Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_O13
(743 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P32490|MKK1_YEAST MAP kinase kinase MKK1/SSP32 102 1e-21
sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11 101 2e-21
sp|Q9P289|MST4_HUMAN Serine/threonine-protein kinase MST4 (... 100 4e-21
sp|O75385|ULK1_HUMAN Serine/threonine-protein kinase ULK1 (... 100 4e-21
sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 (... 100 5e-21
sp|O70405|ULK1_MOUSE Serine/threonine-protein kinase ULK1 (... 100 5e-21
sp|P41892|CDC7_SCHPO Cell division control protein 7 99 9e-21
sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 99 2e-20
sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 98 3e-20
sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinas... 98 3e-20
>sp|P32490|MKK1_YEAST MAP kinase kinase MKK1/SSP32
Length = 508
Score = 102 bits (253), Expect = 1e-21
Identities = 72/247 (29%), Positives = 110/247 (44%), Gaps = 15/247 (6%)
Frame = +1
Query: 43 QVKNQSIVLKRYISDDGDLIEKYRKLINGLIDFQRKGGQERFVKLYSFYPD--RCSFAIG 216
++KN S + + + + +Y+K I + F R E V+ Y + D S I
Sbjct: 239 KLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIA 298
Query: 217 MEWMEGGSMDNYVKNFWP----FTDKQLIRWTHQILGGLDFLHDNNVIFRDLKPSNVLLD 384
ME+M G S+D KN ++K L + +L GL +LH+ VI RD+KP N+LL+
Sbjct: 299 MEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLN 358
Query: 385 ENNNTKLCAFSLSIYLMSNHEMELKRSSSQSKVGVYSYMAPEVLNSEPYDNAADVWSFAA 564
EN KLC F +S E S + + G YMAPE + +PY +DVWS
Sbjct: 359 ENGQVKLCDFGVS--------GEAVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGL 410
Query: 565 VLVNLITGKNPCPDKD------PIDAAFHVARKLEMEYTLPEDT---NQVLKDIITNCAQ 717
++ + GK PC + P + + PE + K I C +
Sbjct: 411 TILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFIDYCLK 470
Query: 718 GDPKKRP 738
D ++RP
Sbjct: 471 KDSRERP 477
>sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11
Length = 738
Score = 101 bits (251), Expect = 2e-21
Identities = 61/213 (28%), Positives = 109/213 (51%), Gaps = 3/213 (1%)
Frame = +1
Query: 109 YRKLINGL---IDFQRKGGQERFVKLYSFYPDRCSFAIGMEWMEGGSMDNYVKNFWPFTD 279
+RK+++ L ++ ++ E V Y + + I +E++ GGS+ + + N+ PF +
Sbjct: 515 HRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGPFEE 574
Query: 280 KQLIRWTHQILGGLDFLHDNNVIFRDLKPSNVLLDENNNTKLCAFSLSIYLMSNHEMELK 459
+ +T QIL G+ +LH N+I RD+K +N+L+D K+ F +S L ++ + K
Sbjct: 575 SLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNK 634
Query: 460 RSSSQSKVGVYSYMAPEVLNSEPYDNAADVWSFAAVLVNLITGKNPCPDKDPIDAAFHVA 639
R+S Q V +M+PEV+ AD+WS V++ + TGK+P PD + A F +
Sbjct: 635 RASLQGSV---FWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQAIFKIG 691
Query: 640 RKLEMEYTLPEDTNQVLKDIITNCAQGDPKKRP 738
E +P K+ + + D + RP
Sbjct: 692 TNTTPE--IPSWATSEGKNFLRKAFELDYQYRP 722
>sp|Q9P289|MST4_HUMAN Serine/threonine-protein kinase MST4 (STE20-like kinase MST4)
