Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_N06
(551 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q29466|VPP1_BOVIN Vacuolar proton translocating ATPase 1... 129 5e-30
sp|Q9Z1G4|VPP1_MOUSE Vacuolar proton translocating ATPase 1... 126 3e-29
sp|P25286|VPP1_RAT Vacuolar proton translocating ATPase 116... 126 3e-29
sp|Q920R6|VPP4_MOUSE Vacuolar proton translocating ATPase 1... 125 5e-29
sp|Q5R422|VPP1_PONPY Vacuolar proton translocating ATPase 1... 124 2e-28
sp|Q93050|VPP1_HUMAN Vacuolar proton translocating ATPase 1... 124 2e-28
sp|Q9HBG4|VPP4_HUMAN Vacuolar proton translocating ATPase 1... 122 8e-28
sp|Q13488|VPP3_HUMAN Vacuolar proton translocating ATPase 1... 102 6e-22
sp|O97681|VPP2_BOVIN Vacuolar proton translocating ATPase 1... 99 5e-21
sp|O13742|VPH1_SCHPO Probable vacuolar ATP synthase 91 kDa ... 99 7e-21
>sp|Q29466|VPP1_BOVIN Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
(V-ATPase 116-kDa isoform a1) (Clathrin-coated
vesicle/synaptic vesicle proton pump 116 kDa subunit)
(Vacuolar proton pump subunit 1) (Vacuolar adenosine
triphosphatase subunit Ac116)
Length = 838
Score = 129 bits (324), Expect = 5e-30
Identities = 74/183 (40%), Positives = 98/183 (53%)
Frame = +2
Query: 2 VLFLLSIFGYLVIEIFYKWVTYTAASSACAPSLLIGLINMFMFTKYDSKTMPCSNKPLFD 181
++F+ S+FGYLVI IFYKW Y A +S APSLLI INMF+F+ DS N L+
Sbjct: 577 IIFMTSLFGYLVILIFYKWTAYNAKTSEKAPSLLIHFINMFLFSYGDS-----GNSMLYS 631
Query: 182 SQFTVQSILVIIAVICIPWMLIIKPVVXXXXXXXXXXXXXXXELLLDPGHVNDGADVDQS 361
Q +Q LV++A++C+PWML+ KP+V L+ G + G +
Sbjct: 632 GQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLG-----TLNFGGIRVG---NGP 683
Query: 362 LKNPVDGVNNAVIKMXXXXXXXXXXXXXXXXXXIFVHQCIHTIEYCLGCISNTASYLRLW 541
+ + + + + VHQ IHTIEYCLGCISNTASYLRLW
Sbjct: 684 TEEDAEIIQHDQLSTHSEDAEEPTEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLW 743
Query: 542 ALS 550
ALS
Sbjct: 744 ALS 746
>sp|Q9Z1G4|VPP1_MOUSE Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
(V-ATPase 116-kDa isoform a1) (Clathrin-coated
vesicle/synaptic vesicle proton pump 116 kDa subunit)
(Vacuolar proton pump subunit 1) (Vacuolar adenosine
triphosphatase subunit Ac116)
Length = 839
Score = 126 bits (317), Expect = 3e-29
Identities = 75/183 (40%), Positives = 97/183 (53%)
Frame = +2
Query: 2 VLFLLSIFGYLVIEIFYKWVTYTAASSACAPSLLIGLINMFMFTKYDSKTMPCSNKPLFD 181
++F+ S+FGYLVI IFYKW Y A SS APSLLI INMF+F+ +S N L+
Sbjct: 584 IIFMSSLFGYLVILIFYKWTAYDAHSSRNAPSLLIHFINMFLFSYPES-----GNAMLYS 638
Query: 182 SQFTVQSILVIIAVICIPWMLIIKPVVXXXXXXXXXXXXXXXELLLDPGHVNDGADVDQS 361
Q +Q L+++A++C+PWML+ KP++ L+ G + G
Sbjct: 639 GQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLG-----TLNFGGIRVG------ 687
Query: 362 LKNPVDGVNNAVIKMXXXXXXXXXXXXXXXXXXIFVHQCIHTIEYCLGCISNTASYLRLW 541
