Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_B21
(496 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P04818|TYSY_HUMAN Thymidylate synthase (TS) (TSase) 156 2e-38
sp|P07607|TYSY_MOUSE Thymidylate synthase (TS) (TSase) 156 3e-38
sp|P45352|TYSY_RAT Thymidylate synthase (TS) (TSase) 155 6e-38
sp|O76511|TYSY_DROME Thymidylate synthase (TS) (TSase) 152 3e-37
sp|P06854|TYSY_SHV21 Thymidylate synthase (TS) (TSase) 150 2e-36
sp|P12462|TYSY_HSVAT Thymidylate synthase (TS) (TSase) 149 3e-36
sp|Q89940|TYSY_EHV2 Thymidylate synthase (TS) (TSase) 147 1e-35
sp|P06785|TYSY_YEAST Thymidylate synthase (TS) (TSase) 141 1e-33
sp|P09249|TYSY_VZVD Thymidylate synthase (TS) (TSase) 140 1e-33
sp|P90463|TYSY_HHV8 Thymidylate synthase (TS) (TSase) 140 1e-33
>sp|P04818|TYSY_HUMAN Thymidylate synthase (TS) (TSase)
Length = 313
Score = 156 bits (395), Expect = 2e-38
Identities = 69/103 (66%), Positives = 87/103 (84%)
Frame = +1
Query: 1 KLYQRSGDMGLGVPFNIASYAIFTCMIAHVTGLKPGRFFHTLGDSHVYLNHIDAMRTQLS 180
+LYQRSGDMGLGVPFNIASYA+ T MIAH+TGLKPG F HTLGD+H+YLNHI+ ++ QL
Sbjct: 211 QLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQ 270
Query: 181 RQPRDFPKLKFRRQVDRIEDFHVDDFVIENYHPHPRIHMDMAL 309
R+PR FPKL+ R+V++I+DF +DF IE Y+PHP I M+MA+
Sbjct: 271 REPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 313
>sp|P07607|TYSY_MOUSE Thymidylate synthase (TS) (TSase)
Length = 307
Score = 156 bits (394), Expect = 3e-38
Identities = 70/103 (67%), Positives = 87/103 (84%)
Frame = +1
Query: 1 KLYQRSGDMGLGVPFNIASYAIFTCMIAHVTGLKPGRFFHTLGDSHVYLNHIDAMRTQLS 180
+LYQRSGDMGLGVPFNIASYA+ T MIAH+TGL+PG F HTLGD+H+YLNHI+ ++ QL
Sbjct: 205 QLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQ 264
Query: 181 RQPRDFPKLKFRRQVDRIEDFHVDDFVIENYHPHPRIHMDMAL 309
R+PR FPKLK R+V+ I+DF V+DF IE Y+PHP I M+MA+
Sbjct: 265 REPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV 307
>sp|P45352|TYSY_RAT Thymidylate synthase (TS) (TSase)
Length = 307
Score = 155 bits (391), Expect = 6e-38
Identities = 69/103 (66%), Positives = 87/103 (84%)
Frame = +1
Query: 1 KLYQRSGDMGLGVPFNIASYAIFTCMIAHVTGLKPGRFFHTLGDSHVYLNHIDAMRTQLS 180
+LYQRSGDMGLGVPFNIASYA+ T MIAH+TGL+PG F HTLGD+H+YLNHI+ ++ QL
Sbjct: 205 QLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQ 264
Query: 181 RQPRDFPKLKFRRQVDRIEDFHVDDFVIENYHPHPRIHMDMAL 309
R+PR FPKL+ R+V+ I+DF V+DF IE Y+PHP I M+MA+
Sbjct: 265 REPRPFPKLRILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV 307
>sp|O76511|TYSY_DROME Thymidylate synthase (TS) (TSase)
Length = 321
Score = 152 bits (385), Expect = 3e-37
Identities = 70/103 (67%), Positives = 84/103 (81%)
Frame = +1
Query: 1 KLYQRSGDMGLGVPFNIASYAIFTCMIAHVTGLKPGRFFHTLGDSHVYLNHIDAMRTQLS 180
+LYQRS DMGLGVPFNIASYA+ T MIAHVTGLKPG F HT+GD+HVYLNH++ ++ QL
Sbjct: 219 QLYQRSADMGLGVPFNIASYALLTHMIAHVTGLKPGDFVHTMGDTHVYLNHVEPLKEQLE 278
Query: 181 RQPRDFPKLKFRRQVDRIEDFHVDDFVIENYHPHPRIHMDMAL 309
R PR FPKL +RQV IEDF +DF I +Y+PHP+I MDMA+
Sbjct: 279 RTPRPFPKLIIKRQVQDIEDFRFEDFQIVDYNPHPKIQMDMAV 321
>sp|P06854|TYSY_SHV21 Thymidylate synthase (TS) (TSase)
Length = 294
Score = 150 bits (379), Expect = 2e-36
Identities = 66/103 (64%), Positives = 83/103 (80%)
Frame = +1
Query: 1 KLYQRSGDMGLGVPFNIASYAIFTCMIAHVTGLKPGRFFHTLGDSHVYLNHIDAMRTQLS 180
+LYQRS DMGLGVPFNIASY++ TCMIAHVT L PG F HT+GD+H+Y++HIDA++ QL+