(MST-4) (Mammalian STE20-like protein kinase 4)
(Serine/threonine-protein kinase MASK) (Mst3 and
SOK1-related kinase)
Length = 416
Score = 100 bits (249), Expect = 4e-21
Identities = 74/244 (30%), Positives = 113/244 (46%), Gaps = 1/244 (0%)
Frame = +1
Query: 10 GMYSEIYKARDQVKNQSIVLKRY-ISDDGDLIEKYRKLINGLIDFQRKGGQERFVKLYSF 186
G + E++K D Q + +K + + D IE ++ I L K Y
Sbjct: 33 GSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD----SSYVTKYYGS 88
Query: 187 YPDRCSFAIGMEWMEGGSMDNYVKNFWPFTDKQLIRWTHQILGGLDFLHDNNVIFRDLKP 366
Y I ME++ GGS + ++ PF + Q+ +IL GLD+LH I RD+K
Sbjct: 89 YLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKA 147
Query: 367 SNVLLDENNNTKLCAFSLSIYLMSNHEMELKRSSSQSKVGVYSYMAPEVLNSEPYDNAAD 546
+NVLL E + KL F ++ L + ++KR++ VG +MAPEV+ YD+ AD
Sbjct: 148 ANVLLSEQGDVKLADFGVAGQLT---DTQIKRNTF---VGTPFWMAPEVIQQSAYDSKAD 201
Query: 547 VWSFAAVLVNLITGKNPCPDKDPIDAAFHVARKLEMEYTLPEDTNQVLKDIITNCAQGDP 726
+WS + L G+ P D P+ F + + TL D + K+ I C DP
Sbjct: 202 IWSLGITAIELAKGEPPNSDMHPMRVLFLIPK--NNPPTLVGDFTKSFKEFIDACLNKDP 259
Query: 727 KKRP 738
RP
Sbjct: 260 SFRP 263
>sp|O75385|ULK1_HUMAN Serine/threonine-protein kinase ULK1 (Unc-51-like kinase 1)
Length = 1050
Score = 100 bits (249), Expect = 4e-21
Identities = 69/251 (27%), Positives = 114/251 (45%), Gaps = 9/251 (3%)
Frame = +1
Query: 10 GMYSEIYKARDQVKNQSIVLKRYISDDGDLIEKYRKLINGLIDFQRKGGQERFVKLYSFY 189
G ++ ++K R + K+ V + I+ + K + L+ I ++ E V LY F
Sbjct: 25 GAFAVVFKGRHREKHDLEVAVKCINKKN--LAKSQTLLGKEIKILKELKHENIVALYDFQ 82
Query: 190 PDRCSFAIGMEWMEGGSMDNYVKNFWPFTDKQLIRWTHQILGGLDFLHDNNVIFRDLKPS 369
S + ME+ GG + +Y+ ++ + + QI G + LH +I RDLKP
Sbjct: 83 EMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQ 142
Query: 370 NVLLDE------NNNT---KLCAFSLSIYLMSNHEMELKRSSSQSKVGVYSYMAPEVLNS 522
N+LL N N+ K+ F + YL SN + + G YMAPEV+ S
Sbjct: 143 NILLSNPAGRRANPNSIRVKIADFGFARYLQSN-------MMAATLCGSPMYMAPEVIMS 195
Query: 523 EPYDNAADVWSFAAVLVNLITGKNPCPDKDPIDAAFHVARKLEMEYTLPEDTNQVLKDII 702
+ YD AD+WS ++ +TGK P P D + + T+P +T+ L+ ++
Sbjct: 196 QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIpreTSAPLRQLL 255
Query: 703 TNCAQGDPKKR 735
Q + K R
Sbjct: 256 LALLQRNHKDR 266
>sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 (STE20-like kinase MST4)
(MST-4) (Mammalian STE20-like protein kinase 4)
Length = 416
Score = 100 bits (248), Expect = 5e-21
Identities = 74/244 (30%), Positives = 113/244 (46%), Gaps = 1/244 (0%)
Frame = +1
Query: 10 GMYSEIYKARDQVKNQSIVLKRY-ISDDGDLIEKYRKLINGLIDFQRKGGQERFVKLYSF 186
G + E++K D Q + +K + + D IE ++ I L K Y
Sbjct: 33 GSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD----SSYVTKYYGS 88
Query: 187 YPDRCSFAIGMEWMEGGSMDNYVKNFWPFTDKQLIRWTHQILGGLDFLHDNNVIFRDLKP 366
Y I ME++ GGS + ++ PF + Q+ +IL GLD+LH I RD+K
Sbjct: 89 YLKGSKLWIIMEYLGGGSALDLLRA-GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKA 147
