Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_P19
(747 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q25074|AQP_HAEIE Aquaporin (Water channel 1) (BfWC1) 110 4e-24
sp|P55088|AQP4_MOUSE Aquaporin 4 (WCH4) (Mercurial-insensit... 110 5e-24
sp|Q9NHW7|AQP_AEDAE Aquaporin AQPAe.a 109 7e-24
sp|O77750|AQP4_BOVIN Aquaporin 4 (WCH4) (Mercurial-insensit... 108 2e-23
sp|Q9V5Z7|AQP_DROME Aquaporin 108 2e-23
sp|P55087|AQP4_HUMAN Aquaporin-4 (AQP-4) (WCH4) (Mercurial-... 106 8e-23
sp|Q923J4|AQP4_DIPME Aquaporin-4 (AQP-4) 106 8e-23
sp|P47863|AQP4_RAT Aquaporin-4 (AQP-4) (WCH4) (Mercurial-in... 105 1e-22
sp|P47864|AQP5_RAT Aquaporin 5 100 5e-21
sp|Q9WTY4|AQP5_MOUSE Aquaporin-5 (AQP-5) 100 7e-21
>sp|Q25074|AQP_HAEIE Aquaporin (Water channel 1) (BfWC1)
Length = 251
Score = 110 bits (275), Expect = 4e-24
Identities = 72/206 (34%), Positives = 109/206 (52%), Gaps = 8/206 (3%)
Frame = +1
Query: 37 LQDIT-TRNFWTALFAECCGTFILVFIGLGACYXXXXXXXXXXXXXXXXXXXV----YVS 201
++DIT + W L AE GTF LV IG+G+C V
Sbjct: 13 VKDITDNKKIWRQLMAELIGTFFLVVIGVGSCTGGSEWSPSIPQIAFTFGLTVATLAQAI 72
Query: 202 GPISGGNINPAVSIGLLVARQISFIRCMLYMLFQVIGALLAAKCISIMTYETFNKTH-GI 378
G ISG +INPAV++G L+ ++S I+ +LY+ Q +GA+ A I + E + G+
Sbjct: 73 GHISGCHINPAVTVGFLIVGEMSIIKSVLYIAVQCVGAIAGAAVIKVGVSEAVSGLDLGV 132
Query: 379 SH--PNVPWDKALFCEIIISFILVFTVMRMCVEKSRSDVERGLAALTIGISIVVGILCGA 552
S + +A+ E +I+FILV V++ + R+D+ +G A L +G+SI G LC
Sbjct: 133 SSFSSTLTVGQAVLIEALITFILV-VVVKGVSDPGRTDI-KGSAPLAVGLSIAAGHLCAI 190
Query: 553 NISGGSMNPARTLGPAIVNNKLNNVW 630
++G SMNPAR+ GPA+V N + W
Sbjct: 191 KLTGASMNPARSFGPAVVQNMWIDHW 216
>sp|P55088|AQP4_MOUSE Aquaporin 4 (WCH4) (Mercurial-insensitive water channel) (MIWC)
Length = 323
Score = 110 bits (274), Expect = 5e-24
Identities = 70/212 (33%), Positives = 109/212 (51%), Gaps = 10/212 (4%)
Frame = +1
Query: 25 IWSSLQDITTRNFWTALFAECCGTFILVFIGLGACYXXXXXXXXXXXXXXXXXXXVYVS- 201
I + + + T+ FW A+ AE T I V +G+G+ +S
Sbjct: 22 IMVAFKGVWTQAFWKAVSAEFLATLIFVLLGVGSTINWGGSENPLPVDMVLISLCFGLSI 81
Query: 202 -------GPISGGNINPAVSIGLLVARQISFIRCMLYMLFQVIGALLAAKCISIMTYETF 360
G ISGG+INPAV++ ++ R+IS + + Y++ Q +GA++ A + ++T +
Sbjct: 82 ATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIIAQCLGAIIGAGILYLVTPPSV 141
Query: 361 NKTHGIS--HPNVPWDKALFCEIIISFILVFTVMRMCVEKSRSDVERGLAALTIGISIVV 534
G++ H N+ L E+II+F LVFT+ C K R+DV G AL IG S+ +
Sbjct: 142 VGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSK-RTDVT-GSIALAIGFSVAI 199
Query: 535 GILCGANISGGSMNPARTLGPAIVNNKLNNVW 630
G L N +G SMNPAR+ GPA++ N W
Sbjct: 200 GHLFAINYTGASMNPARSFGPAVIMGNWANHW 231
