Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_L06
(784 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UBX3|DIC_HUMAN Mitochondrial dicarboxylate carrier 286 4e-77
sp|Q9QZD8|DIC_MOUSE Mitochondrial dicarboxylate carrier 280 2e-75
sp|Q9CR62|M2OM_MOUSE Mitochondrial 2-oxoglutarate/malate ca... 154 2e-37
sp|Q02978|M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate ca... 152 1e-36
sp|P22292|M2OM_BOVIN Mitochondrial 2-oxoglutarate/malate ca... 152 1e-36
sp|P97700|M2OM_RAT Mitochondrial 2-oxoglutarate/malate carr... 147 2e-35
sp|P56499|UCP3_RAT Mitochondrial uncoupling protein 3 (UCP 3) 134 2e-31
sp|O77792|UCP3_BOVIN Mitochondrial uncoupling protein 3 (UC... 134 3e-31
sp|O97562|UCP2_PIG Mitochondrial uncoupling protein 2 (UCP 2) 133 5e-31
sp|P56501|UCP3_MOUSE Mitochondrial uncoupling protein 3 (UC... 132 1e-30
>sp|Q9UBX3|DIC_HUMAN Mitochondrial dicarboxylate carrier
Length = 287
Score = 286 bits (732), Expect = 4e-77
Identities = 142/246 (57%), Positives = 181/246 (73%), Gaps = 4/246 (1%)
Frame = +3
Query: 57 KIGSWYFGGIASAMAAACTHPLDLLKVHLQTQQKKEFGMAGMAIKVVKTDGILALYNGLS 236
++ WYFGG+AS AA CTHPLDLLKVHLQTQQ+ + M GMA++VV+TDGILALY+GLS
Sbjct: 6 RVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALRVVRTDGILALYSGLS 65
Query: 237 ASLLRQLTYSMTRFGLYETYK----ASKKGATPFYEKAGVSMVSGFIGGIVGNPADMVNV 404
ASL RQ+TYS+TRF +YET + +G PF+EK + VSG GG VG PAD+VNV
Sbjct: 66 ASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGTPADLVNV 125
Query: 405 RMQNDMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSGVSMTATRAAFMTFGQLAFYDLF 584
RMQND+K+ + RRNY +A+DG++RVAREEG+ LFSG +M ++R A +T GQL+ YD
Sbjct: 126 RMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQA 185
Query: 585 KQMMIQSGLFSDNIITHFTASTGAAGIATLMTQPFDVMKTRLMNAKPGTYSGLLECGADI 764
KQ+++ +G SDNI THF AS A G AT + QP DV+KTRLMN+K G Y G+ C +
Sbjct: 186 KQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQPLDVLKTRLMNSK-GEYQGVFHCAVET 244
Query: 765 MKTGPL 782
K GPL
Sbjct: 245 AKLGPL 250
>sp|Q9QZD8|DIC_MOUSE Mitochondrial dicarboxylate carrier
Length = 287
Score = 280 bits (717), Expect = 2e-75
Identities = 139/241 (57%), Positives = 174/241 (72%), Gaps = 4/241 (1%)
Frame = +3
Query: 69 WYFGGIASAMAAACTHPLDLLKVHLQTQQKKEFGMAGMAIKVVKTDGILALYNGLSASLL 248
WYFGG+AS AA CTHPLDLLKVHLQTQQ+ + M GMA++VV+TDG LALYNGLSASL
Sbjct: 9 WYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALQVVRTDGFLALYNGLSASLC 68
Query: 249 RQLTYSMTRFGLYETYK----ASKKGATPFYEKAGVSMVSGFIGGIVGNPADMVNVRMQN 416
RQ+TYS+TRF +YET + +G PFY K + +SG GG VG PAD+VNVRMQN
