Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_P24
(849 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8ZAN0|FADB_YERPE Fatty oxidation complex alpha subunit ... 84 4e-16
sp|P21177|FADB_ECOLI Fatty oxidation complex alpha subunit ... 81 4e-15
sp|Q8X8I2|FADB_ECO57 Fatty oxidation complex alpha subunit ... 80 9e-15
sp|Q8Z3C6|FADB_SALTI Fatty oxidation complex alpha subunit ... 79 2e-14
sp|Q9L6L5|FADB_SALTY Fatty oxidation complex alpha subunit ... 79 2e-14
sp|Q13825|AUMH_HUMAN Methylglutaconyl-CoA hydratase, mitoch... 79 2e-14
sp|Q9JLZ3|AUHM_MOUSE Methylglutaconyl-CoA hydratase, mitoch... 78 3e-14
sp|P52046|CRT_CLOAB 3-hydroxybutyryl-CoA dehydratase (Croto... 78 4e-14
sp|Q5R646|ECHM_PONPY Enoyl-CoA hydratase, mitochondrial pre... 70 6e-12
sp|Q64428|ECHA_RAT Trifunctional enzyme alpha subunit, mito... 69 2e-11
>sp|Q8ZAN0|FADB_YERPE Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 729
Score = 84.3 bits (207), Expect = 4e-16
Identities = 54/207 (26%), Positives = 102/207 (49%), Gaps = 3/207 (1%)
Frame = +1
Query: 202 FDGGSVYLKSINNDISHLIIDNPESHNSLTGKMMSQLDDCVQILENQPP-KALIXXXXXX 378
+ ++ L + N I+ L+ D P S N L K ++ L + + +LE Q K L+
Sbjct: 3 YQSETLQLHWLENGIAELVFDAPGSVNKLDTKTVANLGEALNVLEKQSELKGLLLRSAKT 62
Query: 379 XXXXXXNLKFVEKISNSNDGD--RMCKFMQSLTRKIEKLPSLSVALIESVAYGGGAELIL 552
++ + N+ + F ++ ++E LP +++ I A GGG E IL
Sbjct: 63 ALIVGADITEFLSLFNAPPEKLHQWLVFANTIFNRLEDLPVPTISAINGYALGGGCECIL 122
Query: 553 CCDFRYIAQNGKLSFKQRKLGVTTGWGGCHKLIQLIGKQATLKLLLNTEVINAQKALEIG 732
DFR + ++ + KLG+ G+GG +L +L+G + L+++ + + A AL+IG
Sbjct: 123 ATDFRIASPEARIGLPETKLGIMPGFGGSVRLPRLLGADSALEIIATGKDVTANDALKIG 182
Query: 733 LVDKILNSNTPDERLEETVQNVKCIID 813
LVD +++ P++ + + +K ID
Sbjct: 183 LVDAVVD---PEKLVGSALTMLKQAID 206
>sp|P21177|FADB_ECOLI Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 729
Score = 80.9 bits (198), Expect = 4e-15
Identities = 50/206 (24%), Positives = 103/206 (50%), Gaps = 3/206 (1%)
Frame = +1
Query: 202 FDGGSVYLKSINNDISHLIIDNPESHNSLTGKMMSQLDDCVQILENQPP-KALIXXXXXX 378
+ G ++YL + + I+ L+ D P S N L ++ L + + +LE Q K L+
Sbjct: 3 YKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGEAIGVLEQQSDLKGLLLRSNKA 62
Query: 379 XXXXXXNL-KFVEKISNSNDG-DRMCKFMQSLTRKIEKLPSLSVALIESVAYGGGAELIL 552
++ +F+ + + F S+ ++E LP ++A + A GGG E +L
Sbjct: 63 AFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTIAAVNGYALGGGCECVL 122
Query: 553 CCDFRYIAQNGKLSFKQRKLGVTTGWGGCHKLIQLIGKQATLKLLLNTEVINAQKALEIG 732
D+R + ++ + KLG+ G+GG ++ +++G + L+++ + + A +AL+IG
Sbjct: 123 ATDYRLATPDLRIGLPETKLGIMPGFGGSVRMPRMLGADSALEIIAAGKDVGADQALKIG 182
Query: 733 LVDKILNSNTPDERLEETVQNVKCII 810