>sp|Q9NHW7|AQP_AEDAE Aquaporin AQPAe.a
Length = 249
Score = 109 bits (273), Expect = 7e-24
Identities = 73/204 (35%), Positives = 103/204 (50%), Gaps = 8/204 (3%)
Frame = +1
Query: 43 DIT-TRNFWTALFAECCGTFILVFIGLGACYXXXXXXXXXXXXXXXXXXXVYVS-----G 204
DIT RN W L AE GTF LV IG+G+ V + G
Sbjct: 15 DITENRNIWRMLVAEFLGTFFLVSIGIGSTMGWGGDYAPTMTQIAFTFGLVVATLAQAFG 74
Query: 205 PISGGNINPAVSIGLLVARQISFIRCMLYMLFQVIGALLAAKCISIMTYETFNKTHGIS- 381
+SG +INPAV+IGL++ IS ++ Y++ Q +GA+ A I T G++
Sbjct: 75 HVSGCHINPAVTIGLMITADISILKGAFYIVSQCVGAIAGAALIKAATPSDVIGGLGVTG 134
Query: 382 -HPNVPWDKALFCEIIISFILVFTVMRMCVEKSRSDVERGLAALTIGISIVVGILCGANI 558
P + + + E +I+FILVF V +C + RSD+ +G A L IG+SI G L
Sbjct: 135 IDPRLTAGQGVMMEALITFILVFVVHGVC-DNRRSDI-KGSAPLAIGLSITAGHLSAIKY 192
Query: 559 SGGSMNPARTLGPAIVNNKLNNVW 630
+G SMNPAR+ GPA+V + W
Sbjct: 193 TGASMNPARSFGPAVVMGNWTDQW 216
>sp|O77750|AQP4_BOVIN Aquaporin 4 (WCH4) (Mercurial-insensitive water channel) (MIWC)
Length = 323
Score = 108 bits (270), Expect = 2e-23
Identities = 70/212 (33%), Positives = 107/212 (50%), Gaps = 10/212 (4%)
Frame = +1
Query: 25 IWSSLQDITTRNFWTALFAECCGTFILVFIGLGACYXXXXXXXXXXXXXXXXXXXVYVS- 201
I + + + T+ FW A+ AE I V + LG+ +S
Sbjct: 22 IMVAFKGVWTQTFWKAVTAEFLAMLIFVLLSLGSTINWGGAEKPLPVDMVLISLCFGLSI 81
Query: 202 -------GPISGGNINPAVSIGLLVARQISFIRCMLYMLFQVIGALLAAKCISIMTYETF 360
G ISGG+INPAV++ ++ R+IS + + Y+ Q +GA++ A + ++T +
Sbjct: 82 ATMVQCFGHISGGHINPAVTVAMVCTRRISIAKSVFYIAAQCLGAIIGAGILYLVTPPSV 141
Query: 361 NKTHGIS--HPNVPWDKALFCEIIISFILVFTVMRMCVEKSRSDVERGLAALTIGISIVV 534
G++ H N+ L E+II+F LVFT+ C K R+DV G AL IGIS+ +
Sbjct: 142 VGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDSK-RTDVT-GSIALAIGISVAI 199
Query: 535 GILCGANISGGSMNPARTLGPAIVNNKLNNVW 630
G L N +G SMNPAR+ GPA++ N W
Sbjct: 200 GHLFAINYTGASMNPARSFGPAVIMGNWENHW 231
>sp|Q9V5Z7|AQP_DROME Aquaporin
Length = 245
Score = 108 bits (269), Expect = 2e-23
Identities = 70/232 (30%), Positives = 111/232 (47%), Gaps = 3/232 (1%)
Frame = +1
Query: 43 DIT-TRNFWTALFAECCGTFILVFIGLGACYXXXXXXXXXXXXXXXXXXXVYVSGPISGG 219
DIT + W L E GTF L+F+G+G+ + G +SG
Sbjct: 15 DITENKKIWRMLLGELVGTFFLIFVGVGSTTSGSVPQIAFTFGLTVATIAQGL-GHLSGC 73
Query: 220 NINPAVSIGLLVARQISFIRCMLYMLFQVIGALLAAKCISIMTYETFNKTHGISH--PNV 393
+INPAV++G L+ +IS ++ Y++ Q +GA+ A I + G+S P++
Sbjct: 74 HINPAVTLGFLIVGEISILKAAFYIIVQCVGAIAGAAVIKVALDGVAGGDLGVSSFDPSL 133
Query: 394 PWDKALFCEIIISFILVFTVMRMCVEKSRSDVERGLAALTIGISIVVGILCGANISGGSM 573
+A+ E +I+FILVF V++ + R D+ +G A L +G++I G LC +SG SM
Sbjct: 134 NCAQAVLIEALITFILVF-VVKAVSDPGRQDI-KGSAPLAVGLAIAAGHLCAIKLSGASM 191
