Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_D15
(914 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 86 2e-16
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 84 6e-16
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 84 6e-16
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 84 7e-16
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 82 2e-15
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 82 2e-15
sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 82 3e-15
sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Eps... 80 6e-15
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 73 1e-12
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 72 3e-12
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 85.5 bits (210), Expect = 2e-16
Identities = 38/92 (41%), Positives = 55/92 (59%)
Frame = +3
Query: 639 GEFIWRXXXXXXXXXXXXNGINKIIYSDSFYTHKHGYKMCLRVDPDGDGSAKGTHLSLYY 818
G+ IW+ G ++S FYT + GY++C R +GDGS KGTHLSLY+
Sbjct: 404 GKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYF 463
Query: 819 CLMKGEFDDILEWSFKFDLTLSLIDQQTRLAH 914
+M+GEFD +L+W F+ +TL L+DQ + H
Sbjct: 464 VVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNH 495
Score = 65.1 bits (157), Expect = 3e-10
Identities = 30/87 (34%), Positives = 48/87 (55%)
Frame = +3
Query: 135 NGEFVWIIDKISEKMKDAKNGINTTIYSDSFYTHKNGYKMCLSAEPDGFDEDKGNLCFVL 314
+G+ +W + K ++A G +++S FYT + GY++C A +G KG +
Sbjct: 403 SGKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLY 462
Query: 315 FHLMKGEFDDDLMWPFAFDVTFSLINQ 395
F +M+GEFD L WPF VT L++Q
Sbjct: 463 FVVMRGEFDSLLQWPFRQRVTLMLLDQ 489
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 84.0 bits (206), Expect = 6e-16
Identities = 39/89 (43%), Positives = 54/89 (60%)
Frame = +3
Query: 639 GEFIWRXXXXXXXXXXXXNGINKIIYSDSFYTHKHGYKMCLRVDPDGDGSAKGTHLSLYY 818
G FIW+ G I+S +FYT ++GYKMCLRV +GDG+ +GTHLSL++
Sbjct: 352 GVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFF 411
Query: 819 CLMKGEFDDILEWSFKFDLTLSLIDQQTR 905
+MKG D +L+W F +TL L+D R
Sbjct: 412 VVMKGPNDALLQWPFNQKVTLMLLDHNNR 440
Score = 62.4 bits (150), Expect = 2e-09
Identities = 32/86 (37%), Positives = 46/86 (53%)
Frame = +3
Query: 135 NGEFVWIIDKISEKMKDAKNGINTTIYSDSFYTHKNGYKMCLSAEPDGFDEDKGNLCFVL 314
+G F+W I + K ++A G I+S +FYT + GYKMCL +G +G +
Sbjct: 351 DGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLF 410
Query: 315 FHLMKGEFDDDLMWPFAFDVTFSLIN 392
F +MKG D L WPF VT L++
Sbjct: 411 FVVMKGPNDALLQWPFNQKVTLMLLD 436
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 84.0 bits (206), Expect = 6e-16
Identities = 37/86 (43%), Positives = 55/86 (63%)
Frame = +3
Query: 639 GEFIWRXXXXXXXXXXXXNGINKIIYSDSFYTHKHGYKMCLRVDPDGDGSAKGTHLSLYY 818
G+ IW+ +G I+S SFYT + GY++C R +GDGS +G+HLSLY+
Sbjct: 404 GKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYF 463
Query: 819 CLMKGEFDDILEWSFKFDLTLSLIDQ 896
+M+GEFD +L+W F+ +TL L+DQ
Sbjct: 464 VVMRGEFDSLLQWPFRQRVTLMLLDQ 489
Score = 75.5 bits (184), Expect = 2e-13
Identities = 44/135 (32%), Positives = 73/135 (54%), Gaps = 7/135 (5%)
Frame = +3
Query: 12 ITNMKNVENKFANAMEERINKEKDLMKLSK--IVENEDT-----PTLTNGEFVWIIDKIS 170
IT ++N + + A +EE NK + + K + +NE+ T NG+ +W +
Sbjct: 356 ITLLENNDQRLA-VLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYK 414
Query: 171 EKMKDAKNGINTTIYSDSFYTHKNGYKMCLSAEPDGFDEDKGNLCFVLFHLMKGEFDDDL 350
K ++A +G +I+S SFYT + GY++C A +G +G+ + F +M+GEFD L
Sbjct: 415 MKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLL 474
Query: 351 MWPFAFDVTFSLINQ 395
WPF VT L++Q
Sbjct: 475 QWPFRQRVTLMLLDQ 489
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 83.6 bits (205), Expect = 7e-16
