Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_J13
(795 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9N0F1|ODO2_PIG Dihydrolipoyllysine-residue succinyltran... 315 7e-86
sp|P36957|ODO2_HUMAN Dihydrolipoyllysine-residue succinyltr... 313 3e-85
sp|Q9D2G2|ODO2_MOUSE Dihydrolipoyllysine-residue succinyltr... 313 4e-85
sp|Q90512|ODO2_FUGRU Dihydrolipoyllysine-residue succinyltr... 312 8e-85
sp|Q01205|ODO2_RAT Dihydrolipoyllysine-residue succinyltran... 311 1e-84
sp|O94681|ODO2_SCHPO Probable dihydrolipoyllysine-residue s... 271 1e-72
sp|P07016|ODO2_ECOLI Dihydrolipoyllysine-residue succinyltr... 266 4e-71
sp|P19262|ODO2_YEAST Dihydrolipoyllysine-residue succinyltr... 265 1e-70
sp|Q92J43|ODO2_RICCN Dihydrolipoyllysine-residue succinyltr... 261 2e-69
sp|Q9ZDY4|ODO2_RICPR Dihydrolipoyllysine-residue succinyltr... 261 2e-69
>sp|Q9N0F1|ODO2_PIG Dihydrolipoyllysine-residue succinyltransferase component of
2-oxoglutarate dehydrogenase complex, mitochondrial
precursor (Dihydrolipoamide succinyltransferase
component of 2-oxoglutarate dehydrogenase complex) (E2)
(E2K) (E2o) (PE2o)
Length = 455
Score = 315 bits (808), Expect = 7e-86
Identities = 164/231 (70%), Positives = 190/231 (82%), Gaps = 2/231 (0%)
Frame = +1
Query: 109 EQRVKMNRMRIRIAERLKAAQNTCAMLTTFNECDMSAIINIRKKYQEAFQKKHGVKLGFM 288
E R KMNRMR RIA+RLK AQNTCAMLTTFNE DMS I ++R +++EAF KKH +KLGFM
Sbjct: 224 EHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQDMRARHKEAFLKKHNLKLGFM 283
Query: 289 SAFLKGAALALQDQPVVNAVXXXXXXXXXXXXXX--SVAVATPKGLVVPVLRDVQSMGFA 462
SAF+K +A ALQ+QPVVNAV SVAVATP+GLVVPV+R+V++M +A
Sbjct: 284 SAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVETMNYA 343
Query: 463 EIEKGIFELGERARLGQLAIEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGIHATQQ 642
+IE+ I ELGE+AR +LAIEDMDGGTFTISNGGVFGSL GTPIINPPQSAILG+HA
Sbjct: 344 DIERTISELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHAIVD 403
Query: 643 RPVAVDGKVEIRPMMYLALTYDHRLVDGREAVLFLRKIKSFIEDPCVVLLD 795
RPVAV GKVEIRPMMY+ALTYDHRL+DGREAV FLRKIK+ +EDP V+LLD
Sbjct: 404 RPVAVGGKVEIRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLD 454
>sp|P36957|ODO2_HUMAN Dihydrolipoyllysine-residue succinyltransferase component of
2-oxoglutarate dehydrogenase complex, mitochondrial
precursor (Dihydrolipoamide succinyltransferase
component of 2-oxoglutarate dehydrogenase complex) (E2)
(E2K)
Length = 453
Score = 313 bits (803), Expect = 3e-85
Identities = 162/231 (70%), Positives = 188/231 (81%), Gaps = 2/231 (0%)
Frame = +1
Query: 109 EQRVKMNRMRIRIAERLKAAQNTCAMLTTFNECDMSAIINIRKKYQEAFQKKHGVKLGFM 288
E R KMNRMR RIA+RLK AQNTCAMLTTFNE DMS I +R +++EAF KKH +KLGFM
