Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_H16
(821 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ES88|S13A2_MOUSE Solute carrier family 13 member 2 (Re... 168 2e-41
sp|Q13183|S13A2_HUMAN Solute carrier family 13 member 2 (Re... 165 1e-40
sp|Q9Z0Z5|S13A3_RAT Solute carrier family 13 member 3 (Sodi... 160 4e-39
sp|Q28615|S13A2_RABIT Solute carrier family 13 member 2 (Re... 159 1e-38
sp|Q91Y63|S13A3_MOUSE Solute carrier family 13 member 3 (So... 159 1e-38
sp|Q8WWT9|S13A3_HUMAN Solute carrier family 13 member 3 (So... 158 1e-38
sp|Q9JHI4|S13A1_MOUSE Solute carrier family 13 member 1 (Re... 157 4e-38
sp|Q21339|NAD3_CAEEL Sodium-dependent high-affinity dicarbo... 155 1e-37
sp|P70545|S13A2_RAT Solute carrier family 13 member 2 (Inte... 155 1e-37
sp|Q93655|NAD1_CAEEL Sodium-dependent low-affinity dicarbox... 146 8e-35
>sp|Q9ES88|S13A2_MOUSE Solute carrier family 13 member 2 (Renal sodium/dicarboxylate
cotransporter) (Na(+)/dicarboxylate cotransporter 1)
(NaDC-1)
Length = 586
Score = 168 bits (425), Expect = 2e-41
Identities = 91/251 (36%), Positives = 137/251 (54%), Gaps = 7/251 (2%)
Frame = +2
Query: 89 KSMQCGYIIAIVAIFWVTEAMHIAVTSLIPIVLFPAFGILKPGVVAACYMKDITLMIIGG 268
K C Y I ++A+ W TEA+ +AVT+L PI+LFP GI++ V Y KD ++ +GG
Sbjct: 34 KEAYCAYSIILMALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLEYFKDTNILFVGG 93
Query: 269 LIIAKTIEHQNLHRRMALHLLKFMGPNPVFQYLGFMISTWVLSMWISNTATTTMMVTLAN 448
L++A +EH NLH+R+AL +L +G P LGFM+ T LSMWISNTATT MM+ +
Sbjct: 94 LMVAIAVEHWNLHKRIALGVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMLPIGY 153
Query: 449 SVIDQWQYVKKXXXXXXXXXXXQXXXXXXXXXXXXXXXXXXQA------AKENKRIHDVG 610
+V++Q Q +K + + A++ K H
Sbjct: 154 AVLEQLQGSQKDVEEGNSNPSFELQEASPQKEETKLDNGQAVSVSSEPRAQKTKEHHRFS 213
Query: 611 KGLLISIAYSASVGGIATMSGTPPNLVFYGILQDRYKQTLG-LNYGTFMLFGLPLSIICF 787
+GL + I YSAS+GGIAT++GT PNLV G + + + +N+ ++ F P +I
Sbjct: 214 QGLSLCICYSASIGGIATLTGTTPNLVLQGQVNSIFPENSNVVNFASWFGFAFPTMVILL 273
Query: 788 IILWLTLTINF 820
++ WL L + F
Sbjct: 274 LLAWLWLQVLF 284
>sp|Q13183|S13A2_HUMAN Solute carrier family 13 member 2 (Renal sodium/dicarboxylate
cotransporter) (Na(+)/dicarboxylate cotransporter 1)
(NaDC-1)
Length = 592
Score = 165 bits (418), Expect = 1e-40
Identities = 96/257 (37%), Positives = 137/257 (53%), Gaps = 12/257 (4%)
Frame = +2
Query: 86 NKSMQCGYIIAIVAIFWVTEAMHIAVTSLIPIVLFPAFGILKPGVVAACYMKDITLMIIG 265
+K C Y I ++A+FW TEA+ +AVT+L P++LFP GI+ VA Y+KD L+ G
Sbjct: 33 SKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFG 92
Query: 266 GLIIAKTIEHQNLHRRMALHLLKFMGPNPVFQYLGFMISTWVLSMWISNTATTTMMVTLA 445
