Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_N19
(559 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P28053|MMP1_BOVIN Interstitial collagenase precursor (Ma... 65 9e-11
sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor... 65 9e-11
sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor... 64 2e-10
sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (... 64 2e-10
sp|P21692|MMP1_PIG Interstitial collagenase precursor (Matr... 64 3e-10
sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor... 63 4e-10
sp|Q9NPA2|MMP25_HUMAN Matrix metalloproteinase-25 precursor... 63 4e-10
sp|P22894|MMP8_HUMAN Neutrophil collagenase precursor (Matr... 62 1e-09
sp|Q9XSZ5|MMP1_HORSE Interstitial collagenase precursor (Ma... 60 5e-09
sp|P09237|MMP7_HUMAN Matrilysin precursor (Pump-1 protease)... 58 1e-08
>sp|P28053|MMP1_BOVIN Interstitial collagenase precursor (Matrix metalloproteinase-1)
(MMP-1) (Fibroblast collagenase)
Length = 469
Score = 65.5 bits (158), Expect = 9e-11
Identities = 52/181 (28%), Positives = 79/181 (43%), Gaps = 10/181 (5%)
Frame = +1
Query: 46 ESSDEKYVEKFLSDFYDYNENTDR---------LNDAVKNIQKMAGLPTDGKINKELLAH 198
+ D + V+K+L ++Y+ N N + + + +K +QK GL GK + E L
Sbjct: 27 QEQDVETVKKYLENYYNLNSNGKKVERQRNGGLITEKLKQMQKFFGLRVTGKPDAETLNV 86
Query: 199 VGKSRCGGKDVKPKNKRYNAANSKWDK-GTTYRFYIHDERHPTTMTLGEIQRALMIGLSY 375
+ + RCG DV P S W+ TYR E + ++ ++ +A+
Sbjct: 87 MKQPRCGVPDVAPFV--LTPGKSCWENTNLTYRI----ENYTPDLSRADVDQAIEKAFQL 140
Query: 376 WSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFF 555
WS + F KVS Q + +SF +H RD P D PGG LAHAF
Sbjct: 141 WSNVTPLTFTKVSEGQADIM-ISFVRGDH------------RDNSPFDG-PGGNLAHAFQ 186
Query: 556 P 558
P
Sbjct: 187 P 187
>sp|O18767|MMP20_BOVIN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 481
Score = 65.5 bits (158), Expect = 9e-11
Identities = 45/144 (31%), Positives = 69/144 (47%), Gaps = 1/144 (0%)
Frame = +1
Query: 130 VKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIH 306
+K +Q+ GL GK+++ + + + RCG DV N R KW K T TYR
Sbjct: 70 IKELQEFFGLRVTGKLDRATMDVIKRPRCGVPDV--ANYRLFPGEPKWKKNTLTYRI--- 124
Query: 307 DERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNN 486
++ +MT E+ RA+ + L WS+A + F +++ + + +SF +H
Sbjct: 125 -SKYTPSMTPAEVDRAMEMALRAWSSAVPLNFVRINAGEADIM-ISFETGDH-------- 174
Query: 487 FVESRDPYPLDNVPGGVLAHAFFP 558
D YP D P G LAHAF P
Sbjct: 175 ----GDSYPFDG-PRGTLAHAFAP 193
>sp|O60882|MMP20_HUMAN Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 64.3 bits (155), Expect = 2e-10
Identities = 44/144 (30%), Positives = 70/144 (48%), Gaps = 1/144 (0%)
Frame = +1
Query: 130 VKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIH 306
+K +Q GL GK+++ + + K RCG DV N R KW K T TYR
Sbjct: 72 IKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDV--ANYRLFPGEPKWKKNTLTYRI--- 126
Query: 307 DERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNN 486
++ +M+ E+ +A+ + L WS+A + F ++++ + + +SF + +H
Sbjct: 127 -SKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIM-ISFENGDH-------- 176
Query: 487 FVESRDPYPLDNVPGGVLAHAFFP 558
D YP D P G LAHAF P
Sbjct: 177 ----GDSYPFDG-PRGTLAHAFAP 195