Sbjct: 222 EHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFM 281
Query: 289 SAFLKGAALALQDQPVVNAVXXXXXXXXXXXXXX--SVAVATPKGLVVPVLRDVQSMGFA 462
SAF+K +A ALQ+QPVVNAV SVAVATP+GLVVPV+R+V++M FA
Sbjct: 282 SAFVKASAFALQEQPVVNAVIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFA 341
Query: 463 EIEKGIFELGERARLGQLAIEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGIHATQQ 642
+IE+ I ELGE+AR +LAIEDMDGGTFTISNGGVFGSL GTPIINPPQSAILG+H
Sbjct: 342 DIERTITELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFD 401
Query: 643 RPVAVDGKVEIRPMMYLALTYDHRLVDGREAVLFLRKIKSFIEDPCVVLLD 795
RPVA+ GKVE+RPMMY+ALTYDHRL+DGREAV FLRKIK+ +EDP V+LLD
Sbjct: 402 RPVAIGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLD 452
>sp|Q9D2G2|ODO2_MOUSE Dihydrolipoyllysine-residue succinyltransferase component of
2-oxoglutarate dehydrogenase complex, mitochondrial
precursor (Dihydrolipoamide succinyltransferase
component of 2-oxoglutarate dehydrogenase complex) (E2)
(E2K)
Length = 454
Score = 313 bits (801), Expect = 4e-85
Identities = 162/231 (70%), Positives = 189/231 (81%), Gaps = 2/231 (0%)
Frame = +1
Query: 109 EQRVKMNRMRIRIAERLKAAQNTCAMLTTFNECDMSAIINIRKKYQEAFQKKHGVKLGFM 288
E R KMNRMR RIA+RLK AQNTCAMLTTFNE DMS I +R ++++AF KKH +KLGFM
Sbjct: 223 EHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEVDMSNIQEMRARHKDAFLKKHNLKLGFM 282
Query: 289 SAFLKGAALALQDQPVVNAVXXXXXXXXXXXXXX--SVAVATPKGLVVPVLRDVQSMGFA 462
SAF+K +A ALQ+QPVVNAV SVAVATP+GLVVPV+R+V++M +A
Sbjct: 283 SAFVKASAFALQEQPVVNAVIDDATKEVVYRDYIDISVAVATPRGLVVPVIRNVETMNYA 342
Query: 463 EIEKGIFELGERARLGQLAIEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGIHATQQ 642
+IE+ I ELGE+AR +LAIEDMDGGTFTISNGGVFGSL GTPIINPPQSAILG+HA
Sbjct: 343 DIERTINELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHAIFD 402
Query: 643 RPVAVDGKVEIRPMMYLALTYDHRLVDGREAVLFLRKIKSFIEDPCVVLLD 795
RPVAV GKVE+RPMMY+ALTYDHRL+DGREAV FLRKIK+ +EDP V+LLD
Sbjct: 403 RPVAVGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLD 453
>sp|Q90512|ODO2_FUGRU Dihydrolipoyllysine-residue succinyltransferase component of
2-oxoglutarate dehydrogenase complex, mitochondrial
precursor (Dihydrolipoamide succinyltransferase
component of 2-oxoglutarate dehydrogenase complex) (E2)
(E2K)
Length = 409
Score = 312 bits (799), Expect = 8e-85
Identities = 163/231 (70%), Positives = 186/231 (80%), Gaps = 2/231 (0%)
Frame = +1
Query: 109 EQRVKMNRMRIRIAERLKAAQNTCAMLTTFNECDMSAIINIRKKYQEAFQKKHGVKLGFM 288
E RVKM+RMR+RIA+RLK AQNTCAMLTTFNE DMS I +R +++AF KKH +KLGFM
Sbjct: 178 ESRVKMSRMRLRIAQRLKEAQNTCAMLTTFNEVDMSNIQEMRTLHKDAFLKKHSIKLGFM 237
Query: 289 SAFLKGAALALQDQPVVNAVXXXXXXXXXXXXXX--SVAVATPKGLVVPVLRDVQSMGFA 462
SAF+K AA AL DQP VNAV SVAVATPKGLVVPV+R+V++M FA
