Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_J19
(658 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q05319|STUB_DROME Serine proteinase stubble (Stubble-stu... 77 5e-14
sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Pol... 75 1e-13
sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Pol... 73 6e-13
sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polys... 73 6e-13
sp|Q9Y6M0|TEST_HUMAN Testisin precursor (Eosinophil serine ... 72 2e-12
sp|O18783|PLMN_MACEU Plasminogen precursor [Contains: Plasm... 72 2e-12
sp|Q5U405|TMPSD_MOUSE Transmembrane protease, serine 13 (Mo... 72 2e-12
sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma p... 71 2e-12
sp|P48038|ACRO_RABIT Acrosin precursor [Contains: Acrosin l... 71 2e-12
sp|Q8BIK6|TMPS7_MOUSE Transmembrane protease, serine 7 prec... 70 5e-12
>sp|Q05319|STUB_DROME Serine proteinase stubble (Stubble-stubbloid protein) [Contains:
Serine proteinase stubble non-catalytic chain; Serine
proteinase stubble catalytic chain]
Length = 787
Score = 76.6 bits (187), Expect = 5e-14
Identities = 53/158 (33%), Positives = 77/158 (48%), Gaps = 10/158 (6%)
Frame = +1
Query: 109 IHPQYSAVTGDYNLALVK-TSPVAFDINVQPACLPSKNLVPNSLDCITAGWNHKLETNSR 285
+HP+YS +T +Y+LALVK P+ F +V P CLP + + ++ GW E +
Sbjct: 628 VHPKYSFLTYEYDLALVKLEQPLEFAPHVSPICLPETDSLLIGMNATVTGWGRLSEGGTL 687
Query: 286 P--LLGKSVNLYNTTNCKSL------TQFDDDKLARYFCSDNNMGSSAIFNGESGGPLIC 441
P L SV + + NCKS+ +F D + C+ G G+SGGPL
Sbjct: 688 PSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPD---IFLCAGYETGGQDSCQGDSGGPLQA 744
Query: 442 -SIDGSKVIAGVVSKSINSARAASIRLFTRVDYMLPWI 552
S DG +AG++S I A A + TR+ PWI
Sbjct: 745 KSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWI 782
>sp|Q7Z410|TMPS9_HUMAN Transmembrane protease, serine 9 (Polyserase-1) (Polyserase-I)
(Polyserine protease-1) [Contains: Serase-1; Serase-2;
Serase-3]
Length = 1059
Score = 75.1 bits (183), Expect = 1e-13
Identities = 50/153 (32%), Positives = 77/153 (50%), Gaps = 6/153 (3%)
Frame = +1
Query: 112 HPQYSAVTGDYNLALVK-TSPVAFDINVQPACLP-SKNLVPNSLDCITAGWNHKLE---T 276
HP Y+A T D+++A+++ TSP+ F ++QP CLP + ++ P S C+ +GW + E
Sbjct: 281 HPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLV 340
Query: 277 NSRPLLGKSVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPLIC-SIDG 453
L +V L + C SL + R C+ G G+SGGPL+C G
Sbjct: 341 KPEVLQKATVELLDQALCASL--YGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSG 398
Query: 454 SKVIAGVVSKSINSARAASIRLFTRVDYMLPWI 552
+AG+VS I A A ++ RV + WI
Sbjct: 399 RFFLAGIVSWGIGCAEARRPGVYARVTRLRDWI 431
Score = 73.6 bits (179), Expect = 4e-13
Identities = 54/172 (31%), Positives = 83/172 (48%), Gaps = 6/172 (3%)