Sbjct: 69 RQMTYSLTRFAIYETMRDYMTKDSQGPLPFYNKVLLGGISGLTGGFVGTPADLVNVRMQN 128
Query: 417 DMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSGVSMTATRAAFMTFGQLAFYDLFKQMM 596
DMK+ RRNY +A+DG++RVAREE + LFSG +M ++R A +T GQL+ YD KQ++
Sbjct: 129 DMKLPPSQRRNYSHALDGLYRVAREESLRKLFSGATMASSRGALVTVGQLSCYDQAKQLV 188
Query: 597 IQSGLFSDNIITHFTASTGAAGIATLMTQPFDVMKTRLMNAKPGTYSGLLECGADIMKTG 776
+ +G SDNI THF +S A G AT + QP DV+KTRLMN+K G Y G+ C + K G
Sbjct: 189 LSTGYLSDNIFTHFVSSFIAGGCATFLCQPLDVLKTRLMNSK-GEYQGVFHCAMETAKLG 247
Query: 777 P 779
P
Sbjct: 248 P 248
>sp|Q9CR62|M2OM_MOUSE Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute
carrier family 25 member 11)
Length = 314
Score = 154 bits (390), Expect = 2e-37
Identities = 91/235 (38%), Positives = 130/235 (55%), Gaps = 9/235 (3%)
Frame = +3
Query: 45 RPQDKIGSWYFGGIASAMAAACTHPLDLLKVHLQTQ----QKKEFGMAGMAI-KVVKTDG 209
R K + FGG+A A PLDL+K +Q + +E+ + A+ ++KT+G
Sbjct: 17 RTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKTEG 76
Query: 210 ILALYNGLSASLLRQLTYSMTRFGLYETYKASKKGA--TP--FYEKAGVSMVSGFIGGIV 377
+ +Y GLSA LLRQ TY+ TR G+Y GA TP F KA + M +G G V
Sbjct: 77 LKGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKALIGMTAGATGAFV 136
Query: 378 GNPADMVNVRMQNDMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSGVSMTATRAAFMTF 557
G PA++ +RM D ++ + RR YKN + + R+AREEGV L+ G T RA +
Sbjct: 137 GTPAEVALIRMTADGRLPADQRRGYKNVFNALVRIAREEGVPTLWRGCIPTMARAVVVNA 196
Query: 558 GQLAFYDLFKQMMIQSGLFSDNIITHFTASTGAAGIATLMTQPFDVMKTRLMNAK 722
QLA Y KQ ++ SG FSDNI+ HF AS + + T + P D++KTR+ N +
Sbjct: 197 AQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIVKTRIQNMR 251
>sp|Q02978|M2OM_HUMAN Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute
carrier family 25 member 11)
Length = 314
Score = 152 bits (384), Expect = 1e-36
Identities = 89/235 (37%), Positives = 128/235 (54%), Gaps = 9/235 (3%)
Frame = +3
Query: 45 RPQDKIGSWYFGGIASAMAAACTHPLDLLKVHLQTQ----QKKEFGMAGMAI-KVVKTDG 209
R K + FGG+A A PLDL+K +Q + +E+ + A+ ++K +G
Sbjct: 17 RTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEG 76
Query: 210 ILALYNGLSASLLRQLTYSMTRFGLYETYKASKKGA--TP--FYEKAGVSMVSGFIGGIV 377
+ +Y GLSA LLRQ TY+ TR G+Y GA TP F KA + M +G G V
Sbjct: 77 LRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFV 136
Query: 378 GNPADMVNVRMQNDMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSGVSMTATRAAFMTF 557
G PA++ +RM D ++ + RR YKN + + R+ REEGV+ L+ G T RA +
Sbjct: 137 GTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNA 196