Sbjct: 238 SAFVKAAAHALTDQPAVNAVIDGATNEIVYRDYVDISVAVATPKGLVVPVIRNVETMNFA 297
Query: 463 EIEKGIFELGERARLGQLAIEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGIHATQQ 642
+IE+ I LGE+AR +LA+EDMDGGTFTISNGGVFGSL GTPIINPPQSAILG+H Q
Sbjct: 298 DIERTINALGEKARNNELAVEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFQ 357
Query: 643 RPVAVDGKVEIRPMMYLALTYDHRLVDGREAVLFLRKIKSFIEDPCVVLLD 795
RPVAVDGK EIRPMMY+ALTYDHRLVDGREAV FLRKIK+ +EDP +LLD
Sbjct: 358 RPVAVDGKAEIRPMMYVALTYDHRLVDGREAVTFLRKIKAAVEDPRALLLD 408
>sp|Q01205|ODO2_RAT Dihydrolipoyllysine-residue succinyltransferase component of
2-oxoglutarate dehydrogenase complex, mitochondrial
precursor (Dihydrolipoamide succinyltransferase
component of 2-oxoglutarate dehydrogenase complex) (E2)
(E2K)
Length = 454
Score = 311 bits (797), Expect = 1e-84
Identities = 161/231 (69%), Positives = 188/231 (81%), Gaps = 2/231 (0%)
Frame = +1
Query: 109 EQRVKMNRMRIRIAERLKAAQNTCAMLTTFNECDMSAIINIRKKYQEAFQKKHGVKLGFM 288
E R KMNRMR RIA+RLK AQNTCAMLTTFNE DMS I +R ++++AF KKH +KLGFM
Sbjct: 223 EHREKMNRMRQRIAQRLKEAQNTCAMLTTFNEVDMSNIQEMRARHKDAFLKKHNLKLGFM 282
Query: 289 SAFLKGAALALQDQPVVNAVXXXXXXXXXXXXXX--SVAVATPKGLVVPVLRDVQSMGFA 462
SAF+K +A ALQ+QPVVNAV SVAVATP+GLVVPV+R+V++M +A
Sbjct: 283 SAFVKASAFALQEQPVVNAVIDDATKEVVYRDYIDISVAVATPRGLVVPVIRNVETMNYA 342
Query: 463 EIEKGIFELGERARLGQLAIEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGIHATQQ 642
+IE+ I ELGE+AR +LAIEDMDGGTFTISNGGVFGSL GTPIINPPQSAILG+H
Sbjct: 343 DIERTINELGEKARKNELAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFD 402
Query: 643 RPVAVDGKVEIRPMMYLALTYDHRLVDGREAVLFLRKIKSFIEDPCVVLLD 795
RPVAV GKVE+RPMMY+ALTYDHRL+DGREAV FLRKIK+ +EDP V+LLD
Sbjct: 403 RPVAVGGKVEVRPMMYVALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLD 453
>sp|O94681|ODO2_SCHPO Probable dihydrolipoyllysine-residue succinyltransferase component
of 2-oxoglutarate dehydrogenase complex, mitochondrial
precursor (E2) (Probable dihydrolipoamide
succinyltransferase component of 2-oxoglutarate
dehydrogenase complex)
Length = 452
Score = 271 bits (693), Expect = 1e-72
Identities = 138/232 (59%), Positives = 169/232 (72%), Gaps = 4/232 (1%)
Frame = +1
Query: 109 EQRVKMNRMRIRIAERLKAAQNTCAMLTTFNECDMSAIINIRKKYQEAFQKKHGVKLGFM 288
E RVKMNRMR+RIAERLK +QN A LTTFNECDMSA++ +RKKY++ K+ GVK+GFM
Sbjct: 220 EDRVKMNRMRLRIAERLKESQNRAASLTTFNECDMSAVVALRKKYKDEILKETGVKIGFM 279
Query: 289 SAFLKGAALALQDQPVVNAVXXXXXXXXXXXXXX----SVAVATPKGLVVPVLRDVQSMG 456
S F K A++ P +N S+AVATPKGLV PV+R+ +SM
Sbjct: 280 SFFSKACTQAMKQIPAINGSIEGEGKGDTLVYRDFCDLSIAVATPKGLVTPVIRNAESMS 339
Query: 457 FAEIEKGIFELGERARLGQLAIEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGIHAT 636