Identities = 39/89 (43%), Positives = 54/89 (60%)
Frame = +3
Query: 639 GEFIWRXXXXXXXXXXXXNGINKIIYSDSFYTHKHGYKMCLRVDPDGDGSAKGTHLSLYY 818
G FIW+ G I+S +FYT ++GYKMCLR+ +GDG+ +GTHLSL++
Sbjct: 352 GVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFF 411
Query: 819 CLMKGEFDDILEWSFKFDLTLSLIDQQTR 905
+MKG D +L W F +TL L+DQ R
Sbjct: 412 VVMKGPNDALLRWPFNQKVTLMLLDQNNR 440
Score = 62.8 bits (151), Expect = 1e-09
Identities = 36/99 (36%), Positives = 53/99 (53%)
Frame = +3
Query: 99 KIVENEDTPTLTNGEFVWIIDKISEKMKDAKNGINTTIYSDSFYTHKNGYKMCLSAEPDG 278
K++E E + +G F+W I + K ++A G I+S +FYT + GYKMCL +G
Sbjct: 341 KVLEME--ASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNG 398
Query: 279 FDEDKGNLCFVLFHLMKGEFDDDLMWPFAFDVTFSLINQ 395
+G + F +MKG D L WPF VT L++Q
Sbjct: 399 DGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQ 437
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 82.0 bits (201), Expect = 2e-15
Identities = 40/92 (43%), Positives = 52/92 (56%)
Frame = +3
Query: 639 GEFIWRXXXXXXXXXXXXNGINKIIYSDSFYTHKHGYKMCLRVDPDGDGSAKGTHLSLYY 818
G IW+ G +YS FYT GYKMC RV +GDG KGTHLSL++
Sbjct: 416 GVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFF 475
Query: 819 CLMKGEFDDILEWSFKFDLTLSLIDQQTRLAH 914
+M+GE+D +L W FK +TL L+DQ + H
Sbjct: 476 VIMRGEYDALLPWPFKQKVTLMLMDQGSSRRH 507
Score = 61.6 bits (148), Expect = 3e-09
Identities = 32/87 (36%), Positives = 45/87 (51%)
Frame = +3
Query: 135 NGEFVWIIDKISEKMKDAKNGINTTIYSDSFYTHKNGYKMCLSAEPDGFDEDKGNLCFVL 314
NG +W I + ++A G ++YS FYT GYKMC +G KG +
Sbjct: 415 NGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLF 474
Query: 315 FHLMKGEFDDDLMWPFAFDVTFSLINQ 395
F +M+GE+D L WPF VT L++Q
Sbjct: 475 FVIMRGEYDALLPWPFKQKVTLMLMDQ 501
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 82.0 bits (201), Expect = 2e-15
Identities = 40/92 (43%), Positives = 52/92 (56%)
Frame = +3
Query: 639 GEFIWRXXXXXXXXXXXXNGINKIIYSDSFYTHKHGYKMCLRVDPDGDGSAKGTHLSLYY 818
G IW+ G +YS FYT GYKMC RV +GDG KGTHLSL++
Sbjct: 415 GVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFF 474
Query: 819 CLMKGEFDDILEWSFKFDLTLSLIDQQTRLAH 914
+M+GE+D +L W FK +TL L+DQ + H
Sbjct: 475 VIMRGEYDALLPWPFKQKVTLMLMDQGSSRRH 506
Score = 61.6 bits (148), Expect = 3e-09
Identities = 32/87 (36%), Positives = 45/87 (51%)
Frame = +3
Query: 135 NGEFVWIIDKISEKMKDAKNGINTTIYSDSFYTHKNGYKMCLSAEPDGFDEDKGNLCFVL 314
NG +W I + ++A G ++YS FYT GYKMC +G KG +
Sbjct: 414 NGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLF 473
Query: 315 FHLMKGEFDDDLMWPFAFDVTFSLINQ 395
F +M+GE+D L WPF VT L++Q
Sbjct: 474 FVIMRGEYDALLPWPFKQKVTLMLMDQ 500
>sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1
Length = 409
Score = 81.6 bits (200), Expect = 3e-15
Identities = 37/89 (41%), Positives = 54/89 (60%)
Frame = +3
Query: 639 GEFIWRXXXXXXXXXXXXNGINKIIYSDSFYTHKHGYKMCLRVDPDGDGSAKGTHLSLYY 818
G F+W+ G ++S +FYT K+GYK+CLR+ +GDGS K THLSL+
Sbjct: 260 GTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFI 319
Query: 819 CLMKGEFDDILEWSFKFDLTLSLIDQQTR 905
+M+GE+D +L W F+ +T L+DQ R
Sbjct: 320 VIMRGEYDALLPWPFRNKVTFMLLDQNNR 348
Score = 64.3 bits (155), Expect = 5e-10
Identities = 35/126 (27%), Positives = 66/126 (52%)
Frame = +3
Query: 18 NMKNVENKFANAMEERINKEKDLMKLSKIVENEDTPTLTNGEFVWIIDKISEKMKDAKNG 197
++ ++E + + K++ L KL + + + +G F+W I ++++ ++ G
Sbjct: 221 HLLSLEQRVVELQQTLAQKDQVLGKLEHSLRLMEEASF-DGTFLWKITNVTKRCHESVCG 279
Query: 198 INTTIYSDSFYTHKNGYKMCLSAEPDGFDEDKGNLCFVLFHLMKGEFDDDLMWPFAFDVT 377
+++S +FYT K GYK+CL +G K + +M+GE+D L WPF VT
Sbjct: 280 RTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVT 339
