Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_B17
(581 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9QZA6|CD151_RAT Platelet endothelial tetraspan antigen ... 73 6e-13
sp|P24485|CD53_RAT Leukocyte surface antigen CD53 (Cell sur... 72 8e-13
sp|Q61451|CD53_MOUSE Leukocyte surface antigen CD53 (Cell s... 72 8e-13
sp|O35566|C151_MOUSE Platelet-endothelial tetraspan antigen... 71 2e-12
sp|P19397|CD53_HUMAN Leukocyte surface antigen CD53 (Cell s... 70 3e-12
sp|O60637|TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Transmembrane... 70 4e-12
sp|Q9QY33|TSN3_MOUSE Tetraspanin-3 (Tspan-3) (Transmembrane... 70 4e-12
sp|P48509|CD151_HUMAN Platelet-endothelial tetraspan antige... 69 8e-12
sp|P61171|CD151_MACMU Platelet-endothelial tetraspan antige... 68 1e-11
sp|O60635|TSN1_HUMAN Tetraspanin-1 (Tspan-1) (Tetraspan NET... 68 2e-11
>sp|Q9QZA6|CD151_RAT Platelet endothelial tetraspan antigen 3 (CD151 antigen)
Length = 253
Score = 72.8 bits (177), Expect = 6e-13
Identities = 43/171 (25%), Positives = 81/171 (47%), Gaps = 5/171 (2%)
Frame = +1
Query: 61 IFSYS---FLVLLSILCGGFGGWLISQEHWTILLFGTQTIQSMGWVLVAAGILIFLTAIF 231
+F+Y+ +L L+++ G W ++ + I L + T + ++LV AG+++ +T +
Sbjct: 20 LFTYNCCFWLAGLAVMAVGI--WTLALKSDYISLLASSTYLATAYILVVAGVVVMVTGVL 77
Query: 232 GCIGTIKESRCFIIMFXXXXXXXXXXXXXSGTLLFIYKKQAESAVTTHLQKEFTNKY--G 405
GC T KE R + ++ +G L ++Y +Q + + +L+ +Y
Sbjct: 78 GCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMIKRYHQS 137
Query: 406 VDEPYTRLWDEFQPEHKCCGIDSGADYKSTKWYNSPNQDFHRDGEVPLSCC 558
E T D+ Q E CCG ++ D++ ++W S D VP SCC
Sbjct: 138 GHEGVTNAVDKLQQEFHCCGSNNSRDWRDSEWIRSGEAD---SRVVPDSCC 185
>sp|P24485|CD53_RAT Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53)
(Leukocyte antigen MRC OX-44)
Length = 219
Score = 72.4 bits (176), Expect = 8e-13
Identities = 48/155 (30%), Positives = 76/155 (49%), Gaps = 3/155 (1%)
Frame = +1
Query: 37 MCSLKSIN--IFSYSFLVLLSILCG-GFGGWLISQEHWTILLFGTQTIQSMGWVLVAAGI 207
M SLK + +F ++FL + C GFG L+ Q + IL F ++G VLV G
Sbjct: 3 MSSLKLLKYVLFFFNFLFWVCGCCILGFGIHLLVQNTYGIL-FRNLPFLTLGNVLVIVGS 61
Query: 208 LIFLTAIFGCIGTIKESRCFIIMFXXXXXXXXXXXXXSGTLLFIYKKQAESAVTTHLQKE 387
+I + A GC+G+IKE++C ++ F LLF+Y+K+ + V L
Sbjct: 62 IIMVVAFLGCMGSIKENKCLLMSFFVLLLLILLAEVTLAILLFVYEKKINTLVAEGLNDS 121
Query: 388 FTNKYGVDEPYTRLWDEFQPEHKCCGIDSGADYKS 492
+ Y D WD Q + +CCG++ +D+ S
Sbjct: 122 IQH-YHSDNSTRMAWDFIQSQLQCCGVNGSSDWIS 155
>sp|Q61451|CD53_MOUSE Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53)
Length = 219
Score = 72.4 bits (176), Expect = 8e-13
Identities = 44/156 (28%), Positives = 76/156 (48%), Gaps = 4/156 (2%)
Frame = +1
Query: 37 MCSLKSINIFSYSFLVLLSILCG----GFGGWLISQEHWTILLFGTQTIQSMGWVLVAAG 204
M SLK + + F +L + CG GFG + + Q + +L F ++G +LV G
Sbjct: 3 MSSLKLLKYVLFIFNLLFWV-CGCCILGFGIYFLVQNTYGVL-FRNLPFLTLGNILVIVG 60
Query: 205 ILIFLTAIFGCIGTIKESRCFIIMFXXXXXXXXXXXXXSGTLLFIYKKQAESAVTTHLQK 384
+I + A GC+G+IKE++C ++ F LLF+Y+++ + V L
Sbjct: 61 SIIMVVAFLGCMGSIKENKCLLMSFFVLLLIILLAEVTIAILLFVYEQKLNTLVAEGLND 120