Sbjct: 192 QLYQRSADMGLGVPFNIASYSLLTCMIAHVTNLVPGEFIHTIGDAHIYVDHIDALKMQLT 251
Query: 181 RQPRDFPKLKFRRQVDRIEDFHVDDFVIENYHPHPRIHMDMAL 309
R PR FP L+F R V I+DF DD ++ENY+PHP I M MA+
Sbjct: 252 RTPRPFPTLRFARNVSCIDDFKADDIILENYNPHPIIKMHMAV 294
>sp|P12462|TYSY_HSVAT Thymidylate synthase (TS) (TSase)
Length = 290
Score = 149 bits (377), Expect = 3e-36
Identities = 67/103 (65%), Positives = 83/103 (80%)
Frame = +1
Query: 1 KLYQRSGDMGLGVPFNIASYAIFTCMIAHVTGLKPGRFFHTLGDSHVYLNHIDAMRTQLS 180
+LYQRS DMGLGVPFNIASY++ TCMIAHVT L PG F HTLGD+HVY+NH+DA+ QL+
Sbjct: 188 QLYQRSADMGLGVPFNIASYSLLTCMIAHVTDLVPGEFIHTLGDAHVYVNHVDALTEQLT 247
Query: 181 RQPRDFPKLKFRRQVDRIEDFHVDDFVIENYHPHPRIHMDMAL 309
R PR FP LKF R+V I+DF +D ++ENY+P+P I M MA+
Sbjct: 248 RTPRPFPTLKFARKVASIDDFKANDIILENYNPYPSIKMPMAV 290
>sp|Q89940|TYSY_EHV2 Thymidylate synthase (TS) (TSase)
Length = 289
Score = 147 bits (371), Expect = 1e-35
Identities = 63/103 (61%), Positives = 84/103 (81%)
Frame = +1
Query: 1 KLYQRSGDMGLGVPFNIASYAIFTCMIAHVTGLKPGRFFHTLGDSHVYLNHIDAMRTQLS 180
+LYQRSGDMGLGVPFNIASY++ T M+AH+TGL+PG F H LGD+HVYLNH++ ++ QL+
Sbjct: 187 QLYQRSGDMGLGVPFNIASYSLLTYMVAHLTGLEPGDFIHVLGDAHVYLNHVEPLKLQLT 246
Query: 181 RQPRDFPKLKFRRQVDRIEDFHVDDFVIENYHPHPRIHMDMAL 309
R PR FP+L+ R+V+ I+DF +DF +E YHPH I M+MA+
Sbjct: 247 RSPRPFPRLRILRRVEDIDDFRAEDFALEGYHPHAAIPMEMAV 289
>sp|P06785|TYSY_YEAST Thymidylate synthase (TS) (TSase)
Length = 304
Score = 141 bits (355), Expect = 1e-33
Identities = 65/102 (63%), Positives = 81/102 (79%)
Frame = +1
Query: 4 LYQRSGDMGLGVPFNIASYAIFTCMIAHVTGLKPGRFFHTLGDSHVYLNHIDAMRTQLSR 183
LYQRS DMGLGVPFNIASYA+ T MIA V ++PG F HTLGD+HVY +HIDA++ Q++R
Sbjct: 203 LYQRSCDMGLGVPFNIASYALLTRMIAKVVDMEPGEFIHTLGDAHVYKDHIDALKEQITR 262
Query: 184 QPRDFPKLKFRRQVDRIEDFHVDDFVIENYHPHPRIHMDMAL 309
PR FPKLK +R V I+DF + DF IE+Y+PHPRI M M++
Sbjct: 263 NPRPFPKLKIKRDVKDIDDFKLTDFEIEDYNPHPRIQMKMSV 304
>sp|P09249|TYSY_VZVD Thymidylate synthase (TS) (TSase)
Length = 301
Score = 140 bits (354), Expect = 1e-33
Identities = 63/103 (61%), Positives = 80/103 (77%)
Frame = +1
Query: 1 KLYQRSGDMGLGVPFNIASYAIFTCMIAHVTGLKPGRFFHTLGDSHVYLNHIDAMRTQLS 180
++YQRSGDMGLGVPFNIA YA+ T ++AHVTGLK G HT+GD+H+YLNHIDA++ QL+
Sbjct: 199 QVYQRSGDMGLGVPFNIAGYALLTYIVAHVTGLKTGDLIHTMGDAHIYLNHIDALKVQLA 258
Query: 181 RQPRDFPKLKFRRQVDRIEDFHVDDFVIENYHPHPRIHMDMAL 309
R P+ FP LK R V I DF DDF ++ Y+PHP + M+MAL
Sbjct: 259 RSPKPFPCLKIIRNVTDINDFKWDDFQLDGYNPHPPLKMEMAL 301
>sp|P90463|TYSY_HHV8 Thymidylate synthase (TS) (TSase)
Length = 337
Score = 140 bits (354), Expect = 1e-33
Identities = 63/103 (61%), Positives = 81/103 (78%)
Frame = +1
Query: 1 KLYQRSGDMGLGVPFNIASYAIFTCMIAHVTGLKPGRFFHTLGDSHVYLNHIDAMRTQLS 180
+LYQRSGDMGLGVPFNIASY++ T M+AHVTGL+PG F HTLGD+H+Y HI+ +R QL+
Sbjct: 235 QLYQRSGDMGLGVPFNIASYSLLTYMLAHVTGLRPGEFIHTLGDAHIYKTHIEPLRLQLT 294
Query: 181 RQPRDFPKLKFRRQVDRIEDFHVDDFVIENYHPHPRIHMDMAL 309
R PR FP+L+ R V +E+F DDF + +Y PHP I M+MA+
Sbjct: 295 RTPRPFPRLEILRSVSSMEEFTPDDFRLVDYCPHPTIRMEMAV 337
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,288,434
Number of Sequences: 369166
Number of extensions: 1296120
Number of successful extensions: 4026
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3818
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3984
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 3069744620
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)