Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_L18
(558 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q63ZU0|ADA_XENTR Adenosine deaminase (Adenosine aminohyd... 154 1e-37
sp|Q6DG22|ADA_BRARE Adenosine deaminase (Adenosine aminohyd... 154 1e-37
sp|Q6GP70|ADA_XENLA Adenosine deaminase (Adenosine aminohyd... 150 2e-36
sp|Q5ZKP6|ADA_CHICK Adenosine deaminase (Adenosine aminohyd... 150 2e-36
sp|P56658|ADA_BOVIN Adenosine deaminase (Adenosine aminohyd... 145 9e-35
sp|P00813|ADA_HUMAN Adenosine deaminase (Adenosine aminohyd... 140 2e-33
sp|Q920P6|ADA_RAT Adenosine deaminase (Adenosine aminohydro... 137 1e-32
sp|P03958|ADA_MOUSE Adenosine deaminase (Adenosine aminohyd... 135 5e-32
sp|Q8XHH8|ADD_CLOPE Adenosine deaminase (Adenosine aminohyd... 83 5e-16
sp|Q7MDL6|ADD_VIBVY Adenosine deaminase (Adenosine aminohyd... 79 6e-15
>sp|Q63ZU0|ADA_XENTR Adenosine deaminase (Adenosine aminohydrolase)
Length = 358
Score = 154 bits (390), Expect = 1e-37
Identities = 84/185 (45%), Positives = 112/185 (60%), Gaps = 8/185 (4%)
Frame = +1
Query: 28 ETTPNSLFALLNES--------RVVSKAILCALREGDLKEPNVLDLAIKYKPHGVVGIDL 183
+ TP+ + L+N+ + +++ILC +R V++L KY+ VV IDL
Sbjct: 122 DITPDEVVDLVNQGLRKGEKAFNIKARSILCCMRHMPSWSTEVVELCKKYQNDTVVAIDL 181
Query: 184 AGDEQHSVESEGTHSDIVKLFQRAKRERIHRTVHAGENGNYQMIQEAINVLHAERIGHGY 363
AGDE + ES H K ++ A + IHRTVHAGE G +++EA+ VL AERIGHGY
Sbjct: 182 AGDESLNCESYPGHR---KAYEEAVKCGIHRTVHAGEVGPSSVVKEAVEVLKAERIGHGY 238
Query: 364 HILDDENYYNELKQTNIHFEVCPSSSFLTGAVHIDPDRHPFHTFSKDKVNYSINCDDIMI 543
H +D N Y EL + N+HFEVCP SS+LTGA H D +HP F KDK NYS+N DD +I
Sbjct: 239 HTTEDPNLYKELLEKNMHFEVCPWSSYLTGACHPDFTKHPATQFRKDKANYSLNTDDPLI 298
Query: 544 TGRIL 558
G L
Sbjct: 299 FGSTL 303
>sp|Q6DG22|ADA_BRARE Adenosine deaminase (Adenosine aminohydrolase)
Length = 359
Score = 154 bits (389), Expect = 1e-37
Identities = 81/177 (45%), Positives = 108/177 (61%), Gaps = 8/177 (4%)
Frame = +1
Query: 28 ETTPNSLFALLNES--------RVVSKAILCALREGDLKEPNVLDLAIKYKPHGVVGIDL 183
+ TP+ + L+N+ + +++ILC +R V++L K+ GVV IDL
Sbjct: 123 DITPDDVVDLVNQGFKEGEQAFKTKARSILCCMRHMPNWSMEVVELCKKFHKDGVVAIDL 182
Query: 184 AGDEQHSVESEGTHSDIVKLFQRAKRERIHRTVHAGENGNYQMIQEAINVLHAERIGHGY 363
AGDE + ES H K F+ A R +HRTVHAGE G +++EA+ VL AERIGHGY
Sbjct: 183 AGDESMNCESYPGHK---KAFEEAVRSNVHRTVHAGEVGPASVVREAVEVLKAERIGHGY 239