Frame = +1
Query: 94 INSVFIHPQYSAVTGDYNLALVK-TSPVAFDINVQPACLP-SKNLVPNSLDCITAGWNHK 267
+ V +HP Y+ D++LA+++ SP+AF+ +QP CLP + P C+ +GW +
Sbjct: 575 LRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNT 634
Query: 268 LETNSRP--LLGK-SVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPLI 438
E N+ LL K SV + + C L F R C+ G G+SGGPL
Sbjct: 635 QEGNATKPELLQKASVGIIDQKTCSVLYNFS--LTDRMICAGFLEGKVDSCQGDSGGPLA 692
Query: 439 CS-IDGSKVIAGVVSKSINSARAASIRLFTRVDYMLPWIKLTMNNNP*QFKP 591
C G +AG+VS I A+ ++TR+ + WI M++ P P
Sbjct: 693 CEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMSSQPLPMSP 744
Score = 59.3 bits (142), Expect = 9e-09
Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 5/155 (3%)
Frame = +1
Query: 103 VFIHPQYSAVTGDYNLALVKTS-PVAFDINVQPACLPSKN-LVPNSLDCITAGWNHKLET 276
++ HP Y+ T DY++AL++ + PV V+P CLP P+ C+ GW E
Sbjct: 901 IYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREG 960
Query: 277 NS--RPLLGKSVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPLIC-SI 447
S R L +V L + C+ + +R C+ G +G++GGPL C
Sbjct: 961 GSMARQLQKAAVRLLSEQTCRRF--YPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREP 1018
Query: 448 DGSKVIAGVVSKSINSARAASIRLFTRVDYMLPWI 552
G V+ GV S R ++TRV + WI
Sbjct: 1019 SGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053
>sp|P69525|TMPS9_MOUSE Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1;
Serase-2; Serase-3]
Length = 1065
Score = 73.2 bits (178), Expect = 6e-13
Identities = 51/153 (33%), Positives = 75/153 (49%), Gaps = 6/153 (3%)
Frame = +1
Query: 112 HPQYSAVTGDYNLALVKTS-PVAFDINVQPACLPSKNLV-PNSLDCITAGWNHKLE---T 276
HP Y A T D+++A+++ + P+ F VQPACLP+ V P C+ +GW + E
Sbjct: 283 HPAYDADTADFDVAVLELARPLPFGRYVQPACLPAATHVFPPGKKCLISGWGYLKEDFLV 342
Query: 277 NSRPLLGKSVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPLICSI-DG 453
L +V L + + C SL + R C+ G G+SGGPL+C G
Sbjct: 343 KPEVLQKATVELLDQSLCSSL--YGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSG 400
Query: 454 SKVIAGVVSKSINSARAASIRLFTRVDYMLPWI 552
+AG+VS I A A ++TRV + WI
Sbjct: 401 RFFLAGIVSWGIGCAEARRPGVYTRVTRLRDWI 433
Score = 70.5 bits (171), Expect = 4e-12
Identities = 49/167 (29%), Positives = 82/167 (49%), Gaps = 6/167 (3%)
Frame = +1
Query: 94 INSVFIHPQYSAVTGDYNLALVKTS-PVAFDINVQPACLP-SKNLVPNSLDCITAGWNHK 267
+ V +HP+Y+ D+++AL++ + P+ F+ +QP CLP + + P C+ +GW +
Sbjct: 577 LRRVALHPRYNPGILDFDVALLELAQPLVFNKYIQPVCLPLAIHKFPVGRKCMISGWGNM 636
Query: 268 LETNSRP---LLGKSVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPLI 438
E N+ L SV + C +L F R C+ G G+SGGPL
Sbjct: 637 QEGNATKPDILQKASVGIIEQKMCGALYNFS--LTDRMLCAGFLEGRVDSCQGDSGGPLA 694
Query: 439 CS-IDGSKVIAGVVSKSINSARAASIRLFTRVDYMLPWIKLTMNNNP 576
C G +AG+VS I A+A ++ R+ + WI M+++P