Query: 574 NPARTLGPAIVNNKLNNVWXXXXXXXXXXXXXXXVQQLLFTSELSKDYLFNY 729
NPAR+ GPA+V W + +L+F D +Y
Sbjct: 192 NPARSFGPAVVQGVWTYHWVYWVGPIAGGLLAGIIYRLIFKVRKGDDETDSY 243
>sp|P55087|AQP4_HUMAN Aquaporin-4 (AQP-4) (WCH4) (Mercurial-insensitive water channel)
(MIWC)
Length = 323
Score = 106 bits (264), Expect = 8e-23
Identities = 69/212 (32%), Positives = 106/212 (50%), Gaps = 10/212 (4%)
Frame = +1
Query: 25 IWSSLQDITTRNFWTALFAECCGTFILVFIGLGACYXXXXXXXXXXXXXXXXXXXVYVS- 201
I + + + T+ FW A+ AE I V + LG+ +S
Sbjct: 22 IMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSI 81
Query: 202 -------GPISGGNINPAVSIGLLVARQISFIRCMLYMLFQVIGALLAAKCISIMTYETF 360
G ISGG+INPAV++ ++ R+IS + + Y+ Q +GA++ A + ++T +
Sbjct: 82 ATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSV 141
Query: 361 NKTHGIS--HPNVPWDKALFCEIIISFILVFTVMRMCVEKSRSDVERGLAALTIGISIVV 534
G++ H N+ L E+II+F LVFT+ C K R+DV G AL IG S+ +
Sbjct: 142 VGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSK-RTDVT-GSIALAIGFSVAI 199
Query: 535 GILCGANISGGSMNPARTLGPAIVNNKLNNVW 630
G L N +G SMNPAR+ GPA++ N W
Sbjct: 200 GHLFAINYTGASMNPARSFGPAVIMGNWENHW 231
>sp|Q923J4|AQP4_DIPME Aquaporin-4 (AQP-4)
Length = 324
Score = 106 bits (264), Expect = 8e-23
Identities = 69/212 (32%), Positives = 106/212 (50%), Gaps = 10/212 (4%)
Frame = +1
Query: 25 IWSSLQDITTRNFWTALFAECCGTFILVFIGLGACYXXXXXXXXXXXXXXXXXXXVYVS- 201
I + + + T+ FW A+ AE I V + LG+ +S
Sbjct: 22 IMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGKENPLPVDMVLISLCFGLSI 81
Query: 202 -------GPISGGNINPAVSIGLLVARQISFIRCMLYMLFQVIGALLAAKCISIMTYETF 360
G ISGG+INPAV++ ++ R+IS + + Y+ Q +GA++ A + ++T +
Sbjct: 82 ATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSV 141
Query: 361 NKTHGIS--HPNVPWDKALFCEIIISFILVFTVMRMCVEKSRSDVERGLAALTIGISIVV 534
G++ H N+ L E+II+F LVFT+ C K R+DV G AL IG S+ +
Sbjct: 142 VGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSK-RTDVT-GSIALAIGFSVAI 199
Query: 535 GILCGANISGGSMNPARTLGPAIVNNKLNNVW 630
G L N +G SMNPAR+ GPA++ N W
Sbjct: 200 GHLFAINYTGASMNPARSFGPAVIMGNWENHW 231
>sp|P47863|AQP4_RAT Aquaporin-4 (AQP-4) (WCH4) (Mercurial-insensitive water channel)
(MIWC)
Length = 323
Score = 105 bits (262), Expect = 1e-22
Identities = 68/212 (32%), Positives = 106/212 (50%), Gaps = 10/212 (4%)
Frame = +1
Query: 25 IWSSLQDITTRNFWTALFAECCGTFILVFIGLGACYXXXXXXXXXXXXXXXXXXXVYVS- 201
I + + + T+ FW A+ AE I V + +G+ +S
Sbjct: 22 IMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSVGSTINWGGSENPLPVDMVLISLCFGLSI 81
Query: 202 -------GPISGGNINPAVSIGLLVARQISFIRCMLYMLFQVIGALLAAKCISIMTYETF 360
G ISGG+INPAV++ ++ R+IS + + Y+ Q +GA++ A + ++T +