Query: 367 SNVLLDENNNTKLCAFSLSIYLMSNHEMELKRSSSQSKVGVYSYMAPEVLNSEPYDNAAD 546
+NVLL E + KL F ++ L + ++KR++ VG +MAPEV+ YD+ AD
Sbjct: 148 ANVLLSEQGDVKLADFGVAGQLT---DTQIKRNTF---VGTPFWMAPEVIQQSAYDSKAD 201
Query: 547 VWSFAAVLVNLITGKNPCPDKDPIDAAFHVARKLEMEYTLPEDTNQVLKDIITNCAQGDP 726
+WS + L G+ P D P+ F + + TL D + K+ I C DP
Sbjct: 202 IWSLGITAIELAKGEPPNSDMHPMRVLFLIPK--NNPPTLIGDFTKSFKEFIDACLNKDP 259
Query: 727 KKRP 738
RP
Sbjct: 260 SFRP 263
>sp|O70405|ULK1_MOUSE Serine/threonine-protein kinase ULK1 (Unc-51-like kinase 1)
(Serine/threonine-protein kinase Unc51.1)
Length = 1051
Score = 100 bits (248), Expect = 5e-21
Identities = 67/251 (26%), Positives = 111/251 (44%), Gaps = 9/251 (3%)
Frame = +1
Query: 10 GMYSEIYKARDQVKNQSIVLKRYISDDGDLIEKYRKLINGLIDFQRKGGQERFVKLYSFY 189
G ++ ++K R + K+ V + I+ + K + L+ I ++ E V LY F
Sbjct: 25 GAFAVVFKGRHREKHDLEVAVKCINKKN--LAKSQTLLGKEIKILKELKHENIVALYDFQ 82
Query: 190 PDRCSFAIGMEWMEGGSMDNYVKNFWPFTDKQLIRWTHQILGGLDFLHDNNVIFRDLKPS 369
S + ME+ GG + +Y+ ++ + + QI G + LH +I RDLKP
Sbjct: 83 EMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQ 142
Query: 370 NVLLDE---------NNNTKLCAFSLSIYLMSNHEMELKRSSSQSKVGVYSYMAPEVLNS 522
N+LL N K+ F + YL SN + + G YMAPEV+ S
Sbjct: 143 NILLSNPGGRRANPSNIRVKIADFGFARYLQSN-------MMAATLCGSPMYMAPEVIMS 195
Query: 523 EPYDNAADVWSFAAVLVNLITGKNPCPDKDPIDAAFHVARKLEMEYTLPEDTNQVLKDII 702
+ YD AD+WS ++ +TGK P P D + + +P +T+ L+ ++
Sbjct: 196 QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIpreTSAPLRQLL 255
Query: 703 TNCAQGDPKKR 735
Q + K R
Sbjct: 256 LALLQRNHKDR 266
>sp|P41892|CDC7_SCHPO Cell division control protein 7
Length = 1062
Score = 99.4 bits (246), Expect = 9e-21
Identities = 64/244 (26%), Positives = 110/244 (45%)
Frame = +1
Query: 10 GMYSEIYKARDQVKNQSIVLKRYISDDGDLIEKYRKLINGLIDFQRKGGQERFVKLYSFY 189
G + +Y+ + +++ +K+ +++ +I ID + VK Y
Sbjct: 18 GAFGAVYRGLNIKNGETVAVKKVKLSK--MLKSDLSVIKMEIDLLKNLDHPNIVKYRGSY 75
Query: 190 PDRCSFAIGMEWMEGGSMDNYVKNFWPFTDKQLIRWTHQILGGLDFLHDNNVIFRDLKPS 369
S I +E+ E GS+ + KNF + + +T Q+L GL +LH+ VI RD+K +
Sbjct: 76 QTNDSLCIILEYCENGSLRSICKNFGKIPENLVALYTFQVLQGLLYLHNQGVIHRDIKGA 135
Query: 370 NVLLDENNNTKLCAFSLSIYLMSNHEMELKRSSSQSKVGVYSYMAPEVLNSEPYDNAADV 549
N+L ++ KL F ++ ++ S VG +MAPEV+ A+D+
Sbjct: 136 NILTTKDGTIKLADFGVA--------TKINALEDHSVVGSPYWMAPEVIELVGATTASDI 187
Query: 550 WSFAAVLVNLITGKNPCPDKDPIDAAFHVARKLEMEYTLPEDTNQVLKDIITNCAQGDPK 729
WS ++ L+ G P D DP A F + + + LP + + K + C Q DP
Sbjct: 188 WSVGCTVIELLDGNPPYYDLDPTSALFRMVK--DEHPPLPSNISSAAKSFLMQCFQKDPN 245
Query: 730 KRPK 741
R K
Sbjct: 246 LRIK 249
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 98.6 bits (244), Expect = 2e-20
Identities = 63/213 (29%), Positives = 103/213 (48%), Gaps = 3/213 (1%)
Frame = +1
Query: 10 GMYSEIYKARDQVKNQSIVLKRYISD-DGDLIEKYRKLINGLIDFQRKGGQERFVKLYSF 186
G + +Y D + + K+ D D K + I + ER V+ Y
Sbjct: 371 GAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGC 430