GL++A +EH NLH+R+AL +L +G P LGFM+ T LSMWISNTAT+ MMV +A
Sbjct: 93 GLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIA 152
Query: 446 NSVIDQWQYVKKXXXXXXXXXXXQXXXXXXXXXXXXXXXXXXQA-----AKENKRIHDVG 610
++V+DQ + QA A R H
Sbjct: 153 HAVLDQLHSSQASSNVEEGSNNPTFELQEPSPQKEVTKLDNGQALPVTSASSEGRAHLSQ 212
Query: 611 KGLLIS------IAYSASVGGIATMSGTPPNLVFYGILQDRYKQTLG-LNYGTFMLFGLP 769
K L ++ + YSAS+GGIAT++GT PNLV G + + Q +N+ ++ F P
Sbjct: 213 KHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFP 272
Query: 770 LSIICFIILWLTLTINF 820
+I ++ WL L I F
Sbjct: 273 TMVILLLLAWLWLQILF 289
>sp|Q9Z0Z5|S13A3_RAT Solute carrier family 13 member 3 (Sodium-dependent high-affinity
dicarboxylate transporter 2) (Na(+)/dicarboxylate
cotransporter 3) (NaDC-3) (rNaDC3)
Length = 600
Score = 160 bits (405), Expect = 4e-39
Identities = 88/260 (33%), Positives = 141/260 (54%), Gaps = 19/260 (7%)
Frame = +2
Query: 89 KSMQCGYIIAIVAIFWVTEAMHIAVTSLIPIVLFPAFGILKPGVVAACYMKDITLMIIGG 268
K +C Y+I ++A++W TEA+ ++VT+L+PI+LFP GIL V Y D + + G
Sbjct: 37 KEGRCLYVILLMAVYWCTEALPLSVTALLPIILFPFMGILPSSKVCPQYFLDTNFLFLSG 96
Query: 269 LIIAKTIEHQNLHRRMALHLLKFMGPNPVFQYLGFMISTWVLSMWISNTATTTMMVTLAN 448
LI+A IE +NLHRR+AL +L +G P LG M++T LSMW+SNTA+T MM+ +A+
Sbjct: 97 LIMASAIEERNLHRRIALKVLMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIAS 156
Query: 449 SVI-------DQWQYVKKXXXXXXXXXXXQXXXXXXXXXXXXXXXXXXQA---------- 577
+++ D + + + A
Sbjct: 157 AILKSLFGQRDTRKDLpreGEDSTAAVRGNGLRTVPTEMQFLASSEGGHAEDVEAPLELP 216
Query: 578 --AKENKRIHDVGKGLLISIAYSASVGGIATMSGTPPNLVFYGILQDRYKQTLGLNYGTF 751
+KE + ++ KG LISI YSAS+GG AT++GT PNL+ G L+ + Q +N+G++
Sbjct: 217 DDSKEEEHRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSW 276
Query: 752 MLFGLPLSIICFIILWLTLT 811
+F PL ++ ++ WL ++
Sbjct: 277 FIFAFPLMLLFLLVGWLWIS 296
>sp|Q28615|S13A2_RABIT Solute carrier family 13 member 2 (Renal sodium/dicarboxylate
cotransporter) (Na(+)/dicarboxylate cotransporter 1)
(NaDC-1)
Length = 593
Score = 159 bits (401), Expect = 1e-38
Identities = 87/257 (33%), Positives = 135/257 (52%), Gaps = 13/257 (5%)
Frame = +2
Query: 89 KSMQCGYIIAIVAIFWVTEAMHIAVTSLIPIVLFPAFGILKPGVVAACYMKDITLMIIGG 268
K C Y I ++A+FW T+A+ +AVT+L+P+ LFP GI++ V Y+KD ++ IGG
Sbjct: 34 KEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLEYLKDTNVLFIGG 93
Query: 269 LIIAKTIEHQNLHRRMALHLLKFMGPNPVFQYLGFMISTWVLSMWISNTATTTMMVTLAN 448
L++A +EH NLH+R+AL +L G P LGFM+ T LSMWISNTA+T MMV +A+
Sbjct: 94 LLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIAH 153
Query: 449 SVIDQWQYVKKXXXXXXXXXXXQXXXXXXXXXXXXXXXXXXQAAKENKRIH--------- 601
