Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_O09
(426 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Z319|CORIN_MOUSE Atrial natriuteric peptide-converting... 45 5e-05
sp|P98158|LRP2_RAT Low-density lipoprotein receptor-related... 45 8e-05
sp|Q9Y5Q5|CORIN_HUMAN Atrial natriuteric peptide-converting... 43 2e-04
sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase)... 42 5e-04
sp|Q04833|LRP_CAEEL Low-density lipoprotein receptor-relate... 41 0.001
sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contai... 41 0.001
sp|Q07954|LRP1_HUMAN Low-density lipoprotein receptor-relat... 39 0.004
sp|P35950|LDLR_CRIGR Low-density lipoprotein receptor precu... 39 0.005
sp|Q9JI18|LRP1B_MOUSE Low-density lipoprotein receptor-rela... 39 0.005
sp|P35951|LDLR_MOUSE Low-density lipoprotein receptor precu... 38 0.008
>sp|Q9Z319|CORIN_MOUSE Atrial natriuteric peptide-converting enzyme (pro-ANP-converting
enzyme) (Corin) (Low density lipoprotein
receptor-related protein 4)
Length = 1113
Score = 45.4 bits (106), Expect = 5e-05
Identities = 18/35 (51%), Positives = 20/35 (57%)
Frame = +2
Query: 89 GCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
GC E A W C +CL ICDG PDCP+ DE
Sbjct: 683 GCKERALWECPFNKQCLKHTLICDGFPDCPDSMDE 717
Score = 33.9 bits (76), Expect = 0.15
Identities = 11/27 (40%), Positives = 19/27 (70%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALC 208
G+C++ +++CDG+ DC +K DE C
Sbjct: 421 GRCIAAEWVCDGDHDCVDKSDEVNCSC 447
Score = 32.3 bits (72), Expect = 0.43
Identities = 12/27 (44%), Positives = 15/27 (55%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALC 208
GKCL + +CDG DC + DE C
Sbjct: 384 GKCLHYSLLCDGYDDCGDPSDEQNCDC 410
Score = 30.8 bits (68), Expect = 1.2
Identities = 11/25 (44%), Positives = 16/25 (64%)
Frame = +2
Query: 122 TPGKCLSFDFICDGEPDCPEKYDED 196
T G+C+ F CDG+ DC + DE+
Sbjct: 456 TSGQCIPSTFQCDGDEDCKDGSDEE 480
>sp|P98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 precursor
(Megalin) (Glycoprotein 330) (gp330)
Length = 4660
Score = 44.7 bits (104), Expect = 8e-05
Identities = 16/29 (55%), Positives = 20/29 (68%)
Frame = +2
Query: 110 WPCKTPGKCLSFDFICDGEPDCPEKYDED 196
W C G+C+S D +CDG PDCPE DE+
Sbjct: 270 WACPGSGRCISIDKVCDGVPDCPEGDDEN 298
Score = 38.9 bits (89), Expect = 0.005
Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 7/68 (10%)
Frame = +2
Query: 47 CFNIFEKRESKAGNGCPESAP-------WPCKTPGKCLSFDFICDGEPDCPEKYDEDAAL 205
C +++ R++ GCP P + C+ G C+ + CDG PDC DE
Sbjct: 1208 CDGVYDCRDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTG- 1266
Query: 206 CIAKDRPP 229
C+ K P
Sbjct: 1267 CVPKTCSP 1274
Score = 34.3 bits (77), Expect = 0.11
Identities = 18/42 (42%), Positives = 24/42 (57%)
Frame = +2
Query: 83 GNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
G CP +A + CK C+ +ICDGE DC + DE+ LC
Sbjct: 3841 GTYCP-AAMFECKNH-VCIQSFWICDGENDCVDGSDEEIHLC 3880
Score = 33.9 bits (76), Expect = 0.15
Identities = 16/39 (41%), Positives = 20/39 (51%)
Frame = +2
Query: 92 CPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
CP S W C C++ +CDG DCP DE + LC
Sbjct: 1313 CP-STQWQCPGYSTCINLSALCDGVFDCPNGTDE-SPLC 1349
Score = 33.5 bits (75), Expect = 0.19
Identities = 11/23 (47%), Positives = 18/23 (78%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDED 196
G+C+S +++CDG+ DC + DED