P + +A I VHQ IHTIEYCLGCISNTASYLRLW
Sbjct: 688 -NGPTE--EDAEIIQHDQLSTHSEDAEEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLW 744
Query: 542 ALS 550
ALS
Sbjct: 745 ALS 747
>sp|P25286|VPP1_RAT Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
(V-ATPase 116-kDa isoform a1) (Clathrin-coated
vesicle/synaptic vesicle proton pump 116 kDa subunit)
(Vacuolar proton pump subunit 1) (Vacuolar adenosine
triphosphatase subunit Ac116)
Length = 838
Score = 126 bits (317), Expect = 3e-29
Identities = 72/183 (39%), Positives = 98/183 (53%)
Frame = +2
Query: 2 VLFLLSIFGYLVIEIFYKWVTYTAASSACAPSLLIGLINMFMFTKYDSKTMPCSNKPLFD 181
++F+ S+FGYLVI IFYKW Y A SS APSLLI INMF+F+ +S N L+
Sbjct: 577 IIFMSSLFGYLVILIFYKWTAYDAHSSRNAPSLLIHFINMFLFSYPES-----GNAMLYS 631
Query: 182 SQFTVQSILVIIAVICIPWMLIIKPVVXXXXXXXXXXXXXXXELLLDPGHVNDGADVDQS 361
Q +Q L+++A++C+PWML+ KP++ L+ G + G +
Sbjct: 632 GQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLG-----TLNFGGIRVG---NGP 683
Query: 362 LKNPVDGVNNAVIKMXXXXXXXXXXXXXXXXXXIFVHQCIHTIEYCLGCISNTASYLRLW 541
+ + + + + VHQ IHTIEYCLGCISNTASYLRLW
Sbjct: 684 TEEDAEIIQHDQLSTHSEDAEEPTEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLW 743
Query: 542 ALS 550
ALS
Sbjct: 744 ALS 746
>sp|Q920R6|VPP4_MOUSE Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4
(V-ATPase 116-kDa isoform a4) (Vacuolar proton
translocating ATPase 116 kDa subunit a kidney isoform)
Length = 833
Score = 125 bits (315), Expect = 5e-29
Identities = 77/183 (42%), Positives = 94/183 (51%)
Frame = +2
Query: 2 VLFLLSIFGYLVIEIFYKWVTYTAASSACAPSLLIGLINMFMFTKYDSKTMPCSNKPLFD 181
++F+LS+FGYLV I +KW Y A +S APS+LI I MF+F DS SN PL+
Sbjct: 580 MIFMLSLFGYLVFMIIFKWCRYDAHTSRKAPSILIHFIGMFLFDYDDS-----SNAPLYG 634
Query: 182 SQFTVQSILVIIAVICIPWMLIIKPVVXXXXXXXXXXXXXXXELLLDPGHVNDGADVDQS 361
Q VQ+ VIIA++ +PWML+IKP V D + D S
Sbjct: 635 HQQEVQTFFVIIALVSVPWMLLIKPFVLRAKHQKSQLQSFTIH--------EDAVEGDHS 686
Query: 362 LKNPVDGVNNAVIKMXXXXXXXXXXXXXXXXXXIFVHQCIHTIEYCLGCISNTASYLRLW 541
++ K IFVHQ IHTIEYCLGCISNTASYLRLW
Sbjct: 687 --------GHSSKKTAGAHGMKDGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLW 738
Query: 542 ALS 550
ALS
Sbjct: 739 ALS 741
>sp|Q5R422|VPP1_PONPY Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
(V-ATPase 116-kDa isoform a1)
Length = 837
Score = 124 bits (310), Expect = 2e-28
Identities = 72/183 (39%), Positives = 97/183 (53%)
Frame = +2
Query: 2 VLFLLSIFGYLVIEIFYKWVTYTAASSACAPSLLIGLINMFMFTKYDSKTMPCSNKPLFD 181
++F+ S+FGYLVI IFYKW Y A +S APSLLI INMF+F+ +S L+
Sbjct: 576 IIFMTSLFGYLVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPES-----GYSMLYS 630
Query: 182 SQFTVQSILVIIAVICIPWMLIIKPVVXXXXXXXXXXXXXXXELLLDPGHVNDGADVDQS 361
Q +Q LV++A++C+PWML+ KP+V L+ G + G +