Sbjct: 695 CEETPGVFYLAGIVSWGIGCAQAKKPGVYARITRLKDWILKAMSSDP 741
Score = 65.5 bits (158), Expect = 1e-10
Identities = 46/154 (29%), Positives = 71/154 (46%), Gaps = 4/154 (2%)
Frame = +1
Query: 103 VFIHPQYSAVTGDYNLALVKTS-PVAFDINVQPACLPSKNLVPNSLDCITAGWNHKLETN 279
++ HP Y+ T DY++AL++ + PV V+P CLP P+ C+ GW E
Sbjct: 908 IYRHPFYNIYTLDYDVALLELAGPVRRSRLVRPICLPGPARPPDGARCVITGWGSLREGG 967
Query: 280 S--RPLLGKSVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPLIC-SID 450
S R L +V + + C+ + +R C+ G +G++GGPL C
Sbjct: 968 SMARQLQKAAVRVLSEQTCRRF--YPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPS 1025
Query: 451 GSKVIAGVVSKSINSARAASIRLFTRVDYMLPWI 552
G V+ GV S R ++TRV +L WI
Sbjct: 1026 GQWVLTGVTSWGYGCGRPHFPGVYTRVAAVLGWI 1059
>sp|P69526|TMPS9_RAT Transmembrane protease, serine 9 (Polyserase-1) (Polyserine
protease-1) (Polyserase-I) [Contains: Serase-1;
Serase-2; Serase-3]
Length = 1061
Score = 73.2 bits (178), Expect = 6e-13
Identities = 52/153 (33%), Positives = 75/153 (49%), Gaps = 6/153 (3%)
Frame = +1
Query: 112 HPQYSAVTGDYNLALVKTS-PVAFDINVQPACLPSKNLV-PNSLDCITAGWNHKLE---T 276
HP Y+A T D+++A+++ + P+ F VQPACLP+ V P C+ +GW + E
Sbjct: 283 HPAYNADTADFDVAVLELARPLPFGRYVQPACLPAATHVFPPRKKCLISGWGYLKEDFLV 342
Query: 277 NSRPLLGKSVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPLICSI-DG 453
L +V L + C SL + R C+ G G+SGGPL+C G
Sbjct: 343 KPEVLQKATVELLDQNLCSSL--YGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSG 400
Query: 454 SKVIAGVVSKSINSARAASIRLFTRVDYMLPWI 552
+AGVVS I A A ++TRV + WI
Sbjct: 401 RFFLAGVVSWGIGCAEARRPGVYTRVTRLRDWI 433
Score = 72.4 bits (176), Expect = 1e-12
Identities = 50/167 (29%), Positives = 83/167 (49%), Gaps = 6/167 (3%)
Frame = +1
Query: 94 INSVFIHPQYSAVTGDYNLALVKTS-PVAFDINVQPACLP-SKNLVPNSLDCITAGWNHK 267
+ SV +HP+Y+ D+++AL++ + P+ F+ +QP CLP + + P C+ +GW +
Sbjct: 577 LRSVALHPRYNPGILDFDVALLELAQPLVFNKYIQPVCLPLAIHKFPVGRKCMISGWGNM 636
Query: 268 LETNSRP---LLGKSVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPLI 438
E N+ L SV + C +L F R C+ G G+SGGPL
Sbjct: 637 QEGNATKPDILQKASVGIIEQKMCGALYNFS--LTDRMLCAGFLEGRVDSCQGDSGGPLA 694
Query: 439 CS-IDGSKVIAGVVSKSINSARAASIRLFTRVDYMLPWIKLTMNNNP 576
C G +AG+VS I A+A ++ R+ + WI M+++P
Sbjct: 695 CEETPGVFYLAGIVSWGIGCAQAKKPGVYARITRLKDWILKAMSSDP 741
Score = 65.9 bits (159), Expect = 9e-11
Identities = 46/154 (29%), Positives = 70/154 (45%), Gaps = 4/154 (2%)
Frame = +1
Query: 103 VFIHPQYSAVTGDYNLALVKTS-PVAFDINVQPACLPSKNLVPNSLDCITAGWNHKLETN 279
++ HP Y+ T DY++AL++ + PV V+P CLP P C+ GW E
Sbjct: 904 IYRHPFYNIYTLDYDVALLELAGPVRRSRLVRPICLPGPTRPPEGARCVITGWGSLREGG 963
Query: 280 S--RPLLGKSVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPLIC-SID 450