Query: 378 FSLINQ 395
F L++Q
Sbjct: 340 FMLLDQ 345
>sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced
protein 6)
Length = 416
Score = 80.5 bits (197), Expect = 6e-15
Identities = 36/89 (40%), Positives = 54/89 (60%)
Frame = +3
Query: 639 GEFIWRXXXXXXXXXXXXNGINKIIYSDSFYTHKHGYKMCLRVDPDGDGSAKGTHLSLYY 818
G F+W+ G ++S +FYT K+GYK+CLR+ +GDG+ K THLSL+
Sbjct: 267 GTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFI 326
Query: 819 CLMKGEFDDILEWSFKFDLTLSLIDQQTR 905
+M+GE+D +L W F+ +T L+DQ R
Sbjct: 327 VIMRGEYDALLPWPFRNKVTFMLLDQNNR 355
Score = 64.7 bits (156), Expect = 3e-10
Identities = 35/123 (28%), Positives = 64/123 (52%)
Frame = +3
Query: 27 NVENKFANAMEERINKEKDLMKLSKIVENEDTPTLTNGEFVWIIDKISEKMKDAKNGINT 206
++E + + K++ L KL + + + + +G F+W I ++ + ++ G
Sbjct: 231 SLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASF-DGTFLWKITNVTRRCHESACGRTV 289
Query: 207 TIYSDSFYTHKNGYKMCLSAEPDGFDEDKGNLCFVLFHLMKGEFDDDLMWPFAFDVTFSL 386
+++S +FYT K GYK+CL +G K + +M+GE+D L WPF VTF L
Sbjct: 290 SLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFML 349
Query: 387 INQ 395
++Q
Sbjct: 350 LDQ 352
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 73.2 bits (178), Expect = 1e-12
Identities = 38/103 (36%), Positives = 59/103 (57%), Gaps = 3/103 (2%)
Frame = +3
Query: 597 ELLKIKMDQHKLNFGE---FIWRXXXXXXXXXXXXNGINKIIYSDSFYTHKHGYKMCLRV 767
EL +++ + +L+ G IW+ N +S +FYTHK+GYK+ +
Sbjct: 291 ELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSA 350
Query: 768 DPDGDGSAKGTHLSLYYCLMKGEFDDILEWSFKFDLTLSLIDQ 896
+G+GS +GTHLSLY ++ G FD++LEW F +T SL+DQ
Sbjct: 351 FLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQ 393
Score = 68.6 bits (166), Expect = 2e-11
Identities = 37/108 (34%), Positives = 62/108 (57%)
Frame = +3
Query: 72 KEKDLMKLSKIVENEDTPTLTNGEFVWIIDKISEKMKDAKNGINTTIYSDSFYTHKNGYK 251
+ ++L +L + E E+ ++G +W I ++++AK N +S +FYTHK GYK
Sbjct: 288 QRQELQELRR--ELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYK 345
Query: 252 MCLSAEPDGFDEDKGNLCFVLFHLMKGEFDDDLMWPFAFDVTFSLINQ 395
+ +SA +G +G + ++ G FD+ L WPFA VTFSL++Q
Sbjct: 346 LQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQ 393
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 71.6 bits (174), Expect = 3e-12
Identities = 36/103 (34%), Positives = 58/103 (56%), Gaps = 3/103 (2%)
Frame = +3
Query: 597 ELLKIKMDQHKLNFGE---FIWRXXXXXXXXXXXXNGINKIIYSDSFYTHKHGYKMCLRV 767
EL +++ + +L+ G IW+ N +S +FYTHK+GYK+ +
Sbjct: 291 ELQELRRELEELSIGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSA 350
Query: 768 DPDGDGSAKGTHLSLYYCLMKGEFDDILEWSFKFDLTLSLIDQ 896
+G+GS +GTHLS+Y ++ G FD++LEW +T SL+DQ
Sbjct: 351 SLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPLARRVTFSLLDQ 393
Score = 67.8 bits (164), Expect = 4e-11
Identities = 36/108 (33%), Positives = 61/108 (56%)
Frame = +3
Query: 72 KEKDLMKLSKIVENEDTPTLTNGEFVWIIDKISEKMKDAKNGINTTIYSDSFYTHKNGYK 251
+ ++L +L + E E+ ++G +W I ++++AK N +S +FYTHK GYK
Sbjct: 288 QRQELQELRR--ELEELSIGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYK 345
Query: 252 MCLSAEPDGFDEDKGNLCFVLFHLMKGEFDDDLMWPFAFDVTFSLINQ 395
+ +SA +G +G + ++ G FD+ L WP A VTFSL++Q
Sbjct: 346 LQVSASLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPLARRVTFSLLDQ 393
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,572,653
Number of Sequences: 369166
Number of extensions: 1650953
Number of successful extensions: 4321
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4054
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4315
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9318621220
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)