Sbjct: 2918 GRCISGNWVCDGDNDCGDMSDED 2940
Score = 33.1 bits (74), Expect = 0.25
Identities = 17/55 (30%), Positives = 25/55 (45%), Gaps = 3/55 (5%)
Frame = +2
Query: 53 NIFEKRESKAGNGCPESAP---WPCKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
N + S N P + P C+T C+ F+CDG+ DC + DE+ C
Sbjct: 2806 NCHDNDTSDEKNCPPHTCPPDFTKCQTTNICVPRAFLCDGDNDCGDGSDENPIYC 2860
Score = 32.7 bits (73), Expect = 0.33
Identities = 10/23 (43%), Positives = 18/23 (78%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDED 196
G+C++ +++CDG+ DC + DED
Sbjct: 232 GQCINQNWVCDGDDDCQDSGDED 254
Score = 32.3 bits (72), Expect = 0.43
Identities = 14/39 (35%), Positives = 20/39 (51%), Gaps = 4/39 (10%)
Frame = +2
Query: 89 GCP----ESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
GCP ES + C G C+ ++CD + DC + DE
Sbjct: 61 GCPPRSCESGLFLCPAEGTCIPSSWVCDEDKDCSDGADE 99
Score = 31.6 bits (70), Expect = 0.73
Identities = 12/31 (38%), Positives = 18/31 (58%)
Frame = +2
Query: 101 SAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
S + C +P +C+ + CDGE DC + DE
Sbjct: 2867 SNEFQCLSPQRCIPSYWFCDGEADCADGSDE 2897
Score = 30.8 bits (68), Expect = 1.2
Identities = 15/50 (30%), Positives = 28/50 (56%)
Frame = +2
Query: 44 ECFNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
+C + +++++ AG C SA + G+C+ ++ CD DCP+ DE
Sbjct: 92 DCSDGADEQQNCAGTTC--SAQQMTCSNGQCIPSEYRCDHVSDCPDGSDE 139
Score = 30.8 bits (68), Expect = 1.2
Identities = 14/44 (31%), Positives = 21/44 (47%)
Frame = +2
Query: 98 ESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPP 229
ES W C +C+ + CD DC + DED + C ++ P
Sbjct: 3597 ESNEWQCANK-RCIPQSWQCDSVNDCLDNSDEDTSHCASRTCRP 3639
Score = 30.4 bits (67), Expect = 1.6
Identities = 14/31 (45%), Positives = 17/31 (54%)
Frame = +2
Query: 101 SAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
S +PC GKC+ F CDG DC + DE
Sbjct: 1027 SLSFPCNN-GKCVPSFFRCDGVDDCHDNSDE 1056
Score = 30.4 bits (67), Expect = 1.6
Identities = 16/70 (22%), Positives = 28/70 (40%), Gaps = 3/70 (4%)
Frame = +2
Query: 29 YLYSSECFNIFEKRESKAG---NGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDA 199
Y Y + +N +AG C + + C G+C+ ++C+G +C + D
Sbjct: 2757 YHYRCDYYNDCGDNSDEAGCLFRNCNSTTEFTCSN-GRCIPLSYVCNGINNCHDNDTSDE 2815
Query: 200 ALCIAKDRPP 229
C PP
Sbjct: 2816 KNCPPHTCPP 2825
Score = 30.4 bits (67), Expect = 1.6
Identities = 14/41 (34%), Positives = 21/41 (51%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPPAVIMEQF 250
G+C+ F+CD + DC + DE LC + P + QF
Sbjct: 3044 GRCIPRFFVCDEDNDCGDGSDEQEHLCHTPE--PTCPLHQF 3082
Score = 29.3 bits (64), Expect = 3.6
Identities = 11/27 (40%), Positives = 14/27 (51%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALC 208
G C S +C+ DC + DED LC
Sbjct: 3565 GNCTSPQALCNARQDCADGSDEDRVLC 3591
Score = 29.3 bits (64), Expect = 3.6
Identities = 12/38 (31%), Positives = 18/38 (47%)
Frame = +2
Query: 80 AGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
A C + CKT +C+ +C+G DC + DE
Sbjct: 3676 AAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDCRDNSDE 3713
Score = 28.9 bits (63), Expect = 4.7
Identities = 14/52 (26%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Frame = +2
Query: 41 SECFNIFEKRESKAGNGCPESAPWPCKTPG-KCLSFDFICDGEPDCPEKYDE 193
++C + +++ +A C P + P +C+S ++CDG+ DC + DE
Sbjct: 1133 NDCSDGSDEKNCQASGTCQ---PTQFRCPDHRCISPLYVCDGDKDCADGSDE 1181