Query: 385 EFTNKYGVDEPYTRLWDEFQPEHKCCGIDSGADYKS 492
+ Y D + WD Q + +CCG++ +D+ S
Sbjct: 121 SIQH-YHSDNSTMKAWDFIQTQLQCCGVNGSSDWTS 155
>sp|O35566|C151_MOUSE Platelet-endothelial tetraspan antigen 3 (PETA-3) (GP27) (Membrane
glycoprotein SFA-1) (CD151 antigen)
Length = 253
Score = 70.9 bits (172), Expect = 2e-12
Identities = 42/171 (24%), Positives = 81/171 (47%), Gaps = 5/171 (2%)
Frame = +1
Query: 61 IFSYS---FLVLLSILCGGFGGWLISQEHWTILLFGTQTIQSMGWVLVAAGILIFLTAIF 231
+F+Y+ +L L+++ G W ++ + I L + T + ++LV AG+++ +T +
Sbjct: 20 LFTYNCCFWLAGLAVMAVGI--WTLALKSDYISLLASSTYLATAYILVVAGVVVMVTGVL 77
Query: 232 GCIGTIKESRCFIIMFXXXXXXXXXXXXXSGTLLFIYKKQAESAVTTHLQKEFTNKY--G 405
GC T KE R + ++ +G L ++Y +Q + + +L+ +Y
Sbjct: 78 GCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMVKRYHQS 137
Query: 406 VDEPYTRLWDEFQPEHKCCGIDSGADYKSTKWYNSPNQDFHRDGEVPLSCC 558
E + D+ Q E CCG ++ D++ ++W S D VP SCC
Sbjct: 138 GHEGVSSAVDKLQQEFHCCGSNNSQDWQDSEWIRSGEAD---SRVVPDSCC 185
>sp|P19397|CD53_HUMAN Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53)
(Tetraspanin-25) (Tspan-25)
Length = 219
Score = 70.5 bits (171), Expect = 3e-12
Identities = 45/156 (28%), Positives = 76/156 (48%), Gaps = 4/156 (2%)
Frame = +1
Query: 37 MCSLKSINIFSYSFLVLLSILCG----GFGGWLISQEHWTILLFGTQTIQSMGWVLVAAG 204
M SLK + + F LL +CG GFG +L+ ++ +L ++ ++G V V G
Sbjct: 3 MSSLKLLKYVLF-FFNLLFWICGCCILGFGIYLLIHNNFGVLFHNLPSL-TLGNVFVIVG 60
Query: 205 ILIFLTAIFGCIGTIKESRCFIIMFXXXXXXXXXXXXXSGTLLFIYKKQAESAVTTHLQK 384
+I + A GC+G+IKE++C ++ F LLF+Y+++ V L
Sbjct: 61 SIIMVVAFLGCMGSIKENKCLLMSFFILLLIILLAEVTLAILLFVYEQKLNEYVAKGL-T 119
Query: 385 EFTNKYGVDEPYTRLWDEFQPEHKCCGIDSGADYKS 492
+ ++Y D WD Q +CCGI+ +D+ S
Sbjct: 120 DSIHRYHSDNSTKAAWDSIQSFLQCCGINGTSDWTS 155
>sp|O60637|TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8)
(Tetraspanin TM4-A)
Length = 253
Score = 70.1 bits (170), Expect = 4e-12
Identities = 37/125 (29%), Positives = 63/125 (50%), Gaps = 1/125 (0%)
Frame = +1
Query: 187 VLVAAGILIFLTAIFGCIGTIKESRCFIIMFXXXXXXXXXXXXXSGTLLFIYKKQAESAV 366
V++A G L+F+ + GC TI+ESRC + F L ++Y+ + E+ V
Sbjct: 56 VIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEV 115
Query: 367 TTHLQKEFTNKYGVD-EPYTRLWDEFQPEHKCCGIDSGADYKSTKWYNSPNQDFHRDGEV 543
+QK + G + + +R D Q + CCGI + +D+++T W+ ++ V
Sbjct: 116 DRSIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKET-----KNQSV 170
Query: 544 PLSCC 558
PLSCC
Sbjct: 171 PLSCC 175
>sp|Q9QY33|TSN3_MOUSE Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8)
(Tetraspanin TM4-A) (OSP-associated protein 1) (OAP-1)
Length = 253
Score = 70.1 bits (170), Expect = 4e-12
Identities = 37/125 (29%), Positives = 63/125 (50%), Gaps = 1/125 (0%)
Frame = +1
Query: 187 VLVAAGILIFLTAIFGCIGTIKESRCFIIMFXXXXXXXXXXXXXSGTLLFIYKKQAESAV 366
V++A G L+F+ + GC TI+ESRC + F L ++Y+ + E+ V
Sbjct: 56 VIIAVGALLFIIGLIGCCATIRESRCGLATFVFILLLVFVTEVVVVVLGYVYRAKVENEV 115
Query: 367 TTHLQKEFTNKYGVD-EPYTRLWDEFQPEHKCCGIDSGADYKSTKWYNSPNQDFHRDGEV 543
+QK + G + + +R D Q + CCGI + +D+++T W+ ++ V
Sbjct: 116 DRSIQKVYKTYNGTNSDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKET-----KNQSV 170