EIE I LG +AR G+LAIEDM GTFTISNGG+FGSL GTPIIN PQ+A+LG+HA
Sbjct: 340 LLEIESAIATLGSKARAGKLAIEDMASGTFTISNGGIFGSLYGTPIINLPQTAVLGLHAI 399
Query: 637 QQRPVAVDGKVEIRPMMYLALTYDHRLVDGREAVLFLRKIKSFIEDPCVVLL 792
++RPV ++G+V RPMMYLALTYDHR+VDGREAV FLR +K +IEDP +LL
Sbjct: 400 KERPVVINGQVVPRPMMYLALTYDHRMVDGREAVTFLRLVKEYIEDPAKMLL 451
>sp|P07016|ODO2_ECOLI Dihydrolipoyllysine-residue succinyltransferase component of
2-oxoglutarate dehydrogenase complex (E2)
(Dihydrolipoamide succinyltransferase component of
2-oxoglutarate dehydrogenase complex)
Length = 405
Score = 266 bits (681), Expect = 4e-71
Identities = 135/229 (58%), Positives = 173/229 (75%)
Frame = +1
Query: 109 EQRVKMNRMRIRIAERLKAAQNTCAMLTTFNECDMSAIINIRKKYQEAFQKKHGVKLGFM 288
E+RV M R+R R+AERL A+N+ AMLTTFNE +M I+++RK+Y EAF+K+HG++LGFM
Sbjct: 176 EKRVPMTRLRKRVAERLLEAKNSTAMLTTFNEVNMKPIMDLRKQYGEAFEKRHGIRLGFM 235
Query: 289 SAFLKGAALALQDQPVVNAVXXXXXXXXXXXXXXSVAVATPKGLVVPVLRDVQSMGFAEI 468
S ++K AL+ P VNA S+AV+TP+GLV PVLRDV ++G A+I
Sbjct: 236 SFYVKAVVEALKRYPEVNASIDGDDVVYHNYFDVSMAVSTPRGLVTPVLRDVDTLGMADI 295
Query: 469 EKGIFELGERARLGQLAIEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGIHATQQRP 648
EK I EL + R G+L +ED+ GG FTI+NGGVFGSLM TPIINPPQSAILG+HA + RP
Sbjct: 296 EKKIKELAVKGRDGKLTVEDLTGGNFTITNGGVFGSLMSTPIINPPQSAILGMHAIKDRP 355
Query: 649 VAVDGKVEIRPMMYLALTYDHRLVDGREAVLFLRKIKSFIEDPCVVLLD 795
+AV+G+VEI PMMYLAL+YDHRL+DGRE+V FL IK +EDP +LLD
Sbjct: 356 MAVNGQVEILPMMYLALSYDHRLIDGRESVGFLVTIKELLEDPTRLLLD 404
>sp|P19262|ODO2_YEAST Dihydrolipoyllysine-residue succinyltransferase component of
2-oxoglutarate dehydrogenase complex, mitochondrial
precursor (E2) (Dihydrolipoamide succinyltransferase
component of 2-oxoglutarate dehydrogenase complex)
Length = 463
Score = 265 bits (677), Expect = 1e-70
Identities = 135/228 (59%), Positives = 163/228 (71%)
Frame = +1
Query: 109 EQRVKMNRMRIRIAERLKAAQNTCAMLTTFNECDMSAIINIRKKYQEAFQKKHGVKLGFM 288
E RVKMNRMR+RIAERLK +QNT A LTTFNE DMSA++ +RK Y++ KK G K GFM
Sbjct: 235 ETRVKMNRMRLRIAERLKESQNTAASLTTFNEVDMSALMEMRKLYKDEIIKKTGTKFGFM 294
Query: 289 SAFLKGAALALQDQPVVNAVXXXXXXXXXXXXXXSVAVATPKGLVVPVLRDVQSMGFAEI 468
F K LA +D P VN SVAVATPKGLV PV+R+ +S+ +I
Sbjct: 295 GLFSKACTLAAKDIPAVNGAIEGDQIVYRDYTDISVAVATPKGLVTPVVRNAESLSVLDI 354
Query: 469 EKGIFELGERARLGQLAIEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGIHATQQRP 648
E I L +AR G+L +EDM GGTFTISNGGVFGSL GTPIIN PQ+A+LG+H ++RP
Sbjct: 355 ENEIVRLSHKARDGKLTLEDMTGGTFTISNGGVFGSLYGTPIINSPQTAVLGLHGVKERP 414
Query: 649 VAVDGKVEIRPMMYLALTYDHRLVDGREAVLFLRKIKSFIEDPCVVLL 792
V V+G++ RPMMYLALTYDHRL+DGREAV FL+ +K IEDP +LL
Sbjct: 415 VTVNGQIVSRPMMYLALTYDHRLLDGREAVTFLKTVKELIEDPRKMLL 462