Score = 28.5 bits (62), Expect = 6.2
Identities = 18/62 (29%), Positives = 27/62 (43%), Gaps = 1/62 (1%)
Frame = +2
Query: 101 SAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPPAVI-MEQFITKWKDWFI 277
SA + C C++ + CDG DC + DE RPP + ++F + I
Sbjct: 1190 SAQFKCADGSSCINSRYRCDGVYDCRDNSDEAG----CPTRPPGMCHPDEFQCQGDGTCI 1245
Query: 278 PN 283
PN
Sbjct: 1246 PN 1247
>sp|Q9Y5Q5|CORIN_HUMAN Atrial natriuteric peptide-converting enzyme (pro-ANP-converting
enzyme) (Corin) (Heart-specific serine proteinase ATC2)
(Transmembrane protease, serine 10)
Length = 1042
Score = 43.1 bits (100), Expect = 2e-04
Identities = 17/35 (48%), Positives = 20/35 (57%)
Frame = +2
Query: 89 GCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
GC E W C + +CL ICDG PDCP+ DE
Sbjct: 615 GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDE 649
Score = 34.7 bits (78), Expect = 0.086
Identities = 11/27 (40%), Positives = 19/27 (70%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALC 208
G+C++ +++CDG+ DC +K DE C
Sbjct: 353 GRCIAMEWVCDGDHDCVDKSDEVNCSC 379
Score = 34.3 bits (77), Expect = 0.11
Identities = 18/53 (33%), Positives = 27/53 (50%)
Frame = +2
Query: 50 FNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
+N + +A C E+ + C T GKCL++ +CDG DC + DE C
Sbjct: 292 YNDCDDWSDEAHCNCSENL-FHCHT-GKCLNYSLVCDGYDDCGDLSDEQNCDC 342
Score = 29.3 bits (64), Expect = 3.6
Identities = 10/23 (43%), Positives = 15/23 (65%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDED 196
G+C+ F CDG+ DC + DE+
Sbjct: 390 GQCIPSTFQCDGDEDCKDGSDEE 412
Score = 29.3 bits (64), Expect = 3.6
Identities = 11/20 (55%), Positives = 13/20 (65%)
Frame = +2
Query: 134 CLSFDFICDGEPDCPEKYDE 193
C+S D CDGE DC + DE
Sbjct: 667 CVSRDLWCDGEADCSDSSDE 686
Score = 28.5 bits (62), Expect = 6.2
Identities = 11/31 (35%), Positives = 17/31 (54%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALCIAKD 220
G+C+ CDG+ DC + DE+ C +D
Sbjct: 590 GQCVLASRRCDGQADCDDDSDEENCGCKERD 620
>sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic mini chain; Enteropeptidase non-catalytic
heavy chain; Enteropeptidase catalytic light chain]
Length = 1034
Score = 42.0 bits (97), Expect = 5e-04
Identities = 15/32 (46%), Positives = 21/32 (65%)
Frame = +2
Query: 113 PCKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
PC KC++ D CDGE +CP+ DED+ +C
Sbjct: 205 PCADALKCIAVDLFCDGELNCPDGSDEDSKIC 236
>sp|Q04833|LRP_CAEEL Low-density lipoprotein receptor-related protein precursor (LRP)
Length = 4753
Score = 40.8 bits (94), Expect = 0.001
Identities = 16/41 (39%), Positives = 24/41 (58%), Gaps = 2/41 (4%)
Frame = +2
Query: 107 PW--PCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDR 223
PW C G+C+ F CDG+ DC ++ DE LC++ +R
Sbjct: 3711 PWMFKCAATGRCIPRRFTCDGDDDCGDRSDEADTLCMSAER 3751
Score = 38.1 bits (87), Expect = 0.008
Identities = 17/45 (37%), Positives = 23/45 (51%)
Frame = +2
Query: 92 CPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRP 226
C + + C T GKC+ ++CD E DC + DE A C RP
Sbjct: 3833 CDDVGEFRCATSGKCIPRRWMCDTENDCGDNSDELDASCGGTTRP 3877
Score = 34.7 bits (78), Expect = 0.086
Identities = 13/37 (35%), Positives = 19/37 (51%)
Frame = +2
Query: 116 CKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRP 226
C+ KC+ + CDG+ DC + DED C +P