>sp|P79287|MMP20_PIG Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 483
Score = 64.3 bits (155), Expect = 2e-10
Identities = 45/144 (31%), Positives = 68/144 (47%), Gaps = 1/144 (0%)
Frame = +1
Query: 130 VKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKGT-TYRFYIH 306
+K +Q GL GK+++ + + + RCG DV N R KW K T TYR
Sbjct: 72 IKELQAFFGLRVTGKLDRTTMDVIKRPRCGVPDV--ANYRLFPGEPKWKKNTLTYRI--- 126
Query: 307 DERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNN 486
++ +MT E+ +A+ + L WS+A + F +V+ + + +SF +H
Sbjct: 127 -SKYTPSMTPAEVDKAMEMALQAWSSAVPLSFVRVNAGEADIM-ISFETGDH-------- 176
Query: 487 FVESRDPYPLDNVPGGVLAHAFFP 558
D YP D P G LAHAF P
Sbjct: 177 ----GDSYPFDG-PRGTLAHAFAP 195
>sp|P21692|MMP1_PIG Interstitial collagenase precursor (Matrix metalloproteinase-1)
(MMP-1) [Contains: 18 kDa interstitial collagenase]
Length = 469
Score = 63.5 bits (153), Expect = 3e-10
Identities = 51/181 (28%), Positives = 79/181 (43%), Gaps = 10/181 (5%)
Frame = +1
Query: 46 ESSDEKYVEKFLSDFYDYNE---------NTDRLNDAVKNIQKMAGLPTDGKINKELLAH 198
+ D + V+K+L ++Y+ N N+ + + +K +Q+ GL GK + E L
Sbjct: 27 QEQDVEIVQKYLKNYYNLNSDGVPVEKKRNSGLVVEKLKQMQQFFGLKVTGKPDAETLNV 86
Query: 199 VGKSRCGGKDVKPKNKRYNAANSKWDKG-TTYRFYIHDERHPTTMTLGEIQRALMIGLSY 375
+ + RCG DV N +W+ TYR E + ++ ++ RA+
Sbjct: 87 MKQPRCGVPDVA--EFVLTPGNPRWENTHLTYRI----ENYTPDLSREDVDRAIEKAFQL 140
Query: 376 WSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFF 555
WS + F KVS Q + +SF +H RD P D PGG LAHAF
Sbjct: 141 WSNVSPLTFTKVSEGQADIM-ISFVRGDH------------RDNSPFDG-PGGNLAHAFQ 186
Query: 556 P 558
P
Sbjct: 187 P 187
>sp|P57748|MMP20_MOUSE Matrix metalloproteinase-20 precursor (MMP-20) (Enamel
metalloproteinase) (Enamelysin)
Length = 482
Score = 63.2 bits (152), Expect = 4e-10
Identities = 44/144 (30%), Positives = 68/144 (47%), Gaps = 1/144 (0%)
Frame = +1
Query: 130 VKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKPKNKRYNAANSKWDKG-TTYRFYIH 306
+K +Q GL GK+++ + + K RCG DV N R KW K TYR
Sbjct: 71 IKELQIFFGLKVTGKLDQNTMNVIKKPRCGVPDV--ANYRLFPGEPKWKKNILTYRI--- 125
Query: 307 DERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNN 486
++ +M+ E+ +A+ + L WSTA + F ++++ + + +SF +H
Sbjct: 126 -SKYTPSMSPTEVDKAIQMALHAWSTAVPLNFVRINSGEADIM-ISFETGDH-------- 175
Query: 487 FVESRDPYPLDNVPGGVLAHAFFP 558
D YP D P G LAHAF P
Sbjct: 176 ----GDSYPFDG-PRGTLAHAFAP 194
>sp|Q9NPA2|MMP25_HUMAN Matrix metalloproteinase-25 precursor (MMP-25) (Membrane-type
matrix metalloproteinase 6) (MT-MMP 6) (Membrane-type-6
matrix metalloproteinase) (MT6-MMP) (Leukolysin)
Length = 562
Score = 63.2 bits (152), Expect = 4e-10
Identities = 47/161 (29%), Positives = 76/161 (47%), Gaps = 9/161 (5%)
Frame = +1
Query: 103 ENTDRLNDAVKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDV------KPKNKRYNAAN 264
++ ++L DA+K +Q+ AGLP G+++ +A + K RC DV + +RY +
Sbjct: 53 QSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSG 112
Query: 265 SKWDKGT-TYRFYIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKVSNKQGSM--F 435
S W K T T+R + + ++ ++ + L W + F +V + QG
Sbjct: 113 SVWKKRTLTWR--VRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDI 170