Query: 364 HILDDENYYNELKQTNIHFEVCPSSSFLTGAVHIDPDRHPFHTFSKDKVNYSINCDD 534
H L+D+N Y +L N+HFE+CP SS LTGA D +HP TF KDK NYS+N DD
Sbjct: 240 HTLEDQNLYKQLLHQNMHFEMCPVSSRLTGACEPDFTKHPLITFKKDKANYSLNTDD 296
>sp|Q6GP70|ADA_XENLA Adenosine deaminase (Adenosine aminohydrolase)
Length = 358
Score = 150 bits (380), Expect = 2e-36
Identities = 82/185 (44%), Positives = 111/185 (60%), Gaps = 8/185 (4%)
Frame = +1
Query: 28 ETTPNSLFALLNES--------RVVSKAILCALREGDLKEPNVLDLAIKYKPHGVVGIDL 183
+ TP+ + L+N+ + +++ILC +R V++L KY+ VV IDL
Sbjct: 122 DITPDEVVDLVNQGLRKGEKTFNIKARSILCCMRHMPNWSSEVIELCKKYQNDTVVAIDL 181
Query: 184 AGDEQHSVESEGTHSDIVKLFQRAKRERIHRTVHAGENGNYQMIQEAINVLHAERIGHGY 363
AGDE + ES H K ++ A + IHRTVHAGE G +++EA+ VL AERIGHGY
Sbjct: 182 AGDESLNCESYPGHR---KAYEEAVKCGIHRTVHAGEVGPPSVVKEAVEVLKAERIGHGY 238
Query: 364 HILDDENYYNELKQTNIHFEVCPSSSFLTGAVHIDPDRHPFHTFSKDKVNYSINCDDIMI 543
H +D N Y EL + N+HFEVCP SS+LT A H D +HP F KDK N+S+N DD +I
Sbjct: 239 HTTEDPNLYKELLENNMHFEVCPWSSYLTSACHPDFTKHPATQFRKDKANFSLNTDDPLI 298
Query: 544 TGRIL 558
G L
Sbjct: 299 FGSTL 303
>sp|Q5ZKP6|ADA_CHICK Adenosine deaminase (Adenosine aminohydrolase)
Length = 357
Score = 150 bits (379), Expect = 2e-36
Identities = 83/180 (46%), Positives = 110/180 (61%), Gaps = 8/180 (4%)
Frame = +1
Query: 28 ETTPNSLFALLNES--------RVVSKAILCALREGDLKEPNVLDLAIKYKPHGVVGIDL 183
+ TP + L+N+ R+ +++ILC +R P V++L KY+ + VV IDL
Sbjct: 124 DLTPEEVVNLVNQGLQDGERNFRIKARSILCCMRHMPSWSPEVVELCKKYQNNSVVAIDL 183
Query: 184 AGDEQHSVESEGTHSDIVKLFQRAKRERIHRTVHAGENGNYQMIQEAINVLHAERIGHGY 363
AGDE S D ++ A+R IHRTVHAGE G MI+EA+ +L AERIGHGY
Sbjct: 184 AGDELLMASS-----DHKAAYEEAERCGIHRTVHAGEAGPATMIKEAVYLLKAERIGHGY 238
Query: 364 HILDDENYYNELKQTNIHFEVCPSSSFLTGAVHIDPDRHPFHTFSKDKVNYSINCDDIMI 543
H+L+D Y EL +T +HFEVCP SS+LTGA D +HP F KD+ NYSIN DD +I
Sbjct: 239 HVLEDPELYRELLRTRMHFEVCPWSSYLTGACLPDFRKHPVVQFKKDQANYSINTDDPLI 298
>sp|P56658|ADA_BOVIN Adenosine deaminase (Adenosine aminohydrolase)
Length = 363
Score = 145 bits (365), Expect = 9e-35
Identities = 77/180 (42%), Positives = 109/180 (60%), Gaps = 8/180 (4%)
Frame = +1
Query: 28 ETTPNSLFALLNESR--------VVSKAILCALREGDLKEPNVLDLAIKYKPHGVVGIDL 183
+ TP+ + +L+N+ V ++ILC +R V++L KY+ VV IDL
Sbjct: 123 DLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAIDL 182
Query: 184 AGDEQHSVESEGTHSDIVKLFQRAKRERIHRTVHAGENGNYQMIQEAINVLHAERIGHGY 363