Query: 187 YPDRC--SFAIGMEWMEGGSMDNYVKNFWPFTDKQLIRWTHQILGGLDFLHDNNVIFRDL 360
DR + I ME+M GGS+ + +K + T+ ++T QIL G+ +LH N ++ RD+
Sbjct: 431 LRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDI 490
Query: 361 KPSNVLLDENNNTKLCAFSLSIYLMSNHEMELKRSSSQSKVGVYSYMAPEVLNSEPYDNA 540
K +N+L D N KL F S L + + + + +S G +M+PEV++ E Y
Sbjct: 491 KGANILRDSAGNVKLGDFGASKRLQT---ICMSGTGMRSVTGTPYWMSPEVISGEGYGRK 547
Query: 541 ADVWSFAAVLVNLITGKNPCPDKDPIDAAFHVA 639
ADVWS +V ++T K P + + + A F +A
Sbjct: 548 ADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIA 580
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 97.8 bits (242), Expect = 3e-20
Identities = 63/213 (29%), Positives = 102/213 (47%), Gaps = 3/213 (1%)
Frame = +1
Query: 10 GMYSEIYKARDQVKNQSIVLKRYISD-DGDLIEKYRKLINGLIDFQRKGGQERFVKLYSF 186
G + +Y D + + K+ D D K + I + ER V+ Y
Sbjct: 371 GAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGC 430
Query: 187 YPDRCS--FAIGMEWMEGGSMDNYVKNFWPFTDKQLIRWTHQILGGLDFLHDNNVIFRDL 360
DR I ME+M GGS+ + +K + T+ ++T QIL G+ +LH N ++ RD+
Sbjct: 431 LRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDI 490
Query: 361 KPSNVLLDENNNTKLCAFSLSIYLMSNHEMELKRSSSQSKVGVYSYMAPEVLNSEPYDNA 540
K +N+L D N KL F S L + + + + +S G +M+PEV++ E Y
Sbjct: 491 KGANILRDSAGNVKLGDFGASKRLQT---ICMSGTGIRSVTGTPYWMSPEVISGEGYGRK 547
Query: 541 ADVWSFAAVLVNLITGKNPCPDKDPIDAAFHVA 639
ADVWS +V ++T K P + + + A F +A
Sbjct: 548 ADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIA 580
>sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase
kinase 2) (MEK kinase 2) (MEKK 2)
Length = 618
Score = 97.8 bits (242), Expect = 3e-20
Identities = 64/215 (29%), Positives = 110/215 (51%), Gaps = 5/215 (2%)
Frame = +1
Query: 10 GMYSEIYKARDQVKNQSIVLKRYISDDGDLIEKYRKLINGL---IDFQRKGGQERFVKLY 180
G + +Y D + + +K+ + D D E ++ +N L I + ER V+ Y
Sbjct: 364 GAFGRVYLCYDVDTGRELAVKQ-VQFDPDSPETSKE-VNALECEIQLLKNFLHERIVQYY 421
Query: 181 SFY--PDRCSFAIGMEWMEGGSMDNYVKNFWPFTDKQLIRWTHQILGGLDFLHDNNVIFR 354
P + +I ME+M GGS+ + +K + T+ ++T QIL G+ +LH N ++ R
Sbjct: 422 GCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYTRQILEGVHYLHSNMILHR 481
Query: 355 DLKPSNVLLDENNNTKLCAFSLSIYLMSNHEMELKRSSSQSKVGVYSYMAPEVLNSEPYD 534
D+K +N+L D N KL F S L + + L + +S G +M+PEV++ + Y
Sbjct: 482 DIKGANILRDSTGNVKLGDFGASKRLQT---ICLSGTGMKSVTGTPYWMSPEVISGQGYG 538
Query: 535 NAADVWSFAAVLVNLITGKNPCPDKDPIDAAFHVA 639
AD+WS A +V ++T K P + + + A F +A
Sbjct: 539 RKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIA 573
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,247,184
Number of Sequences: 369166
Number of extensions: 1986598
Number of successful extensions: 8681
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6702
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7109
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6728100400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)