Sbjct: 1108 CRNTKKCIPAQYGCDGDNDCGDYSDEDVKYCKDGQKP 1144
Score = 34.3 bits (77), Expect = 0.11
Identities = 15/56 (26%), Positives = 29/56 (51%)
Frame = +2
Query: 41 SECFNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
++C + +++ GN + + C G+C+ ++CDG+ DC + DED C
Sbjct: 1169 NDCGDGSDEKLEMCGNATCAANQFSCAN-GRCIPIYWLCDGDNDCYDGTDEDKERC 1223
Score = 32.3 bits (72), Expect = 0.43
Identities = 13/21 (61%), Positives = 15/21 (71%)
Frame = +2
Query: 131 KCLSFDFICDGEPDCPEKYDE 193
KC+S FICDGE DC + DE
Sbjct: 3018 KCISRAFICDGEDDCGDGSDE 3038
Score = 30.8 bits (68), Expect = 1.2
Identities = 13/31 (41%), Positives = 20/31 (64%)
Frame = +2
Query: 101 SAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
S + CK G+C+ ++ CDGE DC ++ DE
Sbjct: 1058 STQFQCKN-GRCIPKEWKCDGENDCLDESDE 1087
Score = 30.8 bits (68), Expect = 1.2
Identities = 16/64 (25%), Positives = 26/64 (40%)
Frame = +2
Query: 35 YSSECFNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIA 214
Y ++C + S+ C + C G C+ CD +PDC + DE+ C
Sbjct: 2775 YPTQC--VLRGSNSEPAKECLPPYNFQCGD-GSCILLGATCDSKPDCADASDENPNYCNT 2831
Query: 215 KDRP 226
+ P
Sbjct: 2832 RSCP 2835
Score = 30.4 bits (67), Expect = 1.6
Identities = 13/34 (38%), Positives = 16/34 (47%)
Frame = +2
Query: 92 CPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
CP W C G C+ +CDG DC + DE
Sbjct: 262 CPPGK-WNCPGTGHCIDQLKLCDGSKDCADGADE 294
Score = 29.6 bits (65), Expect = 2.8
Identities = 10/24 (41%), Positives = 17/24 (70%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDA 199
G+C+ +++CDGE DC + DE +
Sbjct: 1323 GRCILNNWLCDGENDCGDGSDESS 1346
Score = 29.6 bits (65), Expect = 2.8
Identities = 10/25 (40%), Positives = 16/25 (64%)
Frame = +2
Query: 134 CLSFDFICDGEPDCPEKYDEDAALC 208
C+ F+CDG+ DC + DE ++ C
Sbjct: 3971 CIPRKFMCDGDNDCGDNSDETSSEC 3995
Score = 29.3 bits (64), Expect = 3.6
Identities = 16/57 (28%), Positives = 28/57 (49%), Gaps = 2/57 (3%)
Frame = +2
Query: 44 ECFNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKY--DEDAALC 208
+C + ++ + + C E +PC G C++ +CDG DC ++ DE A C
Sbjct: 2858 DCGDGSDELDCPSAVACAEGT-FPCSN-GHCINQTKVCDGHNDCHDEQVSDESLATC 2912
Score = 29.3 bits (64), Expect = 3.6
Identities = 11/32 (34%), Positives = 16/32 (50%)
Frame = +2
Query: 116 CKTPGKCLSFDFICDGEPDCPEKYDEDAALCI 211
C C+ +CDG DC +K DE+ C+
Sbjct: 2926 CPNTNICIQPADLCDGYDDCGDKADENQLFCM 2957
Score = 28.9 bits (63), Expect = 4.7
Identities = 12/38 (31%), Positives = 18/38 (47%)
Frame = +2
Query: 116 CKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPP 229
C +C+ CDG+ DC + DED+ A+ P
Sbjct: 1235 CANGRQCVPLRNHCDGQSDCEDGSDEDSCAVTAESCTP 1272
Score = 28.9 bits (63), Expect = 4.7
Identities = 11/31 (35%), Positives = 16/31 (51%)
Frame = +2
Query: 116 CKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
C + G C+ + CDG+ DC + DE C
Sbjct: 1277 CVSSGLCIPASWKCDGQQDCDDGSDEPKFGC 1307
Score = 28.9 bits (63), Expect = 4.7
Identities = 10/27 (37%), Positives = 16/27 (59%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALC 208
G+C+ + CDG+ DC + +DE C
Sbjct: 2971 GRCIPETWQCDGDNDCSDGWDETHTNC 2997
Score = 28.9 bits (63), Expect = 4.7
Identities = 11/21 (52%), Positives = 14/21 (66%)
Frame = +2
Query: 131 KCLSFDFICDGEPDCPEKYDE 193
KC+ + CDGEPDC + DE
Sbjct: 3640 KCIPKLWYCDGEPDCRDGSDE 3660
Score = 28.1 bits (61), Expect = 8.1