LVD ++ + E+ V+ K ++
Sbjct: 183 LVDGVV-------KAEKLVEGAKAVL 201
>sp|Q8X8I2|FADB_ECO57 Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 729
Score = 79.7 bits (195), Expect = 9e-15
Identities = 47/188 (25%), Positives = 96/188 (51%), Gaps = 3/188 (1%)
Frame = +1
Query: 202 FDGGSVYLKSINNDISHLIIDNPESHNSLTGKMMSQLDDCVQILENQPP-KALIXXXXXX 378
+ G ++YL + + I+ L+ D P S N L ++ L + + +LE Q K L+
Sbjct: 3 YKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGEAIGVLEQQSDLKGLLLRSNKA 62
Query: 379 XXXXXXNL-KFVEKISNSNDG-DRMCKFMQSLTRKIEKLPSLSVALIESVAYGGGAELIL 552
++ +F+ + + F S+ ++E LP ++A + A GGG E +L
Sbjct: 63 AFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTIAAVNGYALGGGCECVL 122
Query: 553 CCDFRYIAQNGKLSFKQRKLGVTTGWGGCHKLIQLIGKQATLKLLLNTEVINAQKALEIG 732
D+R + ++ + KLG+ G+GG ++ +++G + L+++ + + A +AL+IG
Sbjct: 123 ATDYRLATPDLRIGLPETKLGIMPGFGGSVRMPRMLGADSALEIIAAGKDVGADQALKIG 182
Query: 733 LVDKILNS 756
LVD ++ +
Sbjct: 183 LVDGVVKA 190
>sp|Q8Z3C6|FADB_SALTI Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 729
Score = 79.0 bits (193), Expect = 2e-14
Identities = 48/186 (25%), Positives = 95/186 (51%), Gaps = 3/186 (1%)
Frame = +1
Query: 202 FDGGSVYLKSINNDISHLIIDNPESHNSLTGKMMSQLDDCVQILENQPP-KALIXXXXXX 378
+ G ++YL + + I+ L+ D P S N L ++ L +++LE Q K L+
Sbjct: 3 YKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGQALEVLEKQHDLKGLLLRSNKA 62
Query: 379 XXXXXXNL-KFVEK-ISNSNDGDRMCKFMQSLTRKIEKLPSLSVALIESVAYGGGAELIL 552
++ +F+ + + F S+ ++E LP ++A + A GGG E +L
Sbjct: 63 AFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTLAAVNGYALGGGCECVL 122
Query: 553 CCDFRYIAQNGKLSFKQRKLGVTTGWGGCHKLIQLIGKQATLKLLLNTEVINAQKALEIG 732
D+R + ++ + KLG+ G+GG +L +++G + L+++ + + A+ AL+IG
Sbjct: 123 ATDYRLATPDLRIGLPETKLGIMPGFGGSVRLPRMLGADSALEIIAAGKDVGAEHALKIG 182
Query: 733 LVDKIL 750
LVD ++
Sbjct: 183 LVDGVV 188
>sp|Q9L6L5|FADB_SALTY Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 729
Score = 79.0 bits (193), Expect = 2e-14
Identities = 48/186 (25%), Positives = 95/186 (51%), Gaps = 3/186 (1%)
Frame = +1
Query: 202 FDGGSVYLKSINNDISHLIIDNPESHNSLTGKMMSQLDDCVQILENQPP-KALIXXXXXX 378
+ G ++YL + + I+ L+ D P S N L ++ L +++LE Q K L+
Sbjct: 3 YKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGQALEVLEKQHDLKGLLLRSNKA 62
Query: 379 XXXXXXNL-KFVEK-ISNSNDGDRMCKFMQSLTRKIEKLPSLSVALIESVAYGGGAELIL 552
++ +F+ + + F S+ ++E LP ++A + A GGG E +L
Sbjct: 63 AFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTLAAVNGYALGGGCECVL 122
Query: 553 CCDFRYIAQNGKLSFKQRKLGVTTGWGGCHKLIQLIGKQATLKLLLNTEVINAQKALEIG 732
D+R + ++ + KLG+ G+GG +L +++G + L+++ + + A+ AL+IG