+V+ + + + A+ +
Sbjct: 154 AVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLESGEHMTQ 213
Query: 602 ---DVGKGLLISIAYSASVGGIATMSGTPPNLVFYGILQDRYKQTLG-LNYGTFMLFGLP 769
+G+ + + YSAS+GGIAT++GT PNLV G + + Q +N+ ++ F P
Sbjct: 214 EQLRFSQGMSLCVCYSASIGGIATLTGTTPNLVLQGQMTSLFPQNPNVVNFASWFGFAFP 273
Query: 770 LSIICFIILWLTLTINF 820
+ +I ++ WL L I F
Sbjct: 274 IMVILLLLSWLWLQILF 290
>sp|Q91Y63|S13A3_MOUSE Solute carrier family 13 member 3 (Sodium-dependent high-affinity
dicarboxylate transporter 2) (Na(+)/dicarboxylate
cotransporter 3) (NaDC-3) (mNaDC3)
Length = 600
Score = 159 bits (401), Expect = 1e-38
Identities = 87/260 (33%), Positives = 138/260 (53%), Gaps = 19/260 (7%)
Frame = +2
Query: 89 KSMQCGYIIAIVAIFWVTEAMHIAVTSLIPIVLFPAFGILKPGVVAACYMKDITLMIIGG 268
K +C Y+I ++A++W TEA+ ++VT+L+PI+LFP GIL V Y D + + G
Sbjct: 37 KEGRCLYVILLMAVYWCTEALPLSVTALLPIILFPFMGILPSSKVCPQYFLDTNFLFLSG 96
Query: 269 LIIAKTIEHQNLHRRMALHLLKFMGPNPVFQYLGFMISTWVLSMWISNTATTTMMVTLAN 448
LI+A IE NLHRR+AL +L +G P LG M++T LSMW+SNTA+T MM+ +A+
Sbjct: 97 LIMASAIEEWNLHRRIALKVLMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIAS 156
Query: 449 SVIDQWQYVKKXXXXXXXXXXXQXXXXXXXXXXXXXXXXXXQAA---------------- 580
+++ ++ A+
Sbjct: 157 AILKSLFGQREARKDLpreGDESTAAVQGNGLRTVPTEMQFLASSEGGHTEDAEAPMELP 216
Query: 581 ---KENKRIHDVGKGLLISIAYSASVGGIATMSGTPPNLVFYGILQDRYKQTLGLNYGTF 751
KE + ++ KG LISI YSAS+GG AT++GT PNL+ G L+ + Q +N+G++
Sbjct: 217 DDSKEEEHRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSW 276
Query: 752 MLFGLPLSIICFIILWLTLT 811
+F PL ++ ++ WL ++
Sbjct: 277 FIFAFPLMLLFLLVGWLWIS 296
>sp|Q8WWT9|S13A3_HUMAN Solute carrier family 13 member 3 (Sodium-dependent high-affinity
dicarboxylate transporter 2) (Na(+)/dicarboxylate
cotransporter 3) (NaDC-3) (hNaDC3)
Length = 602
Score = 158 bits (400), Expect = 1e-38
Identities = 89/262 (33%), Positives = 138/262 (52%), Gaps = 21/262 (8%)
Frame = +2
Query: 89 KSMQCGYIIAIVAIFWVTEAMHIAVTSLIPIVLFPAFGILKPGVVAACYMKDITLMIIGG 268
K +C ++I ++A++W TEA+ ++VT+L+PIVLFP GIL V Y D + + G
Sbjct: 37 KEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSG 96
Query: 269 LIIAKTIEHQNLHRRMALHLLKFMGPNPVFQYLGFMISTWVLSMWISNTATTTMMVTLAN 448
LI+A IE NLHRR+AL +L +G P LG M++T LSMW+SNTA+T MM+ +AN
Sbjct: 97 LIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIAN 156
Query: 449 SVIDQWQYVKKXXXXXXXXXXXQXXXXXXXXXXXXXXXXXXQAA---------------- 580
+++ K+ A+
Sbjct: 157 AILKSLFGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGETEVPLDL 216
Query: 581 -----KENKRIHDVGKGLLISIAYSASVGGIATMSGTPPNLVFYGILQDRYKQTLGLNYG 745