Identities = 10/22 (45%), Positives = 14/22 (63%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDE 193
GKC+ ++ CDG DC + DE
Sbjct: 63 GKCIRTEWKCDGSGDCSDGEDE 84
Score = 28.1 bits (61), Expect = 8.1
Identities = 10/31 (32%), Positives = 16/31 (51%)
Frame = +2
Query: 116 CKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
C + +C+ C+G+ DC + DED C
Sbjct: 3800 CSSSYRCIPNWAFCNGQDDCRDNSDEDKQRC 3830
>sp|P97435|ENTK_MOUSE Enteropeptidase (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1069
Score = 40.8 bits (94), Expect = 0.001
Identities = 15/32 (46%), Positives = 19/32 (59%)
Frame = +2
Query: 113 PCKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
PC C++ D CDGE +CP+ DED LC
Sbjct: 235 PCAHAWNCVATDLFCDGEVNCPDGSDEDTGLC 266
>sp|Q07954|LRP1_HUMAN Low-density lipoprotein receptor-related protein 1 precursor (LRP)
(Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E
receptor) (APOER) (CD91)
Length = 4544
Score = 39.3 bits (90), Expect = 0.004
Identities = 17/47 (36%), Positives = 27/47 (57%)
Frame = +2
Query: 92 CPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPPA 232
C S + CK +C+S ++CDG+ DC + DE+ +A RPP+
Sbjct: 1104 CDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLA-CRPPS 1149
Score = 35.4 bits (80), Expect = 0.051
Identities = 12/27 (44%), Positives = 17/27 (62%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALC 208
G+C++F CDG P C +K DE + C
Sbjct: 2535 GECINFSLTCDGVPHCKDKSDEKPSYC 2561
Score = 35.0 bits (79), Expect = 0.066
Identities = 17/46 (36%), Positives = 25/46 (54%)
Frame = +2
Query: 92 CPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPP 229
CP S + C+ +C+ ++CDG+ DC DE A C A+ PP
Sbjct: 895 CP-SDRFKCEN-NRCIPNRWLCDGDNDCGNSEDESNATCSARTCPP 938
Score = 33.5 bits (75), Expect = 0.19
Identities = 13/31 (41%), Positives = 18/31 (58%)
Frame = +2
Query: 116 CKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
C+ C+S + CDGE DCP+ DE +C
Sbjct: 34 CRDQITCISKGWRCDGERDCPDGSDEAPEIC 64
Score = 33.1 bits (74), Expect = 0.25
Identities = 13/31 (41%), Positives = 17/31 (54%)
Frame = +2
Query: 116 CKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
CK G+C+ + CDGE DC + DE C
Sbjct: 3501 CKDSGRCIPARWKCDGEDDCGDGSDEPKEEC 3531
Score = 32.7 bits (73), Expect = 0.33
Identities = 17/67 (25%), Positives = 30/67 (44%)
Frame = +2
Query: 35 YSSECFNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIA 214
YS E + ++ GC + + C+ G C+ + CDG+ DC + DE + +
Sbjct: 1043 YSDETHANCTNQATRPPGGC-HTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVT 1101
Query: 215 KDRPPAV 235
P+V
Sbjct: 1102 HVCDPSV 1108
Score = 32.7 bits (73), Expect = 0.33
Identities = 17/48 (35%), Positives = 22/48 (45%)
Frame = +2
Query: 53 NIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDED 196
N E E A CP + P+ CK CL CDG +C + DE+
Sbjct: 3682 NSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEE 3729
Score = 32.3 bits (72), Expect = 0.43
Identities = 24/75 (32%), Positives = 37/75 (49%)
Frame = +2
Query: 35 YSSECFNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIA 214
Y ++C + ++ ES C ES + C G+C++ + CDG+ DC + DE
Sbjct: 3557 YDNDCGDNSDE-ESCTPRPCSESE-FSCAN-GRCIAGRWKCDGDHDCADGSDE------- 3606
Query: 215 KDRPPAVIMEQFITK 259
KD P M+QF K
Sbjct: 3607 KDCTPRCDMDQFQCK 3621
Score = 32.0 bits (71), Expect = 0.56
Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 1/54 (1%)