Query: 558 GQLAFYDLFKQMMIQSGLFSDNIITHFTASTGAAGIATLMTQPFDVMKTRLMNAK 722
QLA Y KQ ++ SG FSDNI+ HF AS + + T + P D+ KTR+ N +
Sbjct: 197 AQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMR 251
Score = 47.4 bits (111), Expect = 5e-05
Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 4/115 (3%)
Frame = +3
Query: 186 IKVVKTDGILALYNGLSASLLRQLTYSMTRFGLYETYKASKKGATPFYEKA----GVSMV 353
I++ + +G+L L+ G ++ R + + + Y K + F + SM+
Sbjct: 169 IRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMI 228
Query: 354 SGFIGGIVGNPADMVNVRMQNDMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSG 518
SG + P D+ R+QN + + + YKN +D +F+V R EG L+ G
Sbjct: 229 SGLVTTAASMPVDIAKTRIQNMRMI--DGKPEYKNGLDVLFKVVRYEGFFSLWKG 281
>sp|P22292|M2OM_BOVIN Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP)
Length = 314
Score = 152 bits (383), Expect = 1e-36
Identities = 89/235 (37%), Positives = 129/235 (54%), Gaps = 9/235 (3%)
Frame = +3
Query: 45 RPQDKIGSWYFGGIASAMAAACTHPLDLLKVHLQTQ----QKKEFGMAGMA-IKVVKTDG 209
R K + FGG+A A PLDL+K +Q + +E+ + A I +++ +G
Sbjct: 17 RTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALISILRAEG 76
Query: 210 ILALYNGLSASLLRQLTYSMTRFGLYETYKASKKGA--TP--FYEKAGVSMVSGFIGGIV 377
+ +Y GLSA LLRQ TY+ TR G+Y GA TP F KA + M +G G V
Sbjct: 77 LRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFV 136
Query: 378 GNPADMVNVRMQNDMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSGVSMTATRAAFMTF 557
G PA++ +RM D ++ + RR YKN + +FR+ +EEGV L+ G T RA +
Sbjct: 137 GTPAEVALIRMTADGRLPVDQRRGYKNVFNALFRIVQEEGVPTLWRGCIPTMARAVVVNA 196
Query: 558 GQLAFYDLFKQMMIQSGLFSDNIITHFTASTGAAGIATLMTQPFDVMKTRLMNAK 722
QLA Y KQ ++ SG FSDNI+ HF AS + + T + P D++KTR+ N +
Sbjct: 197 AQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIVKTRIQNMR 251
>sp|P97700|M2OM_RAT Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (Solute
carrier family 25 member 11)
Length = 314
Score = 147 bits (372), Expect = 2e-35
Identities = 88/235 (37%), Positives = 127/235 (54%), Gaps = 9/235 (3%)
Frame = +3
Query: 45 RPQDKIGSWYFGGIASAMAAACTHPLDLLKVHLQTQ----QKKEFGMAGMAI-KVVKTDG 209
R K + FGG+A A PLDL+ +Q + +E+ + A+ ++K +G
Sbjct: 17 RTSPKSVKFLFGGLAGMGATVFVQPLDLVXNRMQLSGEGAKTREYKTSFHALTSILKAEG 76
Query: 210 ILALYNGLSASLLRQLTYSMTRFGLYETYKASKKGA--TP--FYEKAGVSMVSGFIGGIV 377
+ +Y GLSA LLRQ TY+ TR G+Y GA TP F KA + M +G G V
Sbjct: 77 LRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKALIGMTAGATGAFV 136
Query: 378 GNPADMVNVRMQNDMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSGVSMTATRAAFMTF 557
G PA++ +RM D ++ + RR YKN + + R+AREEGV L+ G T RA +
Sbjct: 137 GPPAEVALIRMTADGRLPADQRRGYKNVFNALIRIAREEGVPTLWRGCIPTMARAVVVNA 196
Query: 558 GQLAFYDLFKQMMIQSGLFSDNIITHFTASTGAAGIATLMTQPFDVMKTRLMNAK 722
QLA Y KQ ++ SG FSDNI+ HF A + + T + P D++KTR+ N +
Sbjct: 197 AQLASYSQSKQFLLDSGYFSDNILCHFCAIMISGLVTTAASMPVDIVKTRIQNMR 251
>sp|P56499|UCP3_RAT Mitochondrial uncoupling protein 3 (UCP 3)
Length = 308
Score = 134 bits (338), Expect = 2e-31
Identities = 81/246 (32%), Positives = 126/246 (51%), Gaps = 11/246 (4%)
Frame = +3
Query: 48 PQDKIGSWYFGGIASAMAAACTHPLDLLKVHLQTQ------QKKEF-GMAGMAIKVVKTD 206
P + + G A+ A T PLD KV LQ Q Q ++ G+ G + +V+T+
Sbjct: 10 PPTTVVKFLGAGTAACFADLLTFPLDTAKVRLQIQGENPGVQSVQYRGVLGTILTMVRTE 69
Query: 207 GILALYNGLSASLLRQLTYSMTRFGLYETYKASKKGATPFYEKAGVSMVSGFIGGIVG-- 380
G + Y+GL A L RQ++++ R GLY++ K + + +++G G +
Sbjct: 70 GPRSPYSGLVAGLHRQMSFASIRIGLYDSVKQFYTPKGTDHSSVAIRILAGCTTGAMAVT 129
Query: 381 --NPADMVNVRMQNDMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSGVSMTATRAAFMT 554
P D+V VR Q +++ R Y+ +D +AREEGV L+ G TR A +
Sbjct: 130 CAQPTDVVKVRFQAMIRLGTGGERKYRGTMDAYRTIAREEGVRGLWKGTWPNITRNAIVN 189
Query: 555 FGQLAFYDLFKQMMIQSGLFSDNIITHFTASTGAAGIATLMTQPFDVMKTRLMNAKPGTY 734
++ YD+ K+ ++ S LF+DN HF ++ GA AT++ P DV+KTR MNA PG Y
Sbjct: 190 CAEMVTYDIIKEKLLDSHLFTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNAPPGRY 249
Query: 735 SGLLEC 752
L C
Sbjct: 250 RSPLHC 255
>sp|O77792|UCP3_BOVIN Mitochondrial uncoupling protein 3 (UCP 3)
Length = 311
Score = 134 bits (337), Expect = 3e-31
Identities = 81/250 (32%), Positives = 124/250 (49%), Gaps = 14/250 (5%)
Frame = +3
Query: 45 RPQDKIGSWYFGGIASAMAAACTHPLDLLKVHLQTQQKKEFGMA----------GMAIKV 194
RP + G A+ A T PLD KV LQ Q + + +A G + +
Sbjct: 9 RPPTTSVKFLAAGTAACFADLLTFPLDTAKVRLQIQGENQAALAARSAQYRGVLGTILTM 68
Query: 195 VKTDGILALYNGLSASLLRQLTYSMTRFGLYETYKA--SKKGA--TPFYEKAGVSMVSGF 362
V+T+G +LY+GL A L RQ++++ R GLY++ K + KG+ + + +G
Sbjct: 69 VRTEGPRSLYSGLVAGLQRQMSFASIRIGLYDSVKQFYTPKGSDHSSIITRILAGCTTGA 128
Query: 363 IGGIVGNPADMVNVRMQNDMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSGVSMTATRA 542
+ P D+V +R Q M R Y +D +AREEGV L+ G+ TR
Sbjct: 129 MAVTCAQPTDVVKIRFQASMHTGLGGNRKYSGTMDAYRTIAREEGVRGLWKGILPNITRN 188
Query: 543 AFMTFGQLAFYDLFKQMMIQSGLFSDNIITHFTASTGAAGIATLMTQPFDVMKTRLMNAK 722
A + G++ YD+ K+ ++ L +DN HF ++ GA ATL+ P DV+KTR MN+
Sbjct: 189 AIVNCGEMVTYDIIKEKLLDYHLLTDNFPCHFVSAFGAGFCATLVASPVDVVKTRYMNSP 248
Query: 723 PGTYSGLLEC 752
PG Y +C
Sbjct: 249 PGQYHSPFDC 258
>sp|O97562|UCP2_PIG Mitochondrial uncoupling protein 2 (UCP 2)