S R L +V + + C+ + +R C+ G +G++GGPL C
Sbjct: 964 SMARQLQKAAVRVLSEQTCRRF--YPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPS 1021
Query: 451 GSKVIAGVVSKSINSARAASIRLFTRVDYMLPWI 552
G V+ GV S R ++TRV +L WI
Sbjct: 1022 GQWVLTGVTSWGYGCGRPHFPGVYTRVAAVLGWI 1055
>sp|Q9Y6M0|TEST_HUMAN Testisin precursor (Eosinophil serine protease 1) (ESP-1)
Length = 314
Score = 71.6 bits (174), Expect = 2e-12
Identities = 48/166 (28%), Positives = 75/166 (45%), Gaps = 9/166 (5%)
Frame = +1
Query: 94 INSVFIHPQYSAVTGDYNLALVKTS-PVAFDINVQPACLPSKNL-VPNSLDCITAGWNHK 267
++++++ P+Y Y++ALVK S PV + ++QP CL + N DC GW +
Sbjct: 121 VSNIYLSPRYLG-NSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYI 179
Query: 268 LETNSRP----LLGKSVNLYNTTNCKSLT---QFDDDKLARYFCSDNNMGSSAIFNGESG 426
E + P L V + N + C L F D C+ N G G+SG
Sbjct: 180 KEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSG 239
Query: 427 GPLICSIDGSKVIAGVVSKSINSARAASIRLFTRVDYMLPWIKLTM 564
GPL C+ +G GVVS + R ++T + + WI+ M
Sbjct: 240 GPLACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM 285
>sp|O18783|PLMN_MACEU Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Plasmin heavy chain A, short form; Plasmin light
chain B]
Length = 806
Score = 71.6 bits (174), Expect = 2e-12
Identities = 47/146 (32%), Positives = 73/146 (50%), Gaps = 3/146 (2%)
Frame = +1
Query: 145 NLALVKTS-PVAFDINVQPACLPSKN-LVPNSLDCITAGWNHKLETNSRPLLGK-SVNLY 315
++AL+K + P A + V PACLPS++ +VP+ C GW T+ R LL + S+ +
Sbjct: 661 DIALLKLNRPAAINDKVIPACLPSQDFMVPDRTLCHVTGWGDTQGTSPRGLLKQASLPVI 720
Query: 316 NTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPLICSIDGSKVIAGVVSKSINS 495
+ C + + C+ + +G G+SGGPLIC D V+ GV S +
Sbjct: 721 DNRVCNRHEYLNGRVKSTELCAGHLVGRGDSCQGDSGGPLICFEDDKYVLQGVTSWGLGC 780
Query: 496 ARAASIRLFTRVDYMLPWIKLTMNNN 573
AR ++ RV + WI+ M NN
Sbjct: 781 ARPNKPGVYVRVSRYISWIEDVMKNN 806
>sp|Q5U405|TMPSD_MOUSE Transmembrane protease, serine 13 (Mosaic serine protease)
(Membrane-type mosaic serine protease)
Length = 543
Score = 71.6 bits (174), Expect = 2e-12
Identities = 46/165 (27%), Positives = 77/165 (46%), Gaps = 5/165 (3%)
Frame = +1
Query: 91 NINSVFIHPQYSAVTGDYNLALVKTS-PVAFDINVQPACLPSKNLVPNSLD-CITAGWNH 264
+I+ + I+ Y+ DY++AL++ S P+ ++ PACLP + C G+
Sbjct: 372 SISQIIINGNYTDEQDDYDIALIRLSKPLTLSAHIHPACLPMHGQTFGLNETCWITGFGK 431
Query: 265 KLETNSR--PLLGK-SVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPL 435
ET+ + P L + VNL + C +D R C+ + G G+SGGPL
Sbjct: 432 TKETDEKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPL 491
Query: 436 ICSIDGSKVIAGVVSKSINSARAASIRLFTRVDYMLPWIKLTMNN 570
+C + +AGV S + ++T+V +LPWI M +
Sbjct: 492 VCEQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWIYRKMES 536
>sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 71.2 bits (173), Expect = 2e-12
Identities = 44/158 (27%), Positives = 73/158 (46%), Gaps = 3/158 (1%)
Frame = +1
Query: 88 NNINSVFIHPQYSAVTGDYNLALVKT-SPVAFDINVQPACLPSKNLVPNSL-DCITAGWN 261
+ I + IH Y G++++AL+K +P+ + +P CLPSK +C GW
Sbjct: 464 SQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWG 523
Query: 262 HKLETNSRPLLGKSVNLYNTTNCKSLTQFDDDKLA-RYFCSDNNMGSSAIFNGESGGPLI 438
E + + VN+ TN + ++ D K+ R C+ G G+SGGPL+
Sbjct: 524 FSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLV 583
Query: 439 CSIDGSKVIAGVVSKSINSARAASIRLFTRVDYMLPWI 552
C +G + G+ S AR ++T+V + WI
Sbjct: 584 CKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWI 621
>sp|P48038|ACRO_RABIT Acrosin precursor [Contains: Acrosin light chain; Acrosin heavy
chain]
Length = 431
Score = 71.2 bits (173), Expect = 2e-12
Identities = 50/168 (29%), Positives = 75/168 (44%), Gaps = 8/168 (4%)
Frame = +1
Query: 94 INSVFIHPQYSAVTGDYNLALVK-TSPVAFDINVQPACLPSKNLVPNSL--DCITAGWNH 264
+ V H QY+ +T ++AL+K T PV + P CLP+ P C AGW +
Sbjct: 123 VEKVVTHDQYNYMTEGNDIALLKITPPVPCGPFIGPGCLPNSKAGPPKAAQTCYVAGWGY 182
Query: 265 KLETNSRP---LLGKSVNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIFNGESGGPL 435
E RP L+ V+L N C S ++ A C+ G G+SGGPL
Sbjct: 183 VKENAPRPSPTLMEARVDLINLELCNSTQWYNGRITASNLCAGYPSGKIDTCQGDSGGPL 242
Query: 436 ICSIDGSK--VIAGVVSKSINSARAASIRLFTRVDYMLPWIKLTMNNN 573
+C + + V+ G+ S + ARA ++T L WI + +N
Sbjct: 243 MCRENQGEPFVVQGITSWGVGCARAKRPGIYTATWPFLDWIASRIGSN 290
>sp|Q8BIK6|TMPS7_MOUSE Transmembrane protease, serine 7 precursor
Length = 572
Score = 70.1 bits (170), Expect = 5e-12
Identities = 50/169 (29%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Frame = +1
Query: 73 NWAYTNNINSVFIHPQYSAVTGDYNLALVKTS---PVAFDINVQPACLP-SKNLVPNSLD 240
N + + + + +H Y++ T DY++AL++ S P +QP C+P + V +
Sbjct: 399 NAKFISPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPAGQKVRSGEK 458
Query: 241 CITAGWNHKLETNSR--PLLGKS-VNLYNTTNCKSLTQFDDDKLARYFCSDNNMGSSAIF 411
C GW + E +S+ P+L ++ V L + T C S +R C+ G S
Sbjct: 459 CWVTGWGRRHEADSKGSPVLQQAEVELIDQTVCVSTYGIIT---SRMLCAGVMSGKSDAC 515
Query: 412 NGESGGPLIC--SIDGSKVIAGVVSKSINSARAASIRLFTRVDYMLPWI 552
G+SGGPL C DG ++ G+VS R ++TRV +PWI
Sbjct: 516 KGDSGGPLSCRRKSDGKWILTGIVSWGHGCGRPNFPGVYTRVSSFVPWI 564
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,712,418
Number of Sequences: 369166
Number of extensions: 1366993
Number of successful extensions: 3574
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3235
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3334
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5462583840
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)