Frame = +2
Query: 71 ESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAK-DRPP 229
E+ + C S + C + G+C+ + CDG+ DC + DE A C + RPP
Sbjct: 1008 EAGCSHSC-SSTQFKCNS-GRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPP 1059
Score = 31.2 bits (69), Expect = 0.96
Identities = 19/47 (40%), Positives = 24/47 (51%), Gaps = 7/47 (14%)
Frame = +2
Query: 92 CPESAPWP----CKTPGKCLSFDFICDGEPDCPEKYDE---DAALCI 211
CPE P C T G C + FICDG+ DC + DE D +C+
Sbjct: 3369 CPEFKCRPGQFQCST-GICTNPAFICDGDNDCQDNSDEANCDIHVCL 3414
Score = 30.4 bits (67), Expect = 1.6
Identities = 16/45 (35%), Positives = 21/45 (46%), Gaps = 7/45 (15%)
Frame = +2
Query: 95 PESAPWPCKTPG-------KCLSFDFICDGEPDCPEKYDEDAALC 208
P P P PG +C+ + CDG+ DC + DE ALC
Sbjct: 846 PSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALC 890
Score = 30.4 bits (67), Expect = 1.6
Identities = 19/54 (35%), Positives = 28/54 (51%)
Frame = +2
Query: 71 ESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPPA 232
E+ C E A + C+ +C+S ++CDG DC + DE AA C K P+
Sbjct: 2727 ETHCNKFCSE-AQFECQNH-RCISKQWLCDGSDDCGDGSDE-AAHCEGKTCGPS 2777
Score = 29.3 bits (64), Expect = 3.6
Identities = 12/39 (30%), Positives = 19/39 (48%)
Frame = +2
Query: 113 PCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPP 229
PC+ C + ++CDG DC + DE + + R P
Sbjct: 2659 PCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCP 2697
Score = 28.9 bits (63), Expect = 4.7
Identities = 11/34 (32%), Positives = 21/34 (61%)
Frame = +2
Query: 92 CPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
C S+ + C + G+C++ +C+G+ DC + DE
Sbjct: 2904 CNASSQFLCSS-GRCVAEALLCNGQDDCGDSSDE 2936
Score = 28.5 bits (62), Expect = 6.2
Identities = 13/47 (27%), Positives = 25/47 (53%)
Frame = +2
Query: 62 EKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAA 202
E + + CP + + C + G+C+ + CD + DC ++ DE A+
Sbjct: 926 ESNATCSARTCPPNQ-FSCAS-GRCIPISWTCDLDDDCGDRSDESAS 970
Score = 28.5 bits (62), Expect = 6.2
Identities = 15/55 (27%), Positives = 26/55 (47%)
Frame = +2
Query: 38 SSECFNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAA 202
S +C + ++ G C S+ + C C+ ++CDG+ DC + DE A
Sbjct: 2756 SDDCGDGSDEAAHCEGKTCGPSS-FSCPGTHVCVPERWLCDGDKDCADGADESIA 2809
>sp|P35950|LDLR_CRIGR Low-density lipoprotein receptor precursor (LDL receptor)
Length = 854
Score = 38.9 bits (89), Expect = 0.005
Identities = 12/29 (41%), Positives = 21/29 (72%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALCIA 214
GKC++ ++CDG P+CP+ DE + C++
Sbjct: 37 GKCIASKWVCDGSPECPDGSDESSETCMS 65
Score = 31.2 bits (69), Expect = 0.96
Identities = 14/30 (46%), Positives = 18/30 (60%), Gaps = 3/30 (10%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDE---DAALC 208
GKC+S F+CD + DC + DE AA C
Sbjct: 119 GKCISQKFVCDQDQDCVDGSDEAHCQAATC 148
Score = 29.6 bits (65), Expect = 2.8
Identities = 14/45 (31%), Positives = 22/45 (48%), Gaps = 9/45 (20%)
Frame = +2
Query: 89 GCPESAPW---PCKT------PGKCLSFDFICDGEPDCPEKYDED 196
G +A W PC + +C+ ++CDG DC +K DE+
Sbjct: 186 GRDTAAAWSSSPCSSLEFHCGSSECIHRSWVCDGSADCKDKSDEE 230
>sp|Q9JI18|LRP1B_MOUSE Low-density lipoprotein receptor-related protein 1B precursor
(Low-density lipoprotein receptor-related protein-deleted
in tumor) (LRP-DIT)
Length = 4599
Score = 38.9 bits (89), Expect = 0.005
Identities = 17/53 (32%), Positives = 30/53 (56%), Gaps = 7/53 (13%)