Sbjct: 123 ATDYRLATPDLRIGLPETKLGIMPGFGGSVRLPRMLGADSALEIIAAGKDVGAEHALKIG 182
Query: 733 LVDKIL 750
LVD ++
Sbjct: 183 LVDGVV 188
>sp|Q13825|AUMH_HUMAN Methylglutaconyl-CoA hydratase, mitochondrial precursor
(AU-specific RNA-binding enoyl-CoA hydratase)
(AU-binding protein/enoyl-CoA hydratase)
Length = 339
Score = 78.6 bits (192), Expect = 2e-14
Identities = 57/203 (28%), Positives = 95/203 (46%), Gaps = 2/203 (0%)
Frame = +1
Query: 157 RNYSSISSIKDWLNDFDGGSVYLKSINNDISHLIIDNPESHNSLTGKMMSQLDDCVQILE 336
R YSS +D L +L+ N I L I+ NSL+ ++ L V L+
Sbjct: 65 RGYSSEMKTEDELR-----VRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALK 119
Query: 337 NQPP--KALIXXXXXXXXXXXXNLKFVEKISNSNDGDRMCKFMQSLTRKIEKLPSLSVAL 510
+ +I +LK K+S+S G + K ++++ I LP ++A
Sbjct: 120 SDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSK-IRAVINDIANLPVPTIAA 178
Query: 511 IESVAYGGGAELILCCDFRYIAQNGKLSFKQRKLGVTTGWGGCHKLIQLIGKQATLKLLL 690
I+ +A GGG EL L CD R A + K+ + KL + G GG +L + IG +L+
Sbjct: 179 IDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIF 238
Query: 691 NTEVINAQKALEIGLVDKILNSN 759
+ V++ ++A +GL+ +L N
Sbjct: 239 SARVLDGKEAKAVGLISHVLEQN 261
>sp|Q9JLZ3|AUHM_MOUSE Methylglutaconyl-CoA hydratase, mitochondrial precursor
(AU-specific RNA-binding enoyl-CoA hydratase)
(AU-binding enoyl-CoA hydratase) (muAUH)
Length = 314
Score = 78.2 bits (191), Expect = 3e-14
Identities = 57/203 (28%), Positives = 94/203 (46%), Gaps = 2/203 (0%)
Frame = +1
Query: 157 RNYSSISSIKDWLNDFDGGSVYLKSINNDISHLIIDNPESHNSLTGKMMSQLDDCVQILE 336
R YSS +D L +L+ N I L I+ N+L+ ++ L V L+
Sbjct: 40 RGYSSEVKTEDELR-----VRHLEEENRGIVVLGINRAYGKNALSKNLLKMLSKAVDALK 94
Query: 337 NQPP--KALIXXXXXXXXXXXXNLKFVEKISNSNDGDRMCKFMQSLTRKIEKLPSLSVAL 510
+ +I +LK K+ +S G + K ++S+ I LP ++A
Sbjct: 95 SDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSK-IRSVINDIANLPVPTIAA 153
Query: 511 IESVAYGGGAELILCCDFRYIAQNGKLSFKQRKLGVTTGWGGCHKLIQLIGKQATLKLLL 690
I+ +A GGG EL L CD R A + K+ + KL + G GG +L + IG +L+
Sbjct: 154 IDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMSLAKELIF 213
Query: 691 NTEVINAQKALEIGLVDKILNSN 759
+ V++ Q+A +GL+ +L N
Sbjct: 214 SARVLDGQEAKAVGLISHVLEQN 236
>sp|P52046|CRT_CLOAB 3-hydroxybutyryl-CoA dehydratase (Crotonase)
Length = 261
Score = 77.8 bits (190), Expect = 4e-14
Identities = 50/202 (24%), Positives = 93/202 (46%), Gaps = 1/202 (0%)
Frame = +1
Query: 244 ISHLIIDNPESHNSLTGKMMSQLDDCVQILENQPPKALIXXXXXXXXXXXXNLKFVE-KI 420
++ + I+ P++ N+L + ++D + +EN + E K
Sbjct: 14 VAVVTINRPKALNALNSDTLKEMDYVIGEIENDSEVLAVILTGAGEKSFVAGADISEMKE 73
Query: 421 SNSNDGDRMCKFMQSLTRKIEKLPSLSVALIESVAYGGGAELILCCDFRYIAQNGKLSFK 600
N+ +G + + R++E L +A + A GGG E+ + CD R + N +