KE++ ++ KG LISI YSAS+GG AT++GT PNL+ G L+ + Q +N+G
Sbjct: 217 PADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFG 276
Query: 746 TFMLFGLPLSIICFIILWLTLT 811
++ +F PL ++ + WL ++
Sbjct: 277 SWFIFAFPLMLLFLLAGWLWIS 298
>sp|Q9JHI4|S13A1_MOUSE Solute carrier family 13 member 1 (Renal sodium/sulfate
cotransporter) (Na(+)/sulfate cotransporter) (NaSi-1)
Length = 594
Score = 157 bits (396), Expect = 4e-38
Identities = 85/271 (31%), Positives = 141/271 (52%), Gaps = 31/271 (11%)
Frame = +2
Query: 89 KSMQCGYIIAIVAIFWVTEAMHIAVTSLIPIVLFPAFGILKPGVVAACYMKDITLMIIGG 268
K QC YI+ ++AIFW+TEA+ +++T+L+P ++FP FGI++ VA+ Y KD L++IG
Sbjct: 33 KEAQCAYILFVIAIFWITEALPLSITALLPGLMFPMFGIMRSSQVASAYFKDFHLLLIGV 92
Query: 269 LIIAKTIEHQNLHRRMALHLLKFMGPNPVFQYLGFMISTWVLSMWISNTATTTMMVTLAN 448
+ +A +IE NLH+R+AL ++ +G NP + LGFM ST LSMW+SNT+T M++ +
Sbjct: 93 ICLATSIEKWNLHKRIALRMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIVE 152
Query: 449 SVIDQWQYVKKXXXXXXXXXXXQXXXXXXXXXXXXXXXXXXQAAKENK----RIHDVGKG 616
+V Q + + + ++ K HD GK
Sbjct: 153 AVAQQIISAEAEAEATQMTYFNESAAHGLDIDETVIGQETNEKKEKTKPAPGSSHDKGKV 212
Query: 617 ---------------------------LLISIAYSASVGGIATMSGTPPNLVFYGILQDR 715
+ +S+AYS+++GG+ T++GT NL+F R
Sbjct: 213 SRKMETEKNAVTGAKYRSRKDHMMCKLMCLSVAYSSTIGGLTTITGTSTNLIFSEHFNTR 272
Query: 716 YKQTLGLNYGTFMLFGLPLSIICFIILWLTL 808
Y LN+G++ LF P+++I ++ W+ L
Sbjct: 273 YPDCRCLNFGSWFLFSFPVALILLLLSWIWL 303
>sp|Q21339|NAD3_CAEEL Sodium-dependent high-affinity dicarboxylate transporter 3
(Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (ceNaDC3)
Length = 566
Score = 155 bits (393), Expect = 1e-37
Identities = 85/242 (35%), Positives = 128/242 (52%), Gaps = 1/242 (0%)
Frame = +2
Query: 98 QCGYIIAIVAIFWVTEAMHIAVTSLIPIVLFPAFGILKPGVVAACYMKDITLMIIGGLII 277
+C Y + I+A++W++E M +AVT+++P+VLFP G+L A YM D + IGGLI+
Sbjct: 76 KCAYCVCIIAVYWMSEVMPLAVTAMLPVVLFPLVGVLDANTTAKEYMNDTNFLFIGGLIM 135
Query: 278 AKTIEHQNLHRRMALHLLKFMGPNPVFQYLGFMISTWVLSMWISNTATTTMMVTLANSVI 457
A +E +LH R+AL +L+ +G P + LGFM T +LS +ISNTATT MMV + SV+
Sbjct: 136 AAAVEKCDLHERVALSVLRCVGSEPKWIMLGFMTVTALLSSFISNTATTAMMVPIGQSVV 195
Query: 458 DQWQYVKKXXXXXXXXXXXQXXXXXXXXXXXXXXXXXXQAAKENKRIHDVGKGLLISIAY 637
Q + + GL++SI +
Sbjct: 196 QQ--------------------------LISSFQHHPTNGERGRLGCKKMATGLVLSICF 229
Query: 638 SASVGGIATMSGTPPNLVFYGILQDRYKQTLG-LNYGTFMLFGLPLSIICFIILWLTLTI 814
+A++GG T +GTP NLV G L + + G LNY T++ F PL ++C + W+TL
Sbjct: 230 AANIGGTGTATGTPSNLVMLGQLSALFPKVDGSLNYVTWIFFAYPLMLLCLFVAWMTLVS 289
Query: 815 NF 820
F
Sbjct: 290 FF 291
>sp|P70545|S13A2_RAT Solute carrier family 13 member 2 (Intestinal sodium/dicarboxylate