Sbjct: 82 ATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYITAQCLGAIIGAGILYLVTPPSV 141
Query: 361 NKTHGIS--HPNVPWDKALFCEIIISFILVFTVMRMCVEKSRSDVERGLAALTIGISIVV 534
G++ H N+ L E+II+F LVFT+ C K R+DV G AL IG S+ +
Sbjct: 142 VGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSK-RTDVT-GSVALAIGFSVAI 199
Query: 535 GILCGANISGGSMNPARTLGPAIVNNKLNNVW 630
G L N +G SMNPAR+ GPA++ N W
Sbjct: 200 GHLFAINYTGASMNPARSFGPAVIMGNWENHW 231
>sp|P47864|AQP5_RAT Aquaporin 5
Length = 265
Score = 100 bits (248), Expect = 5e-21
Identities = 63/200 (31%), Positives = 101/200 (50%), Gaps = 6/200 (3%)
Frame = +1
Query: 40 QDITTRNFWTALFAECCGTFILVFIGLGACYXXXXXXXXXXXXXXXXXXXV----YVSGP 207
+++ + F+ A+FAE T I VF GLG+ + GP
Sbjct: 3 KEVCSLAFFKAVFAEFLATLIFVFFGLGSALKWPSALPTILQISIAFGLAIGTLAQALGP 62
Query: 208 ISGGNINPAVSIGLLVARQISFIRCMLYMLFQVIGALLAAKCISIMT--YETFNKTHGIS 381
+SGG+INPA+++ LL+ QIS +R + Y+ Q++GA+ A + + N
Sbjct: 63 VSGGHINPAITLALLIGNQISLLRAVFYVAAQLVGAIAGAGILYWLAPLNARGNLAVNAL 122
Query: 382 HPNVPWDKALFCEIIISFILVFTVMRMCVEKSRSDVERGLAALTIGISIVVGILCGANIS 561
+ N KA+ E+I++F L + + S V G AL+IG+S+ +G L G +
Sbjct: 123 NNNTTPGKAMVVELILTFQLALCIFSSTDSRRTSPV--GSPALSIGLSVTLGHLVGIYFT 180
Query: 562 GGSMNPARTLGPAIVNNKLN 621
G SMNPAR+ GPA+V N+ +
Sbjct: 181 GCSMNPARSFGPAVVMNRFS 200
>sp|Q9WTY4|AQP5_MOUSE Aquaporin-5 (AQP-5)
Length = 265
Score = 99.8 bits (247), Expect = 7e-21
Identities = 63/201 (31%), Positives = 103/201 (51%), Gaps = 7/201 (3%)
Frame = +1
Query: 40 QDITTRNFWTALFAECCGTFILVFIGLGACYXXXXXXXXXXXXXXXXXXXV----YVSGP 207
+++ + F+ A+FAE T I VF GLG+ + GP
Sbjct: 3 KEVCSVAFFKAVFAEFLATLIFVFFGLGSALKWPSALPTILQISIAFGLAIGTLAQALGP 62
Query: 208 ISGGNINPAVSIGLLVARQISFIRCMLYMLFQVIGALLAAKCISIMTYETFN---KTHGI 378
+SGG+INPA+++ LL+ QIS +R + Y+ Q++GA+ A + + + +
Sbjct: 63 VSGGHINPAITLALLIGNQISLLRAIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNAL 122
Query: 379 SHPNVPWDKALFCEIIISFILVFTVMRMCVEKSRSDVERGLAALTIGISIVVGILCGANI 558
S+ P KA+ E+I++F L + + S V G AL+IG+S+ +G L G
Sbjct: 123 SNNTTP-GKAVVVELILTFQLALCIFSSTDSRRTSPV--GSPALSIGLSVTLGHLVGIYF 179
Query: 559 SGGSMNPARTLGPAIVNNKLN 621
+G SMNPAR+ GPA+V N+ +
Sbjct: 180 TGCSMNPARSFGPAVVMNRFS 200
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,735,773
Number of Sequences: 369166
Number of extensions: 1503926
Number of successful extensions: 4225
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3651
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3909
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6776504000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)