Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_I15
(557 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinas... 103 2e-22
sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinas... 103 4e-22
sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 ... 99 5e-21
sp|Q03497|STE20_YEAST Serine/threonine-protein kinase STE20 99 7e-21
sp|P35465|PAK1_RAT Serine/threonine-protein kinase PAK 1 (p... 98 2e-20
sp|O88643|PAK1_MOUSE Serine/threonine-protein kinase PAK 1 ... 97 3e-20
sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (S... 97 4e-20
sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p... 97 4e-20
sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24 97 4e-20
sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 ... 97 4e-20
>sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 (Arabidospsis
NPK1-related protein kinase 1)
Length = 666
Score = 103 bits (258), Expect = 2e-22
Identities = 73/185 (39%), Positives = 100/185 (54%), Gaps = 1/185 (0%)
Frame = +1
Query: 1 LDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANW 180
L++LH+ I+HRD+KG IL+DN IKL F ++K + ++ T A+S GT W
Sbjct: 185 LEYLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTG----AKSMKGTPYW 240
Query: 181 TAPEVINGEGYGSSADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQKKIEFAYPLK 357
APEVI G+ SADIWS G ++E++TGKAP AI+ +GT K
Sbjct: 241 MAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTL 300
Query: 358 CSDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSAMEAD*FT*RVDIFSWIN*NNTYMLP 537
SDA K F+ CL P RPT +L+KH F+ + T D+ S +N N + LP
Sbjct: 301 SSDA-KDFLLKCLQEVPNLRPTASELLKHPFVMGKHKESAST---DLGSVLN-NLSTPLP 355
Query: 538 K*INN 552
INN
Sbjct: 356 LQINN 360
>sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 (Arabidospsis
NPK1-related protein kinase 2)
Length = 651
Score = 103 bits (256), Expect = 4e-22
Identities = 61/152 (40%), Positives = 85/152 (55%), Gaps = 1/152 (0%)
Frame = +1
Query: 1 LDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANW 180
L++LH+ I+HRD+KG IL+DN IKL F ++K + ++ + A+S GT W
Sbjct: 184 LEYLHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISG----AKSMKGTPYW 239
Query: 181 TAPEVINGEGYGSSADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQKKIEFAYPLK 357
APEVI G+ SADIWS G ++E++TGKAP AI+ +GT K P
Sbjct: 240 MAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKS-HPPIPDN 298
Query: 358 CSDALKSFVDPCLDPEPLNRPTVKDLMKHEFL 453
S F+ CL EP RPT +L+KH F+
Sbjct: 299 ISSDANDFLLKCLQQEPNLRPTASELLKHPFV 330
>sp|Q13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P65-PAK) (Alpha-PAK)
Length = 545
Score = 99.4 bits (246), Expect = 5e-21
Identities = 54/155 (34%), Positives = 83/155 (53%), Gaps = 1/155 (0%)
Frame = +1
Query: 1 LDFLHSQNILHRDLKGPKILLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTAN 177
L+FLHS ++HRD+K ILL + +KL F A++ P+ S + + GT
Sbjct: 377 LEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPY 429
Query: 178 WTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLK 357
W APEV+ + YG DIWS G + +E+I G+ P +A+Y + T E P K
Sbjct: 430 WMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEK 489
Query: 358 CSDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSA 462
S + F++ CLD + R + K+L++H+FL A
Sbjct: 490 LSAIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIA 524
>sp|Q03497|STE20_YEAST Serine/threonine-protein kinase STE20
Length = 939
Score = 99.0 bits (245), Expect = 7e-21
Identities = 55/158 (34%), Positives = 82/158 (51%)
Frame = +1
Query: 1 LDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANW 180
L+FLHS+ +LHRD+K ILL DIKL F + N + GT W
Sbjct: 727 LEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINEL------NLKRTTMVGTPYW 780
Query: 181 TAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKC 360
APEV++ + YG DIWS G +++E+I G+ P +A+Y + T + P
Sbjct: 781 MAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENL 840
Query: 361 SDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSAMEAD 474
S +LK F+D CL EP +R + +L+ E++ EA+
Sbjct: 841 SSSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEAN 878
>sp|P35465|PAK1_RAT Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2)
Length = 544
Score = 97.8 bits (242), Expect = 2e-20
Identities = 53/155 (34%), Positives = 83/155 (53%), Gaps = 1/155 (0%)
Frame = +1
Query: 1 LDFLHSQNILHRDLKGPKILLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTAN 177
L+FLHS ++HRD+K ILL + +KL F A++ P+ S + + GT
Sbjct: 376 LEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPY 428
Query: 178 WTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLK 357
W APEV+ + YG DIWS G + +E+I G+ P +A+Y + T E P K
Sbjct: 429 WMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEK 488