Sbjct: 74 MNTIEGRKFGILGNKVFRRLELLEKPVIAAVNGFALGGGCEIAMSCDIRIASSNARFGQP 133
Query: 601 QRKLGVTTGWGGCHKLIQLIGKQATLKLLLNTEVINAQKALEIGLVDKILNSNTPDERLE 780
+ LG+T G+GG +L +L+G +L+ + I A +AL IGLV+K++ +
Sbjct: 134 EVGLGITPGFGGTQRLSRLVGMGMAKQLIFTAQNIKADEALRIGLVNKVVEPS------- 186
Query: 781 ETVQNVKCIIDEIPQNVLFAIK 846
E + K I ++I N A+K
Sbjct: 187 ELMNTAKEIANKIVSNAPVAVK 208
>sp|Q5R646|ECHM_PONPY Enoyl-CoA hydratase, mitochondrial precursor (Short chain enoyl-CoA
hydratase) (SCEH) (Enoyl-CoA hydratase 1)
Length = 290
Score = 70.5 bits (171), Expect = 6e-12
Identities = 46/188 (24%), Positives = 91/188 (48%), Gaps = 2/188 (1%)
Frame = +1
Query: 235 NNDISHLIIDNPESHNSLTGKMMSQLDDCVQILENQPPK-ALIXXXXXXXXXXXXNLKFV 411
NN + + ++ P++ N+L ++ +L+ ++I E P A++ ++K +
Sbjct: 44 NNTVGLIQLNRPKALNALCDGLIDELNQALKIFEEDPAVGAIVLTGGDKAFAAGADIKEM 103
Query: 412 EKISNSND-GDRMCKFMQSLTRKIEKLPSLSVALIESVAYGGGAELILCCDFRYIAQNGK 588
+ +S + + K LT+ + +A + A+GGG EL + CD Y + +
Sbjct: 104 QNLSFQDCYSSKFLKHWDHLTQ----IKKPVIAAVNGYAFGGGCELAMMCDIIYAGEKAQ 159
Query: 589 LSFKQRKLGVTTGWGGCHKLIQLIGKQATLKLLLNTEVINAQKALEIGLVDKILNSNTPD 768
+ + +G G GG +L + +GK ++++L + I+AQ A + GLV KI T
Sbjct: 160 FAQPEILIGTIPGAGGTQRLTRTVGKSLAMEMVLTGDRISAQDAKQAGLVSKICPVET-- 217
Query: 769 ERLEETVQ 792
+EE +Q
Sbjct: 218 -LVEEAIQ 224
>sp|Q64428|ECHA_RAT Trifunctional enzyme alpha subunit, mitochondrial precursor
(TP-alpha) [Includes: Long-chain enoyl-CoA hydratase ;
Long chain 3-hydroxyacyl-CoA dehydrogenase ]
Length = 763
Score = 68.9 bits (167), Expect = 2e-11
Identities = 48/199 (24%), Positives = 96/199 (48%), Gaps = 10/199 (5%)
Frame = +1
Query: 232 INNDISHLIIDNPESH-NSLTGKMMSQLDDCVQIL--ENQPPKALIXXXXXXXXXXXXNL 402
+ D++ + I++P S N+L ++ S+ + + + +Q A++ ++
Sbjct: 45 VKGDVAVIRINSPNSKVNTLNKEVQSEFVEVMNEIWANDQIRSAVLISSKPGCFVAGADI 104
Query: 403 KFVEKISNSNDGDRMCKFMQSLTRKIEKLPSLSVALIESVAYGGGAELILCCDFRYIAQN 582
+ + + R+ + Q + K+EK P VA I GGG EL + C +R ++
Sbjct: 105 NMLASCTTPQEAARISQEGQKMFEKLEKSPKPVVAAISGSCLGGGLELAIACQYRIATKD 164
Query: 583 GK--LSFKQRKLGVTTGWGGCHKLIQLIGKQATLKLLLNTEVINAQKALEIGLVDKILNS 756
K L + LG+ G GG +L +++G A ++L I A +A ++GLVD++++
Sbjct: 165 RKTVLGVPEVLLGILPGAGGTQRLPKMVGVPAAFDMMLTGRNIRADRAKKMGLVDQLVDP 224
Query: 757 -----NTPDERLEETVQNV 798
+P+ER E ++ V
Sbjct: 225 LGPGIKSPEERTIEYLEEV 243
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,033,593
Number of Sequences: 369166
Number of extensions: 1662782
Number of successful extensions: 4330
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4169
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4321
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)