AGDE ++E VK + A + +HRTVHAGE G+ +++EA++ L ER+GHGY
Sbjct: 183 AGDE--TIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGY 240
Query: 364 HILDDENYYNELKQTNIHFEVCPSSSFLTGAVHIDPDRHPFHTFSKDKVNYSINCDDIMI 543
H L+D YN L+Q N+HFEVCP SS+LTGA D + HP F D+VNYS+N DD +I
Sbjct: 241 HTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTE-HPVVRFKNDQVNYSLNTDDPLI 299
>sp|P00813|ADA_HUMAN Adenosine deaminase (Adenosine aminohydrolase)
Length = 363
Score = 140 bits (353), Expect = 2e-33
Identities = 74/180 (41%), Positives = 110/180 (61%), Gaps = 8/180 (4%)
Frame = +1
Query: 28 ETTPNSLFALLNESR--------VVSKAILCALREGDLKEPNVLDLAIKYKPHGVVGIDL 183
+ TP+ + AL+ + V +++ILC +R P V++L KY+ VV IDL
Sbjct: 123 DLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDL 182
Query: 184 AGDEQHSVESEGTHSDIVKLFQRAKRERIHRTVHAGENGNYQMIQEAINVLHAERIGHGY 363
AGDE ++ V+ +Q A + IHRTVHAGE G+ ++++EA+++L ER+GHGY
Sbjct: 183 AGDE--TIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY 240
Query: 364 HILDDENYYNELKQTNIHFEVCPSSSFLTGAVHIDPDRHPFHTFSKDKVNYSINCDDIMI 543
H L+D+ YN L+Q N+HFE+CP SS+LTGA D + H D+ NYS+N DD +I
Sbjct: 241 HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTE-HAVIRLKNDQANYSLNTDDPLI 299
>sp|Q920P6|ADA_RAT Adenosine deaminase (Adenosine aminohydrolase)
Length = 352
Score = 137 bits (346), Expect = 1e-32
Identities = 73/180 (40%), Positives = 109/180 (60%), Gaps = 8/180 (4%)
Frame = +1
Query: 28 ETTPNSLFALLNESR--------VVSKAILCALREGDLKEPNVLDLAIKYKPHGVVGIDL 183
+ TP+ + L+N+ + ++ILC +R P VL+L KY VV +DL
Sbjct: 123 DLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSPEVLELCKKYHQKTVVAMDL 182
Query: 184 AGDEQHSVESEGTHSDIVKLFQRAKRERIHRTVHAGENGNYQMIQEAINVLHAERIGHGY 363
AGDE ++E V+ ++ A ++ IHRTVHAGE G+ ++++EA+++L ER+GHGY
Sbjct: 183 AGDE--TIEGSSLFPGHVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGY 240
Query: 364 HILDDENYYNELKQTNIHFEVCPSSSFLTGAVHIDPDRHPFHTFSKDKVNYSINCDDIMI 543
H ++DE YN L + N+HFEVCP SS+LTGA + H F D+ NYS+N DD +I
Sbjct: 241 HTIEDEALYNRLLKENMHFEVCPWSSYLTGAWN-PKTTHAVVRFKDDQANYSLNSDDPLI 299
>sp|P03958|ADA_MOUSE Adenosine deaminase (Adenosine aminohydrolase)
Length = 352
Score = 135 bits (341), Expect = 5e-32
Identities = 75/181 (41%), Positives = 108/181 (59%), Gaps = 9/181 (4%)
Frame = +1
Query: 28 ETTPNSLFALLNESR--------VVSKAILCALREGDLKEPNVLDLAIKYKPHGVVGIDL 183