>sp|Q92J43|ODO2_RICCN Dihydrolipoyllysine-residue succinyltransferase component of
2-oxoglutarate dehydrogenase complex (E2)
(Dihydrolipoamide succinyltransferase component of
2-oxoglutarate dehydrogenase complex)
Length = 395
Score = 261 bits (667), Expect = 2e-69
Identities = 132/228 (57%), Positives = 170/228 (74%)
Frame = +1
Query: 112 QRVKMNRMRIRIAERLKAAQNTCAMLTTFNECDMSAIINIRKKYQEAFQKKHGVKLGFMS 291
QRV+M+R+R IA+RLK +QNT A+LTTFNE DMS +I +R +Y+E F+KKH VKLGFMS
Sbjct: 167 QRVRMSRLRKTIAQRLKDSQNTAAILTTFNEIDMSKVIALRNQYKEEFEKKHAVKLGFMS 226
Query: 292 AFLKGAALALQDQPVVNAVXXXXXXXXXXXXXXSVAVATPKGLVVPVLRDVQSMGFAEIE 471
F+K AL+ P VNA VAV T +GLVVPV+RD MGFAE+E
Sbjct: 227 FFVKATIEALKLIPSVNAEIDGDDLVYKNYYDIGVAVGTEQGLVVPVVRDADKMGFAEVE 286
Query: 472 KGIFELGERARLGQLAIEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGIHATQQRPV 651
K I L ++AR G+L++ D+ GGTF+ISNGGV+GSL+ TPIINPPQS ILG+H T++R V
Sbjct: 287 KTIGILAKQAREGKLSMADLSGGTFSISNGGVYGSLLSTPIINPPQSGILGLHKTEERAV 346
Query: 652 AVDGKVEIRPMMYLALTYDHRLVDGREAVLFLRKIKSFIEDPCVVLLD 795
+DGK+EIRPMMY+AL+YDHR++DG+E V FL KIK IE+P +LL+
Sbjct: 347 VIDGKIEIRPMMYIALSYDHRIIDGKEGVSFLVKIKQLIENPEKLLLN 394
>sp|Q9ZDY4|ODO2_RICPR Dihydrolipoyllysine-residue succinyltransferase component of
2-oxoglutarate dehydrogenase complex (E2)
(Dihydrolipoamide succinyltransferase component of
2-oxoglutarate dehydrogenase complex)
Length = 401
Score = 261 bits (667), Expect = 2e-69
Identities = 129/228 (56%), Positives = 172/228 (75%)
Frame = +1
Query: 112 QRVKMNRMRIRIAERLKAAQNTCAMLTTFNECDMSAIINIRKKYQEAFQKKHGVKLGFMS 291
QRV+M+R+R IA+RLK +QNT A+LTTFNE DMS +I +R +Y+E F+KKH VKLGFMS
Sbjct: 173 QRVRMSRLRKTIAQRLKDSQNTAAILTTFNEIDMSKVIALRNQYKEEFEKKHTVKLGFMS 232
Query: 292 AFLKGAALALQDQPVVNAVXXXXXXXXXXXXXXSVAVATPKGLVVPVLRDVQSMGFAEIE 471
F+K AL+ P +NA VAV T +GLVVPV+RD MGFA++E
Sbjct: 233 FFVKATIEALKLIPSINAEIDGDDLLYKNYYDIGVAVGTDQGLVVPVVRDADKMGFADVE 292
Query: 472 KGIFELGERARLGQLAIEDMDGGTFTISNGGVFGSLMGTPIINPPQSAILGIHATQQRPV 651
+ I +L ++AR G+L++ D+ GGTF+ISNGGV+GSL+ TPIINPPQS ILG+H T++R V
Sbjct: 293 QAIGDLAKKAREGKLSMSDLSGGTFSISNGGVYGSLLSTPIINPPQSGILGLHKTEERAV 352
Query: 652 AVDGKVEIRPMMYLALTYDHRLVDGREAVLFLRKIKSFIEDPCVVLLD 795
+DGK+EIRPMMY+AL+YDHR++DG+E V FL KIK+ IE+P +LL+
Sbjct: 353 VIDGKIEIRPMMYIALSYDHRIIDGKEGVSFLVKIKNLIENPEKLLLN 400
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,926,937
Number of Sequences: 369166
Number of extensions: 1953187
Number of successful extensions: 5687
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5396
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5639
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7473924075
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)