYNRRCIPHG-------KLCDGEND 2576
Query: 222 CNDGK*NLDC 251
C D LDC
Sbjct: 2577 CGDNSDELDC 2586
>sp|P98155|VLDLR_HUMAN Very low-density lipoprotein receptor precursor (VLDL receptor)
Length = 873
Score = 29.6 bits (65), Expect = 2.2
Identities = 13/30 (43%), Positives = 17/30 (56%)
Frame = +3
Query: 162 CGKGGCLSIGNLRCCNNKDLCNDGK*NLDC 251
C G C+S + CN +D C+DG LDC
Sbjct: 161 CSSGRCISRNFV--CNGQDDCSDGSDELDC 188
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,325,666
Number of Sequences: 369166
Number of extensions: 463602
Number of successful extensions: 1349
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1263
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1347
length of database: 68,354,980
effective HSP length: 67
effective length of database: 55,977,735
effective search space used: 1679332050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)