Sbjct: 631 GQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLG-----TLNFGGIRVG---NGP 682
Query: 362 LKNPVDGVNNAVIKMXXXXXXXXXXXXXXXXXXIFVHQCIHTIEYCLGCISNTASYLRLW 541
+ + + + + VHQ IHTIEYCLGCISNTASYLRLW
Sbjct: 683 TEEDAEIIQHDQLSTHSEDADEPTEDEVFDFGATMVHQAIHTIEYCLGCISNTASYLRLW 742
Query: 542 ALS 550
ALS
Sbjct: 743 ALS 745
>sp|Q93050|VPP1_HUMAN Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
(V-ATPase 116-kDa isoform a1) (Clathrin-coated
vesicle/synaptic vesicle proton pump 116 kDa subunit)
(Vacuolar proton pump subunit 1) (Vacuolar adenosine
triphosphatase subunit Ac116)
Length = 837
Score = 124 bits (310), Expect = 2e-28
Identities = 72/183 (39%), Positives = 97/183 (53%)
Frame = +2
Query: 2 VLFLLSIFGYLVIEIFYKWVTYTAASSACAPSLLIGLINMFMFTKYDSKTMPCSNKPLFD 181
++F+ S+FGYLVI IFYKW Y A +S APSLLI INMF+F+ +S L+
Sbjct: 576 IIFMTSLFGYLVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPES-----GYSMLYS 630
Query: 182 SQFTVQSILVIIAVICIPWMLIIKPVVXXXXXXXXXXXXXXXELLLDPGHVNDGADVDQS 361
Q +Q LV++A++C+PWML+ KP+V L+ G + G +
Sbjct: 631 GQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLG-----TLNFGGIRVG---NGP 682
Query: 362 LKNPVDGVNNAVIKMXXXXXXXXXXXXXXXXXXIFVHQCIHTIEYCLGCISNTASYLRLW 541
+ + + + + VHQ IHTIEYCLGCISNTASYLRLW
Sbjct: 683 TEEDAEIIQHDQLSTHSEDADEPSEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLW 742
Query: 542 ALS 550
ALS
Sbjct: 743 ALS 745
>sp|Q9HBG4|VPP4_HUMAN Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4
(V-ATPase 116-kDa isoform a4) (Vacuolar proton
translocating ATPase 116 kDa subunit a kidney isoform)
Length = 840
Score = 122 bits (305), Expect = 8e-28
Identities = 72/183 (39%), Positives = 93/183 (50%)
Frame = +2
Query: 2 VLFLLSIFGYLVIEIFYKWVTYTAASSACAPSLLIGLINMFMFTKYDSKTMPCSNKPLFD 181
++F+L +FGYLV I +KW + S APS+LI INMF+F DS SN PL+
Sbjct: 580 MIFILCLFGYLVFMIIFKWCCFDVHVSQHAPSILIHFINMFLFNYSDS-----SNAPLYK 634
Query: 182 SQFTVQSILVIIAVICIPWMLIIKPVVXXXXXXXXXXXXXXXELLLDPGHVNDGADVDQS 361
Q VQS V++A+I +PWML+IKP + + + + D S
Sbjct: 635 HQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQ-----EDATENIEGDSS 689
Query: 362 LKNPVDGVNNAVIKMXXXXXXXXXXXXXXXXXXIFVHQCIHTIEYCLGCISNTASYLRLW 541
+ G + +FVHQ IHTIEYCLGCISNTASYLRLW
Sbjct: 690 SPSSRSGQRTSA----DTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLW 745
Query: 542 ALS 550
ALS
Sbjct: 746 ALS 748
>sp|Q13488|VPP3_HUMAN Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
(V-ATPase 116-kDa isoform a3) (Osteoclastic proton pump
116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune
regulator 1) (T cell immune response cDNA7 protein)
(TIRC7)
Length = 830
Score = 102 bits (254), Expect = 6e-22
Identities = 68/188 (36%), Positives = 93/188 (49%), Gaps = 7/188 (3%)
Frame = +2