Query: 436 SLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFP 558
+ FA A H +D YP D + GG LAHAFFP
Sbjct: 171 LIDFARAFH------------QDSYPFDGL-GGTLAHAFFP 198
>sp|P22894|MMP8_HUMAN Neutrophil collagenase precursor (Matrix metalloproteinase-8)
(MMP-8) (PMNL collagenase) (PMNL-CL)
Length = 467
Score = 61.6 bits (148), Expect = 1e-09
Identities = 48/181 (26%), Positives = 78/181 (43%), Gaps = 10/181 (5%)
Frame = +1
Query: 46 ESSDEKYVEKFLSDFYDYNEN---------TDRLNDAVKNIQKMAGLPTDGKINKELLAH 198
+ + K V+ +L FY N T+ + + +K +Q+ GL GK N+E L
Sbjct: 26 KEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDM 85
Query: 199 VGKSRCGGKDVKPKNKRYNAANSKWDK-GTTYRFYIHDERHPTTMTLGEIQRALMIGLSY 375
+ K RCG D N KW++ TYR + ++ E++RA+
Sbjct: 86 MKKPRCGVPD--SGGFMLTPGNPKWERTNLTYRI----RNYTPQLSEAEVERAIKDAFEL 139
Query: 376 WSTAGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFF 555
WS A + F ++S + + +++F +H D P D P G+LAHAF
Sbjct: 140 WSVASPLIFTRISQGEADI-NIAFYQRDH------------GDNSPFDG-PNGILAHAFQ 185
Query: 556 P 558
P
Sbjct: 186 P 186
>sp|Q9XSZ5|MMP1_HORSE Interstitial collagenase precursor (Matrix metalloproteinase-1)
(MMP-1)
Length = 469
Score = 59.7 bits (143), Expect = 5e-09
Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 10/178 (5%)
Frame = +1
Query: 55 DEKYVEKFLSDFYDYNENTDRLN---------DAVKNIQKMAGLPTDGKINKELLAHVGK 207
D + V+K+L ++Y+ + +++ + +K +Q+ GL GK + E L + +
Sbjct: 30 DVEMVQKYLENYYNLKSDGEQIEKQRHRSPVVEKLKQMQEFFGLKVTGKPDAETLNVMKQ 89
Query: 208 SRCGGKDVKPKNKRYNAANSKWDKG-TTYRFYIHDERHPTTMTLGEIQRALMIGLSYWST 384
RCG DV N +W+ TYR E + + ++ +A+ WS
Sbjct: 90 PRCGVPDVA--EFVLTEGNPRWENTHLTYRI----ENYTPDLPRADVDQAIEKAFQLWSN 143
Query: 385 AGDIYFAKVSNKQGSMFSLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFP 558
+ F KVS Q + +SF +H RD P D PGG LAHAF P
Sbjct: 144 VSPLTFTKVSEGQADIM-ISFVRGDH------------RDNSPFDG-PGGNLAHAFQP 187
>sp|P09237|MMP7_HUMAN Matrilysin precursor (Pump-1 protease) (Uterine metalloproteinase)
(Matrix metalloproteinase-7) (MMP-7) (Matrin)
Length = 267
Score = 58.2 bits (139), Expect = 1e-08
Identities = 52/169 (30%), Positives = 70/169 (41%), Gaps = 6/169 (3%)
Frame = +1
Query: 70 EKFLSDFYDYNENTDRLNDA---VKNIQKMAGLPTDGKINKELLAHVGKSRCGGKDVKPK 240
+ +L FY Y+ T N +K +QK GLP G +N ++ + K RCG DV
Sbjct: 36 QDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEY 95
Query: 241 NKRYNAANSKW-DKGTTYRF--YIHDERHPTTMTLGEIQRALMIGLSYWSTAGDIYFAKV 411
+ N + KW K TYR Y D H T + R + L+ W ++F KV
Sbjct: 96 SLFPN--SPKWTSKVVTYRIVSYTRDLPHIT------VDRLVSKALNMWGKEIPLHFRKV 147
Query: 412 SNKQGSMFSLSFADAEHVQYDVHNNFVESRDPYPLDNVPGGVLAHAFFP 558
+ + FA H D YP D PG LAHAF P
Sbjct: 148 VWGTADIM-IGFARGAH------------GDSYPFDG-PGNTLAHAFAP 182
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,094,778
Number of Sequences: 369166
Number of extensions: 1297471
Number of successful extensions: 3891
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3703
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3851
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3980545740
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)