Length = 309
Score = 133 bits (335), Expect = 5e-31
Identities = 86/252 (34%), Positives = 130/252 (51%), Gaps = 19/252 (7%)
Frame = +3
Query: 81 GIASAMAAACTHPLDLLKVHLQTQQKKEF-----------GMAGMAIKVVKTDGILALYN 227
G A+ +A T PLD KV LQ Q ++ G+ G + +V+ +G +LYN
Sbjct: 21 GTAACIADLITFPLDTAKVRLQIQGERRGPVQAAASAQYRGVLGTILTMVRNEGPRSLYN 80
Query: 228 GLSASLLRQLTYSMTRFGLYETYKAS-KKGATPFYEKAGVSM------VSGFIGGIVGNP 386
GL A L RQ++++ R GLY++ K KG+ E AG+ +G + V P
Sbjct: 81 GLVAGLQRQMSFASVRIGLYDSVKHFYTKGS----EHAGIGSRLLAGSTTGALAVAVAQP 136
Query: 387 ADMVNVRMQNDMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSGVSMTATRAAFMTFGQL 566
D+V VR Q + R Y++ VD +AREEG+ L+ G S R A + +L
Sbjct: 137 TDVVKVRFQAQARAGGG--RRYRSTVDAYKTIAREEGLRGLWKGTSPNVARNAIVNCAEL 194
Query: 567 AFYDLFKQMMIQSGLFSDNIITHFTASTGAAGIATLMTQPFDVMKTRLMNAKPGTYSGLL 746
YDL K ++++ L +D++ HFT++ GA T++ P DV+KTR MN+ PG YS
Sbjct: 195 VTYDLIKDTLLKADLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSAPGQYSSAG 254
Query: 747 ECGADIM-KTGP 779
C ++ K GP
Sbjct: 255 HCALTMLQKEGP 266
>sp|P56501|UCP3_MOUSE Mitochondrial uncoupling protein 3 (UCP 3)
Length = 308
Score = 132 bits (332), Expect = 1e-30
Identities = 83/248 (33%), Positives = 130/248 (52%), Gaps = 13/248 (5%)
Frame = +3
Query: 48 PQDKIGSWYFGGIASAMAAACTHPLDLLKVHLQTQ------QKKEF-GMAGMAIKVVKTD 206
P + + G A+ A T PLD KV LQ Q Q ++ G+ G + +V+T+
Sbjct: 10 PPTTVVKFLGAGTAACFADLLTFPLDTAKVRLQIQGENPGAQSVQYRGVLGTILTMVRTE 69
Query: 207 GILALYNGLSASLLRQLTYSMTRFGLYETYKA--SKKGATPFYEKAGVSMVSGFIGGIVG 380
G + Y+GL A L RQ++++ R GLY++ K + KGA + + +++G G +
Sbjct: 70 GPRSPYSGLVAGLHRQMSFASIRIGLYDSVKQFYTPKGAD--HSSVAIRILAGCTTGAMA 127
Query: 381 ----NPADMVNVRMQNDMKVAKELRRNYKNAVDGMFRVAREEGVVVLFSGVSMTATRAAF 548
P D+V VR Q +++ R Y+ +D +AREEGV L+ G TR A
Sbjct: 128 VTCAQPTDVVKVRFQAMIRLGTGGERKYRGTMDAYRTIAREEGVRGLWKGTWPNITRNAI 187
Query: 549 MTFGQLAFYDLFKQMMIQSGLFSDNIITHFTASTGAAGIATLMTQPFDVMKTRLMNAKPG 728
+ ++ YD+ K+ +++S LF+DN HF ++ GA AT++ P DV+KTR MNA G
Sbjct: 188 VNCAEMVTYDIIKEKLLESHLFTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNAPLG 247
Query: 729 TYSGLLEC 752
Y L C
Sbjct: 248 RYRSPLHC 255
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,227,298
Number of Sequences: 369166
Number of extensions: 1795778
Number of successful extensions: 5315
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4576
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5028
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7357347200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)