Query: 8 FLLSIFGYLVIEIFYKWVTYTAASSACAPSLLIGLINMFMFTKYDSKTMPCSNKPLFDSQ 187
FLL +FGYLV + YKW+ AA +A APS+LI INMF+F+ SN+ L+ Q
Sbjct: 576 FLLGLFGYLVFLVIYKWLCVWAARAASAPSILIHFINMFLFSHSP------SNRLLYPRQ 629
Query: 188 FTVQSILVIIAVICIPWMLIIKPVVXXXXXXXXXXXXXXXEL------LLD-PGHVNDGA 346
VQ+ LV++A+ +P +L+ P+ LLD P +G
Sbjct: 630 EVVQATLVVLALAMVPILLLGTPLHLLHRHRRRLRRRPADRQEENKAGLLDLPDASVNGW 689
Query: 347 DVDQSLKNPVDGVNNAVIKMXXXXXXXXXXXXXXXXXXIFVHQCIHTIEYCLGCISNTAS 526
D+ +D A + + +HQ IHTIE+CLGC+SNTAS
Sbjct: 690 SSDEEKAGGLDDEEEAEL----------------VPSEVLMHQAIHTIEFCLGCVSNTAS 733
Query: 527 YLRLWALS 550
YLRLWALS
Sbjct: 734 YLRLWALS 741
>sp|O97681|VPP2_BOVIN Vacuolar proton translocating ATPase 116 kDa subunit A isoform 2
(V-ATPase 116-kDa isoform a2)
Length = 854
Score = 99.4 bits (246), Expect = 5e-21
Identities = 64/190 (33%), Positives = 91/190 (47%), Gaps = 7/190 (3%)
Frame = +2
Query: 2 VLFLLSIFGYLVIEIFYKWVTYTAASSACAPSLLIGLINMFMFTKYDSKTMPCSNKPLFD 181
+LF+L IFGYL+ I YKW+ Y+A +S APS+LI I+MF+F D+ L+
Sbjct: 591 LLFMLCIFGYLIFMIIYKWLVYSAETSRTAPSILIEFISMFLFLASDT-------GGLYP 643
Query: 182 SQFTVQSILVIIAVICIPWMLIIKPVVXXXXXXXXXXXXXXXELLL-------DPGHVND 340
Q VQ +L++I V+ +P + + KP+ + +
Sbjct: 644 GQEHVQRLLLLITVLSVPVLFLGKPLFLLWLHRGRSCFGVGRSGYTLVRKDSEEEVSLLG 703
Query: 341 GADVDQSLKNPVDGVNNAVIKMXXXXXXXXXXXXXXXXXXIFVHQCIHTIEYCLGCISNT 520
G D+++ DG + I + Q IH+IEYCLGCISNT
Sbjct: 704 GQDIEEGNNQMEDGCREVTCE-------------EFDFGEILMTQIIHSIEYCLGCISNT 750
Query: 521 ASYLRLWALS 550
ASYLRLWALS
Sbjct: 751 ASYLRLWALS 760
>sp|O13742|VPH1_SCHPO Probable vacuolar ATP synthase 91 kDa subunit (Vacuolar ATPase 91 kDa
subunit)
Length = 805
Score = 99.0 bits (245), Expect = 7e-21
Identities = 70/183 (38%), Positives = 91/183 (49%)
Frame = +2
Query: 2 VLFLLSIFGYLVIEIFYKWVTYTAASSACAPSLLIGLINMFMFTKYDSKTMPCSNKPLFD 181
++FL +IFGYLVI I YKW A PSLL LI MF+ + L+
Sbjct: 564 LIFLEAIFGYLVITIVYKWCIDWKAKDLQPPSLLNMLILMFL-------SPGTLEDQLYP 616
Query: 182 SQFTVQSILVIIAVICIPWMLIIKPVVXXXXXXXXXXXXXXXELLLDPGHVNDGADVDQS 361
Q +Q LVI A+IC+PW+LI+KP V L H N+ + QS
Sbjct: 617 GQKYLQVGLVIAALICVPWLLIVKPFV------------------LWRRHSNE-ENKYQS 657
Query: 362 LKNPVDGVNNAVIKMXXXXXXXXXXXXXXXXXXIFVHQCIHTIEYCLGCISNTASYLRLW 541
L + + V+ A M + +HQ IHTIE+CLGC+S+TASYLRLW
Sbjct: 658 LNSDLPNVDEADALM--AVDSQEKQAEPFELGEVVIHQVIHTIEFCLGCVSHTASYLRLW 715
Query: 542 ALS 550
ALS
Sbjct: 716 ALS 718
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,072,525
Number of Sequences: 369166
Number of extensions: 1021904
Number of successful extensions: 2877
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2772
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2857
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3882260660
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)