cotransporter) (Na(+)/dicarboxylate cotransporter 1)
(NaDC-1)
Length = 587
Score = 155 bits (393), Expect = 1e-37
Identities = 91/251 (36%), Positives = 129/251 (51%), Gaps = 7/251 (2%)
Frame = +2
Query: 89 KSMQCGYIIAIVAIFWVTEAMHIAVTSLIPIVLFPAFGILKPGVVAACYMKDITLMIIGG 268
K C Y I ++A+ W TEA+ +AVT L PIVLF GI+ Y KD ++ +GG
Sbjct: 34 KEAYCAYSIILMALLWCTEALPLAVTVLFPIVLFLLMGIMDASEGLE-YFKDTNILFVGG 92
Query: 269 LIIAKTIEHQNLHRRMALHLLKFMGPNPVFQYLGFMISTWVLSMWISNTATTTMMVTLAN 448
L++A +EH NLH+R+AL +L +G LGFM+ T LSMWISNTATT MMV + +
Sbjct: 93 LMVAIAVEHWNLHKRIALQVLLIIGVRAALLLLGFMLVTAFLSMWISNTATTAMMVPIGH 152
Query: 449 SVIDQWQYVKKXXXXXXXXXXXQXXXXXXXXXXXXXXXXXXQAAKENKRI------HDVG 610
+V++Q Q KK + +A R H
Sbjct: 153 AVLEQLQASKKDVEGGNNNPTFELQEECPQKEVTKLDNGQPVSAPSEPRTQKTQEHHRFS 212
Query: 611 KGLLISIAYSASVGGIATMSGTPPNLVFYGILQDRYKQTLG-LNYGTFMLFGLPLSIICF 787
+GL + I YSAS+GGI ++GT PNLV G + + Q +N+ ++ F P II
Sbjct: 213 QGLSLCICYSASIGGIDNLTGTTPNLVLQGQVNSLFPQNANVVNFASWFGFAFPTMIILL 272
Query: 788 IILWLTLTINF 820
++ WL L + F
Sbjct: 273 LLAWLWLQVLF 283
>sp|Q93655|NAD1_CAEEL Sodium-dependent low-affinity dicarboxylate transporter 1
(Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (ceNaDC1)
Length = 582
Score = 146 bits (368), Expect = 8e-35
Identities = 82/246 (33%), Positives = 130/246 (52%), Gaps = 9/246 (3%)
Frame = +2
Query: 98 QCGYIIAIVAIFWVTEAMHIAVTSLIPIVLFPAFGILKPGVVAACYMKDITLMIIGGLII 277
+C Y +A++ +WV EA+ +A+T+ IP++LFP FGI++ VA Y+ D + +GGL++
Sbjct: 43 KCLYCVAVMGSYWVFEALPLAITAFIPMILFPLFGIMRSEEVARAYLPDTCFLFMGGLMV 102
Query: 278 AKTIEHQNLHRRMALHLLKFMGPNPVFQYLGFMISTWVLSMWISNTATTTMMVTLANSVI 457
A +E LH R+AL +LK +G P GFM T LSMWISNTATT +MV + SVI
Sbjct: 103 ALAVEKCELHARVALFVLKTVGSEPARVMAGFMGVTGFLSMWISNTATTALMVPILQSVI 162
Query: 458 DQW--QYVKKXXXXXXXXXXXQXXXXXXXXXXXXXXXXXXQAAKE------NKRIHDVGK 613
+ + + + +E + R + K
Sbjct: 163 TELVSNHRMEDLVALCEAHHNSSRKHSVGMRRLSLPNENNEIKREEMDTAMSpreQKMAK 222
Query: 614 GLLISIAYSASVGGIATMSGTPPNLVFYGILQDRYK-QTLGLNYGTFMLFGLPLSIICFI 790
GL++S+ +SA++GG AT++GT NLV G L + + G+N+ ++++F P+ C I
Sbjct: 223 GLMLSVCFSANIGGAATITGTASNLVLVGQLNELFPGADTGVNFLSWLIFAFPMVFCCLI 282
Query: 791 ILWLTL 808
W L
Sbjct: 283 YCWCVL 288
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,528,958
Number of Sequences: 369166
Number of extensions: 1621435
Number of successful extensions: 4294
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4104
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4279
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7907893860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)