+ TP+ + L+N+ + ++ILC +R VL+L KY VV +DL
Sbjct: 123 DVTPDDVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSLEVLELCKKYNQKTVVAMDL 182
Query: 184 AGDEQHSVESEGTHSDIVKLFQRAKRERIHRTVHAGENGNYQMIQEAINVLHAERIGHGY 363
AGDE ++E V+ ++ A + IHRTVHAGE G+ ++++EA+++L ER+GHGY
Sbjct: 183 AGDE--TIEGSSLFPGHVEAYEGAVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGY 240
Query: 364 HILDDENYYNELKQTNIHFEVCPSSSFLTGAVHIDP-DRHPFHTFSKDKVNYSINCDDIM 540
H ++DE YN L + N+HFEVCP SS+LTGA DP H F DK NYS+N DD +
Sbjct: 241 HTIEDEALYNRLLKENMHFEVCPWSSYLTGA--WDPKTTHAVVRFKNDKANYSLNTDDPL 298
Query: 541 I 543
I
Sbjct: 299 I 299
>sp|Q8XHH8|ADD_CLOPE Adenosine deaminase (Adenosine aminohydrolase)
Length = 332
Score = 82.8 bits (203), Expect = 5e-16
Identities = 46/124 (37%), Positives = 70/124 (56%)
Frame = +1
Query: 163 GVVGIDLAGDEQHSVESEGTHSDIVKLFQRAKRERIHRTVHAGENGNYQMIQEAINVLHA 342
GVV IDLAG E EG ++ + A+ T+HAGE G + +++AI +L A
Sbjct: 162 GVVAIDLAGGEL-----EGFVKPYEEVMKLARESGFRVTIHAGETGYGKNVRDAIELLGA 216
Query: 343 ERIGHGYHILDDENYYNELKQTNIHFEVCPSSSFLTGAVHIDPDRHPFHTFSKDKVNYSI 522
ERIGHG I +DE YN +K+ + E+CP S+ T V+ D HP + + KD + ++
Sbjct: 217 ERIGHGLFIFNDEEAYNLVKEKGVTLEMCPKSNIDTKGVNKYED-HPIYKYHKDNIRVNL 275
Query: 523 NCDD 534
+ D+
Sbjct: 276 STDN 279
>sp|Q7MDL6|ADD_VIBVY Adenosine deaminase (Adenosine aminohydrolase)
Length = 331
Score = 79.3 bits (194), Expect = 6e-15
Identities = 50/135 (37%), Positives = 68/135 (50%)
Frame = +1
Query: 130 VLDLAIKYKPHGVVGIDLAGDEQHSVESEGTHSDIVKLFQRAKRERIHRTVHAGENGNYQ 309
VL+ K+ G+V DLAG E G + V Q AK T+HAGE G Q
Sbjct: 151 VLEAGAKHLNDGIVAFDLAGSE-----IPGFCHEFVPYAQYAKELGYRITIHAGEQGAGQ 205
Query: 310 MIQEAINVLHAERIGHGYHILDDENYYNELKQTNIHFEVCPSSSFLTGAVHIDPDRHPFH 489
+ +AI++L AER+GHG I + Y +K + E CPSS+ T AV+ HP
Sbjct: 206 NVYDAISLLGAERVGHGIFIHNHPEAYQLVKGEEVALETCPSSNVQTKAVN-SLSEHPIK 264
Query: 490 TFSKDKVNYSINCDD 534
F KD + +IN D+
Sbjct: 265 AFYKDGIAVTINTDN 279
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,626,494
Number of Sequences: 369166
Number of extensions: 1389012
Number of successful extensions: 4163
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3897
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4124
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3980545740
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)