Frame = +2
Query: 71 ESKAGNG----CPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE---DAALC 208
+ K NG C + C++ G+C++ ++CDG+ DC ++ DE D+ LC
Sbjct: 1084 DEKGCNGTIRLCDHKTKFSCRSTGRCINNAWVCDGDVDCEDQSDEEDCDSFLC 1136
Score = 37.0 bits (84), Expect = 0.017
Identities = 13/31 (41%), Positives = 19/31 (61%)
Frame = +2
Query: 116 CKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
C C+S ++CDG+PDCP++ DE C
Sbjct: 39 CHDHVTCVSQSWLCDGDPDCPDQSDESLDTC 69
Score = 37.0 bits (84), Expect = 0.017
Identities = 17/42 (40%), Positives = 22/42 (52%), Gaps = 3/42 (7%)
Frame = +2
Query: 92 CPESAPW---PCKTPGKCLSFDFICDGEPDCPEKYDEDAALC 208
C S W C KC+S +ICDGE DC + DE ++C
Sbjct: 2716 CDSSCSWNQFACSVK-KCISKHWICDGEDDCGDSLDESDSIC 2756
Score = 36.2 bits (82), Expect = 0.030
Identities = 16/38 (42%), Positives = 23/38 (60%), Gaps = 4/38 (10%)
Frame = +2
Query: 92 CPESAPWP----CKTPGKCLSFDFICDGEPDCPEKYDE 193
CPE++ P CKT C+S ++CD +PDC + DE
Sbjct: 3431 CPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDE 3468
Score = 35.4 bits (80), Expect = 0.051
Identities = 13/35 (37%), Positives = 20/35 (57%)
Frame = +2
Query: 92 CPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDED 196
CP + P+ C+ CL + IC+G DC + DE+
Sbjct: 3715 CPPTRPYRCRNDRICLQLEKICNGINDCGDNSDEE 3749
Score = 32.7 bits (73), Expect = 0.33
Identities = 17/53 (32%), Positives = 27/53 (50%)
Frame = +2
Query: 35 YSSECFNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
+S E K E+++ GC + + C+ G C+ + CDGE DC + DE
Sbjct: 1034 FSDETHINCTKEEARSPAGCIGNE-FQCRPDGNCIPDLWRCDGEKDCEDGSDE 1085
Score = 32.7 bits (73), Expect = 0.33
Identities = 21/48 (43%), Positives = 24/48 (50%), Gaps = 7/48 (14%)
Frame = +2
Query: 92 CPESAPWP----CKTPGKCLSFDFICDGEPDCPEKYDE---DAALCIA 214
CPE P C T G C FICDGE DC + DE D +C+A
Sbjct: 3352 CPEFKCQPGRFQCGT-GLCALPAFICDGENDCGDNSDELNCDTHVCLA 3398
Score = 32.3 bits (72), Expect = 0.43
Identities = 14/50 (28%), Positives = 26/50 (52%)
Frame = +2
Query: 44 ECFNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
+C + ++ +S G + + C+ C+ ++CDGE DCP+ DE
Sbjct: 2744 DCGDSLDESDSICGAVTCAADMFSCQGSHACVPQHWLCDGERDCPDGSDE 2793
Score = 32.3 bits (72), Expect = 0.43
Identities = 21/60 (35%), Positives = 30/60 (50%)
Frame = +2
Query: 101 SAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPPAVIMEQFITKWKDWFIP 280
S+ + C + G CLS C+GEPDC + DE + K+ +QF K K + IP
Sbjct: 3596 SSEYMCASGG-CLSASLKCNGEPDCVDGSDEMDCVIECKE-------DQFQCKNKAYCIP 3647
Score = 30.4 bits (67), Expect = 1.6
Identities = 11/27 (40%), Positives = 14/27 (51%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALC 208
G C+ + CDG P C +K DE C
Sbjct: 2521 GDCVDYVLTCDGIPHCKDKSDEKLLYC 2547
Score = 30.4 bits (67), Expect = 1.6
Identities = 14/27 (51%), Positives = 16/27 (59%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALC 208
G+CLS + CDG DC KY ED C
Sbjct: 3563 GQCLSAKWKCDGHEDC--KYGEDEKNC 3587
Score = 30.0 bits (66), Expect = 2.1
Identities = 17/47 (36%), Positives = 23/47 (48%), Gaps = 1/47 (2%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDE-DAALCIAKDRPPAVIMEQFITKWK 265
G C+S F CDGE DC + DE + +KD+ + KWK
Sbjct: 3525 GDCVSSRFWCDGEFDCADGSDEKNCETSCSKDQFQCSNGQCLSAKWK 3571
Score = 30.0 bits (66), Expect = 2.1
Identities = 12/32 (37%), Positives = 17/32 (53%)
Frame = +2