Query: 544 PLSCC 558
PLSCC
Sbjct: 171 PLSCC 175
>sp|P48509|CD151_HUMAN Platelet-endothelial tetraspan antigen 3 (PETA-3) (GP27) (Membrane
glycoprotein SFA-1) (CD151 antigen) (Tetraspanin-24)
(Tspan-24)
Length = 253
Score = 68.9 bits (167), Expect = 8e-12
Identities = 43/171 (25%), Positives = 79/171 (46%), Gaps = 5/171 (2%)
Frame = +1
Query: 61 IFSYS---FLVLLSILCGGFGGWLISQEHWTILLFGTQTIQSMGWVLVAAGILIFLTAIF 231
+F+Y+ +L L+++ G W ++ + I L + T + ++LV AG ++ +T +
Sbjct: 20 LFTYNCCFWLAGLAVMAVGI--WTLALKSDYISLLASGTYLATAYILVVAGTVVMVTGVL 77
Query: 232 GCIGTIKESRCFIIMFXXXXXXXXXXXXXSGTLLFIYKKQAESAVTTHLQKEFTNKY--G 405
GC T KE R + ++ +G L + Y +Q + + +L+ T +Y
Sbjct: 78 GCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTRRYHQS 137
Query: 406 VDEPYTRLWDEFQPEHKCCGIDSGADYKSTKWYNSPNQDFHRDGEVPLSCC 558
E T D+ Q E CCG ++ D++ ++W S VP SCC
Sbjct: 138 GHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAG---GRVVPDSCC 185
>sp|P61171|CD151_MACMU Platelet-endothelial tetraspan antigen 3 (PETA-3) (CD151 antigen)
sp|P61170|CD151_CERAE Platelet-endothelial tetraspan antigen 3 (PETA-3) (CD151 antigen)
Length = 253
Score = 68.2 bits (165), Expect = 1e-11
Identities = 42/171 (24%), Positives = 79/171 (46%), Gaps = 5/171 (2%)
Frame = +1
Query: 61 IFSYS---FLVLLSILCGGFGGWLISQEHWTILLFGTQTIQSMGWVLVAAGILIFLTAIF 231
+F+Y+ +L L+++ G W ++ + I L + T + ++LV AG ++ +T +
Sbjct: 20 LFTYNCCFWLAGLAVMAVGI--WTLALKSDYISLLASGTYLATAYILVVAGAVVMVTGVL 77
Query: 232 GCIGTIKESRCFIIMFXXXXXXXXXXXXXSGTLLFIYKKQAESAVTTHLQKEFTNKYGV- 408
GC T KE R + ++ +G L ++Y +Q + + +L+ +Y
Sbjct: 78 GCCATFKERRNLLRLYFILLLIIFLLEIIAGVLAYVYYQQLNTELKENLKDTMAKRYHQP 137
Query: 409 -DEPYTRLWDEFQPEHKCCGIDSGADYKSTKWYNSPNQDFHRDGEVPLSCC 558
E T D+ Q E CCG ++ D++ ++W R VP SCC
Sbjct: 138 GHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRLREA---RGRVVPDSCC 185
>sp|O60635|TSN1_HUMAN Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C)
Length = 241
Score = 67.8 bits (164), Expect = 2e-11
Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 9/167 (5%)
Frame = +1
Query: 85 LLSILCGG----FGGWLISQEHWTILLFGTQTIQSM-----GWVLVAAGILIFLTAIFGC 237
LL LCG G W+ + +FG + +M G+ L+AAG+++F GC
Sbjct: 16 LLIFLCGAALLAVGIWVSIDGASFLKIFGPLSSSAMQFVNVGYFLIAAGVVVFALGFLGC 75
Query: 238 IGTIKESRCFIIMFXXXXXXXXXXXXXSGTLLFIYKKQAESAVTTHLQKEFTNKYGVDEP 417
G ES+C ++ F + + +Y AE +T + YG E
Sbjct: 76 YGAKTESKCALVTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYGSQED 135
Query: 418 YTRLWDEFQPEHKCCGIDSGADYKSTKWYNSPNQDFHRDGEVPLSCC 558
+T++W+ KCCG + D++ + + F + P CC
Sbjct: 136 FTQVWNTTMKGLKCCGFTNYTDFEDSPY-------FKENSAFPPFCC 175
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,128,018
Number of Sequences: 369166
Number of extensions: 1441823
Number of successful extensions: 3920
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3793
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3895
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4308286840
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)