Query: 358 CSDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSA 462
S + F++ CL+ + R + K+L++H+FL A
Sbjct: 489 LSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIA 523
>sp|O88643|PAK1_MOUSE Serine/threonine-protein kinase PAK 1 (p21-activated kinase 1)
(PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase
PAK-A)
Length = 545
Score = 97.1 bits (240), Expect = 3e-20
Identities = 53/155 (34%), Positives = 82/155 (52%), Gaps = 1/155 (0%)
Frame = +1
Query: 1 LDFLHSQNILHRDLKGPKILLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTAN 177
L+FLHS ++HRD+K ILL + +KL F A++ P+ S + + GT
Sbjct: 377 LEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPY 429
Query: 178 WTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLK 357
W APEV+ + YG DIWS G + +E+I G+ P +A+Y + T E P K
Sbjct: 430 WMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEK 489
Query: 358 CSDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSA 462
S + F+ CL+ + R + K+L++H+FL A
Sbjct: 490 LSAIFRDFLQCCLEMDVEKRGSAKELLQHQFLKIA 524
>sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3)
(Mammalian STE20-like protein kinase 3)
Length = 443
Score = 96.7 bits (239), Expect = 4e-20
Identities = 58/153 (37%), Positives = 80/153 (52%), Gaps = 2/153 (1%)
Frame = +1
Query: 1 LDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANW 180
LD+LHS+ +HRD+K +LL + ++KL F A D + RN GT W
Sbjct: 144 LDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK--RNTFV----GTPFW 197
Query: 181 TAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRL--GTQKKIEFAYPL 354
APEVI Y S ADIWS G +EL G+ P L + ++ + +E Y
Sbjct: 198 MAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNY-- 255
Query: 355 KCSDALKSFVDPCLDPEPLNRPTVKDLMKHEFL 453
S LK FV+ CL+ EP RPT K+L+KH+F+
Sbjct: 256 --SKPLKEFVEACLNKEPSFRPTAKELLKHKFI 286
>sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (p65-PAK)
Length = 544
Score = 96.7 bits (239), Expect = 4e-20
Identities = 52/155 (33%), Positives = 82/155 (52%), Gaps = 1/155 (0%)
Frame = +1
Query: 1 LDFLHSQNILHRDLKGPKILLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTAN 177
LDFLHS ++HRD+K ILL + +KL F A++ P+ S + + GT
Sbjct: 375 LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPY 427
Query: 178 WTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLK 357
W APEV+ + YG DIWS G + +E++ G+ P +A+Y + T E P +
Sbjct: 428 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPER 487
Query: 358 CSDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSA 462
S + F++ CL+ + R + K+L++H FL A
Sbjct: 488 LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLA 522
>sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24
Length = 431
Score = 96.7 bits (239), Expect = 4e-20
Identities = 58/153 (37%), Positives = 80/153 (52%), Gaps = 2/153 (1%)
Frame = +1
Query: 1 LDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANW 180
LD+LHS+ +HRD+K +LL + ++KL F A D + RN GT W
Sbjct: 132 LDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK--RNTFV----GTPFW 185
Query: 181 TAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRL--GTQKKIEFAYPL 354
APEVI Y S ADIWS G +EL G+ P L + ++ + +E Y
Sbjct: 186 MAPEVIKQSAYDSKADIWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLEGNY-- 243
Query: 355 KCSDALKSFVDPCLDPEPLNRPTVKDLMKHEFL 453
S LK FV+ CL+ EP RPT K+L+KH+F+
Sbjct: 244 --SKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (Oligophrenin-3)
sp|Q7YQL3|PAK3_PONPY Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3)
sp|Q7YQL4|PAK3_PANTR Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3)
Length = 559
Score = 96.7 bits (239), Expect = 4e-20
Identities = 52/155 (33%), Positives = 82/155 (52%), Gaps = 1/155 (0%)
Frame = +1
Query: 1 LDFLHSQNILHRDLKGPKILLDNNLDIKLCGF-MSAKMFPDASSETFRNHVAESNHGTAN 177
LDFLHS ++HRD+K ILL + +KL F A++ P+ S + + GT
Sbjct: 390 LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS-------TMVGTPY 442
Query: 178 WTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLK 357
W APEV+ + YG DIWS G + +E++ G+ P +A+Y + T E P +
Sbjct: 443 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPER 502
Query: 358 CSDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSA 462
S + F++ CL+ + R + K+L++H FL A
Sbjct: 503 LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLA 537
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,353,981
Number of Sequences: 369166
Number of extensions: 1365454
Number of successful extensions: 6609
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4993
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5229
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3980545740
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)