Query: 134 CLSFDFICDGEPDCPEKYDEDAALCIAKDRPP 229
C ++CDGE DC + DE +C+ PP
Sbjct: 3686 CKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPP 3717
Score = 29.6 bits (65), Expect = 2.8
Identities = 17/60 (28%), Positives = 26/60 (43%)
Frame = +2
Query: 38 SSECFNIFEKRESKAGNGCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAK 217
S CFN + CP+ + C+ +C+ ++CDG DC DE C A+
Sbjct: 878 SVTCFN----------HSCPDDQ-FKCQN-NRCIPKRWLCDGANDCGSNEDESNQTCTAR 925
Score = 29.6 bits (65), Expect = 2.8
Identities = 15/44 (34%), Positives = 24/44 (54%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPPAVIMEQFITK 259
G+C+ ++CD E DC ++ DE A+ + P + QFI K
Sbjct: 937 GRCIPTAWLCDREDDCGDQTDEVASC----EFPTCEPLTQFICK 976
Score = 29.6 bits (65), Expect = 2.8
Identities = 12/35 (34%), Positives = 18/35 (51%)
Frame = +2
Query: 89 GCPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
GCP G+C+ ++CDG+ DC + DE
Sbjct: 2688 GCPS---------GRCILNTWVCDGQKDCEDGLDE 2713
Score = 29.3 bits (64), Expect = 3.6
Identities = 11/31 (35%), Positives = 16/31 (51%)
Frame = +2
Query: 134 CLSFDFICDGEPDCPEKYDEDAALCIAKDRP 226
C+ + CDG+ DC + DED+ C P
Sbjct: 857 CIQARWKCDGDDDCLDGSDEDSVTCFNHSCP 887
Score = 28.5 bits (62), Expect = 6.2
Identities = 12/34 (35%), Positives = 20/34 (58%)
Frame = +2
Query: 92 CPESAPWPCKTPGKCLSFDFICDGEPDCPEKYDE 193
C + CK+ G+C+S + CD + DC ++ DE
Sbjct: 967 CEPLTQFICKS-GRCISNKWHCDTDDDCGDRSDE 999
Score = 28.5 bits (62), Expect = 6.2
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALCIAKD-RPPA 232
G+C+ + CDG+ DC + DE C ++ R PA
Sbjct: 1016 GRCIPGHWACDGDNDCGDFSDETHINCTKEEARSPA 1051
Score = 28.1 bits (61), Expect = 8.1
Identities = 10/27 (37%), Positives = 15/27 (55%)
Frame = +2
Query: 116 CKTPGKCLSFDFICDGEPDCPEKYDED 196
CK C+ ++CDG DC + DE+
Sbjct: 3639 CKNKAYCIPIRWLCDGIYDCVDGSDEE 3665
>sp|P35951|LDLR_MOUSE Low-density lipoprotein receptor precursor (LDL receptor)
Length = 864
Score = 38.1 bits (87), Expect = 0.008
Identities = 12/29 (41%), Positives = 20/29 (68%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALCIA 214
GKC++ ++CDG P+CP+ DE C++
Sbjct: 37 GKCIASKWVCDGSPECPDGSDESPKTCMS 65
Score = 33.9 bits (76), Expect = 0.15
Identities = 21/52 (40%), Positives = 27/52 (51%), Gaps = 4/52 (7%)
Frame = +2
Query: 89 GCPESA----PWPCKTPGKCLSFDFICDGEPDCPEKYDEDAALCIAKDRPPA 232
GCP + C+ GKC+S F+CDG+ DC + DE A C A PA
Sbjct: 103 GCPPKTCSQDDFRCQD-GKCISPQFVCDGDRDCLDGSDE--AHCPATTCGPA 151
Score = 31.6 bits (70), Expect = 0.73
Identities = 13/32 (40%), Positives = 20/32 (62%)
Frame = +2
Query: 131 KCLSFDFICDGEPDCPEKYDEDAALCIAKDRP 226
+C+ ++CDGE DC +K DE+ +A RP
Sbjct: 209 ECIHRSWVCDGEADCKDKSDEEHC-AVATCRP 239
Score = 29.6 bits (65), Expect = 2.8
Identities = 11/27 (40%), Positives = 15/27 (55%)
Frame = +2
Query: 128 GKCLSFDFICDGEPDCPEKYDEDAALC 208
G+C+S D +CD DC + DE C
Sbjct: 288 GECISLDKVCDSARDCQDWSDEPIKEC 314
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,598,322
Number of Sequences: 369166
Number of extensions: 966176
Number of successful extensions: 3558
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3022
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3551
length of database: 68,354,980
effective HSP length: 99
effective length of database: 50,066,215
effective search space used: 2102781030
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)